| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.193533 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0730057 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0619954 |
| CEP250 | centrosomal protein 250kDa | 0.0449877 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0441505 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0438983 |
| SET | SET nuclear proto-oncogene | 0.042889 |
| TXNRD1 | thioredoxin reductase 1 | 0.0423773 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.042007 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0410246 |
| TPX2 | TPX2, microtubule-associated | 0.0384593 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0379909 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0352418 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.031237 |
| CALR | calreticulin | 0.0307259 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0300557 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0297631 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0297402 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0275454 |
| BRD2 | bromodomain containing 2 | 0.0273778 |
| MRE11 | MRE11 homolog, double strand break repair nuclease | 0.0266202 |
| SQSTM1 | sequestosome 1 | 0.0258157 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0257291 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0245918 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0245822 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0243658 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0242171 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0241104 |
| RPL3 | ribosomal protein L3 | 0.0235432 |
| FLNA | filamin A, alpha | 0.0233781 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0233388 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0231395 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0228276 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0227255 |
| WDR70 | WD repeat domain 70 | 0.0226173 |
| DST | dystonin | 0.022419 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0223168 |
| BRD8 | bromodomain containing 8 | 0.0220901 |
| RPL4 | ribosomal protein L4 | 0.0218458 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0215283 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0215111 |
| SIK3 | SIK family kinase 3 | 0.0214563 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0209074 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0207314 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0204801 |
| PNN | pinin, desmosome associated protein | 0.0204132 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0203881 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0202624 |
| PCM1 | pericentriolar material 1 | 0.0202198 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0201118 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0199463 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0196958 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0194398 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0194281 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0193465 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0193333 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0192601 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.019219 |
| SEPTIN2 | septin 2 | 0.0190618 |
| RAB10 | RAB10, member RAS oncogene family | 0.0188227 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.0186028 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0184013 |
| SSRP1 | structure specific recognition protein 1 | 0.0183626 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0182584 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.018208 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0180931 |
| FOSL2 | FOS-like antigen 2 | 0.0180899 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0178839 |
| ATF3 | activating transcription factor 3 | 0.0178256 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0177836 |
| DENND4A | DENN/MADD domain containing 4A | 0.0177556 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0177023 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0177015 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0176685 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0176377 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.017458 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0174365 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0173632 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0172425 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0172111 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0171449 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.0166066 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0164708 |
| SRCAP | Snf2-related CREBBP activator protein | 0.016457 |
| TUBB | tubulin, beta class I | 0.0163838 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0162091 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0161171 |
| HMGB2 | high mobility group box 2 | 0.0160324 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.0157424 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.015731 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0157207 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0156493 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0156105 |
| CYCS | cytochrome c, somatic | 0.0156078 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0154956 |
| CPNE1 | copine I | 0.0154676 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0154294 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0152927 |
| KIF22 | kinesin family member 22 | 0.0151878 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0151862 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | -0.200891 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.170035 |
| TMSB10 | thymosin beta 10 | -0.12578 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.118077 |
| VIM | vimentin | -0.114356 |
| HMGA2 | high mobility group AT-hook 2 | -0.114162 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.106572 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0969879 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0959187 |
| MT2A | metallothionein 2A | -0.094724 |
| ASPH | aspartate beta-hydroxylase | -0.084306 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.081236 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0809266 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0765328 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.075942 |
| CD44 | CD44 molecule (Indian blood group) | -0.0752165 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0748116 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0724402 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0707537 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0699063 |
| FMNL2 | formin-like 2 | -0.0687901 |
| ANGPTL4 | angiopoietin-like 4 | -0.0657525 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0626547 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.06131 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.060056 |
| FLNB | filamin B, beta | -0.0555694 |
| SNX14 | sorting nexin 14 | -0.0540718 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0533727 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0533044 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0524288 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0517113 |
| AHNAK | AHNAK nucleoprotein | -0.0514482 |
| EGR1 | early growth response 1 | -0.0511388 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0507137 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0504766 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.049733 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0485493 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0480411 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0479292 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0475794 |
| FMN1 | formin 1 | -0.0474166 |
| SVIL | supervillin | -0.0471053 |
| CDCP1 | CUB domain containing protein 1 | -0.0468651 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0466058 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0465338 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0462919 |
| IER3 | immediate early response 3 | -0.0461752 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0453114 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0449224 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0448222 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0442832 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0442283 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0439622 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0416896 |
| DNER | delta/notch-like EGF repeat containing | -0.0412376 |
| PCED1B | PC-esterase domain containing 1B | -0.0412074 |
| ATM | ATM serine/threonine kinase | -0.0408622 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0407732 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0403633 |
| ANO6 | anoctamin 6 | -0.0402516 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0401918 |
| RPL35A | ribosomal protein L35a | -0.040034 |
| PCNX4 | pecanex 4 | -0.0397207 |
| DTNA | dystrobrevin, alpha | -0.0396979 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0394604 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0394171 |
| NF1 | neurofibromin 1 | -0.0376126 |
| OSMR | oncostatin M receptor | -0.0373575 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0365933 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0363287 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0363147 |
| SPAG9 | sperm associated antigen 9 | -0.0362459 |
| PGK1 | phosphoglycerate kinase 1 | -0.0359755 |
| POTEF | POTE ankyrin domain family, member F | -0.035956 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0354291 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.035406 |
| FAM3C | family with sequence similarity 3, member C | -0.0349796 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0345287 |
| MCL1 | myeloid cell leukemia 1 | -0.0341946 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0341335 |
| VCL | vinculin | -0.0341053 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0339944 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0338979 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.033538 |
| ACER3 | alkaline ceramidase 3 | -0.0334027 |
| PFN1 | profilin 1 | -0.0332068 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0327651 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.032741 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0325567 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0324883 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0316339 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0311756 |
| ATG7 | autophagy related 7 | -0.0307659 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0307204 |
| ETV1 | ets variant 1 | -0.0304898 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0302886 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0302027 |
| GLRX | glutaredoxin (thioltransferase) | -0.0301105 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0300681 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0298333 |
