Tranilast_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0439326
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0433288
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0397493
ZFAND3 zinc finger, AN1-type domain 3 0.0351527
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0349692
DSCAM Down syndrome cell adhesion molecule 0.0342864
ITPRID2 ITPR interacting domain containing 2 0.033768
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0304929
SPAG9 sperm associated antigen 9 0.0303022
HELZ helicase with zinc finger 0.0302621
NAMPT nicotinamide phosphoribosyltransferase 0.0294405
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.029199
ZFC3H1 zinc finger, C3H1-type containing 0.0286406
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0274266
RUNX1 runt-related transcription factor 1 0.0272225
SMAD3 SMAD family member 3 0.0261863
TLE4 transducin-like enhancer of split 4 0.0256433
NRIP1 nuclear receptor interacting protein 1 0.0256242
PDE10A phosphodiesterase 10A 0.024681
WAC WW domain containing adaptor with coiled-coil 0.0245284
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242173
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0240717
CARD16 caspase recruitment domain family, member 16 0.0240552
ETNK1 ethanolamine kinase 1 0.023809
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0236635
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0233913
CEMIP cell migration inducing protein, hyaluronan binding 0.0221938
ARHGAP9 Rho GTPase activating protein 9 0.0218315
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0217128
PELI1 pellino E3 ubiquitin protein ligase 1 0.0213561
KCTD3 potassium channel tetramerization domain containing 3 0.0210799
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0210394
SVIL supervillin 0.0208607
NCKAP1 NCK-associated protein 1 0.0204388
AFF4 AF4/FMR2 family, member 4 0.0204219
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0203346
RNF145 ring finger protein 145 0.020257
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0201389
PRKD1 protein kinase D1 0.0199624
EXT1 exostosin glycosyltransferase 1 0.0197408
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.019729
ZSWIM6 zinc finger, SWIM-type containing 6 0.0196844
BBX bobby sox homolog (Drosophila) 0.0196686
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0192823
CLTC clathrin, heavy chain (Hc) 0.0190643
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0190626
SMG7 SMG7 nonsense mediated mRNA decay factor 0.019005
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0188769
NFE2L2 nuclear factor, erythroid 2-like 2 0.0188494
BIRC2 baculoviral IAP repeat containing 2 0.0187112
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0186366
COG6 component of oligomeric golgi complex 6 0.0184906
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0184773
CKAP5 cytoskeleton associated protein 5 0.0183864
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.01838
PDZRN3 PDZ domain containing ring finger 3 0.0183294
NBAS neuroblastoma amplified sequence 0.0181271
OLA1 Obg-like ATPase 1 0.0179386
HSPA8 heat shock 70kDa protein 8 0.0179188
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0178484
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0175183
NCOA7 nuclear receptor coactivator 7 0.0174646
ATL2 atlastin GTPase 2 0.0174426
SRSF1 serine/arginine-rich splicing factor 1 0.0173855
NUMB numb homolog (Drosophila) 0.0172448
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0171591
RBM33 RNA binding motif protein 33 0.0171362
DNAAF9 dynein axonemal assembly factor 9 0.017093
AHR aryl hydrocarbon receptor 0.0170746
SERINC1 serine incorporator 1 0.0169807
MTREX Mtr4 exosome RNA helicase 0.0168457
LYST lysosomal trafficking regulator 0.0167685
AQR aquarius intron-binding spliceosomal factor 0.0166989
SETD2 SET domain containing 2 0.0164894
LARP4B La ribonucleoprotein domain family, member 4B 0.0161641
FMN1 formin 1 0.0161413
MEMO1 mediator of cell motility 1 0.0160857
TLK2 tousled-like kinase 2 0.0160468
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0160086
TRPS1 trichorhinophalangeal syndrome I 0.0159339
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.015889
RHEB Ras homolog enriched in brain 0.0158887
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0158768
PCNX1 pecanex 1 0.0158677
FRMD4A FERM domain containing 4A 0.015857
MACF1 microtubule-actin crosslinking factor 1 0.0158036
SCAF4 SR-related CTD-associated factor 4 0.0157679
CADM1 cell adhesion molecule 1 0.0157621
SIK3 SIK family kinase 3 0.0155672
YEATS2 YEATS domain containing 2 0.0155123
COL4A1 collagen, type IV, alpha 1 0.0153272
COPS2 COP9 signalosome subunit 2 0.0151724
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0150441
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.014978
SIK2 salt-inducible kinase 2 0.014928
MEF2A myocyte enhancer factor 2A 0.0149131
ARFIP1 ADP-ribosylation factor interacting protein 1 0.0148861
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0148717
UGCG UDP-glucose ceramide glucosyltransferase 0.0148186
WDFY3 WD repeat and FYVE domain containing 3 0.0147913

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.313731
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230057
IGF2 insulin-like growth factor 2 -0.195265
PTMA prothymosin, alpha -0.176541
VIM vimentin -0.144514
RPS6 ribosomal protein S6 -0.111544
AKAP12 A kinase (PRKA) anchor protein 12 -0.104422
RPL23 ribosomal protein L23 -0.0930949
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0818655
RPL34 ribosomal protein L34 -0.0776134
RPS19 ribosomal protein S19 -0.0729287
RPL19 ribosomal protein L19 -0.0716219
RPLP1 ribosomal protein, large, P1 -0.0701419
RPS3 ribosomal protein S3 -0.069968
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0685176
RPS12 ribosomal protein S12 -0.0668763
FTL ferritin, light polypeptide -0.066115
EIF1 eukaryotic translation initiation factor 1 -0.0649729
RPS24 ribosomal protein S24 -0.0620712
TMSB10 thymosin beta 10 -0.0599852
RPL35A ribosomal protein L35a -0.0594494
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0590236
RPL26 ribosomal protein L26 -0.0571586
HILPDA hypoxia inducible lipid droplet-associated -0.0556207
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0547648
RPL37A ribosomal protein L37a -0.0536393
RPL32 ribosomal protein L32 -0.0528946
TPT1 tumor protein, translationally-controlled 1 -0.0526059
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0487771
RPL37 ribosomal protein L37 -0.0484602
ACTG1 actin gamma 1 -0.0479284
NDRG1 N-myc downstream regulated 1 -0.0475129
RPL31 ribosomal protein L31 -0.0472207
RPS17 ribosomal protein S17 -0.04659
RPL36 ribosomal protein L36 -0.0442188
TRIB2 tribbles pseudokinase 2 -0.0439095
NALF1 NALCN channel auxiliary factor 1 -0.0435643
RPS14 ribosomal protein S14 -0.0432467
RPS8 ribosomal protein S8 -0.040944
CRH corticotropin releasing hormone -0.0401885
RPL38 ribosomal protein L38 -0.0395029
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0391476
RPS29 ribosomal protein S29 -0.0391078
RPS27 ribosomal protein S27 -0.0388195
RPS25 ribosomal protein S25 -0.0384961
GNAS GNAS complex locus -0.0382777
LSAMP limbic system-associated membrane protein -0.0362817
RPL12 ribosomal protein L12 -0.0362212
RPS16 ribosomal protein S16 -0.0359637
WDR45B WD repeat domain 45B -0.0358493
S100A9 S100 calcium binding protein A9 -0.0353393
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0351236
SYT1 synaptotagmin I -0.0350789
RPL9 ribosomal protein L9 -0.0349701
H3-3B H3.3 histone B -0.0347223
DDIT4 DNA-damage-inducible transcript 4 -0.0345621
RPL11 ribosomal protein L11 -0.0345525
B2M beta-2-microglobulin -0.0344652
RPS23 ribosomal protein S23 -0.034033
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0340022
RPL28 ribosomal protein L28 -0.0334922
RPL18 ribosomal protein L18 -0.0323995
PTPRD protein tyrosine phosphatase, receptor type, D -0.0317542
NCAM2 neural cell adhesion molecule 2 -0.0311864
RPS11 ribosomal protein S11 -0.0309986
RPLP0 ribosomal protein, large, P0 -0.0307501
LMAN1 lectin, mannose-binding, 1 -0.030733
RPS27A ribosomal protein S27a -0.0300198
RPL27 ribosomal protein L27 -0.0299124
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0295717
DSTN destrin (actin depolymerizing factor) -0.0291481
TPI1 triosephosphate isomerase 1 -0.029025
RPL7A ribosomal protein L7a -0.0290147
LDHA lactate dehydrogenase A -0.0284141
PRRC2C proline-rich coiled-coil 2C -0.0282001
RACK1 receptor for activated C kinase 1 -0.0280651
RPS13 ribosomal protein S13 -0.0279493
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0277016
RPL35 ribosomal protein L35 -0.0275346
RPS5 ribosomal protein S5 -0.0270772
MSI2 musashi RNA-binding protein 2 -0.0269813
RPS21 ribosomal protein S21 -0.0268577
RPL5 ribosomal protein L5 -0.0267146
IGFBP3 insulin-like growth factor binding protein 3 -0.0263662
KTN1 kinectin 1 (kinesin receptor) -0.0260596
RPL8 ribosomal protein L8 -0.0259547
SCG2 secretogranin II -0.0256216
S100A6 S100 calcium binding protein A6 -0.0255215
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0252887
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0252709
ASPH aspartate beta-hydroxylase -0.0251418
TBX2 T-box 2 -0.0246553
RPLP2 ribosomal protein, large, P2 -0.0244814
ANXA2 annexin A2 -0.0242473
CCNI cyclin I -0.0240186
NAP1L1 nucleosome assembly protein 1-like 1 -0.024007
LDHB lactate dehydrogenase B -0.0238714
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0238354
VDAC1 voltage-dependent anion channel 1 -0.0237443
NACA nascent polypeptide-associated complex alpha subunit -0.0235766