Trametinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.130163
EXT1 exostosin glycosyltransferase 1 0.125859
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.079546
CFB complement factor B 0.0758511
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0748426
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0586201
TNS3 tensin 3 0.0583943
ENAH enabled homolog (Drosophila) 0.0558348
OSMR oncostatin M receptor 0.052459
TXNRD1 thioredoxin reductase 1 0.0521742
RUNX2 runt-related transcription factor 2 0.050845
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0500237
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0499677
FTL ferritin, light polypeptide 0.0491516
PALLD palladin, cytoskeletal associated protein 0.04657
ZFP36L1 ZFP36 ring finger protein-like 1 0.0424819
SFTPA2 surfactant protein A2 0.039745
AOPEP aminopeptidase O (putative) 0.039644
B2M beta-2-microglobulin 0.0385837
THBS1 thrombospondin 1 0.0381134
GPC6 glypican 6 0.0359114
TGFB2 transforming growth factor, beta 2 0.035517
SOX4 SRY (sex determining region Y)-box 4 0.0355117
NTN4 netrin 4 0.0350427
ANKRD28 ankyrin repeat domain 28 0.0348811
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.033536
RNF213 ring finger protein 213 0.0326167
CD109 CD109 molecule 0.0326124
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0322806
IFI16 interferon, gamma-inducible protein 16 0.0318782
PELI1 pellino E3 ubiquitin protein ligase 1 0.0317606
PLIN2 perilipin 2 0.0303338
SAMD4A sterile alpha motif domain containing 4A 0.0298969
ADD3 adducin 3 (gamma) 0.0297614
STC2 stanniocalcin 2 0.0286975
DST dystonin 0.0286681
PTGR1 prostaglandin reductase 1 0.0283756
MGST1 microsomal glutathione S-transferase 1 0.0269198
FMN1 formin 1 0.0267991
SOD2 superoxide dismutase 2, mitochondrial 0.0267725
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0265956
TRIO trio Rho guanine nucleotide exchange factor 0.0261489
MYOF myoferlin 0.0259917
IFI27 interferon, alpha-inducible protein 27 0.0258151
BICC1 BicC family RNA binding protein 1 0.0257933
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0250929
PRKCSH protein kinase C substrate 80K-H 0.0250007
MYH9 myosin, heavy chain 9, non-muscle 0.0245417
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0243097
LIFR leukemia inhibitory factor receptor alpha 0.0240255
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0232916
PCBP3 poly(rC) binding protein 3 0.0227899
IL1R1 interleukin 1 receptor, type I 0.0226548
ARHGAP42 Rho GTPase activating protein 42 0.0221877
ZEB2 zinc finger E-box binding homeobox 2 0.0219352
FBXO32 F-box protein 32 0.0215277
ZMIZ1 zinc finger, MIZ-type containing 1 0.0210124
RASAL2 RAS protein activator like 2 0.0209072
CAB39 calcium binding protein 39 0.0204083
MKI67 marker of proliferation Ki-67 0.020202
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0200926
ACTG1 actin gamma 1 0.0199104
ENO2 enolase 2 (gamma, neuronal) 0.0198951
IGFBP3 insulin-like growth factor binding protein 3 0.0192765
LMCD1 LIM and cysteine-rich domains 1 0.0191693
HMGB3 high mobility group box 3 0.0189839
SSBP2 single-stranded DNA binding protein 2 0.0184599
MMP13 matrix metallopeptidase 13 0.0183937
SOS1 son of sevenless homolog 1 (Drosophila) 0.0181015
FNDC3B fibronectin type III domain containing 3B 0.0180887
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0180253
SLC22A23 solute carrier family 22, member 23 0.0179987
HEG1 heart development protein with EGF-like domains 1 0.0178042
ZNF608 zinc finger protein 608 0.0177598
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0176813
KLHL5 kelch-like family member 5 0.0175364
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0174912
MTUS1 microtubule associated tumor suppressor 1 0.0170721
IFI6 interferon, alpha-inducible protein 6 0.0170702
SPIDR scaffolding protein involved in DNA repair 0.0164958
CP ceruloplasmin (ferroxidase) 0.0163936
MX2 MX dynamin-like GTPase 2 0.0163234
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.016111
SIRT1 sirtuin 1 0.0159739
HLA-A major histocompatibility complex, class I, A 0.0159167
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0156398
GBP2 guanylate binding protein 2, interferon-inducible 0.0155439
DUSP16 dual specificity phosphatase 16 0.0154636
ZFHX3 zinc finger homeobox 3 0.0154285
LURAP1L leucine rich adaptor protein 1-like 0.0154259
STON2 stonin 2 0.0151951
PARP14 poly (ADP-ribose) polymerase family, member 14 0.015159
RBM47 RNA binding motif protein 47 0.0150884
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0149757
DLG1 discs, large homolog 1 (Drosophila) 0.0147281
UGCG UDP-glucose ceramide glucosyltransferase 0.0145518
CADM1 cell adhesion molecule 1 0.0145415
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0145184
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0142869
C1R complement component 1, r subcomponent 0.0142809

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.219114
HMGA2 high mobility group AT-hook 2 -0.190849
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176443
CXCL8 chemokine (C-X-C motif) ligand 8 -0.175958
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.15701
NRG1 neuregulin 1 -0.148075
ITGA1 integrin, alpha 1 -0.13227
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.112662
NAMPT nicotinamide phosphoribosyltransferase -0.0974241
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0917557
FN1 fibronectin 1 -0.0917371
ASPH aspartate beta-hydroxylase -0.0808823
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0739381
CANX calnexin -0.0658429
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0642678
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0641692
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0632243
MT2A metallothionein 2A -0.0626927
RICTOR RPTOR independent companion of MTOR, complex 2 -0.055747
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0553983
GRB10 growth factor receptor-bound protein 10 -0.0501555
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0477793
PTK2 protein tyrosine kinase 2 -0.0475306
EFNA5 ephrin-A5 -0.0449989
EREG epiregulin -0.0447142
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0440177
NPAS2 neuronal PAS domain protein 2 -0.0413778
MCTP2 multiple C2 domains, transmembrane 2 -0.0411393
SPAG9 sperm associated antigen 9 -0.0409434
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0394012
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0385129
TOP1 topoisomerase (DNA) I -0.0384985
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0381843
P4HB prolyl 4-hydroxylase, beta polypeptide -0.037991
PELO pelota homolog (Drosophila) -0.0367555
OSBPL8 oxysterol binding protein-like 8 -0.0354276
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.033866
TMSB4X thymosin beta 4, X-linked -0.0333587
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0327413
SUCO SUN domain containing ossification factor -0.0325518
HPCAL1 hippocalcin-like 1 -0.0322906
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0305994
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0303424
HMGA1 high mobility group AT-hook 1 -0.0301225
MCTP1 multiple C2 domains, transmembrane 1 -0.0294602
NRIP1 nuclear receptor interacting protein 1 -0.0294138
KDM5B lysine (K)-specific demethylase 5B -0.0289089
INTS6 integrator complex subunit 6 -0.0284618
BHLHE40 basic helix-loop-helix family, member e40 -0.0284229
DUSP6 dual specificity phosphatase 6 -0.0283024
FNBP1 formin binding protein 1 -0.0279625
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0278844
COPA coatomer protein complex, subunit alpha -0.0278821
AGO2 argonaute RISC catalytic component 2 -0.0272877
HELZ helicase with zinc finger -0.0264822
ETV1 ets variant 1 -0.0262591
LCORL ligand dependent nuclear receptor corepressor-like -0.0260637
BIRC6 baculoviral IAP repeat containing 6 -0.0258076
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0257941
COG5 component of oligomeric golgi complex 5 -0.0255644
RLF rearranged L-myc fusion -0.0255586
TFPI2 tissue factor pathway inhibitor 2 -0.0253765
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0253698
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0252047
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0248297
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0247525
SHB Src homology 2 domain containing adaptor protein B -0.0244963
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0243297
EMP1 epithelial membrane protein 1 -0.0240666
CD44 CD44 molecule (Indian blood group) -0.0239515
CALU calumenin -0.0236329
ELL2 elongation factor, RNA polymerase II, 2 -0.0234945
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0234226
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0234045
WWTR1 WW domain containing transcription regulator 1 -0.0233537
RPS27A ribosomal protein S27a -0.0233322
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0232471
FBXW11 F-box and WD repeat domain containing 11 -0.0231165
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0230875
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0230498
MYO10 myosin X -0.0230265
SYT1 synaptotagmin I -0.0230148
CDCP1 CUB domain containing protein 1 -0.023003
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0228111
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0228089
FAM3C family with sequence similarity 3, member C -0.0227249
FNDC3A fibronectin type III domain containing 3A -0.0226311
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0226176
MACF1 microtubule-actin crosslinking factor 1 -0.0226111
RAB1A RAB1A, member RAS oncogene family -0.022576
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0225722
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0224308
BICD1 bicaudal D homolog 1 (Drosophila) -0.022351
IER3 immediate early response 3 -0.0223382
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0223337
PKM pyruvate kinase, muscle -0.0221907
TGFA transforming growth factor, alpha -0.0218663
TRA2A transformer 2 alpha homolog (Drosophila) -0.0218259
USP3 ubiquitin specific peptidase 3 -0.0217775
SPDYA speedy/RINGO cell cycle regulator family member A -0.0215519