| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0583656 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0549133 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0463761 |
| FLNA | filamin A, alpha | 0.0331727 |
| CALR | calreticulin | 0.0295582 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0295535 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0293846 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0284719 |
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 | 0.0277403 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0277033 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0266963 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0265946 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0261486 |
| MB21D2 | Mab-21 domain containing 2 | 0.0260197 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0259507 |
| CORO1C | coronin, actin binding protein, 1C | 0.0257026 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.0254534 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0253126 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0251201 |
| H1-5 | H1.5 linker histone, cluster member | 0.0250388 |
| ACTG1 | actin gamma 1 | 0.0249019 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0248594 |
| DMXL1 | Dmx-like 1 | 0.0243869 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0239968 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.023489 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0225704 |
| TRAK1 | trafficking protein, kinesin binding 1 | 0.0221213 |
| SMYD3 | SET and MYND domain containing 3 | 0.0220695 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0217792 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0217788 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0217641 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0216147 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0212001 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0211673 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0201597 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0200959 |
| AHNAK | AHNAK nucleoprotein | 0.0196012 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0194103 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0193253 |
| MKRN2 | makorin ring finger protein 2 | 0.0191172 |
| CRY1 | cryptochrome circadian clock 1 | 0.0189968 |
| APP | amyloid beta (A4) precursor protein | 0.018525 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0185195 |
| OAZ1 | ornithine decarboxylase antizyme 1 | 0.0184682 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0183403 |
| GPC3 | glypican 3 | 0.018258 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0182234 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0181423 |
| MT2A | metallothionein 2A | 0.0179598 |
| FOXO1 | forkhead box O1 | 0.0179451 |
| THBS1 | thrombospondin 1 | 0.0178659 |
| ADAR | adenosine deaminase, RNA-specific | 0.0177886 |
| PGPEP1L | pyroglutamyl-peptidase I-like | 0.0176631 |
| RAB31 | RAB31, member RAS oncogene family | 0.0175683 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0175207 |
| DENND4A | DENN/MADD domain containing 4A | 0.01749 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.01746 |
| TMED5 | transmembrane emp24 protein transport domain containing 5 | 0.0174137 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0173704 |
| RAB30 | RAB30, member RAS oncogene family | 0.0170927 |
| SERINC1 | serine incorporator 1 | 0.0168819 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0168736 |
| RPS15A | ribosomal protein S15a | 0.016846 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0166977 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0165394 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0164674 |
| NCKAP1 | NCK-associated protein 1 | 0.0163981 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0160933 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0159961 |
| RANBP2 | RAN binding protein 2 | 0.0158364 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0158114 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0156523 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.015577 |
| AUTS2 | autism susceptibility candidate 2 | 0.0155697 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | 0.0154551 |
| SARNP | SAP domain containing ribonucleoprotein | 0.015249 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0152229 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.0150674 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0150415 |
| FOXP2 | forkhead box P2 | 0.0149857 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0149715 |
| EP300 | E1A binding protein p300 | 0.0149014 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0148651 |
| RPL3 | ribosomal protein L3 | 0.01485 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.0147632 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | 0.0147061 |
| DCTN1 | dynactin 1 | 0.0146676 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0145917 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0145791 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.014533 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0144921 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0144718 |
| CEP250 | centrosomal protein 250kDa | 0.0144544 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0143301 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0142437 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0141956 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0141392 |
| KHSRP | KH-type splicing regulatory protein | 0.0141321 |
| SPAG5 | sperm associated antigen 5 | 0.0140161 |
| USP24 | ubiquitin specific peptidase 24 | 0.0140071 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | -0.147178 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.142742 |
| VIM | vimentin | -0.124713 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.114422 |
| FNDC3B | fibronectin type III domain containing 3B | -0.110762 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.10009 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0985891 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.095193 |
| PHIP | pleckstrin homology domain interacting protein | -0.0906099 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.089716 |
| RPS6 | ribosomal protein S6 | -0.0879579 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0869142 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0860437 |
| ITGAV | integrin, alpha V | -0.0829451 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0807459 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0780074 |
| POTEF | POTE ankyrin domain family, member F | -0.0773411 |
| CADM2 | cell adhesion molecule 2 | -0.070806 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0700964 |
| PFN1 | profilin 1 | -0.0657096 |
| HDAC9 | histone deacetylase 9 | -0.0639327 |
| COL5A2 | collagen, type V, alpha 2 | -0.0618127 |
| MED13L | mediator complex subunit 13-like | -0.0617291 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0598954 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0591164 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0580957 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0568005 |
| DST | dystonin | -0.0567804 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0567644 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0557327 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0547293 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0511166 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0507214 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0504888 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0498789 |
| PCDH9 | protocadherin 9 | -0.0498228 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0490867 |
| TMSB10 | thymosin beta 10 | -0.0483633 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0481745 |
| PEG10 | paternally expressed 10 | -0.0478115 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0473834 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0468911 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0453245 |
| RPS8 | ribosomal protein S8 | -0.0453191 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0444857 |
| SRP54 | signal recognition particle 54kDa | -0.0443366 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0436746 |
| NFIA | nuclear factor I/A | -0.0432977 |
| THOC2 | THO complex 2 | -0.0431984 |
| CENPF | centromere protein F, 350/400kDa | -0.0426442 |
| PRKD1 | protein kinase D1 | -0.0426144 |
| RPS2 | ribosomal protein S2 | -0.0423309 |
| GNAS | GNAS complex locus | -0.0416469 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0412309 |
| SNX6 | sorting nexin 6 | -0.0395671 |
| TUBA1B | tubulin, alpha 1b | -0.0393584 |
| PGK1 | phosphoglycerate kinase 1 | -0.0389787 |
| GOLGA4 | golgin A4 | -0.0389014 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0384948 |
| MEIS2 | Meis homeobox 2 | -0.0384899 |
| RAD51B | RAD51 paralog B | -0.0379298 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0378205 |
| RPLP0 | ribosomal protein, large, P0 | -0.0377116 |
| RPS16 | ribosomal protein S16 | -0.0369534 |
| NRG1 | neuregulin 1 | -0.036671 |
| LPIN2 | lipin 2 | -0.0366459 |
| SETD5 | SET domain containing 5 | -0.0359618 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0357489 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0351817 |
| ENO1 | enolase 1, (alpha) | -0.0350982 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0349134 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0344148 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0343712 |
| RPLP1 | ribosomal protein, large, P1 | -0.0335012 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0333576 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0323121 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0320147 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0320067 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0318625 |
| NHSL1 | NHS-like 1 | -0.0318477 |
| TOX | thymocyte selection-associated high mobility group box | -0.0317269 |
| PRTG | protogenin | -0.0316671 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | -0.0312546 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0312047 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.031079 |
| YBX1 | Y box binding protein 1 | -0.0309054 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0306635 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0306299 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0305176 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0301097 |
| HMGA1 | high mobility group AT-hook 1 | -0.030034 |
| NEBL | nebulette | -0.0296001 |
| TMSB4X | thymosin beta 4, X-linked | -0.0293907 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0291337 |
| RBM25 | RNA binding motif protein 25 | -0.0290296 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0286323 |
| RPL35A | ribosomal protein L35a | -0.0284606 |
| PRELID2 | PRELI domain containing 2 | -0.0284231 |
| ZNF217 | zinc finger protein 217 | -0.0284024 |
| SHROOM3 | shroom family member 3 | -0.0283276 |
