| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.224665 |
| PTMA | prothymosin, alpha | 0.0693205 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0676972 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.06285 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0621898 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0549412 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0524986 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0505413 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0471342 |
| HMGB2 | high mobility group box 2 | 0.0469634 |
| MYOF | myoferlin | 0.0467537 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0434075 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0428735 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.042807 |
| CFB | complement factor B | 0.0414187 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0411265 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0406715 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0404605 |
| TXNIP | thioredoxin interacting protein | 0.0399759 |
| CD47 | CD47 molecule | 0.0395923 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0394322 |
| RNF213 | ring finger protein 213 | 0.0386616 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0373573 |
| CALR | calreticulin | 0.03731 |
| FHIT | fragile histidine triad | 0.036433 |
| FAM13A | family with sequence similarity 13, member A | 0.0356152 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0348656 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0340185 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0340059 |
| ADAR | adenosine deaminase, RNA-specific | 0.0328282 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0327961 |
| RUNX1 | runt-related transcription factor 1 | 0.0321489 |
| NEBL | nebulette | 0.0311447 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0310765 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0307856 |
| PCDH7 | protocadherin 7 | 0.0307613 |
| DSPP | dentin sialophosphoprotein | 0.0301012 |
| TUFT1 | tuftelin 1 | 0.0289904 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.028777 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.028567 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0284115 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0278957 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0278158 |
| COBL | cordon-bleu WH2 repeat protein | 0.0277297 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0275519 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0273357 |
| FBXO32 | F-box protein 32 | 0.0272543 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.027236 |
| FOXN3 | forkhead box N3 | 0.0270777 |
| PARD3 | par-3 family cell polarity regulator | 0.0269046 |
| TMEM131L | transmembrane 131 like | 0.0264651 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0264314 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0261851 |
| STEAP4 | STEAP family member 4 | 0.0261645 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0260474 |
| UBC | ubiquitin C | 0.0259643 |
| GPD2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.0258214 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0256641 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0256443 |
| MUC1 | mucin 1, cell surface associated | 0.0255647 |
| RAD51B | RAD51 paralog B | 0.0252524 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0249956 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0248962 |
| AOPEP | aminopeptidase O (putative) | 0.0247306 |
| SMYD3 | SET and MYND domain containing 3 | 0.0243727 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0242854 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.024217 |
| B2M | beta-2-microglobulin | 0.0240261 |
| ANKRD13A | ankyrin repeat domain 13A | 0.0238217 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0234535 |
| IL6ST | interleukin 6 signal transducer | 0.0232292 |
| MATR3 | matrin 3 | 0.0224639 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0224295 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0224271 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0224106 |
| JAK1 | Janus kinase 1 | 0.0223698 |
| TFG | TRK-fused gene | 0.0223001 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0220581 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0220557 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0219979 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0219935 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0219861 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.021895 |
| OGA | O-GlcNAcase | 0.0218923 |
| PHF3 | PHD finger protein 3 | 0.0218609 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0217883 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0217847 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0217693 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0216881 |
| RNF145 | ring finger protein 145 | 0.0215117 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0214334 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.0212634 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0211025 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0210146 |
| GOLGA4 | golgin A4 | 0.0209004 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.020856 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0208257 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0208238 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0207456 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0207102 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.292747 |
| GRB10 | growth factor receptor-bound protein 10 | -0.163678 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.137482 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.112861 |
| POTEF | POTE ankyrin domain family, member F | -0.102114 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0867806 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0865034 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0847281 |
| ACTG1 | actin gamma 1 | -0.0795556 |
| ASPH | aspartate beta-hydroxylase | -0.0773774 |
| RCOR1 | REST corepressor 1 | -0.0761337 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0748838 |
| HMGA1 | high mobility group AT-hook 1 | -0.0741879 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0715133 |
| CCND1 | cyclin D1 | -0.0714349 |
| EFNA5 | ephrin-A5 | -0.070086 |
| TOP1 | topoisomerase (DNA) I | -0.0697961 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0695053 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.067693 |
| DTNA | dystrobrevin, alpha | -0.0654271 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0606986 |
| TMSB10 | thymosin beta 10 | -0.0585743 |
| EGR1 | early growth response 1 | -0.05847 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0572745 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0562102 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0558976 |
| FAM3C | family with sequence similarity 3, member C | -0.0547179 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0539109 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0535131 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0526699 |
| LMO7 | LIM domain 7 | -0.0524874 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0524019 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0508162 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0507444 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0502147 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0500113 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0489918 |
| LAMC2 | laminin, gamma 2 | -0.0486505 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0475595 |
| PTK2 | protein tyrosine kinase 2 | -0.0468843 |
| CDCP1 | CUB domain containing protein 1 | -0.0453826 |
| RAI14 | retinoic acid induced 14 | -0.0435346 |
| FAM107B | family with sequence similarity 107, member B | -0.0433324 |
| SMAD3 | SMAD family member 3 | -0.042467 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0408094 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0403823 |
| DUSP6 | dual specificity phosphatase 6 | -0.039026 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.03871 |
| TMEM165 | transmembrane protein 165 | -0.0380715 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0370985 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0366723 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0355549 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0349907 |
| LAMB3 | laminin, beta 3 | -0.0347158 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.034638 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0345009 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0344561 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0342631 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0339864 |
| FTL | ferritin, light polypeptide | -0.0339539 |
| MAP1B | microtubule-associated protein 1B | -0.0336467 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.033044 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0325358 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0324716 |
| PRKCA | protein kinase C, alpha | -0.0324264 |
| RASA2 | RAS p21 protein activator 2 | -0.0319043 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.031831 |
| ARF4 | ADP-ribosylation factor 4 | -0.0314898 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0308005 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0304021 |
| NF1 | neurofibromin 1 | -0.0301294 |
| TMSB4X | thymosin beta 4, X-linked | -0.0299245 |
| EZR | ezrin | -0.0293868 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0293764 |
| MYO5B | myosin VB | -0.0292019 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0289253 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0288468 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | -0.0285728 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0284487 |
| MCL1 | myeloid cell leukemia 1 | -0.0284184 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0282621 |
| F11R | F11 receptor | -0.028207 |
| S100A10 | S100 calcium binding protein A10 | -0.0281819 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0280984 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0279717 |
| CSTB | cystatin B (stefin B) | -0.0275507 |
| MYO1E | myosin IE | -0.0274 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0272545 |
| MSI2 | musashi RNA-binding protein 2 | -0.0272113 |
| RPL35A | ribosomal protein L35a | -0.0271127 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0266297 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.026578 |
| FOSL1 | FOS-like antigen 1 | -0.026473 |
| SLTM | SAFB-like, transcription modulator | -0.0263301 |
| UPP1 | uridine phosphorylase 1 | -0.0262337 |
| VGLL3 | vestigial-like family member 3 | -0.0261698 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0259029 |
| GOLGB1 | golgin B1 | -0.0257479 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0256843 |
| CD44 | CD44 molecule (Indian blood group) | -0.0254143 |
