| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0441892 |
| PLEC | plectin | 0.0334471 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0333135 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0293128 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0284892 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.027429 |
| KRT6A | keratin 6A, type II | 0.0273175 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0272065 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0268342 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0266211 |
| IFI44L | interferon-induced protein 44-like | 0.02354 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0234193 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0220397 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0215879 |
| EGFR | epidermal growth factor receptor | 0.0215733 |
| PLAT | plasminogen activator, tissue | 0.0209971 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0202996 |
| MXRA5 | matrix-remodelling associated 5 | 0.0199096 |
| ITGB8 | integrin, beta 8 | 0.0193497 |
| FLNA | filamin A, alpha | 0.0175568 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0172529 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0164365 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0164189 |
| RPL3 | ribosomal protein L3 | 0.0161668 |
| TGM2 | transglutaminase 2 | 0.0160969 |
| PLA2R1 | phospholipase A2 receptor 1, 180kDa | 0.0160195 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0151206 |
| SLC45A4 | solute carrier family 45, member 4 | 0.0147732 |
| SMAD3 | SMAD family member 3 | 0.0147413 |
| EHF | ets homologous factor | 0.0144947 |
| FLG | filaggrin | 0.0141036 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0139387 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0138075 |
| GBP4 | guanylate binding protein 4 | 0.0136526 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0134984 |
| IFI44 | interferon-induced protein 44 | 0.0132523 |
| MX1 | MX dynamin-like GTPase 1 | 0.0129702 |
| KIF16B | kinesin family member 16B | 0.0128882 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0128616 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0125395 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0125074 |
| RNF152 | ring finger protein 152 | 0.0120715 |
| FAT2 | FAT atypical cadherin 2 | 0.0120148 |
| SEPTIN9 | septin 9 | 0.0119766 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.011922 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0118637 |
| PRELID2 | PRELI domain containing 2 | 0.0116509 |
| PLPP1 | phospholipid phosphatase 1 | 0.0116193 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.011466 |
| GUCY1A1 | guanylate cyclase 1 soluble subunit alpha 1 | 0.0113807 |
| C1D | C1D nuclear receptor corepressor | 0.0112942 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0112775 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0110354 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0109912 |
| LAMA5 | laminin, alpha 5 | 0.0109735 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0108551 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0108273 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.010821 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0108202 |
| LIMK2 | LIM domain kinase 2 | 0.0107624 |
| APOL1 | apolipoprotein L, 1 | 0.010724 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.0107108 |
| PPL | periplakin | 0.0106506 |
| JPH2 | junctophilin 2 | 0.0105629 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0104407 |
| AOPEP | aminopeptidase O (putative) | 0.0102833 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0101876 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.00978637 |
| AUTS2 | autism susceptibility candidate 2 | 0.00978435 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0097757 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.00977394 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00953837 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.00953796 |
| APOL2 | apolipoprotein L, 2 | 0.00953039 |
| TRIM22 | tripartite motif containing 22 | 0.00942547 |
| CFB | complement factor B | 0.00940211 |
| ADAR | adenosine deaminase, RNA-specific | 0.00927464 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.00919157 |
| TAPBP | TAP binding protein (tapasin) | 0.00889481 |
| APOL6 | apolipoprotein L, 6 | 0.00882598 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.008755 |
| SGMS1 | sphingomyelin synthase 1 | 0.00867854 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0085539 |
| THBS1 | thrombospondin 1 | 0.00843823 |
| PLXNB2 | plexin B2 | 0.00840125 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00835618 |
| GLYAT | glycine-N-acyltransferase | 0.00835551 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.00829434 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.00823525 |
| MYO18A | myosin XVIIIA | 0.00816759 |
| MX2 | MX dynamin-like GTPase 2 | 0.0081467 |
| CEP250 | centrosomal protein 250kDa | 0.00811348 |
| DAND5 | DAN domain family member 5, BMP antagonist | 0.00806054 |
| CLDN1 | claudin 1 | 0.00805032 |
| DAPK1 | death-associated protein kinase 1 | 0.00801481 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.00791754 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.00791655 |
| PLCE1 | phospholipase C, epsilon 1 | 0.00789479 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.00787665 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00780771 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.308757 |
| FLNB | filamin B, beta | -0.153815 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.133738 |
| NDRG1 | N-myc downstream regulated 1 | -0.114274 |
| STC1 | stanniocalcin 1 | -0.113704 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.10767 |
| TMSB10 | thymosin beta 10 | -0.0964055 |
| ITGA6 | integrin, alpha 6 | -0.0951027 |
| PTMA | prothymosin, alpha | -0.085669 |
| CD44 | CD44 molecule (Indian blood group) | -0.0829715 |
| MTSS1 | metastasis suppressor 1 | -0.081217 |
| EMP1 | epithelial membrane protein 1 | -0.0796193 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0788945 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0753508 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0743608 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0723826 |
| RPS6 | ribosomal protein S6 | -0.07044 |
| S100A10 | S100 calcium binding protein A10 | -0.0687828 |
| RPS21 | ribosomal protein S21 | -0.0665774 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0655228 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.065229 |
| ANXA2 | annexin A2 | -0.0620465 |
| ENO1 | enolase 1, (alpha) | -0.0599794 |
| MT2A | metallothionein 2A | -0.0596332 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0595986 |
| TMSB4X | thymosin beta 4, X-linked | -0.058342 |
| RPS8 | ribosomal protein S8 | -0.0558758 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0557497 |
| RAI14 | retinoic acid induced 14 | -0.0537425 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0537154 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0536689 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0529298 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0515041 |
| GNAS | GNAS complex locus | -0.0513404 |
| ASPH | aspartate beta-hydroxylase | -0.0500573 |
| RPLP1 | ribosomal protein, large, P1 | -0.0496617 |
| GOLGA4 | golgin A4 | -0.0494817 |
| B2M | beta-2-microglobulin | -0.0484295 |
| RPLP2 | ribosomal protein, large, P2 | -0.0483724 |
| LDHA | lactate dehydrogenase A | -0.0475222 |
| MYO10 | myosin X | -0.0466127 |
| PGK1 | phosphoglycerate kinase 1 | -0.0457209 |
| LMNA | lamin A/C | -0.0456836 |
| RBM39 | RNA binding motif protein 39 | -0.0456584 |
| DUSP6 | dual specificity phosphatase 6 | -0.044999 |
| RPL11 | ribosomal protein L11 | -0.0437981 |
| PODXL | podocalyxin-like | -0.0428015 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0418012 |
| RPS24 | ribosomal protein S24 | -0.0412965 |
| POTEF | POTE ankyrin domain family, member F | -0.0412791 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0411189 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0410362 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0409245 |
| CANX | calnexin | -0.0405976 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0392892 |
| RPS13 | ribosomal protein S13 | -0.0392363 |
| SPAG9 | sperm associated antigen 9 | -0.0390654 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0386427 |
| MEF2A | myocyte enhancer factor 2A | -0.038069 |
| SQLE | squalene epoxidase | -0.0380294 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0378292 |
| RPL35A | ribosomal protein L35a | -0.0371279 |
| IGF2 | insulin-like growth factor 2 | -0.0366974 |
| CDK6 | cyclin-dependent kinase 6 | -0.0366145 |
| HM13 | histocompatibility (minor) 13 | -0.0363076 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0360463 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0359994 |
| S100A6 | S100 calcium binding protein A6 | -0.0359548 |
| HMGA2 | high mobility group AT-hook 2 | -0.0358205 |
| RPL34 | ribosomal protein L34 | -0.0357884 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0356263 |
| MORF4L2 | mortality factor 4 like 2 | -0.035593 |
| CALU | calumenin | -0.0355165 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0352331 |
| RPS19 | ribosomal protein S19 | -0.0350746 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0350574 |
| RPL12 | ribosomal protein L12 | -0.0349704 |
| TOP1 | topoisomerase (DNA) I | -0.0349553 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0348628 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0341706 |
| FOXP1 | forkhead box P1 | -0.0331549 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0330102 |
| YBX3 | Y box binding protein 3 | -0.0329387 |
| RPS25 | ribosomal protein S25 | -0.0324998 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0324155 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.032415 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0321064 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0320568 |
| RASAL2 | RAS protein activator like 2 | -0.0315253 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0314844 |
| RPL8 | ribosomal protein L8 | -0.0314601 |
| FOSL1 | FOS-like antigen 1 | -0.0313405 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0313329 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0312958 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0311994 |
| RPLP0 | ribosomal protein, large, P0 | -0.031045 |
| PLS3 | plastin 3 | -0.0310319 |
| HLA-B | major histocompatibility complex, class I, B | -0.0310271 |
| RPS3 | ribosomal protein S3 | -0.0309731 |
| RPL27A | ribosomal protein L27a | -0.0309661 |
