Trametinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.159812
FN1 fibronectin 1 0.151451
CFB complement factor B 0.135605
LRMDA leucine rich melanocyte differentiation associated 0.12658
TF transferrin 0.110759
APOB apolipoprotein B 0.0894774
DSPP dentin sialophosphoprotein 0.0767982
LMCD1 LIM and cysteine-rich domains 1 0.0690485
EEF2 eukaryotic translation elongation factor 2 0.0679665
MYH9 myosin, heavy chain 9, non-muscle 0.0471515
RPL3 ribosomal protein L3 0.0450176
SAMD4A sterile alpha motif domain containing 4A 0.043705
FGA fibrinogen alpha chain 0.0433273
ZMIZ1 zinc finger, MIZ-type containing 1 0.0392162
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0391366
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0385566
SMAD3 SMAD family member 3 0.0375802
MBNL3 muscleblind-like splicing regulator 3 0.0373532
EFNA1 ephrin-A1 0.0368772
GPC3 glypican 3 0.0359921
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0357074
ECE1 endothelin converting enzyme 1 0.0356579
VCL vinculin 0.0350552
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0340534
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0327587
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0324405
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0322339
RNF213 ring finger protein 213 0.0318463
ORM1 orosomucoid 1 0.0314064
FLNB filamin B, beta 0.0299163
RPS27A ribosomal protein S27a 0.0292438
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0282379
ZBTB20 zinc finger and BTB domain containing 20 0.0280719
SMYD3 SET and MYND domain containing 3 0.0276674
RAD51B RAD51 paralog B 0.0257384
UBC ubiquitin C 0.0256482
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0254803
JAK1 Janus kinase 1 0.0249162
PEG10 paternally expressed 10 0.0244639
ALPK2 alpha-kinase 2 0.0243907
RPS12 ribosomal protein S12 0.0241034
VIL1 villin 1 0.0235739
GSE1 Gse1 coiled-coil protein 0.0235727
FGG fibrinogen gamma chain 0.023278
A2M alpha-2-macroglobulin 0.0232702
PDLIM5 PDZ and LIM domain 5 0.0231658
TMEM51 transmembrane protein 51 0.0231528
CALD1 caldesmon 1 0.022891
CMIP c-Maf inducing protein 0.02265
WDPCP WD repeat containing planar cell polarity effector 0.022407
CLEC16A C-type lectin domain family 16, member A 0.0223524
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0216243
JUN jun proto-oncogene 0.0209308
MRTFA myocardin related transcription factor A 0.0207136
PTPRK protein tyrosine phosphatase, receptor type, K 0.0207007
NPNT nephronectin 0.0201639
TGFBI transforming growth factor, beta-induced, 68kDa 0.0198528
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0197422
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0196937
ENKUR enkurin, TRPC channel interacting protein 0.0193377
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0189888
CTNND1 catenin (cadherin-associated protein), delta 1 0.0187774
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0187369
RPL37A ribosomal protein L37a 0.0187338
INHBE inhibin, beta E 0.0186285
MSI2 musashi RNA-binding protein 2 0.0185783
SDC2 syndecan 2 0.0184472
AFDN afadin, adherens junction formation factor 0.0183972
VEGFA vascular endothelial growth factor A 0.0179929
DNAH17 dynein, axonemal, heavy chain 17 0.0179137
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.0177947
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0177711
KRT8 keratin 8, type II 0.0171985
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0171795
FGB fibrinogen beta chain 0.017147
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.0170632
CALR calreticulin 0.0170525
SDC4 syndecan 4 0.0170071
FBXO17 F-box protein 17 0.0169509
FABP1 fatty acid binding protein 1, liver 0.0168579
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0167979
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.016767
HDLBP high density lipoprotein binding protein 0.0167504
RPS17 ribosomal protein S17 0.016709
EIF4B eukaryotic translation initiation factor 4B 0.0166893
TNS1 tensin 1 0.0166768
PTPRF protein tyrosine phosphatase, receptor type, F 0.016633
TNS3 tensin 3 0.016594
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0165683
FLNA filamin A, alpha 0.0165086
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.0164142
RPL23 ribosomal protein L23 0.0163099
NFE2L1 nuclear factor, erythroid 2-like 1 0.0162827
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0161292
TBC1D22A TBC1 domain family, member 22A 0.0159947
CEP250 centrosomal protein 250kDa 0.0159151
IGF2 insulin-like growth factor 2 0.0158813
TPM1 tropomyosin 1 (alpha) 0.0157978
FAM107B family with sequence similarity 107, member B 0.0157419
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0156542

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.40528
ERRFI1 ERBB receptor feedback inhibitor 1 -0.143345
SLC38A2 solute carrier family 38, member 2 -0.13609
AKAP12 A kinase (PRKA) anchor protein 12 -0.0915049
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0850852
FBF1 Fas (TNFRSF6) binding factor 1 -0.0835608
MAML2 mastermind-like 2 (Drosophila) -0.0825388
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0822826
EHBP1 EH domain binding protein 1 -0.0801011
GMDS GDP-mannose 4,6-dehydratase -0.0769474
FNDC3B fibronectin type III domain containing 3B -0.0737444
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0648591
ELL2 elongation factor, RNA polymerase II, 2 -0.0618937
TIMP1 TIMP metallopeptidase inhibitor 1 -0.060895
FRMD5 FERM domain containing 5 -0.0562159
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0554552
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0553795
TM4SF1 transmembrane 4 L six family member 1 -0.0548588
CCL20 chemokine (C-C motif) ligand 20 -0.0515049
MT2A metallothionein 2A -0.0498428
HMGA1 high mobility group AT-hook 1 -0.0491339
RPLP0 ribosomal protein, large, P0 -0.0490162
FMNL2 formin-like 2 -0.0480155
RPS6 ribosomal protein S6 -0.046298
TPT1 tumor protein, translationally-controlled 1 -0.0454566
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0443609
APOA2 apolipoprotein A-II -0.0443192
EML4 echinoderm microtubule associated protein like 4 -0.0422604
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0410838
TMEM123 transmembrane protein 123 -0.0407413
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0406709
AHSG alpha-2-HS-glycoprotein -0.0392864
SESTD1 SEC14 and spectrin domains 1 -0.0383061
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0375711
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0368954
PDIA3 protein disulfide isomerase family A, member 3 -0.0355691
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0348588
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342228
FAM135A family with sequence similarity 135, member A -0.032995
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0325179
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0322679
PTBP3 polypyrimidine tract binding protein 3 -0.0321807
MALT1 MALT1 paracaspase -0.0315966
MARCKS myristoylated alanine-rich protein kinase C substrate -0.030853
GOLGA4 golgin A4 -0.0303727
MBNL2 muscleblind-like splicing regulator 2 -0.0301764
TRIO trio Rho guanine nucleotide exchange factor -0.0298526
SLC38A1 solute carrier family 38, member 1 -0.0293704
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0291285
INSIG2 insulin induced gene 2 -0.0283877
TOP1 topoisomerase (DNA) I -0.0281575
STAU1 staufen double-stranded RNA binding protein 1 -0.0280072
ASPH aspartate beta-hydroxylase -0.0276864
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0271382
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0271087
PERP PERP, TP53 apoptosis effector -0.0267424
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0267104
PARD3 par-3 family cell polarity regulator -0.0263186
ZMYND8 zinc finger, MYND-type containing 8 -0.0262763
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0261067
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0259423
RAI14 retinoic acid induced 14 -0.0257665
GLS2 glutaminase 2 (liver, mitochondrial) -0.0257463
LYZ lysozyme -0.0255724
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0254465
ARHGAP12 Rho GTPase activating protein 12 -0.0249424
WDFY2 WD repeat and FYVE domain containing 2 -0.0249335
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.024679
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0244578
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0244297
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0243079
H1-0 H1.0 linker histone -0.024041
EXT1 exostosin glycosyltransferase 1 -0.0239037
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0238208
USP34 ubiquitin specific peptidase 34 -0.0233922
WDR45B WD repeat domain 45B -0.0232389
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0223003
RPL35A ribosomal protein L35a -0.0222519
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0220631
RDX radixin -0.0220509
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0213977
SEC31A SEC31 homolog A (S. cerevisiae) -0.0212315
RBM25 RNA binding motif protein 25 -0.0211909
DENND4A DENN/MADD domain containing 4A -0.0210327
LMAN1 lectin, mannose-binding, 1 -0.0209968
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0209566
FNDC3A fibronectin type III domain containing 3A -0.0206304
RPL27A ribosomal protein L27a -0.0203145
PLIN2 perilipin 2 -0.0200987
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.02005
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0196102
EGR1 early growth response 1 -0.0195313
FTL ferritin, light polypeptide -0.0194837
EPAS1 endothelial PAS domain protein 1 -0.019455
UBA6 ubiquitin-like modifier activating enzyme 6 -0.019443
DOCK4 dedicator of cytokinesis 4 -0.0193969
ADAM9 ADAM metallopeptidase domain 9 -0.0192978
ARL5B ADP-ribosylation factor-like 5B -0.0192089
NPAS2 neuronal PAS domain protein 2 -0.0191203
OSBPL10 oxysterol binding protein-like 10 -0.0188797