Tranilast_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.146471
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.111556
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0785082
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0756587
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0755864
BIRC3 baculoviral IAP repeat containing 3 0.0730625
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0721062
ACTG1 actin gamma 1 0.0673052
MMP12 matrix metallopeptidase 12 0.06498
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0628268
SMC4 structural maintenance of chromosomes 4 0.0587696
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0527046
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0523747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0507364
RTN4 reticulon 4 0.0502594
TXNRD1 thioredoxin reductase 1 0.050199
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0494183
MKI67 marker of proliferation Ki-67 0.0488858
ANXA1 annexin A1 0.046016
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.045847
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0454898
TUBA1B tubulin, alpha 1b 0.045233
KPNB1 karyopherin (importin) beta 1 0.0447388
IPO7 importin 7 0.0437111
XPO1 exportin 1 0.0436352
CENPF centromere protein F, 350/400kDa 0.0420859
NLGN1 neuroligin 1 0.0417146
GJA1 gap junction protein, alpha 1, 43kDa 0.0404648
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0398931
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.039374
ECT2 epithelial cell transforming 2 0.0390595
YAP1 Yes-associated protein 1 0.0382831
RAB7A RAB7A, member RAS oncogene family 0.0372464
RRM2 ribonucleotide reductase M2 0.0366328
TMEM41B transmembrane protein 41B 0.0362436
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0362248
PABPC1 poly(A) binding protein, cytoplasmic 1 0.03556
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0349647
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0348001
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0343889
CLTC clathrin, heavy chain (Hc) 0.0343283
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0339614
TPM3 tropomyosin 3 0.0333389
ADGRG6 adhesion G protein-coupled receptor G6 0.0333025
TMEM123 transmembrane protein 123 0.0329977
EEF2 eukaryotic translation elongation factor 2 0.0329144
LMO7 LIM domain 7 0.0325459
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0324785
BCHE butyrylcholinesterase 0.0321086
EDARADD EDAR-associated death domain 0.0320635
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0320367
TPX2 TPX2, microtubule-associated 0.0313505
SET SET nuclear proto-oncogene 0.0309512
POTEF POTE ankyrin domain family, member F 0.0308409
MYL12B myosin, light chain 12B, regulatory 0.0304309
ATP5F1B ATP synthase F1 subunit beta 0.0301345
UBC ubiquitin C 0.0297704
NCAPD2 non-SMC condensin I complex, subunit D2 0.0296829
CLDN1 claudin 1 0.0295188
SLC38A2 solute carrier family 38, member 2 0.029318
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0290825
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0287497
TM4SF1 transmembrane 4 L six family member 1 0.0275018
ENO1 enolase 1, (alpha) 0.0273066
AKAP12 A kinase (PRKA) anchor protein 12 0.0270808
SERBP1 SERPINE1 mRNA binding protein 1 0.0270334
TUBA1C tubulin, alpha 1c 0.0266638
KIF18B kinesin family member 18B 0.0266482
DLC1 DLC1 Rho GTPase activating protein 0.0260764
CCN2 cellular communication network factor 2 0.0256688
RASAL2 RAS protein activator like 2 0.0252101
DST dystonin 0.0242931
IL6ST interleukin 6 signal transducer 0.0239542
CBX3 chromobox homolog 3 0.0238231
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0232125
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0232106
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.023164
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0231502
PLK2 polo-like kinase 2 0.0228666
CCNL1 cyclin L1 0.0225036
VMP1 vacuole membrane protein 1 0.0224497
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0222177
PTMS parathymosin 0.0221403
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0221259
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0220481
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0219452
ATAD2 ATPase family, AAA domain containing 2 0.0219394
PRR11 proline rich 11 0.0219191
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0218271
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0217307
SGO2 shugoshin 2 0.0216841
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0215887
DIAPH3 diaphanous-related formin 3 0.0215158
TM9SF3 transmembrane 9 superfamily member 3 0.0213312
PRDX1 peroxiredoxin 1 0.0210026
BIRC2 baculoviral IAP repeat containing 2 0.0208539
MIS18BP1 MIS18 binding protein 1 0.020563
TPI1 triosephosphate isomerase 1 0.0205618
H3-3B H3.3 histone B 0.0205125
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0202121

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.0891499
RPS12 ribosomal protein S12 -0.0832303
RPS3 ribosomal protein S3 -0.0614775
RPL37A ribosomal protein L37a -0.0545433
RPS6 ribosomal protein S6 -0.0521655
RPLP2 ribosomal protein, large, P2 -0.0503921
RPL36 ribosomal protein L36 -0.050076
RPS19 ribosomal protein S19 -0.0499204
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0475327
RPS23 ribosomal protein S23 -0.046701
RPS8 ribosomal protein S8 -0.044802
ZBTB20 zinc finger and BTB domain containing 20 -0.0428485
RPS29 ribosomal protein S29 -0.0420095
RPL12 ribosomal protein L12 -0.0397811
EHBP1 EH domain binding protein 1 -0.0383886
CNRIP1 cannabinoid receptor interacting protein 1 -0.0382509
EIF1 eukaryotic translation initiation factor 1 -0.0372465
RPL23 ribosomal protein L23 -0.0348659
RPL13A ribosomal protein L13a -0.0336945
ZNF638 zinc finger protein 638 -0.0330002
HMGA2 high mobility group AT-hook 2 -0.0304449
RPS13 ribosomal protein S13 -0.0298917
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0296686
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0293767
RPL34 ribosomal protein L34 -0.0292503
RPS27A ribosomal protein S27a -0.0292153
MBD5 methyl-CpG binding domain protein 5 -0.0287263
PCDH7 protocadherin 7 -0.0283686
RPL32 ribosomal protein L32 -0.0271253
RPL19 ribosomal protein L19 -0.0267505
RPL27 ribosomal protein L27 -0.0263819
RPL31 ribosomal protein L31 -0.0261137
CAMKMT calmodulin-lysine N-methyltransferase -0.025464
INTS6 integrator complex subunit 6 -0.0238214
RPL8 ribosomal protein L8 -0.0234026
RPL28 ribosomal protein L28 -0.0233265
RPS10 ribosomal protein S10 -0.0229942
TBC1D5 TBC1 domain family, member 5 -0.0224657
RPS27 ribosomal protein S27 -0.0224493
EXOC6B exocyst complex component 6B -0.0221001
ZNF292 zinc finger protein 292 -0.0213725
RPS21 ribosomal protein S21 -0.0211737
RPL9 ribosomal protein L9 -0.0207363
FHIT fragile histidine triad -0.0206909
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -0.0203556
RPL5 ribosomal protein L5 -0.0201843
RPL26 ribosomal protein L26 -0.0199706
TNRC6B trinucleotide repeat containing 6B -0.0196781
RPL21 ribosomal protein L21 -0.0194104
RACK1 receptor for activated C kinase 1 -0.0193666
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0192757
GHR growth hormone receptor -0.0189685
RPL38 ribosomal protein L38 -0.0189352
GPBP1 GC-rich promoter binding protein 1 -0.0189248
EXOC4 exocyst complex component 4 -0.0184885
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0183047
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0179644
COG5 component of oligomeric golgi complex 5 -0.0177675
CCSER1 coiled-coil serine-rich protein 1 -0.0176706
SYT1 synaptotagmin I -0.0176347
RABGAP1L RAB GTPase activating protein 1-like -0.017584
RPS14 ribosomal protein S14 -0.0175601
TBC1D32 TBC1 domain family, member 32 -0.0175353
SBF2 SET binding factor 2 -0.0174008
TRIO trio Rho guanine nucleotide exchange factor -0.0172219
MED13L mediator complex subunit 13-like -0.017171
RYK receptor-like tyrosine kinase -0.0170455
BIRC6 baculoviral IAP repeat containing 6 -0.0168801
RCC1 regulator of chromosome condensation 1 -0.0164979
WSB1 WD repeat and SOCS box containing 1 -0.0164447
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0164429
GPHN gephyrin -0.0163298
KDM5B lysine (K)-specific demethylase 5B -0.0159638
ATP5F1E ATP synthase F1 subunit epsilon -0.0159094
RSL24D1 ribosomal L24 domain containing 1 -0.0158932
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0158484
ANK2 ankyrin 2, neuronal -0.0156734
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0156643
THSD7A thrombospondin, type I, domain containing 7A -0.0154916
CFDP1 craniofacial development protein 1 -0.0154193
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0153565
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0153356
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.0152541
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0150686
NEBL nebulette -0.0148752
WWOX WW domain containing oxidoreductase -0.0147764
RPL11 ribosomal protein L11 -0.0145933
MON2 MON2 homolog (S. cerevisiae) -0.0145933
FER fer (fps/fes related) tyrosine kinase -0.0145604
GOLGA4 golgin A4 -0.0144911
RPL35 ribosomal protein L35 -0.0144842
PRKN parkin RBR E3 ubiquitin protein ligase -0.0143867
GARS1 glycyl-tRNA synthetase 1 -0.0143685
HM13 histocompatibility (minor) 13 -0.0143328
BABAM2 BRISC and BRCA1 A complex member 2 -0.0140925
MIPOL1 mirror-image polydactyly 1 -0.0140834
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0140256
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0139967
RAD51B RAD51 paralog B -0.0139858
RPS15 ribosomal protein S15 -0.0139002