| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.220797 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.192578 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.1276 |
| RNF213 | ring finger protein 213 | 0.110224 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.10116 |
| LMO7 | LIM domain 7 | 0.0990317 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0937273 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0907275 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0765203 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0764967 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0758792 |
| MYOF | myoferlin | 0.0719148 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.069997 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0685401 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.066996 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0663727 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0638809 |
| DSPP | dentin sialophosphoprotein | 0.053308 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0493494 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0468144 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0450606 |
| B2M | beta-2-microglobulin | 0.0449325 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0433332 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0423352 |
| CST3 | cystatin C | 0.0410279 |
| KRT7 | keratin 7, type II | 0.0383623 |
| NTN4 | netrin 4 | 0.0373347 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.036577 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0359852 |
| CAV2 | caveolin 2 | 0.0356753 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0346039 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0344592 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0342022 |
| TJP1 | tight junction protein 1 | 0.0332858 |
| LDHA | lactate dehydrogenase A | 0.0331442 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0329817 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0324437 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0321233 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0319313 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0317589 |
| OSMR | oncostatin M receptor | 0.0300628 |
| MGAT4C | MGAT4 family, member C | 0.029711 |
| CP | ceruloplasmin (ferroxidase) | 0.0287244 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0284241 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0283748 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0283242 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0276196 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0273414 |
| RAB10 | RAB10, member RAS oncogene family | 0.0272529 |
| PRDX1 | peroxiredoxin 1 | 0.027026 |
| MYO1B | myosin IB | 0.0270166 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0265126 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0262617 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0261186 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0256091 |
| PTEN | phosphatase and tensin homolog | 0.0255639 |
| KIAA0319 | KIAA0319 | 0.0254002 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0253883 |
| KRT80 | keratin 80, type II | 0.0250767 |
| CPE | carboxypeptidase E | 0.0249166 |
| ALPK1 | alpha-kinase 1 | 0.0248786 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0247959 |
| TMSB10 | thymosin beta 10 | 0.0247807 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.024778 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0246693 |
| JAK1 | Janus kinase 1 | 0.0246268 |
| TES | testin LIM domain protein | 0.0243469 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0242065 |
| MACC1 | metastasis associated in colon cancer 1 | 0.02368 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0234491 |
| TAOK3 | TAO kinase 3 | 0.0233969 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0231164 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0230893 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0229928 |
| STC2 | stanniocalcin 2 | 0.0229204 |
| DSCAM | Down syndrome cell adhesion molecule | 0.022596 |
| AHR | aryl hydrocarbon receptor | 0.0225548 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.022338 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0220715 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0220064 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0218444 |
| RBM47 | RNA binding motif protein 47 | 0.0207776 |
| PDE8A | phosphodiesterase 8A | 0.0204638 |
| DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides | 0.0202043 |
| RPL3 | ribosomal protein L3 | 0.0200521 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0197331 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0194676 |
| JUP | junction plakoglobin | 0.0194408 |
| POTEF | POTE ankyrin domain family, member F | 0.019365 |
| RHOV | ras homolog family member V | 0.0190804 |
| ACTG1 | actin gamma 1 | 0.0190292 |
| NEBL | nebulette | 0.0185013 |
| ARRDC3 | arrestin domain containing 3 | 0.0184697 |
| CTSL | cathepsin L | 0.0182109 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0181754 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0181497 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0179288 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0179058 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.01759 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 0.0175898 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.127945 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.126184 |
| MT2A | metallothionein 2A | -0.119189 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.117146 |
| EGFR | epidermal growth factor receptor | -0.114315 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.109174 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.100298 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0981451 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0920377 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0890183 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0871124 |
| MCL1 | myeloid cell leukemia 1 | -0.0853833 |
| TOP1 | topoisomerase (DNA) I | -0.0816799 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0782151 |
| SLTM | SAFB-like, transcription modulator | -0.0766386 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0755871 |
| LAMC2 | laminin, gamma 2 | -0.0731014 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.071708 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0691984 |
| NABP1 | nucleic acid binding protein 1 | -0.0659449 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0653616 |
| INTS6 | integrator complex subunit 6 | -0.0622012 |
| RPLP1 | ribosomal protein, large, P1 | -0.0579931 |
| STC1 | stanniocalcin 1 | -0.0504679 |
| SMAD3 | SMAD family member 3 | -0.0486453 |
| RUNX1 | runt-related transcription factor 1 | -0.0478688 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0464422 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0464124 |
| PTMA | prothymosin, alpha | -0.0459619 |
| CANX | calnexin | -0.0456959 |
| H1-0 | H1.0 linker histone | -0.0448963 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.044637 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0446032 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0438385 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0431678 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0420593 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0412785 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0403956 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.039812 |
| CDCP1 | CUB domain containing protein 1 | -0.0397055 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0383748 |
| USP34 | ubiquitin specific peptidase 34 | -0.0378149 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0375952 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0367689 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0362515 |
| RPLP0 | ribosomal protein, large, P0 | -0.0361852 |
| MORF4L2 | mortality factor 4 like 2 | -0.0350087 |
| EFNA5 | ephrin-A5 | -0.0349965 |
| UVRAG | UV radiation resistance associated | -0.0349569 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0345124 |
| RPS24 | ribosomal protein S24 | -0.0341455 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0338075 |
| RPS8 | ribosomal protein S8 | -0.0334725 |
| RPL35A | ribosomal protein L35a | -0.0334424 |
| GPATCH2L | G patch domain containing 2-like | -0.0329073 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0327823 |
| SMYD3 | SET and MYND domain containing 3 | -0.032493 |
| ASPH | aspartate beta-hydroxylase | -0.0323809 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0320212 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0318675 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0317327 |
| RPS6 | ribosomal protein S6 | -0.0315984 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0312713 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0312116 |
| JMJD1C | jumonji domain containing 1C | -0.0311409 |
| EGR1 | early growth response 1 | -0.031058 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0308448 |
| IER3 | immediate early response 3 | -0.0307116 |
| CD163L1 | CD163 molecule-like 1 | -0.0300864 |
| RPS25 | ribosomal protein S25 | -0.030034 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0296026 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0293358 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0293195 |
| NF1 | neurofibromin 1 | -0.0293012 |
| ATG7 | autophagy related 7 | -0.0287937 |
| RPS3 | ribosomal protein S3 | -0.0286412 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0285568 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0284181 |
| HOMER1 | homer scaffolding protein 1 | -0.0283646 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0278465 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0277355 |
| ATP13A3 | ATPase type 13A3 | -0.027436 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0273685 |
| ENSA | endosulfine alpha | -0.0272891 |
| FBXO11 | F-box protein 11 | -0.0271335 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0269576 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0269377 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0268307 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0262174 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0261132 |
| RASA2 | RAS p21 protein activator 2 | -0.026051 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0259603 |
| RPL34 | ribosomal protein L34 | -0.0257201 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0255132 |
| CCNL1 | cyclin L1 | -0.0255052 |
| AHNAK | AHNAK nucleoprotein | -0.0254325 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0252891 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.025238 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0251368 |
| SQSTM1 | sequestosome 1 | -0.0249975 |
