Tranilast_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.0943822
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0721611
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0682673
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0593162
RUNX1 runt-related transcription factor 1 0.0423574
STK24 serine/threonine kinase 24 0.0398561
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0387067
SMAD3 SMAD family member 3 0.037826
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0377826
GMDS GDP-mannose 4,6-dehydratase 0.0364447
NRIP1 nuclear receptor interacting protein 1 0.0357457
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0349504
DIAPH1 diaphanous-related formin 1 0.0344081
IFNGR1 interferon gamma receptor 1 0.0328566
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0327391
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0313249
ANKRD10 ankyrin repeat domain 10 0.0312425
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0312218
MYO1E myosin IE 0.0309981
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0308797
LPP LIM domain containing preferred translocation partner in lipoma 0.029897
EXT1 exostosin glycosyltransferase 1 0.0281114
RAD51B RAD51 paralog B 0.0281049
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0275047
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0271558
NF1 neurofibromin 1 0.0268833
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0257864
VWA8 von Willebrand factor A domain containing 8 0.024921
SHB Src homology 2 domain containing adaptor protein B 0.0248403
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0248018
ARGLU1 arginine and glutamate rich 1 0.0246122
RIGI RNA sensor RIG-I 0.0243585
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0241217
USP9X ubiquitin specific peptidase 9, X-linked 0.0237525
C6ORF132 chromosome 6 open reading frame 132 0.0236053
SIL1 SIL1 nucleotide exchange factor 0.0232942
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0232692
SPPL3 signal peptide peptidase like 3 0.0230383
MYO5B myosin VB 0.0230042
BCL2L1 BCL2-like 1 0.0228276
XPO4 exportin 4 0.0227996
DENND1A DENN/MADD domain containing 1A 0.0227253
WDFY3 WD repeat and FYVE domain containing 3 0.0225579
NAMPT nicotinamide phosphoribosyltransferase 0.0224068
SPIDR scaffolding protein involved in DNA repair 0.0223114
MED13L mediator complex subunit 13-like 0.0221757
SBF2 SET binding factor 2 0.0221588
SAMD12 sterile alpha motif domain containing 12 0.021962
OARD1 O-acyl-ADP-ribose deacylase 1 0.0217545
FOXJ3 forkhead box J3 0.0217277
EPHB2 EPH receptor B2 0.0216436
ITGA6 integrin, alpha 6 0.0216298
TXNRD1 thioredoxin reductase 1 0.021458
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0213932
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0211188
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.021086
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0208693
RNF38 ring finger protein 38 0.0207506
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0206292
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0205893
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.020412
ANKRD11 ankyrin repeat domain 11 0.0202757
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0199295
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0197468
SRSF4 serine/arginine-rich splicing factor 4 0.0196828
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.019597
CTNND1 catenin (cadherin-associated protein), delta 1 0.019592
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0194777
ZC3H13 zinc finger CCCH-type containing 13 0.0194491
ZNFX1 zinc finger, NFX1-type containing 1 0.0192045
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0190123
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0189507
RNF43 ring finger protein 43 0.0188085
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0187465
ARHGAP26 Rho GTPase activating protein 26 0.0187352
NEBL nebulette 0.0186948
FAT1 FAT atypical cadherin 1 0.0186657
VMP1 vacuole membrane protein 1 0.0185947
TRIP12 thyroid hormone receptor interactor 12 0.0185717
MYH9 myosin, heavy chain 9, non-muscle 0.0185361
LARP4B La ribonucleoprotein domain family, member 4B 0.0185179
ARL15 ADP-ribosylation factor-like 15 0.018503
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0184319
THOC2 THO complex 2 0.0184106
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.0182324
PHIP pleckstrin homology domain interacting protein 0.0181743
SERINC5 serine incorporator 5 0.018162
LMTK2 lemur tyrosine kinase 2 0.0180793
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0180398
RASA2 RAS p21 protein activator 2 0.017995
PRKCE protein kinase C, epsilon 0.0179537
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0179448
IGF2R insulin-like growth factor 2 receptor 0.017855
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.017656
TAS2R14 taste receptor, type 2, member 14 0.0176348
RABGAP1L RAB GTPase activating protein 1-like 0.0175979
NCOA3 nuclear receptor coactivator 3 0.0175724
EHBP1 EH domain binding protein 1 0.017551
DOCK9 dedicator of cytokinesis 9 0.0175284
TJP1 tight junction protein 1 0.0175069

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.203952
TPT1 tumor protein, translationally-controlled 1 -0.167296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.160775
PTMA prothymosin, alpha -0.149807
HLA-B major histocompatibility complex, class I, B -0.116952
LCN2 lipocalin 2 -0.114381
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114299
ZMYND8 zinc finger, MYND-type containing 8 -0.106731
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0862774
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0859088
PERP PERP, TP53 apoptosis effector -0.0818571
IFI6 interferon, alpha-inducible protein 6 -0.0803358
RPS6 ribosomal protein S6 -0.0701037
EGR1 early growth response 1 -0.0647331
FTH1 ferritin, heavy polypeptide 1 -0.064285
EZR ezrin -0.0625908
FTL ferritin, light polypeptide -0.0618163
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0609227
HLA-A major histocompatibility complex, class I, A -0.0592445
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0587204
KRT19 keratin 19, type I -0.0561398
SQSTM1 sequestosome 1 -0.05612
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0560155
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0558245
TMSB10 thymosin beta 10 -0.0546244
PKM pyruvate kinase, muscle -0.0544996
MT2A metallothionein 2A -0.053149
ENO1 enolase 1, (alpha) -0.0530343
PDIA3 protein disulfide isomerase family A, member 3 -0.0520412
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.05075
LDHA lactate dehydrogenase A -0.048873
PGK1 phosphoglycerate kinase 1 -0.0485547
ZNF292 zinc finger protein 292 -0.0472824
HLA-E major histocompatibility complex, class I, E -0.0472088
EIF1 eukaryotic translation initiation factor 1 -0.0471963
RPL12 ribosomal protein L12 -0.0466811
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0458072
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0455841
UBC ubiquitin C -0.0454994
XAF1 XIAP associated factor 1 -0.045166
TXNIP thioredoxin interacting protein -0.0447212
CALR calreticulin -0.0434592
DSTN destrin (actin depolymerizing factor) -0.0432421
RHOBTB3 Rho-related BTB domain containing 3 -0.0432153
RPL34 ribosomal protein L34 -0.0431695
RNF149 ring finger protein 149 -0.0430362
RPS19 ribosomal protein S19 -0.0426252
AHI1 Abelson helper integration site 1 -0.0419994
ADM adrenomedullin -0.0416449
RPL26 ribosomal protein L26 -0.0415442
RPL19 ribosomal protein L19 -0.0414291
HLA-C major histocompatibility complex, class I, C -0.0410999
RPL37A ribosomal protein L37a -0.0409364
SEC31A SEC31 homolog A (S. cerevisiae) -0.0402225
WSB1 WD repeat and SOCS box containing 1 -0.040193
IFI27 interferon, alpha-inducible protein 27 -0.0400417
EPCAM epithelial cell adhesion molecule -0.0400234
S100A10 S100 calcium binding protein A10 -0.0395626
RPL35A ribosomal protein L35a -0.039501
IGFBP3 insulin-like growth factor binding protein 3 -0.0383102
IRF1 interferon regulatory factor 1 -0.0379876
TMPRSS4 transmembrane protease, serine 4 -0.0376852
RPL37 ribosomal protein L37 -0.0374711
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0371393
VDAC1 voltage-dependent anion channel 1 -0.036739
LOC112694756 uncharaterized LOC112694756 -0.0366197
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.036082
LOC102724023 ES1 protein homolog, mitochondrial -0.0359597
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0357763
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0356872
RPS27 ribosomal protein S27 -0.0355065
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0354829
S100A9 S100 calcium binding protein A9 -0.0353473
RPL23 ribosomal protein L23 -0.035239
H3-3B H3.3 histone B -0.0351986
NDRG1 N-myc downstream regulated 1 -0.0351858
RPS3 ribosomal protein S3 -0.0346832
WDR45B WD repeat domain 45B -0.0346716
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0346126
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0345678
APOL1 apolipoprotein L, 1 -0.0344187
ZNF395 zinc finger protein 395 -0.0342313
AGR2 anterior gradient 2 -0.0338786
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0335539
GOLGA4 golgin A4 -0.0335393
ANXA2 annexin A2 -0.0334928
EFNB2 ephrin-B2 -0.0333391
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0333338
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0333188
SERF2 small EDRK-rich factor 2 -0.0332326
S100A6 S100 calcium binding protein A6 -0.0328953
RPL11 ribosomal protein L11 -0.0327418
CCNI cyclin I -0.0325061
PTPRF protein tyrosine phosphatase, receptor type, F -0.0320045
RPS12 ribosomal protein S12 -0.0319368
MORF4L2 mortality factor 4 like 2 -0.0316871
TPI1 triosephosphate isomerase 1 -0.0315648
RPS8 ribosomal protein S8 -0.0314174
TFG TRK-fused gene -0.0313159
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0312129