| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.0945465 |
| UBC | ubiquitin C | 0.0856851 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0753253 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0721594 |
| RAD51B | RAD51 paralog B | 0.0650594 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0642875 |
| AHNAK | AHNAK nucleoprotein | 0.0606804 |
| TXNRD1 | thioredoxin reductase 1 | 0.0570025 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0530624 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0527372 |
| RNF213 | ring finger protein 213 | 0.0522067 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0507037 |
| RPS27A | ribosomal protein S27a | 0.0502271 |
| BMP5 | bone morphogenetic protein 5 | 0.0490337 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0443373 |
| ENO1 | enolase 1, (alpha) | 0.0439813 |
| TMSB10 | thymosin beta 10 | 0.0427118 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0416579 |
| RPS3 | ribosomal protein S3 | 0.0415231 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0405355 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0391914 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0383332 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0377547 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0368641 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.036216 |
| WWOX | WW domain containing oxidoreductase | 0.0331355 |
| CEP250 | centrosomal protein 250kDa | 0.032988 |
| RPS4X | ribosomal protein S4, X-linked | 0.0325355 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0324184 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0315574 |
| RPL23 | ribosomal protein L23 | 0.0313685 |
| CAVIN1 | caveolae associated protein 1 | 0.0312508 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.030982 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0299671 |
| LMNA | lamin A/C | 0.0298812 |
| COL5A2 | collagen, type V, alpha 2 | 0.0296805 |
| ADAR | adenosine deaminase, RNA-specific | 0.0295178 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0293966 |
| PLEC | plectin | 0.0291253 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0288312 |
| RPL3 | ribosomal protein L3 | 0.0280746 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0279447 |
| ADA | adenosine deaminase | 0.0275792 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.027148 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0263676 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.026022 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0256632 |
| PRELID2 | PRELI domain containing 2 | 0.0255215 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0254496 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0250914 |
| OGA | O-GlcNAcase | 0.0247135 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0241894 |
| B2M | beta-2-microglobulin | 0.0239507 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.023291 |
| MED13L | mediator complex subunit 13-like | 0.0224478 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 0.0224128 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0222175 |
| DST | dystonin | 0.0219484 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0216591 |
| FLNA | filamin A, alpha | 0.021498 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.021136 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0210594 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | 0.0209274 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0207516 |
| SSH2 | slingshot protein phosphatase 2 | 0.0207052 |
| UTRN | utrophin | 0.0206805 |
| AEBP2 | AE binding protein 2 | 0.0205628 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0204985 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0204374 |
| GNAS | GNAS complex locus | 0.0203537 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0203285 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0203087 |
| HELB | helicase (DNA) B | 0.0202881 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0202797 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0202059 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0201574 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0200676 |
| TENM3 | teneurin transmembrane protein 3 | 0.0200067 |
| MAP7 | microtubule-associated protein 7 | 0.0197955 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0197706 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0197349 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0196179 |
| CEP70 | centrosomal protein 70kDa | 0.0192501 |
| WWC1 | WW and C2 domain containing 1 | 0.0191822 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0191809 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0190119 |
| MYOF | myoferlin | 0.0188782 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0188637 |
| MACROD2 | MACRO domain containing 2 | 0.0187325 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0184802 |
| SYT1 | synaptotagmin I | 0.0184368 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0182114 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.018185 |
| PCBP2 | poly(rC) binding protein 2 | 0.0180856 |
| CUL4A | cullin 4A | 0.0179315 |
| VCP | valosin containing protein | 0.0179007 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0178103 |
| SMAD3 | SMAD family member 3 | 0.0178078 |
| HLA-B | major histocompatibility complex, class I, B | 0.0178039 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0176268 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.302586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.223499 |
| EGR1 | early growth response 1 | -0.154448 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.102793 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0986302 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0780599 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.077834 |
| MCL1 | myeloid cell leukemia 1 | -0.0776145 |
| YBX3 | Y box binding protein 3 | -0.0651157 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0573288 |
| RTN4 | reticulon 4 | -0.0541318 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0530472 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0528481 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0522837 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0522796 |
| PFN1 | profilin 1 | -0.0515102 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0496732 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0483595 |
| POTEF | POTE ankyrin domain family, member F | -0.0481987 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0469785 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0453735 |
| KRT18 | keratin 18, type I | -0.0449983 |
| NF1 | neurofibromin 1 | -0.0446957 |
| JMJD1C | jumonji domain containing 1C | -0.043913 |
| STC1 | stanniocalcin 1 | -0.0434254 |
| CCNL1 | cyclin L1 | -0.0433898 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0431502 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0426427 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0423801 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.041992 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0413144 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.041221 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0409414 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0404191 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0399837 |
| SRPK1 | SRSF protein kinase 1 | -0.0384398 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0384334 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0377889 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0376332 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0373288 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0372656 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.037047 |
| HMGA1 | high mobility group AT-hook 1 | -0.0365583 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0361791 |
| NABP1 | nucleic acid binding protein 1 | -0.0361504 |
| MMP12 | matrix metallopeptidase 12 | -0.0357445 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0357333 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0357249 |
| RPS2 | ribosomal protein S2 | -0.0357023 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0355265 |
| PHIP | pleckstrin homology domain interacting protein | -0.0350366 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0350297 |
| FMNL2 | formin-like 2 | -0.0342214 |
| MORF4L2 | mortality factor 4 like 2 | -0.0337212 |
| CDK17 | cyclin-dependent kinase 17 | -0.0334993 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0330591 |
| STK4 | serine/threonine kinase 4 | -0.032303 |
| FBXO11 | F-box protein 11 | -0.0322945 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0314314 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0313585 |
| SETX | senataxin | -0.0310682 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0309152 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0307428 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.030637 |
| ACTN1 | actinin, alpha 1 | -0.0304317 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0301465 |
| E2F3 | E2F transcription factor 3 | -0.0299265 |
| GOLGA4 | golgin A4 | -0.0297594 |
| PTK2 | protein tyrosine kinase 2 | -0.029281 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0292154 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0291981 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0290755 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0290338 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.0289635 |
| CDCP1 | CUB domain containing protein 1 | -0.0288656 |
| COPA | coatomer protein complex, subunit alpha | -0.0288492 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0286025 |
| HMGA2 | high mobility group AT-hook 2 | -0.0285478 |
| CLTC | clathrin, heavy chain (Hc) | -0.0283671 |
| RPS6 | ribosomal protein S6 | -0.0280892 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0279955 |
| USP34 | ubiquitin specific peptidase 34 | -0.0279647 |
| ANXA5 | annexin A5 | -0.0279337 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0278864 |
| TUBA1B | tubulin, alpha 1b | -0.0277133 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0271584 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0266873 |
| SEPTIN7 | septin 7 | -0.0266156 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0264683 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0264592 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0263461 |
| VMP1 | vacuole membrane protein 1 | -0.0262009 |
| RASA2 | RAS p21 protein activator 2 | -0.0260584 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0260046 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0258735 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0255345 |
| KIF5B | kinesin family member 5B | -0.0254663 |
| ATXN2 | ataxin 2 | -0.0252711 |
| BRD2 | bromodomain containing 2 | -0.0250687 |
| NUP58 | nucleoporin 58 | -0.0250412 |
