Trametinib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.13813
MYH9 myosin, heavy chain 9, non-muscle 0.105299
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0703344
B2M beta-2-microglobulin 0.0686274
IGFBP7 insulin-like growth factor binding protein 7 0.0624297
TGFBI transforming growth factor, beta-induced, 68kDa 0.0590046
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0586241
TRIO trio Rho guanine nucleotide exchange factor 0.0571541
CAVIN1 caveolae associated protein 1 0.0506574
FLNA filamin A, alpha 0.0478829
AHNAK AHNAK nucleoprotein 0.0469834
TMSB10 thymosin beta 10 0.0466556
KYNU kynureninase 0.0458328
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0417974
SAMD4A sterile alpha motif domain containing 4A 0.0402687
COL1A2 collagen, type I, alpha 2 0.0387892
TNS3 tensin 3 0.0366124
SDC4 syndecan 4 0.0345549
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0317232
CD44 CD44 molecule (Indian blood group) 0.0315902
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0300708
CALR calreticulin 0.0297004
COL4A2 collagen, type IV, alpha 2 0.0289966
TNIP1 TNFAIP3 interacting protein 1 0.0277951
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0274259
RPL3 ribosomal protein L3 0.027117
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0269934
FSTL1 follistatin-like 1 0.0265147
SHB Src homology 2 domain containing adaptor protein B 0.0261853
COL5A1 collagen, type V, alpha 1 0.0260766
MSN moesin 0.0259436
COL6A2 collagen, type VI, alpha 2 0.0259237
PLD3 phospholipase D family, member 3 0.0259126
PLEC plectin 0.02583
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0257309
OXSR1 oxidative stress responsive 1 0.0253571
SDC2 syndecan 2 0.025208
HIP1 huntingtin interacting protein 1 0.0251584
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0249711
ZEB2 zinc finger E-box binding homeobox 2 0.0245743
MYO10 myosin X 0.024259
PALLD palladin, cytoskeletal associated protein 0.0242531
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0239883
COL5A2 collagen, type V, alpha 2 0.0238081
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0236494
HERPUD2 HERPUD family member 2 0.0231833
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0227855
PRICKLE2 prickle homolog 2 (Drosophila) 0.0227519
LIMS1 LIM and senescent cell antigen-like domains 1 0.0224676
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0224353
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.022078
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.021946
GSE1 Gse1 coiled-coil protein 0.0218838
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0218539
RHOA ras homolog family member A 0.0218205
C1R complement component 1, r subcomponent 0.021466
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0212888
ARHGAP21 Rho GTPase activating protein 21 0.0210076
OSER1 oxidative stress responsive serine-rich 1 0.0209137
VCL vinculin 0.0205209
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0203556
AMPD3 adenosine monophosphate deaminase 3 0.0202796
LOXL2 lysyl oxidase-like 2 0.0200732
COL7A1 collagen, type VII, alpha 1 0.0200293
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.0197878
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0197154
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0196554
RNF114 ring finger protein 114 0.0194783
EIF4H eukaryotic translation initiation factor 4H 0.0194338
RANBP2 RAN binding protein 2 0.0193838
SFTPA2 surfactant protein A2 0.0193285
IGFBP6 insulin-like growth factor binding protein 6 0.0191852
NCOR1 nuclear receptor corepressor 1 0.0189461
BSDC1 BSD domain containing 1 0.0185421
DCLK2 doublecortin-like kinase 2 0.0183835
KATNAL1 katanin p60 subunit A-like 1 0.0183705
CALD1 caldesmon 1 0.0183574
SRRT serrate, RNA effector molecule 0.0183096
TPST1 tyrosylprotein sulfotransferase 1 0.0182988
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0182829
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.018197
KLF6 Kruppel-like factor 6 0.0181268
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0181144
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0179699
NUDCD3 NudC domain containing 3 0.0178997
ANXA1 annexin A1 0.0178674
WTAP Wilms tumor 1 associated protein 0.0177026
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0175867
IWS1 IWS1 homolog (S. cerevisiae) 0.0175478
C1S complement component 1, s subcomponent 0.017487
FMNL2 formin-like 2 0.017464
VCAN versican 0.0174454
SP100 SP100 nuclear antigen 0.0174162
PLCG1 phospholipase C, gamma 1 0.0173813
PRELID2 PRELI domain containing 2 0.0173649
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0173188
RHOQ ras homolog family member Q 0.0173034
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0172267
KAZN kazrin, periplakin interacting protein 0.0171836
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0171403

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164884
CXCL8 chemokine (C-X-C motif) ligand 8 -0.154044
IGFBP3 insulin-like growth factor binding protein 3 -0.146928
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.122611
FTH1 ferritin, heavy polypeptide 1 -0.118375
FN1 fibronectin 1 -0.0956875
MT2A metallothionein 2A -0.0953102
HMGA2 high mobility group AT-hook 2 -0.0911888
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0890121
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0714804
NAMPT nicotinamide phosphoribosyltransferase -0.070599
MEF2A myocyte enhancer factor 2A -0.0698261
NDRG1 N-myc downstream regulated 1 -0.0682805
EGR1 early growth response 1 -0.0665038
ENO1 enolase 1, (alpha) -0.0612928
RTN4 reticulon 4 -0.0612846
COL6A1 collagen, type VI, alpha 1 -0.0587033
ZNF395 zinc finger protein 395 -0.0573163
DLG1 discs, large homolog 1 (Drosophila) -0.05616
STC1 stanniocalcin 1 -0.055738
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0554323
F3 coagulation factor III (thromboplastin, tissue factor) -0.0544662
PDIA3 protein disulfide isomerase family A, member 3 -0.0534426
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0533751
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0532967
GLIS3 GLIS family zinc finger 3 -0.0521992
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0518036
POTEF POTE ankyrin domain family, member F -0.0514671
ASPH aspartate beta-hydroxylase -0.0496764
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.049068
SEC31A SEC31 homolog A (S. cerevisiae) -0.0480286
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0474643
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.047304
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0444833
MAP1B microtubule-associated protein 1B -0.042619
PSD3 pleckstrin and Sec7 domain containing 3 -0.0418815
HM13 histocompatibility (minor) 13 -0.0405838
KMT2E lysine (K)-specific methyltransferase 2E -0.0402284
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0398219
NF1 neurofibromin 1 -0.0395957
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0382188
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0381579
JMJD1C jumonji domain containing 1C -0.0379467
TOP1 topoisomerase (DNA) I -0.0373404
CDK6 cyclin-dependent kinase 6 -0.0367571
CANX calnexin -0.0366444
RPS6 ribosomal protein S6 -0.0359601
ACBD3 acyl-CoA binding domain containing 3 -0.0357376
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0357288
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0348558
ECE1 endothelin converting enzyme 1 -0.0338378
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0329648
GOLGA4 golgin A4 -0.0328902
SMYD3 SET and MYND domain containing 3 -0.0325222
PDIA6 protein disulfide isomerase family A, member 6 -0.0323395
ELL2 elongation factor, RNA polymerase II, 2 -0.032318
PDE4D phosphodiesterase 4D, cAMP-specific -0.0320665
RPL28 ribosomal protein L28 -0.0319019
TAS2R14 taste receptor, type 2, member 14 -0.0317868
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0314114
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0313104
PICALM phosphatidylinositol binding clathrin assembly protein -0.0312896
CCNI cyclin I -0.0312056
MON2 MON2 homolog (S. cerevisiae) -0.0311062
TMEM123 transmembrane protein 123 -0.0307564
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0305294
SEPTIN7 septin 7 -0.0304348
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0303971
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.030378
PDIA4 protein disulfide isomerase family A, member 4 -0.03012
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0297799
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0297454
PDE10A phosphodiesterase 10A -0.0296688
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0295181
AFF3 AF4/FMR2 family, member 3 -0.0293836
VEGFA vascular endothelial growth factor A -0.0289358
MAML2 mastermind-like 2 (Drosophila) -0.0288237
CLEC1B C-type lectin domain family 1, member B -0.0286053
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0285806
BACE2 beta-site APP-cleaving enzyme 2 -0.028543
FOSL1 FOS-like antigen 1 -0.0285116
MARCHF7 membrane associated ring-CH-type finger 7 -0.0283316
EGFR epidermal growth factor receptor -0.0282287
PCNX1 pecanex 1 -0.0280417
RPL37A ribosomal protein L37a -0.0279987
PTMA prothymosin, alpha -0.0279522
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0272361
EMP1 epithelial membrane protein 1 -0.0271684
IL6 interleukin 6 -0.027109
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.027087
NIPBL Nipped-B homolog (Drosophila) -0.0265181
LDHA lactate dehydrogenase A -0.0262739
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0261216
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0261064
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0261062
VDAC1 voltage-dependent anion channel 1 -0.0259058
ARB2A ARB2 cotranscriptional regulator A -0.0258738
BABAM2 BRISC and BRCA1 A complex member 2 -0.02582
RNF145 ring finger protein 145 -0.025671
RAD21 RAD21 homolog (S. pombe) -0.0256429