Trametinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AGTPBP1 ATP/GTP binding protein 1 0.132311
COL5A2 collagen, type V, alpha 2 0.1102
PM20D1 peptidase M20 domain containing 1 0.0954177
SAMD4A sterile alpha motif domain containing 4A 0.0756925
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0743726
MYOF myoferlin 0.0714078
EEF2 eukaryotic translation elongation factor 2 0.0678905
COL8A1 collagen, type VIII, alpha 1 0.065124
PALLD palladin, cytoskeletal associated protein 0.0616095
TRIO trio Rho guanine nucleotide exchange factor 0.0608141
TXNRD1 thioredoxin reductase 1 0.0594591
MAP7 microtubule-associated protein 7 0.0585667
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0580592
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0515313
IGF1R insulin-like growth factor 1 receptor 0.0508445
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0491534
BASP1 brain abundant, membrane attached signal protein 1 0.0483091
PDLIM5 PDZ and LIM domain 5 0.0464674
CD109 CD109 molecule 0.0460822
ABLIM1 actin binding LIM protein 1 0.0458618
ZEB2 zinc finger E-box binding homeobox 2 0.0452118
CLIP1 CAP-GLY domain containing linker protein 1 0.043916
SPAG9 sperm associated antigen 9 0.0434454
OLFML2A olfactomedin-like 2A 0.0407734
DGKD diacylglycerol kinase, delta 130kDa 0.0407103
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0406136
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0402116
EXT1 exostosin glycosyltransferase 1 0.0397574
MYPN myopalladin 0.0383554
XYLT1 xylosyltransferase I 0.0381516
CREB5 cAMP responsive element binding protein 5 0.0372746
UBC ubiquitin C 0.0358482
KIF16B kinesin family member 16B 0.0357341
WARS1 tryptophanyl-tRNA synthetase 1 0.0349943
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0347422
EZR ezrin 0.0338672
NFX1 nuclear transcription factor, X-box binding 1 0.0336653
ATXN1 ataxin 1 0.032869
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0326827
NTN4 netrin 4 0.0314035
CTIF CBP80/20-dependent translation initiation factor 0.0307938
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0307449
RPL3 ribosomal protein L3 0.0297186
LMNA lamin A/C 0.0296676
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.029552
TBXT T-box transcription factor T 0.029028
FLNA filamin A, alpha 0.0289424
ZFHX3 zinc finger homeobox 3 0.0287584
DST dystonin 0.0282296
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0280615
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0279728
RHOB ras homolog family member B 0.0278471
P3H2 prolyl 3-hydroxylase 2 0.027506
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0270699
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0269767
TGFBI transforming growth factor, beta-induced, 68kDa 0.0268685
MYH9 myosin, heavy chain 9, non-muscle 0.0267929
HSPA8 heat shock 70kDa protein 8 0.0264483
MFSD12 major facilitator superfamily domain containing 12 0.026196
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0259293
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0259105
SORBS2 sorbin and SH3 domain containing 2 0.0257413
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0254407
ACTG1 actin gamma 1 0.0251249
UGDH UDP-glucose 6-dehydrogenase 0.02479
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.024601
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0244292
ANXA1 annexin A1 0.0241085
ENO1 enolase 1, (alpha) 0.024068
B2M beta-2-microglobulin 0.0230532
STC2 stanniocalcin 2 0.022754
AOPEP aminopeptidase O (putative) 0.0224251
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0223547
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0220601
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0219005
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0218638
LGALS3 lectin, galactoside-binding, soluble, 3 0.0218635
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0216287
CHSY3 chondroitin sulfate synthase 3 0.0214848
AHNAK AHNAK nucleoprotein 0.0208526
DISP1 dispatched homolog 1 (Drosophila) 0.0205992
AHNAK2 AHNAK nucleoprotein 2 0.0200263
PRR5L proline rich 5 like 0.0200067
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0197587
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0191762
MGST1 microsomal glutathione S-transferase 1 0.01917
SFTPA2 surfactant protein A2 0.0191367
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0190169
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0187304
ANXA2 annexin A2 0.0185124
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0184482
PCDH15 protocadherin-related 15 0.0184403
OXSR1 oxidative stress responsive 1 0.0176229
LSAMP limbic system-associated membrane protein 0.0175672
NEK7 NIMA-related kinase 7 0.0175381
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.01743
SQSTM1 sequestosome 1 0.017371
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.016965
RPS4X ribosomal protein S4, X-linked 0.0169055
PTEN phosphatase and tensin homolog 0.0168637

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.29078
PSD3 pleckstrin and Sec7 domain containing 3 -0.119244
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0938343
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0921402
CDH13 cadherin 13 -0.0915354
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0901685
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0841175
NPAS2 neuronal PAS domain protein 2 -0.0817441
PDE4D phosphodiesterase 4D, cAMP-specific -0.0796295
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0787977
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0737129
NRCAM neuronal cell adhesion molecule -0.0724771
MAML3 mastermind-like 3 (Drosophila) -0.0724157
DOCK4 dedicator of cytokinesis 4 -0.0635642
GDA guanine deaminase -0.0614093
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0602554
NAMPT nicotinamide phosphoribosyltransferase -0.0597707
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0577891
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0576692
STC1 stanniocalcin 1 -0.0557142
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0556289
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0549433
MCL1 myeloid cell leukemia 1 -0.0542866
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0532219
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0529594
COL4A5 collagen, type IV, alpha 5 -0.0478227
TFPI2 tissue factor pathway inhibitor 2 -0.047778
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0476965
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0475885
COL4A6 collagen, type IV, alpha 6 -0.0431684
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0397647
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0369321
RTN1 reticulon 1 -0.0354052
FN1 fibronectin 1 -0.035047
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0350435
PYGL phosphorylase, glycogen, liver -0.0328592
SLC38A2 solute carrier family 38, member 2 -0.0321279
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0320937
BMERB1 bMERB domain containing 1 -0.0315754
GRAMD1B GRAM domain containing 1B -0.0305038
PCBP3 poly(rC) binding protein 3 -0.0300862
MCTP1 multiple C2 domains, transmembrane 1 -0.0288582
NHSL1 NHS-like 1 -0.0282958
FNDC3A fibronectin type III domain containing 3A -0.0281895
TMSB10 thymosin beta 10 -0.0280598
GLIS3 GLIS family zinc finger 3 -0.0279414
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0270614
FNDC3B fibronectin type III domain containing 3B -0.0268837
DOCK5 dedicator of cytokinesis 5 -0.0254286
CTSC cathepsin C -0.0254062
RPL35A ribosomal protein L35a -0.0240018
BIRC6 baculoviral IAP repeat containing 6 -0.0228556
AVL9 AVL9 homolog (S. cerevisiase) -0.0227342
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0224455
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0221319
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0220104
RPLP1 ribosomal protein, large, P1 -0.0219547
ELL2 elongation factor, RNA polymerase II, 2 -0.0217941
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0217061
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0213357
DPYD dihydropyrimidine dehydrogenase -0.0211123
TPT1 tumor protein, translationally-controlled 1 -0.0210527
SMOC1 SPARC related modular calcium binding 1 -0.0207838
WWTR1 WW domain containing transcription regulator 1 -0.020672
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.020501
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0204908
MFF mitochondrial fission factor -0.0200211
FTH1 ferritin, heavy polypeptide 1 -0.0198841
NALF1 NALCN channel auxiliary factor 1 -0.0196831
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0196629
VCL vinculin -0.0193497
NF1 neurofibromin 1 -0.0192839
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.019265
GLRX glutaredoxin (thioltransferase) -0.0191882
THSD4 thrombospondin, type I, domain containing 4 -0.0190954
IGFBP3 insulin-like growth factor binding protein 3 -0.019002
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0189326
RGS2 regulator of G-protein signaling 2 -0.0188874
KMT2E lysine (K)-specific methyltransferase 2E -0.0186636
GPC6 glypican 6 -0.0185776
EGR1 early growth response 1 -0.0185072
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0184073
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0182129
PTPRM protein tyrosine phosphatase, receptor type, M -0.0182046
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0181107
LIMCH1 LIM and calponin homology domains 1 -0.0179883
RAB3B RAB3B, member RAS oncogene family -0.0178753
OSMR oncostatin M receptor -0.0177818
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0176068
RTN4 reticulon 4 -0.0173923
TOP1 topoisomerase (DNA) I -0.0173853
GOLGA4 golgin A4 -0.0168809
WDFY2 WD repeat and FYVE domain containing 2 -0.0168476
ANKRD28 ankyrin repeat domain 28 -0.0168048
MON2 MON2 homolog (S. cerevisiae) -0.0167618
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0166983
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0166107
CDK17 cyclin-dependent kinase 17 -0.0161619
EPHA4 EPH receptor A4 -0.01607
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0160504