| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.147504 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.145508 |
| COL5A2 | collagen, type V, alpha 2 | 0.143675 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.125508 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0976712 |
| DST | dystonin | 0.0974053 |
| TP63 | tumor protein p63 | 0.0968549 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0952247 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0762456 |
| EGFR | epidermal growth factor receptor | 0.0755933 |
| LDHA | lactate dehydrogenase A | 0.0725606 |
| CFB | complement factor B | 0.0710692 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.066655 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0634804 |
| DPYD | dihydropyrimidine dehydrogenase | 0.061759 |
| RNF213 | ring finger protein 213 | 0.0611695 |
| EPHA4 | EPH receptor A4 | 0.057259 |
| AHNAK | AHNAK nucleoprotein | 0.057208 |
| ANXA1 | annexin A1 | 0.0569188 |
| PGK1 | phosphoglycerate kinase 1 | 0.0541038 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.053041 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0525641 |
| MYOF | myoferlin | 0.05246 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0494382 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0488685 |
| ADAR | adenosine deaminase, RNA-specific | 0.0485616 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.047854 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0443452 |
| PLK2 | polo-like kinase 2 | 0.0437788 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.043772 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0435079 |
| TMEM123 | transmembrane protein 123 | 0.043136 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0427788 |
| ENO1 | enolase 1, (alpha) | 0.0426607 |
| TNS3 | tensin 3 | 0.0415197 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0410259 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0407135 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.040687 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0402918 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0402235 |
| VIM | vimentin | 0.0392607 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0390158 |
| PHF21A | PHD finger protein 21A | 0.0387156 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0383958 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0382809 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0375674 |
| SFTPA2 | surfactant protein A2 | 0.0364543 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0350662 |
| CD109 | CD109 molecule | 0.0349979 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0346399 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0345928 |
| YEATS2 | YEATS domain containing 2 | 0.0345917 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0341277 |
| SQSTM1 | sequestosome 1 | 0.034126 |
| HDLBP | high density lipoprotein binding protein | 0.034109 |
| CANX | calnexin | 0.0339965 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0335034 |
| CUL4B | cullin 4B | 0.0333045 |
| MB21D2 | Mab-21 domain containing 2 | 0.0328542 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0328368 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0308597 |
| CALR | calreticulin | 0.0302638 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0301796 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0300304 |
| RUNX1 | runt-related transcription factor 1 | 0.0298596 |
| CLIC4 | chloride intracellular channel 4 | 0.0297309 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0296717 |
| ARRDC3 | arrestin domain containing 3 | 0.0294303 |
| RIGI | RNA sensor RIG-I | 0.0293818 |
| BPTF | bromodomain PHD finger transcription factor | 0.0291654 |
| ANKRD50 | ankyrin repeat domain 50 | 0.0289996 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0289365 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.028473 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0281877 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0278186 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.027305 |
| LOC112694756 | uncharaterized LOC112694756 | 0.027291 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0269726 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.026568 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0265295 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0264797 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0262201 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.026014 |
| CEP350 | centrosomal protein 350kDa | 0.0259757 |
| B2M | beta-2-microglobulin | 0.0258379 |
| FAM13A | family with sequence similarity 13, member A | 0.0254699 |
| TXNRD1 | thioredoxin reductase 1 | 0.0253473 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0253417 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0251841 |
| TRERF1 | transcriptional regulating factor 1 | 0.0242725 |
| DENND5B | DENN/MADD domain containing 5B | 0.0236122 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0231202 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0230842 |
| SPAG9 | sperm associated antigen 9 | 0.0230081 |
| SSH2 | slingshot protein phosphatase 2 | 0.0229487 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0229087 |
| RAD51B | RAD51 paralog B | 0.0227261 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0225514 |
| TRIM56 | tripartite motif containing 56 | 0.022439 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0224251 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CAPRIN2 | caprin family member 2 | -0.113104 |
| TMSB10 | thymosin beta 10 | -0.0939312 |
| MT2A | metallothionein 2A | -0.0863771 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0846773 |
| PTMA | prothymosin, alpha | -0.0837459 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0800728 |
| PDE10A | phosphodiesterase 10A | -0.0664364 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0640642 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0632803 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0619978 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0619142 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0602134 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0588195 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0584068 |
| EGR1 | early growth response 1 | -0.0582126 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0579215 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0562011 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0561467 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0518682 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0515411 |
| CADM2 | cell adhesion molecule 2 | -0.0504453 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0492387 |
| RPL35A | ribosomal protein L35a | -0.0478228 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0476805 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0445171 |
| FMNL2 | formin-like 2 | -0.0440533 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0439986 |
| CD44 | CD44 molecule (Indian blood group) | -0.0415002 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.041281 |
| RPS6 | ribosomal protein S6 | -0.041258 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0409953 |
| HMGA1 | high mobility group AT-hook 1 | -0.0408371 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0383995 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0377947 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0373481 |
| NAV2 | neuron navigator 2 | -0.0371176 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.03672 |
| PTK2 | protein tyrosine kinase 2 | -0.0364023 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0359738 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0357995 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0357488 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0356956 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0355733 |
| TOP1 | topoisomerase (DNA) I | -0.0355047 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0349033 |
| PYGL | phosphorylase, glycogen, liver | -0.0348802 |
| FOSL1 | FOS-like antigen 1 | -0.0343294 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0341606 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0337707 |
| RPS19 | ribosomal protein S19 | -0.0335463 |
| CMIP | c-Maf inducing protein | -0.0334454 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0333606 |
| RTTN | rotatin | -0.0331828 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.032804 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0316999 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0316896 |
| TGM2 | transglutaminase 2 | -0.0316273 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0305245 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0304744 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0304688 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0301928 |
| NHSL1 | NHS-like 1 | -0.0300939 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0299062 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0296484 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0289254 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0288596 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0287868 |
| RPS8 | ribosomal protein S8 | -0.0276241 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0274668 |
| ETV5 | ets variant 5 | -0.027006 |
| EFNA5 | ephrin-A5 | -0.0266355 |
| RPL37A | ribosomal protein L37a | -0.0264506 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0252621 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.025078 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0250441 |
| DENND1A | DENN/MADD domain containing 1A | -0.0247621 |
| MCL1 | myeloid cell leukemia 1 | -0.024746 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0247237 |
| UPP1 | uridine phosphorylase 1 | -0.0244567 |
| SNX14 | sorting nexin 14 | -0.024424 |
| RPL36 | ribosomal protein L36 | -0.0238257 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0237767 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0236808 |
| FLNB | filamin B, beta | -0.0233271 |
| CDK6 | cyclin-dependent kinase 6 | -0.0232101 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.0230917 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.02303 |
| RPL26 | ribosomal protein L26 | -0.022539 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0224814 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0223782 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0223351 |
| STK17A | serine/threonine kinase 17a | -0.0222257 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0221584 |
| INTS6 | integrator complex subunit 6 | -0.0221219 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0220737 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0218974 |
| ZNF217 | zinc finger protein 217 | -0.0218203 |
| RPLP1 | ribosomal protein, large, P1 | -0.0217446 |
| RPL28 | ribosomal protein L28 | -0.0215191 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0214613 |
