| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.15191 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.137892 |
| IGF2 | insulin-like growth factor 2 | 0.115063 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.104242 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0986695 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0901463 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0892822 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0834271 |
| NDRG1 | N-myc downstream regulated 1 | 0.0791148 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0783831 |
| TENM3 | teneurin transmembrane protein 3 | 0.0782222 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0781847 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0771623 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0754573 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.075185 |
| NEK7 | NIMA-related kinase 7 | 0.070476 |
| RUNX2 | runt-related transcription factor 2 | 0.0672336 |
| ADAR | adenosine deaminase, RNA-specific | 0.0670165 |
| ACTG1 | actin gamma 1 | 0.0661579 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0655101 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0652622 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0638895 |
| MYOF | myoferlin | 0.0628588 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0608583 |
| PDE10A | phosphodiesterase 10A | 0.0608499 |
| SMAD3 | SMAD family member 3 | 0.058486 |
| LOX | lysyl oxidase | 0.0576562 |
| ATXN1 | ataxin 1 | 0.0569121 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.055495 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0546707 |
| SRPK2 | SRSF protein kinase 2 | 0.0543125 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0531918 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0490884 |
| PCBP3 | poly(rC) binding protein 3 | 0.0490599 |
| RAD51B | RAD51 paralog B | 0.0488089 |
| TMEM39A | transmembrane protein 39A | 0.0472558 |
| STC2 | stanniocalcin 2 | 0.0453616 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0446151 |
| SQSTM1 | sequestosome 1 | 0.0445474 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0445367 |
| FAT1 | FAT atypical cadherin 1 | 0.0440812 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0435527 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0434695 |
| SPAG9 | sperm associated antigen 9 | 0.0434278 |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.0413427 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0411998 |
| YAP1 | Yes-associated protein 1 | 0.0409788 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0409445 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0408873 |
| CEP350 | centrosomal protein 350kDa | 0.0408482 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0387208 |
| GNAS | GNAS complex locus | 0.038445 |
| PHF21A | PHD finger protein 21A | 0.0384009 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0378721 |
| PTK2 | protein tyrosine kinase 2 | 0.037701 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0374389 |
| MEF2A | myocyte enhancer factor 2A | 0.0373375 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0358395 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0357203 |
| SPATA13 | spermatogenesis associated 13 | 0.0354481 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0350789 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0350086 |
| VMP1 | vacuole membrane protein 1 | 0.0348471 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0336811 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0329961 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0310467 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0299637 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0294829 |
| EZR | ezrin | 0.0294381 |
| RPS3 | ribosomal protein S3 | 0.0291126 |
| QKI | QKI, KH domain containing, RNA binding | 0.0291014 |
| COPA | coatomer protein complex, subunit alpha | 0.0290743 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0288827 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0284011 |
| FNDC3B | fibronectin type III domain containing 3B | 0.028327 |
| MYO1E | myosin IE | 0.0279411 |
| PRELID2 | PRELI domain containing 2 | 0.0275644 |
| BBX | bobby sox homolog (Drosophila) | 0.0271809 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0270431 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 0.0265649 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0260326 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0258101 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.025654 |
| FOXP1 | forkhead box P1 | 0.0253915 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0251386 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0245053 |
| LDHA | lactate dehydrogenase A | 0.0242974 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.024257 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0242265 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0224159 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.022263 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0222376 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0217462 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.021707 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0216904 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0204406 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0203269 |
| PCBP2 | poly(rC) binding protein 2 | 0.0199868 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0196529 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0191971 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.200118 |
| TMSB10 | thymosin beta 10 | -0.141945 |
| EFNA5 | ephrin-A5 | -0.130131 |
| PTMA | prothymosin, alpha | -0.120856 |
| FN1 | fibronectin 1 | -0.116211 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.113281 |
| GPC6 | glypican 6 | -0.111473 |
| ASPH | aspartate beta-hydroxylase | -0.105394 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.103215 |
| PRKCA | protein kinase C, alpha | -0.0994167 |
| VIM | vimentin | -0.0971492 |
| CCNI | cyclin I | -0.0939005 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0880978 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0873523 |
| MT2A | metallothionein 2A | -0.0870245 |
| FTL | ferritin, light polypeptide | -0.0747608 |
| RIGI | RNA sensor RIG-I | -0.0743925 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0730584 |
| RPLP1 | ribosomal protein, large, P1 | -0.0729449 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0715141 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.069949 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0693162 |
| VCL | vinculin | -0.0646641 |
| GOLGA4 | golgin A4 | -0.0646395 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0629206 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0612856 |
| MCL1 | myeloid cell leukemia 1 | -0.0603678 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0590137 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0570713 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0567209 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0550644 |
| CANX | calnexin | -0.0536419 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0521907 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0519035 |
| EXT1 | exostosin glycosyltransferase 1 | -0.051319 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0501902 |
| HDLBP | high density lipoprotein binding protein | -0.0490306 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0487673 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0477717 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0473846 |
| FAM13A | family with sequence similarity 13, member A | -0.0464712 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0455238 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0440226 |
| KIF5B | kinesin family member 5B | -0.043923 |
| OGA | O-GlcNAcase | -0.0433917 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0430565 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0429321 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0426458 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0411713 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.040674 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0396891 |
| SBF2 | SET binding factor 2 | -0.0395045 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0379691 |
| RPS6 | ribosomal protein S6 | -0.0373242 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0368373 |
| ANXA2 | annexin A2 | -0.0368262 |
| COL5A2 | collagen, type V, alpha 2 | -0.0355764 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0347561 |
| RORA | RAR-related orphan receptor A | -0.0342573 |
| SMYD3 | SET and MYND domain containing 3 | -0.0315801 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0315116 |
| NABP1 | nucleic acid binding protein 1 | -0.0306621 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0301266 |
| CNKSR3 | CNKSR family member 3 | -0.0291275 |
| MORF4L2 | mortality factor 4 like 2 | -0.0286846 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0282007 |
| NAV2 | neuron navigator 2 | -0.0280912 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0274915 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.027189 |
| B2M | beta-2-microglobulin | -0.0267523 |
| PKM | pyruvate kinase, muscle | -0.0261731 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0259825 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0253368 |
| DOCK4 | dedicator of cytokinesis 4 | -0.025033 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0247572 |
| ERBIN | erbb2 interacting protein | -0.0218535 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0210742 |
| ENO1 | enolase 1, (alpha) | -0.0210179 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0199148 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0194171 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0190716 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0189732 |
| STC1 | stanniocalcin 1 | -0.0180996 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0179518 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0177568 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0169159 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0154528 |
| CDH13 | cadherin 13 | -0.0148588 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0131089 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0119953 |
| ANO6 | anoctamin 6 | -0.0119742 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0115039 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0114315 |
| RBM25 | RNA binding motif protein 25 | -0.0111044 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0107986 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0107691 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00979267 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.00975297 |
| NHSL1 | NHS-like 1 | -0.00960388 |
| RPL26 | ribosomal protein L26 | -0.009011 |
