| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.188615 |
| MUC13 | mucin 13, cell surface associated | 0.116289 |
| MYO1E | myosin IE | 0.0850397 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0689483 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0672048 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0668344 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0644311 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0571254 |
| FOXP1 | forkhead box P1 | 0.0552368 |
| SHROOM3 | shroom family member 3 | 0.0549576 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 0.0518116 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0506396 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0484673 |
| DSPP | dentin sialophosphoprotein | 0.0481005 |
| PTEN | phosphatase and tensin homolog | 0.0450456 |
| VEGFA | vascular endothelial growth factor A | 0.0445872 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0418101 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0416686 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0406826 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0389864 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0386277 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0386088 |
| PRELID2 | PRELI domain containing 2 | 0.0383004 |
| RPL3 | ribosomal protein L3 | 0.0379521 |
| POF1B | premature ovarian failure, 1B | 0.037499 |
| USP54 | ubiquitin specific peptidase 54 | 0.0342383 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0339566 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0338137 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0336051 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0331111 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.032358 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0316197 |
| ATP10B | ATPase, class V, type 10B | 0.0314303 |
| PDZD8 | PDZ domain containing 8 | 0.0308707 |
| NRXN3 | neurexin 3 | 0.0297997 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0296769 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0295587 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0290327 |
| VCL | vinculin | 0.0278918 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0277934 |
| MUC17 | mucin 17, cell surface associated | 0.0269238 |
| DUSP16 | dual specificity phosphatase 16 | 0.0266534 |
| INSIG1 | insulin induced gene 1 | 0.0264914 |
| ADD3 | adducin 3 (gamma) | 0.0258593 |
| ACTG1 | actin gamma 1 | 0.0256322 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0255014 |
| RNF213 | ring finger protein 213 | 0.0254092 |
| PALLD | palladin, cytoskeletal associated protein | 0.0253832 |
| ATXN1 | ataxin 1 | 0.0253255 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.0252007 |
| ANXA11 | annexin A11 | 0.0251341 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.0248948 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0247708 |
| MECOM | MDS1 and EVI1 complex locus | 0.024469 |
| RAD51B | RAD51 paralog B | 0.0242938 |
| STK38L | serine/threonine kinase 38 like | 0.0242316 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0240839 |
| MYO5B | myosin VB | 0.023906 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0230931 |
| TMEM45B | transmembrane protein 45B | 0.0230118 |
| ZNF91 | zinc finger protein 91 | 0.0229098 |
| ETV6 | ets variant 6 | 0.022562 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0223942 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.02227 |
| CLOCK | clock circadian regulator | 0.0220686 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0218576 |
| TMPRSS2 | transmembrane protease, serine 2 | 0.0216565 |
| DNM2 | dynamin 2 | 0.0215956 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0215602 |
| TSPAN8 | tetraspanin 8 | 0.021427 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0213067 |
| FHL2 | four and a half LIM domains 2 | 0.0211758 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0209789 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0206077 |
| TNS3 | tensin 3 | 0.0205397 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0190847 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0188598 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0187978 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0187656 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.0187132 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0187032 |
| CDK19 | cyclin-dependent kinase 19 | 0.0186727 |
| PRSS23 | protease, serine, 23 | 0.0186442 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0186379 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0186157 |
| JUN | jun proto-oncogene | 0.0184994 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0184939 |
| DENND4C | DENN/MADD domain containing 4C | 0.0181846 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0181738 |
| MYO1D | myosin ID | 0.0180752 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0177317 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0177064 |
| LRATD1 | LRAT domain containing 1 | 0.0176734 |
| CLIC5 | chloride intracellular channel 5 | 0.0176494 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0174578 |
| PLXNB2 | plexin B2 | 0.0174254 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0173432 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0171963 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0171572 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0170591 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.23482 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.231282 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.139351 |
| ANXA2 | annexin A2 | -0.13015 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.121214 |
| TNS4 | tensin 4 | -0.100326 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0876199 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0777218 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0745363 |
| ASPH | aspartate beta-hydroxylase | -0.0735117 |
| ONECUT3 | one cut homeobox 3 | -0.0718224 |
| GOLGA4 | golgin A4 | -0.0670067 |
| FLNB | filamin B, beta | -0.0660186 |
| PTMA | prothymosin, alpha | -0.0623672 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0616645 |
| H1-0 | H1.0 linker histone | -0.0582461 |
| CADPS | Ca++-dependent secretion activator | -0.0575337 |
| CANX | calnexin | -0.0572588 |
| KIF5B | kinesin family member 5B | -0.0568285 |
| FAT1 | FAT atypical cadherin 1 | -0.0527235 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.05237 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0518669 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0483782 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0470151 |
| KRT18 | keratin 18, type I | -0.0468156 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0467139 |
| MED13L | mediator complex subunit 13-like | -0.0461506 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0454105 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.044051 |
| LMO7 | LIM domain 7 | -0.0431932 |
| AGR2 | anterior gradient 2 | -0.0421001 |
| FERMT1 | fermitin family member 1 | -0.0419237 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0417262 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0416699 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0409206 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0406414 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0393514 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0389547 |
| GPHN | gephyrin | -0.0385426 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0377105 |
| TOP1 | topoisomerase (DNA) I | -0.0375697 |
| TPM4 | tropomyosin 4 | -0.037491 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.037064 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0369512 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0368111 |
| GDF15 | growth differentiation factor 15 | -0.0367487 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.036732 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0362773 |
| RBM39 | RNA binding motif protein 39 | -0.0361412 |
| EHBP1 | EH domain binding protein 1 | -0.0355274 |
| TMSB10 | thymosin beta 10 | -0.0354917 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0353327 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0351751 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0350685 |
| NFIA | nuclear factor I/A | -0.0350292 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.034952 |
| FOXO1 | forkhead box O1 | -0.0344183 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0341022 |
| RPS6 | ribosomal protein S6 | -0.0338357 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0338213 |
| CCND1 | cyclin D1 | -0.0338087 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0338079 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0336511 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0335008 |
| PGK1 | phosphoglycerate kinase 1 | -0.0334589 |
| RNF145 | ring finger protein 145 | -0.0333106 |
| ARF1 | ADP-ribosylation factor 1 | -0.0318099 |
| RPLP1 | ribosomal protein, large, P1 | -0.0317241 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.031449 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.03133 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0308358 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0308197 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0307827 |
| WDR45B | WD repeat domain 45B | -0.0306615 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0305064 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0303601 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0300947 |
| RRBP1 | ribosome binding protein 1 | -0.0289618 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0287807 |
| S100P | S100 calcium binding protein P | -0.0285474 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0285181 |
| PKM | pyruvate kinase, muscle | -0.0285016 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0279893 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0276912 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0276142 |
| FNDC3B | fibronectin type III domain containing 3B | -0.027588 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0275313 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0272967 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0272279 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0272009 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0270627 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0270032 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0269269 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0268083 |
| SETD5 | SET domain containing 5 | -0.0268082 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0267763 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0267487 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0266954 |
| RREB1 | ras responsive element binding protein 1 | -0.0266318 |
| OGA | O-GlcNAcase | -0.0265666 |
