| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.106065 |
| KYNU | kynureninase | 0.0901628 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0873013 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0666782 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0635403 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0606421 |
| KRT17 | keratin 17, type I | 0.0603676 |
| PLEC | plectin | 0.0594747 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0593145 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0579584 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.05469 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0545743 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0534177 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.051135 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0499158 |
| TJP1 | tight junction protein 1 | 0.0471596 |
| MYOF | myoferlin | 0.0469272 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0458713 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0446944 |
| KATNBL1 | katanin p80 subunit B-like 1 | 0.043717 |
| TENM1 | teneurin transmembrane protein 1 | 0.043277 |
| PDE10A | phosphodiesterase 10A | 0.042411 |
| CMIP | c-Maf inducing protein | 0.0420864 |
| IRS2 | insulin receptor substrate 2 | 0.0416066 |
| DSPP | dentin sialophosphoprotein | 0.0405406 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0405336 |
| NCKAP1 | NCK-associated protein 1 | 0.0401615 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0389174 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.038585 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0379252 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0375684 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0370743 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0370109 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0357672 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0355456 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0355381 |
| TRAM1 | translocation associated membrane protein 1 | 0.035454 |
| TULP4 | tubby like protein 4 | 0.0352618 |
| SON | SON DNA binding protein | 0.0351451 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0348041 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0343418 |
| FAM107B | family with sequence similarity 107, member B | 0.0340531 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0339882 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0337871 |
| NEBL | nebulette | 0.0337612 |
| RPL3 | ribosomal protein L3 | 0.0336767 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0336676 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0334518 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0333068 |
| COL1A1 | collagen, type I, alpha 1 | 0.03319 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0331033 |
| SERINC5 | serine incorporator 5 | 0.0328737 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0328132 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0327913 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0327857 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0323643 |
| PMM2 | phosphomannomutase 2 | 0.0321472 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0320372 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0319392 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0319009 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0318281 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.031684 |
| ATF4 | activating transcription factor 4 | 0.0314682 |
| INHBA | inhibin, beta A | 0.0310637 |
| MCU | mitochondrial calcium uniporter | 0.0309363 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0307723 |
| SEPTIN9 | septin 9 | 0.0307524 |
| HMBOX1 | homeobox containing 1 | 0.0305762 |
| CDK19 | cyclin-dependent kinase 19 | 0.0304415 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0304242 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0302699 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0301117 |
| SIK3 | SIK family kinase 3 | 0.0300005 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0297144 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0296992 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0296698 |
| RPL13A | ribosomal protein L13a | 0.0296141 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0295735 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0295163 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0294522 |
| USP47 | ubiquitin specific peptidase 47 | 0.0293381 |
| RPS8 | ribosomal protein S8 | 0.0293198 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0291932 |
| RPL4 | ribosomal protein L4 | 0.0290775 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0289855 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0287157 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0285324 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0285278 |
| CUL4A | cullin 4A | 0.028495 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0283712 |
| GOLGA4 | golgin A4 | 0.0283438 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0282966 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0282297 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0282131 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0279468 |
| ERLEC1 | endoplasmic reticulum lectin 1 | 0.0278798 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0277696 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.027565 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.0273701 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 0.026833 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.163548 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.155702 |
| MYO1E | myosin IE | -0.118067 |
| VIM | vimentin | -0.0869073 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0843759 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.081476 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.078761 |
| FTL | ferritin, light polypeptide | -0.0750269 |
| TMSB10 | thymosin beta 10 | -0.0746342 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.067643 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0662047 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0635217 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.061294 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0587514 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0571008 |
| PTMA | prothymosin, alpha | -0.0566074 |
| SNX9 | sorting nexin 9 | -0.056453 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0563723 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0559477 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.055695 |
| NDRG1 | N-myc downstream regulated 1 | -0.0545155 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0543246 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0529125 |
| SRPK2 | SRSF protein kinase 2 | -0.0521756 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0518188 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.05143 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0499347 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0497513 |
| ERBIN | erbb2 interacting protein | -0.0497349 |
| GPC6 | glypican 6 | -0.0494103 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0486052 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0482848 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.047836 |
| RPS6 | ribosomal protein S6 | -0.0473117 |
| MYO5B | myosin VB | -0.0450381 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0446749 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0445524 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0429726 |
| TOP1 | topoisomerase (DNA) I | -0.0427938 |
| MT2A | metallothionein 2A | -0.0426224 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0425304 |
| EGR1 | early growth response 1 | -0.041884 |
| ACTG1 | actin gamma 1 | -0.0417386 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0415332 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0414786 |
| ATP11B | ATPase, class VI, type 11B | -0.0400893 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0395856 |
| RCOR1 | REST corepressor 1 | -0.0394367 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.039419 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0392733 |
| PGK1 | phosphoglycerate kinase 1 | -0.0389813 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0389782 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0388385 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0380627 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0376724 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0375858 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0375651 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0373092 |
| FOXO3 | forkhead box O3 | -0.0357641 |
| SPAG9 | sperm associated antigen 9 | -0.035618 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0351851 |
| FBXO11 | F-box protein 11 | -0.0347561 |
| RUNX1 | runt-related transcription factor 1 | -0.0345406 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0343427 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0339866 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0339443 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0337333 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0337199 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0333795 |
| RPL11 | ribosomal protein L11 | -0.0331269 |
| RNF145 | ring finger protein 145 | -0.0328313 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0328252 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0327126 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0327079 |
| HMGA1 | high mobility group AT-hook 1 | -0.0323099 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0322685 |
| STC1 | stanniocalcin 1 | -0.0320833 |
| ZNF292 | zinc finger protein 292 | -0.0318415 |
| FMN1 | formin 1 | -0.0316655 |
| NPTN | neuroplastin | -0.0311214 |
| CDCP1 | CUB domain containing protein 1 | -0.0307604 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0306777 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0305628 |
| NHSL1 | NHS-like 1 | -0.030437 |
| SVIL | supervillin | -0.0303561 |
| MED13L | mediator complex subunit 13-like | -0.0298438 |
| JMJD1C | jumonji domain containing 1C | -0.0297757 |
| YAP1 | Yes-associated protein 1 | -0.0296894 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0295508 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0293949 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.029216 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0289349 |
| ASPH | aspartate beta-hydroxylase | -0.028849 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0287328 |
| RNF24 | ring finger protein 24 | -0.0287213 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0285511 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0285452 |
| FAM13A | family with sequence similarity 13, member A | -0.0285439 |
| HBP1 | HMG-box transcription factor 1 | -0.0284889 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0284872 |
