| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.164825 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0853699 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0660793 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0659566 |
| FLNA | filamin A, alpha | 0.0545339 |
| CFB | complement factor B | 0.047772 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0470932 |
| PLIN2 | perilipin 2 | 0.0392753 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0379661 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0332842 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0332599 |
| DST | dystonin | 0.0306497 |
| RNF213 | ring finger protein 213 | 0.0304078 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0303452 |
| CEP250 | centrosomal protein 250kDa | 0.0298017 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0285904 |
| CADM1 | cell adhesion molecule 1 | 0.0280133 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0268085 |
| CALR | calreticulin | 0.0262379 |
| FBXO32 | F-box protein 32 | 0.0261111 |
| TUBB | tubulin, beta class I | 0.0259997 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0240861 |
| ACTG1 | actin gamma 1 | 0.0236615 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0234796 |
| AHNAK | AHNAK nucleoprotein | 0.0227841 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0222697 |
| HLA-C | major histocompatibility complex, class I, C | 0.0216546 |
| FLNB | filamin B, beta | 0.021476 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0213846 |
| RPL3 | ribosomal protein L3 | 0.0208691 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0204279 |
| ANXA1 | annexin A1 | 0.0196573 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0192826 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0189667 |
| FILIP1L | filamin A interacting protein 1-like | 0.018039 |
| RPS4X | ribosomal protein S4, X-linked | 0.0175997 |
| ADM | adrenomedullin | 0.0170029 |
| RND3 | Rho family GTPase 3 | 0.0164371 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0163208 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0161778 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0160066 |
| PLEC | plectin | 0.0159115 |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | 0.0152207 |
| SFTPA2 | surfactant protein A2 | 0.0151227 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0150685 |
| WTAP | Wilms tumor 1 associated protein | 0.014859 |
| KYNU | kynureninase | 0.0146988 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0145952 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0144859 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0143834 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0143494 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0143253 |
| TRIM25 | tripartite motif containing 25 | 0.0142723 |
| FNIP2 | folliculin interacting protein 2 | 0.0137959 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0135031 |
| CAVIN1 | caveolae associated protein 1 | 0.0131531 |
| PCBP3 | poly(rC) binding protein 3 | 0.0131324 |
| APOL2 | apolipoprotein L, 2 | 0.0128989 |
| APOL1 | apolipoprotein L, 1 | 0.012854 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0125509 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | 0.0124671 |
| NRN1 | neuritin 1 | 0.0123666 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0123171 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0122404 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.0121066 |
| LMNA | lamin A/C | 0.0120462 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0120114 |
| COL5A2 | collagen, type V, alpha 2 | 0.0118651 |
| RNF144B | ring finger protein 144B | 0.0116633 |
| FAM219A | family with sequence similarity 219, member A | 0.0113877 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0112446 |
| NONO | non-POU domain containing, octamer-binding | 0.0112286 |
| TUFT1 | tuftelin 1 | 0.0109014 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.010859 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0108088 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0107727 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0107483 |
| MINK1 | misshapen-like kinase 1 | 0.0106808 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0106345 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0105853 |
| PALLD | palladin, cytoskeletal associated protein | 0.0105674 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0104468 |
| NNMT | nicotinamide N-methyltransferase | 0.0104051 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0104029 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0102559 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0101233 |
| RPL4 | ribosomal protein L4 | 0.010119 |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.0100949 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0100185 |
| ENAH | enabled homolog (Drosophila) | 0.00990154 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.00967817 |
| ATF3 | activating transcription factor 3 | 0.00952756 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.00950593 |
| PPL | periplakin | 0.00946448 |
| AHR | aryl hydrocarbon receptor | 0.00940074 |
| OPTN | optineurin | 0.00934418 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.00928443 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.00927784 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.00919932 |
| STC2 | stanniocalcin 2 | 0.00916305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.247392 |
| CD44 | CD44 molecule (Indian blood group) | -0.190776 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.132466 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.109062 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.100872 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0992153 |
| HMGA2 | high mobility group AT-hook 2 | -0.0875675 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0849903 |
| VCAN | versican | -0.0828596 |
| STC1 | stanniocalcin 1 | -0.0790338 |
| EGR1 | early growth response 1 | -0.0786079 |
| GLIS3 | GLIS family zinc finger 3 | -0.0758242 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0746923 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0738688 |
| RPS6 | ribosomal protein S6 | -0.0736283 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0729764 |
| FRMD4A | FERM domain containing 4A | -0.0722549 |
| PDE10A | phosphodiesterase 10A | -0.071469 |
| NAV2 | neuron navigator 2 | -0.0677941 |
| FN1 | fibronectin 1 | -0.0644885 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0623291 |
| VIM | vimentin | -0.0611719 |
| RTN4 | reticulon 4 | -0.0601622 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0586689 |
| VCL | vinculin | -0.0585207 |
| MSN | moesin | -0.0584583 |
| CDCP1 | CUB domain containing protein 1 | -0.0542368 |
| JMJD1C | jumonji domain containing 1C | -0.0539527 |
| CDH13 | cadherin 13 | -0.0535297 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0533372 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0528808 |
| RUNX1 | runt-related transcription factor 1 | -0.0528261 |
| GOLGA4 | golgin A4 | -0.052471 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0523235 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0518267 |
| SPAG9 | sperm associated antigen 9 | -0.0516705 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.050784 |
| MT2A | metallothionein 2A | -0.0500176 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0488543 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0486683 |
| IER3 | immediate early response 3 | -0.047818 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0468923 |
| ASPH | aspartate beta-hydroxylase | -0.046867 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0454262 |
| CENPF | centromere protein F, 350/400kDa | -0.0444169 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0442346 |
| CCNL1 | cyclin L1 | -0.0429165 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0427781 |
| SNX9 | sorting nexin 9 | -0.0427317 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0427256 |
| EFNA5 | ephrin-A5 | -0.0425215 |
| ANXA2 | annexin A2 | -0.0424919 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0423844 |
| VMP1 | vacuole membrane protein 1 | -0.0415068 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.041441 |
| GPC6 | glypican 6 | -0.0407177 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0402693 |
| RPS2 | ribosomal protein S2 | -0.0387581 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.038479 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0384329 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0375834 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0370903 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0370349 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0368533 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0367869 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0367181 |
| HMGA1 | high mobility group AT-hook 1 | -0.0367042 |
| TOP1 | topoisomerase (DNA) I | -0.0363632 |
| TPM1 | tropomyosin 1 (alpha) | -0.0362188 |
| BICC1 | BicC family RNA binding protein 1 | -0.0360419 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0359746 |
| SYAP1 | synapse associated protein 1 | -0.0356469 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0351189 |
| NF1 | neurofibromin 1 | -0.034971 |
| NAV1 | neuron navigator 1 | -0.0341971 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0338496 |
| ZNF292 | zinc finger protein 292 | -0.0332275 |
| MORF4L2 | mortality factor 4 like 2 | -0.0332247 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0330572 |
| PKM | pyruvate kinase, muscle | -0.0328923 |
| DUSP5 | dual specificity phosphatase 5 | -0.0328291 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0327585 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0327306 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0324342 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0323228 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0322674 |
| MKI67 | marker of proliferation Ki-67 | -0.0317276 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0316779 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0315824 |
| FNIP1 | folliculin interacting protein 1 | -0.0314295 |
| SMAD3 | SMAD family member 3 | -0.0313568 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0310392 |
| RPS24 | ribosomal protein S24 | -0.0308745 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0307049 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0305965 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0303858 |
| RAI14 | retinoic acid induced 14 | -0.0302464 |
| ERBIN | erbb2 interacting protein | -0.030222 |
| RBM39 | RNA binding motif protein 39 | -0.0301001 |
| MCL1 | myeloid cell leukemia 1 | -0.0299486 |
