Tranilast_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.0709045
PDE4D phosphodiesterase 4D, cAMP-specific 0.0704974
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0704078
MTSS1 metastasis suppressor 1 0.0628233
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0610309
SLC35F3 solute carrier family 35, member F3 0.0603187
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0594989
BCAR3 breast cancer anti-estrogen resistance 3 0.0489285
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0376981
EFNA5 ephrin-A5 0.0374022
MACF1 microtubule-actin crosslinking factor 1 0.0370632
RAD51B RAD51 paralog B 0.0344748
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0343589
HMGA2 high mobility group AT-hook 2 0.0339155
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.033032
SULF2 sulfatase 2 0.0316381
INTS6 integrator complex subunit 6 0.0302488
LAMC2 laminin, gamma 2 0.0301777
SMYD3 SET and MYND domain containing 3 0.0282262
PODXL podocalyxin-like 0.0280369
PDLIM5 PDZ and LIM domain 5 0.0277386
AKAP13 A kinase (PRKA) anchor protein 13 0.027319
BLCAP bladder cancer associated protein 0.026515
CLIC4 chloride intracellular channel 4 0.025405
EGFR epidermal growth factor receptor 0.0251412
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0249349
DPYD dihydropyrimidine dehydrogenase 0.0247008
ASPH aspartate beta-hydroxylase 0.0243406
RABGAP1L RAB GTPase activating protein 1-like 0.0242075
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0239105
EXT1 exostosin glycosyltransferase 1 0.0235652
ZMYND8 zinc finger, MYND-type containing 8 0.0233748
AOPEP aminopeptidase O (putative) 0.0233374
MYH9 myosin, heavy chain 9, non-muscle 0.0231544
KIAA1671 KIAA1671 0.0231362
MAML2 mastermind-like 2 (Drosophila) 0.0229265
ABI3BP ABI family, member 3 (NESH) binding protein 0.0223992
FOXO1 forkhead box O1 0.0220208
NRIP1 nuclear receptor interacting protein 1 0.0218587
SP100 SP100 nuclear antigen 0.0216929
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0215146
DST dystonin 0.0212825
IFI44L interferon-induced protein 44-like 0.0208777
HDAC9 histone deacetylase 9 0.0205931
DOCK4 dedicator of cytokinesis 4 0.0203947
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0201923
ANO1 anoctamin 1, calcium activated chloride channel 0.0200675
FAF1 Fas (TNFRSF6) associated factor 1 0.0198109
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0194141
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0193713
EXOC4 exocyst complex component 4 0.0193637
LUZP1 leucine zipper protein 1 0.019157
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0190515
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0190507
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0186538
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0184058
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0180916
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0180713
THSD4 thrombospondin, type I, domain containing 4 0.0178288
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0177052
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0172804
LMO7 LIM domain 7 0.0172575
ANTXR2 anthrax toxin receptor 2 0.0170792
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.017054
CSMD2 CUB and Sushi multiple domains 2 0.0169883
TTC28 tetratricopeptide repeat domain 28 0.0169156
CEMIP cell migration inducing protein, hyaluronan binding 0.0168623
MTAP methylthioadenosine phosphorylase 0.0167591
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0167259
FNDC3B fibronectin type III domain containing 3B 0.016483
RIGI RNA sensor RIG-I 0.016157
CUX1 cut-like homeobox 1 0.0161481
CORO2A coronin, actin binding protein, 2A 0.0161464
CNTNAP3 contactin associated protein-like 3 0.0161348
PICALM phosphatidylinositol binding clathrin assembly protein 0.0160067
DGKH diacylglycerol kinase, eta 0.0158186
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0158034
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0156937
HLA-B major histocompatibility complex, class I, B 0.0155914
PLXNA2 plexin A2 0.0154701
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0151944
VCL vinculin 0.015129
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0150209
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0149002
NEK7 NIMA-related kinase 7 0.0148194
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0147103
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0146785
SMAD3 SMAD family member 3 0.0143935
CDK6 cyclin-dependent kinase 6 0.0143817
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0142885
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0142493
UTRN utrophin 0.0142229
CTBP2 C-terminal binding protein 2 0.0141369
LPP LIM domain containing preferred translocation partner in lipoma 0.0139721
RCOR1 REST corepressor 1 0.0139492
MPRIP myosin phosphatase Rho interacting protein 0.0137602
DOK5 docking protein 5 0.0137342
MECOM MDS1 and EVI1 complex locus 0.0136794
RNF217 ring finger protein 217 0.0136514
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.013569

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168147
TMSB10 thymosin beta 10 -0.12654
NDRG1 N-myc downstream regulated 1 -0.106856
CLU clusterin -0.0993132
FLNB filamin B, beta -0.088186
KRT17 keratin 17, type I -0.0868663
RPS21 ribosomal protein S21 -0.0792914
LMNA lamin A/C -0.0789202
RPS6 ribosomal protein S6 -0.0750479
GOLGA4 golgin A4 -0.0693925
TRIO trio Rho guanine nucleotide exchange factor -0.0660013
MT2A metallothionein 2A -0.0659685
ENO1 enolase 1, (alpha) -0.0647032
ANXA1 annexin A1 -0.0617441
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0612888
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0596306
LOC112694756 uncharaterized LOC112694756 -0.0593281
S100A10 S100 calcium binding protein A10 -0.0589692
EMP1 epithelial membrane protein 1 -0.058584
PTMA prothymosin, alpha -0.0567153
RPS8 ribosomal protein S8 -0.0561759
RPS19 ribosomal protein S19 -0.0547106
RPS3 ribosomal protein S3 -0.0537656
RPL11 ribosomal protein L11 -0.0534713
PGK1 phosphoglycerate kinase 1 -0.0530706
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0494953
RPLP2 ribosomal protein, large, P2 -0.0489029
SQLE squalene epoxidase -0.0482718
S100A2 S100 calcium binding protein A2 -0.0482369
GNAS GNAS complex locus -0.0470108
TMSB4X thymosin beta 4, X-linked -0.0463286
DSTN destrin (actin depolymerizing factor) -0.0458344
NAMPT nicotinamide phosphoribosyltransferase -0.0456424
LDHA lactate dehydrogenase A -0.0455936
CAV1 caveolin 1, caveolae protein, 22kDa -0.0455648
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0450059
IFITM3 interferon induced transmembrane protein 3 -0.0440036
EZR ezrin -0.0429917
MT1X metallothionein 1X -0.0425613
RBM39 RNA binding motif protein 39 -0.0425053
S100A9 S100 calcium binding protein A9 -0.0416706
RPS12 ribosomal protein S12 -0.0412894
RPL32 ribosomal protein L32 -0.040644
EIF1 eukaryotic translation initiation factor 1 -0.0400794
WASF2 WAS protein family, member 2 -0.0399014
YBX3 Y box binding protein 3 -0.0398028
CNRIP1 cannabinoid receptor interacting protein 1 -0.0395057
MORF4L2 mortality factor 4 like 2 -0.0389745
KTN1 kinectin 1 (kinesin receptor) -0.0381998
STC1 stanniocalcin 1 -0.0380362
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0379609
RPL8 ribosomal protein L8 -0.0379121
RPL23 ribosomal protein L23 -0.0379093
RPL12 ribosomal protein L12 -0.0377519
LMAN1 lectin, mannose-binding, 1 -0.0375166
TAGLN2 transgelin 2 -0.0356289
GARS1 glycyl-tRNA synthetase 1 -0.0354689
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0352281
CANX calnexin -0.0350429
RPS13 ribosomal protein S13 -0.0344172
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0342262
PFN1 profilin 1 -0.0338534
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0336962
YBX1 Y box binding protein 1 -0.0331278
S100A6 S100 calcium binding protein A6 -0.032536
KRT6A keratin 6A, type II -0.0319523
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0318568
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0314189
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0310634
RACK1 receptor for activated C kinase 1 -0.0309195
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0308759
GUK1 guanylate kinase 1 -0.0302594
OGA O-GlcNAcase -0.0300976
MBNL2 muscleblind-like splicing regulator 2 -0.0300554
CALR calreticulin -0.0294769
RPL36 ribosomal protein L36 -0.0294283
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0293653
RPL37 ribosomal protein L37 -0.0291958
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0291597
RPL5 ribosomal protein L5 -0.0290602
EFHD2 EF-hand domain family, member D2 -0.0285926
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.028439
FSCN1 fascin actin-bundling protein 1 -0.0283024
SRP54 signal recognition particle 54kDa -0.0280528
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0279597
ITCH itchy E3 ubiquitin protein ligase -0.027589
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0274039
DLG1 discs, large homolog 1 (Drosophila) -0.0264439
RPS14 ribosomal protein S14 -0.0262502
AKAP9 A kinase (PRKA) anchor protein 9 -0.0260546
ANXA2 annexin A2 -0.0259986
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0259924
SEC61G Sec61 gamma subunit -0.0259392
RAB2A RAB2A, member RAS oncogene family -0.0258914
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0256455
BHLHE40 basic helix-loop-helix family, member e40 -0.025612
RPL35 ribosomal protein L35 -0.0254871
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0252505
ACBD3 acyl-CoA binding domain containing 3 -0.025175
RPL19 ribosomal protein L19 -0.0251463