Trametinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.436518
FGB fibrinogen beta chain 0.135435
BASP1 brain abundant, membrane attached signal protein 1 0.108375
PDE4D phosphodiesterase 4D, cAMP-specific 0.103749
FGA fibrinogen alpha chain 0.0808108
TXNRD1 thioredoxin reductase 1 0.0684232
FGG fibrinogen gamma chain 0.0614159
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0553171
EEF2 eukaryotic translation elongation factor 2 0.0548483
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0541219
NTN4 netrin 4 0.0481261
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0469872
AKAP12 A kinase (PRKA) anchor protein 12 0.0468672
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0453309
LMNA lamin A/C 0.0442969
GRAMD1B GRAM domain containing 1B 0.0433893
MYOF myoferlin 0.0413094
FLNA filamin A, alpha 0.0407301
RPL3 ribosomal protein L3 0.0403832
CALR calreticulin 0.0387027
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.035772
PLS3 plastin 3 0.0328713
MYH9 myosin, heavy chain 9, non-muscle 0.0290302
RNF213 ring finger protein 213 0.0281039
KLF6 Kruppel-like factor 6 0.0280789
HMOX1 heme oxygenase 1 0.0280727
PDE10A phosphodiesterase 10A 0.0274485
KYNU kynureninase 0.0274062
BMP5 bone morphogenetic protein 5 0.0264712
NNMT nicotinamide N-methyltransferase 0.0259694
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0256052
EFNA1 ephrin-A1 0.0253202
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0246136
ZFHX3 zinc finger homeobox 3 0.0244879
HSPB1 heat shock 27kDa protein 1 0.0239817
TPM4 tropomyosin 4 0.0239769
B2M beta-2-microglobulin 0.0236743
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0228016
SMOC1 SPARC related modular calcium binding 1 0.0225796
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0220111
LOC102724023 ES1 protein homolog, mitochondrial 0.0216676
PLEC plectin 0.0209034
SOX4 SRY (sex determining region Y)-box 4 0.0207391
ZFP36L1 ZFP36 ring finger protein-like 1 0.0200111
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0198387
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0196827
NTM neurotrimin 0.0194418
BICC1 BicC family RNA binding protein 1 0.0192833
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0191615
ZBTB20 zinc finger and BTB domain containing 20 0.0190286
MT1X metallothionein 1X 0.018974
ACTG1 actin gamma 1 0.0189274
NAMPT nicotinamide phosphoribosyltransferase 0.0187692
LAMA5 laminin, alpha 5 0.0186228
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0182811
TNS3 tensin 3 0.0180706
HDGF hepatoma-derived growth factor 0.0180618
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0178562
ARRDC3 arrestin domain containing 3 0.0175763
INHBA inhibin, beta A 0.0175018
POTEF POTE ankyrin domain family, member F 0.0172069
PABPN1 poly(A) binding protein, nuclear 1 0.0167335
CAVIN1 caveolae associated protein 1 0.0167159
VSIG2 V-set and immunoglobulin domain containing 2 0.0164547
CNRIP1 cannabinoid receptor interacting protein 1 0.0163261
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0160798
EIF4A1 eukaryotic translation initiation factor 4A1 0.015605
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0153021
TPI1 triosephosphate isomerase 1 0.0148863
KIAA0319 KIAA0319 0.0147872
HLA-B major histocompatibility complex, class I, B 0.0145645
NEBL nebulette 0.0144817
HLA-A major histocompatibility complex, class I, A 0.0144409
PTEN phosphatase and tensin homolog 0.0143736
IGFBP3 insulin-like growth factor binding protein 3 0.0142402
UBC ubiquitin C 0.0140514
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0139912
NDRG1 N-myc downstream regulated 1 0.0139338
IGFBP4 insulin-like growth factor binding protein 4 0.0137134
RHOV ras homolog family member V 0.0134889
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0134794
RAD51B RAD51 paralog B 0.0131607
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.013151
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0130701
LDHA lactate dehydrogenase A 0.013051
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0128867
THSD7A thrombospondin, type I, domain containing 7A 0.0128375
PRKN parkin RBR E3 ubiquitin protein ligase 0.012811
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0127936
CCL2 chemokine (C-C motif) ligand 2 0.0126372
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0124864
TGFB2 transforming growth factor, beta 2 0.012469
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0124542
RAB9A RAB9A, member RAS oncogene family 0.0119337
FAM168A family with sequence similarity 168, member A 0.011864
ASPH aspartate beta-hydroxylase 0.0117993
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.011506
ENAH enabled homolog (Drosophila) 0.0114224
SFTPA2 surfactant protein A2 0.011234
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0111946

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.186871
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.139628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.138096
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102999
DOCK4 dedicator of cytokinesis 4 -0.0852399
TFPI2 tissue factor pathway inhibitor 2 -0.0721649
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.068601
ZFAND3 zinc finger, AN1-type domain 3 -0.0682795
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.068017
RBM39 RNA binding motif protein 39 -0.0671816
IER3 immediate early response 3 -0.064651
FMNL2 formin-like 2 -0.0645656
UBASH3B ubiquitin associated and SH3 domain containing B -0.052612
FTH1 ferritin, heavy polypeptide 1 -0.0502729
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0486983
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0485489
PARD3 par-3 family cell polarity regulator -0.0477665
TRIO trio Rho guanine nucleotide exchange factor -0.0468855
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0448358
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0444795
EIF1 eukaryotic translation initiation factor 1 -0.0425933
SLC38A2 solute carrier family 38, member 2 -0.0423981
PTK2 protein tyrosine kinase 2 -0.0404028
WDR43 WD repeat domain 43 -0.040278
PUM2 pumilio RNA-binding family member 2 -0.0397321
THSD4 thrombospondin, type I, domain containing 4 -0.0384714
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0380955
TM4SF1 transmembrane 4 L six family member 1 -0.0373189
PDLIM5 PDZ and LIM domain 5 -0.0368541
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0359088
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0350358
SLC38A1 solute carrier family 38, member 1 -0.0345656
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0344417
STC1 stanniocalcin 1 -0.0341852
VIM vimentin -0.0340401
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0329104
DST dystonin -0.0321052
ZNF207 zinc finger protein 207 -0.0317419
NRG1 neuregulin 1 -0.0315138
USP3 ubiquitin specific peptidase 3 -0.0310438
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0307618
USP34 ubiquitin specific peptidase 34 -0.0303017
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0302653
AGO2 argonaute RISC catalytic component 2 -0.0302266
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0299722
SPAG9 sperm associated antigen 9 -0.0297387
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0297328
RPS6 ribosomal protein S6 -0.0293061
FBXO11 F-box protein 11 -0.0291345
MAPK8 mitogen-activated protein kinase 8 -0.0288874
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0288665
NOP58 NOP58 ribonucleoprotein -0.0286885
RASAL2 RAS protein activator like 2 -0.0284251
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0283313
RBM25 RNA binding motif protein 25 -0.0279788
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0278828
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0277755
COG5 component of oligomeric golgi complex 5 -0.0273979
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0273859
RPLP0 ribosomal protein, large, P0 -0.0273817
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0271333
NAV3 neuron navigator 3 -0.0270227
WAC WW domain containing adaptor with coiled-coil -0.0269856
ANKRD11 ankyrin repeat domain 11 -0.026844
TMEM131 transmembrane protein 131 -0.0264301
HMGA1 high mobility group AT-hook 1 -0.0258194
BIRC6 baculoviral IAP repeat containing 6 -0.0258162
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0258123
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0256579
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0255301
RPL35A ribosomal protein L35a -0.0253004
RPS25 ribosomal protein S25 -0.0252388
VEZT vezatin, adherens junctions transmembrane protein -0.0247801
TOP1 topoisomerase (DNA) I -0.0247786
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0245755
NHSL1 NHS-like 1 -0.0245317
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.024449
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0242197
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -0.0240786
CDCP1 CUB domain containing protein 1 -0.024014
PDIA3 protein disulfide isomerase family A, member 3 -0.0237967
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0237293
RPLP1 ribosomal protein, large, P1 -0.023536
RPS16 ribosomal protein S16 -0.0235071
SAMD4A sterile alpha motif domain containing 4A -0.0234553
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0231225
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0231035
C15ORF48 chromosome 15 open reading frame 48 -0.0229429
EGR1 early growth response 1 -0.0227678
NIPBL Nipped-B homolog (Drosophila) -0.0227123
FUS FUS RNA binding protein -0.0226406
KIF5B kinesin family member 5B -0.0224154
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.022252
ECT2 epithelial cell transforming 2 -0.0219848
ERBIN erbb2 interacting protein -0.021976
RPS20 ribosomal protein S20 -0.0219425
RPL19 ribosomal protein L19 -0.021718
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0216221
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0215224
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0212951