| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0913305 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0747879 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0464522 |
| FBN1 | fibrillin 1 | 0.0337538 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0337474 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0313221 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0305982 |
| FAM20C | family with sequence similarity 20, member C | 0.0304679 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0292718 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0277503 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0273579 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0267187 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0263308 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0259835 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0227226 |
| DCLK2 | doublecortin-like kinase 2 | 0.0220083 |
| HDAC9 | histone deacetylase 9 | 0.0216121 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0210489 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0205072 |
| LOXL2 | lysyl oxidase-like 2 | 0.0195597 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0194499 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0191613 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0184162 |
| RPL3 | ribosomal protein L3 | 0.0179452 |
| RNF213 | ring finger protein 213 | 0.0178904 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0175574 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0173493 |
| ANGPTL4 | angiopoietin-like 4 | 0.0170637 |
| B2M | beta-2-microglobulin | 0.0170134 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0169743 |
| CEP250 | centrosomal protein 250kDa | 0.0169182 |
| ADD3 | adducin 3 (gamma) | 0.0168013 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0167692 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0166944 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0166778 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0164983 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0162614 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0154561 |
| IFI44L | interferon-induced protein 44-like | 0.0152711 |
| MYOF | myoferlin | 0.0150837 |
| MX1 | MX dynamin-like GTPase 1 | 0.0149783 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0148087 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.014697 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.0144926 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0141588 |
| DIO2 | deiodinase, iodothyronine, type II | 0.013894 |
| CFB | complement factor B | 0.0138897 |
| PFKP | phosphofructokinase, platelet | 0.0137007 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.0135941 |
| FLNA | filamin A, alpha | 0.013453 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0133654 |
| FAM219A | family with sequence similarity 219, member A | 0.0130364 |
| VEGFA | vascular endothelial growth factor A | 0.0128451 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0126697 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0126575 |
| PLK2 | polo-like kinase 2 | 0.0123795 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0122858 |
| MLPH | melanophilin | 0.0121267 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0119856 |
| NAV2 | neuron navigator 2 | 0.011981 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0119624 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0119082 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0118214 |
| PRELID2 | PRELI domain containing 2 | 0.0117468 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0117063 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0115146 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0114578 |
| C1R | complement component 1, r subcomponent | 0.0113906 |
| YEATS2 | YEATS domain containing 2 | 0.0113613 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0112883 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.011242 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0110743 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0110582 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0108895 |
| MCC | mutated in colorectal cancers | 0.0108628 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0107791 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0107668 |
| TGFB2 | transforming growth factor, beta 2 | 0.0106365 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0106286 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0105434 |
| HMCN1 | hemicentin 1 | 0.0104569 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0103749 |
| ADAR | adenosine deaminase, RNA-specific | 0.0103517 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.010152 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0101451 |
| OPTN | optineurin | 0.0099963 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00998295 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.00997159 |
| MRTFA | myocardin related transcription factor A | 0.00981277 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.00979728 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.00972196 |
| IL6R | interleukin 6 receptor | 0.00961128 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.00959795 |
| ARHGAP17 | Rho GTPase activating protein 17 | 0.00952922 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00949455 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.00941173 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0094095 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.00939979 |
| CADM1 | cell adhesion molecule 1 | 0.00939002 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.00931305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.184723 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.1512 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.135235 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.124049 |
| EFNA5 | ephrin-A5 | -0.106892 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.104797 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101881 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0975977 |
| HMGA2 | high mobility group AT-hook 2 | -0.0947182 |
| VIM | vimentin | -0.0934827 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0865869 |
| STC1 | stanniocalcin 1 | -0.0794354 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0715408 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0688862 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0672742 |
| CDH13 | cadherin 13 | -0.0661655 |
| GLCCI1 | glucocorticoid induced 1 | -0.0656733 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0651638 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0648407 |
| GOLGA4 | golgin A4 | -0.0615032 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0583615 |
| NRP1 | neuropilin 1 | -0.0580561 |
| OSMR | oncostatin M receptor | -0.0565966 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.055723 |
| TMSB10 | thymosin beta 10 | -0.0534583 |
| RBM39 | RNA binding motif protein 39 | -0.0533365 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0528417 |
| CDCP1 | CUB domain containing protein 1 | -0.0522189 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0517463 |
| FTL | ferritin, light polypeptide | -0.0511859 |
| EGR1 | early growth response 1 | -0.051094 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0503226 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0479094 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0476828 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0475268 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0475028 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0469033 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0465054 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.045828 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0442522 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0442436 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0435124 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0434493 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0433618 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0427853 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0426551 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0423817 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0413355 |
| PTMA | prothymosin, alpha | -0.040949 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0401281 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0399853 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0398101 |
| HMGA1 | high mobility group AT-hook 1 | -0.0395095 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0383236 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0376914 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0370022 |
| NRG1 | neuregulin 1 | -0.0364184 |
| IER3 | immediate early response 3 | -0.0361952 |
| LOX | lysyl oxidase | -0.035804 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0354315 |
| RIOK3 | RIO kinase 3 | -0.0352372 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0344254 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0341579 |
| SETD5 | SET domain containing 5 | -0.0339696 |
| CANX | calnexin | -0.0339344 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0338407 |
| JMJD1C | jumonji domain containing 1C | -0.0334594 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0331716 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0329287 |
| PARD3 | par-3 family cell polarity regulator | -0.0325957 |
| PCBP2 | poly(rC) binding protein 2 | -0.032539 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0323048 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0321142 |
| MAP1B | microtubule-associated protein 1B | -0.0318039 |
| RPS6 | ribosomal protein S6 | -0.0316327 |
| SYAP1 | synapse associated protein 1 | -0.0315353 |
| TOP1 | topoisomerase (DNA) I | -0.0309398 |
| ANXA2 | annexin A2 | -0.0308375 |
| RPLP1 | ribosomal protein, large, P1 | -0.0308085 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0307396 |
| USP3 | ubiquitin specific peptidase 3 | -0.0300342 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0296119 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0294765 |
| RPL35A | ribosomal protein L35a | -0.0294183 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0292701 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0290909 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.028522 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0277902 |
| OXSR1 | oxidative stress responsive 1 | -0.0276618 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0275387 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0274928 |
| SPAG9 | sperm associated antigen 9 | -0.0269147 |
| NF1 | neurofibromin 1 | -0.0269132 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0264798 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0264592 |
| MEF2A | myocyte enhancer factor 2A | -0.0264523 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0262838 |
| FBXO11 | F-box protein 11 | -0.0261915 |
| ECE1 | endothelin converting enzyme 1 | -0.0261347 |
| USP34 | ubiquitin specific peptidase 34 | -0.0261022 |
