| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0902765 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0702014 |
| AHNAK | AHNAK nucleoprotein | 0.0500234 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0487354 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0421098 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0345521 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0339322 |
| DIAPH3 | diaphanous-related formin 3 | 0.0339037 |
| HDAC9 | histone deacetylase 9 | 0.0338231 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0333271 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0321475 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0321123 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0312374 |
| MACROD2 | MACRO domain containing 2 | 0.0303641 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0298253 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0267315 |
| RPL31 | ribosomal protein L31 | 0.0235274 |
| MKI67 | marker of proliferation Ki-67 | 0.0234245 |
| VIM | vimentin | 0.0229227 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.0227852 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0215534 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0214152 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0213972 |
| B2M | beta-2-microglobulin | 0.0213605 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0204535 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0193876 |
| TUFT1 | tuftelin 1 | 0.018971 |
| MLIP | muscular LMNA-interacting protein | 0.0188349 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0187391 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0184689 |
| KLF6 | Kruppel-like factor 6 | 0.0179275 |
| H1-4 | H1.4 linker histone, cluster member | 0.0160625 |
| RPL3 | ribosomal protein L3 | 0.0160262 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0156959 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0156894 |
| JUN | jun proto-oncogene | 0.0156876 |
| MYOF | myoferlin | 0.0156627 |
| RPS8 | ribosomal protein S8 | 0.01532 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0150562 |
| SFTPA2 | surfactant protein A2 | 0.0149724 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.014715 |
| PLXNA1 | plexin A1 | 0.0146955 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0145747 |
| RPL4 | ribosomal protein L4 | 0.0139544 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0136495 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0135022 |
| LMO7 | LIM domain 7 | 0.0134933 |
| XIRP2 | xin actin binding repeat containing 2 | 0.0134128 |
| NDRG1 | N-myc downstream regulated 1 | 0.0131495 |
| FLNA | filamin A, alpha | 0.0131123 |
| NAV2 | neuron navigator 2 | 0.013108 |
| ANLN | anillin, actin binding protein | 0.0130962 |
| EFNA5 | ephrin-A5 | 0.0130835 |
| DUSP16 | dual specificity phosphatase 16 | 0.0129642 |
| AEBP2 | AE binding protein 2 | 0.0126265 |
| RPS3 | ribosomal protein S3 | 0.0125963 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0125105 |
| SMAD3 | SMAD family member 3 | 0.0124927 |
| HLA-E | major histocompatibility complex, class I, E | 0.0123431 |
| FN1 | fibronectin 1 | 0.0122303 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0121003 |
| AOPEP | aminopeptidase O (putative) | 0.0118517 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0117136 |
| FOXP2 | forkhead box P2 | 0.0116727 |
| CTTN | cortactin | 0.0116674 |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) | 0.0116388 |
| CDV3 | CDV3 homolog (mouse) | 0.0115439 |
| ANXA1 | annexin A1 | 0.0114984 |
| RPL23 | ribosomal protein L23 | 0.011497 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0114698 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0114413 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.011216 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0111957 |
| IGF2 | insulin-like growth factor 2 | 0.0111524 |
| WWOX | WW domain containing oxidoreductase | 0.0111006 |
| CEP250 | centrosomal protein 250kDa | 0.011098 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0110741 |
| POLH | polymerase (DNA directed), eta | 0.0110282 |
| PDE10A | phosphodiesterase 10A | 0.0109979 |
| RPS12 | ribosomal protein S12 | 0.0108846 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0108375 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0107566 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0106111 |
| TPX2 | TPX2, microtubule-associated | 0.0106097 |
| RASAL2 | RAS protein activator like 2 | 0.0105779 |
| FAT1 | FAT atypical cadherin 1 | 0.010538 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0105265 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0104433 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0104355 |
| RNF213 | ring finger protein 213 | 0.0104137 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0103038 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00999082 |
| CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 0.00998776 |
| DSPP | dentin sialophosphoprotein | 0.00994977 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.00993212 |
| CORO1C | coronin, actin binding protein, 1C | 0.00985457 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.00982294 |
| CLU | clusterin | 0.00976083 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.00972029 |
| PLEC | plectin | 0.00964129 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.247398 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.219232 |
| VCL | vinculin | -0.182262 |
| PKM | pyruvate kinase, muscle | -0.174704 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.132164 |
| FLNB | filamin B, beta | -0.13006 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.12711 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.122026 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.107596 |
| PTMA | prothymosin, alpha | -0.0940402 |
| GOLGA4 | golgin A4 | -0.0914769 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0881931 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0847499 |
| ECT2 | epithelial cell transforming 2 | -0.0844746 |
| NBEA | neurobeachin | -0.0769485 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0768261 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0695189 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0661427 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0658483 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0640497 |
| PFN1 | profilin 1 | -0.0609382 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0597029 |
| RTN4 | reticulon 4 | -0.0591024 |
| TXNRD1 | thioredoxin reductase 1 | -0.0585152 |
| POTEF | POTE ankyrin domain family, member F | -0.0575245 |
| DUSP4 | dual specificity phosphatase 4 | -0.0568879 |
| PYGB | phosphorylase, glycogen; brain | -0.0567893 |
| TJP1 | tight junction protein 1 | -0.0551818 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0549332 |
| S100A6 | S100 calcium binding protein A6 | -0.0540438 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0534942 |
| CCND1 | cyclin D1 | -0.053421 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0521145 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0512228 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0500193 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0496784 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0495665 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0487982 |
| LOXL3 | lysyl oxidase-like 3 | -0.0484681 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0476912 |
| EVI5 | ecotropic viral integration site 5 | -0.0471023 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0469382 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0466763 |
| HMGA1 | high mobility group AT-hook 1 | -0.0454546 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0451196 |
| NF1 | neurofibromin 1 | -0.0450633 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0450277 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0449992 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0445111 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0444461 |
| JMJD1C | jumonji domain containing 1C | -0.044224 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0438755 |
| NUP58 | nucleoporin 58 | -0.0432164 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0426027 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0418816 |
| GLI3 | GLI family zinc finger 3 | -0.0414965 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0412296 |
| DSTN | destrin (actin depolymerizing factor) | -0.0411276 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0410085 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0410021 |
| PARD3 | par-3 family cell polarity regulator | -0.0407956 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | -0.0405969 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.039839 |
| RBM25 | RNA binding motif protein 25 | -0.0397872 |
| LDHA | lactate dehydrogenase A | -0.0397348 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.039431 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0391905 |
| NBAS | neuroblastoma amplified sequence | -0.0388259 |
| SBF2 | SET binding factor 2 | -0.0386837 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0386265 |
| TMEM41B | transmembrane protein 41B | -0.0383791 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0381349 |
| FOXP1 | forkhead box P1 | -0.0374499 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0368267 |
| COPA | coatomer protein complex, subunit alpha | -0.0367398 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0367211 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0365517 |
| DUSP6 | dual specificity phosphatase 6 | -0.036465 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0360614 |
| QKI | QKI, KH domain containing, RNA binding | -0.0358157 |
| COG5 | component of oligomeric golgi complex 5 | -0.0356831 |
| SETD5 | SET domain containing 5 | -0.0346848 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0345262 |
| USP3 | ubiquitin specific peptidase 3 | -0.0340113 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0338237 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | -0.0330025 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0328999 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0325335 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0323583 |
| RBM39 | RNA binding motif protein 39 | -0.0322591 |
| TXNIP | thioredoxin interacting protein | -0.0321017 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0317904 |
| RNF145 | ring finger protein 145 | -0.0317852 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.031696 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0314496 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0313454 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0307594 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.030636 |
| CCNL1 | cyclin L1 | -0.0301781 |
| AHI1 | Abelson helper integration site 1 | -0.0300656 |
