Tranilast_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CENPF centromere protein F, 350/400kDa 0.0327849
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0215774
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0195307
SFPQ splicing factor proline/glutamine-rich 0.0136572
MKI67 marker of proliferation Ki-67 0.0134097
RPL3 ribosomal protein L3 0.0133992
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0123166
MSN moesin 0.0122163
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0113164
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0108936
BIRC2 baculoviral IAP repeat containing 2 0.010518
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0102471
RTN4 reticulon 4 0.0101964
TXNRD1 thioredoxin reductase 1 0.00989441
EZR ezrin 0.00987718
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00984001
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.00950991
TPM3 tropomyosin 3 0.00921517
EEF2 eukaryotic translation elongation factor 2 0.00912174
ANKRD36 ankyrin repeat domain 36 0.00892519
RB1CC1 RB1-inducible coiled-coil 1 0.00876061
MYH9 myosin, heavy chain 9, non-muscle 0.00871432
CKAP5 cytoskeleton associated protein 5 0.00856299
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00842572
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.00790021
TRA2B transformer 2 beta homolog (Drosophila) 0.00780243
BCAR3 breast cancer anti-estrogen resistance 3 0.00728019
SLK STE20-like kinase 0.00710764
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.00710449
PFKL phosphofructokinase, liver 0.00703591
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.00702927
MAT2A methionine adenosyltransferase II, alpha 0.00678419
KTN1 kinectin 1 (kinesin receptor) 0.0067477
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.00660516
TRIP12 thyroid hormone receptor interactor 12 0.00655346
BCLAF1 BCL2-associated transcription factor 1 0.00650089
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00643152
PNN pinin, desmosome associated protein 0.00639825
ETNK1 ethanolamine kinase 1 0.00638528
EIF5 eukaryotic translation initiation factor 5 0.00629882
XPO1 exportin 1 0.00613629
F2R coagulation factor II (thrombin) receptor 0.00612014
SMC4 structural maintenance of chromosomes 4 0.00607343
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00601751
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00574746
EIF4B eukaryotic translation initiation factor 4B 0.00571442
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00570551
CDK19 cyclin-dependent kinase 19 0.00568775
CCNL1 cyclin L1 0.00567767
ECPAS Ecm29 proteasome adaptor and scaffold 0.00560167
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00544847
WASL Wiskott-Aldrich syndrome-like 0.00538103
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00532064
KIF14 kinesin family member 14 0.00528765
ARHGAP11A Rho GTPase activating protein 11A 0.00521458
TNIP1 TNFAIP3 interacting protein 1 0.00520072
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.00514481
TPX2 TPX2, microtubule-associated 0.00511473
CEP95 centrosomal protein 95kDa 0.00508086
SNX9 sorting nexin 9 0.0050599
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.00503314
SRSF4 serine/arginine-rich splicing factor 4 0.00500794
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0049769
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00496318
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00494936
CENPE centromere protein E, 312kDa 0.00492957
FTH1 ferritin, heavy polypeptide 1 0.00489063
PRPF4B pre-mRNA processing factor 4B 0.00485408
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.00477324
RAB27B RAB27B, member RAS oncogene family 0.00476429
IL6ST interleukin 6 signal transducer 0.004761
ADAM17 ADAM metallopeptidase domain 17 0.00475975
MCL1 myeloid cell leukemia 1 0.00471774
PCDH1 protocadherin 1 0.00470974
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.00470037
ATP13A3 ATPase type 13A3 0.00468175
AHCTF1 AT hook containing transcription factor 1 0.00462316
WDR43 WD repeat domain 43 0.00458773
CAPRIN1 cell cycle associated protein 1 0.00457919
PCBP2 poly(rC) binding protein 2 0.00454492
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00451288
CHD4 chromodomain helicase DNA binding protein 4 0.00448376
USP21 ubiquitin specific peptidase 21 0.00445888
HJURP Holliday junction recognition protein 0.00445595
TOP2B topoisomerase (DNA) II beta 180kDa 0.00443585
ARHGAP29 Rho GTPase activating protein 29 0.00440507
SCAF4 SR-related CTD-associated factor 4 0.00430144
KLC1 kinesin light chain 1 0.00429199
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.00428346
PUM2 pumilio RNA-binding family member 2 0.0042552
KMT2E lysine (K)-specific methyltransferase 2E 0.00424664
DIAPH3 diaphanous-related formin 3 0.00424626
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0042434
CEP170 centrosomal protein 170kDa 0.00419408
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.00418035
CHD1 chromodomain helicase DNA binding protein 1 0.00417675
GTF2I general transcription factor IIi 0.00417556
ELOVL5 ELOVL fatty acid elongase 5 0.00414662
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.00411665
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00411511

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.313649
VIM vimentin -0.190992
TMSB10 thymosin beta 10 -0.132105
MT2A metallothionein 2A -0.100521
PTMA prothymosin, alpha -0.0914188
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0688939
FTL ferritin, light polypeptide -0.0662994
CD44 CD44 molecule (Indian blood group) -0.0603318
RPL35A ribosomal protein L35a -0.0581103
TP63 tumor protein p63 -0.0580309
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0559499
RPS8 ribosomal protein S8 -0.0537588
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0507557
TPT1 tumor protein, translationally-controlled 1 -0.050005
HLA-B major histocompatibility complex, class I, B -0.0499185
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0486025
RPS19 ribosomal protein S19 -0.0466224
RPL12 ribosomal protein L12 -0.0458355
TMSB4X thymosin beta 4, X-linked -0.0397044
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0385533
RPS6 ribosomal protein S6 -0.0380298
LDHA lactate dehydrogenase A -0.0375884
PGK1 phosphoglycerate kinase 1 -0.0369608
ACTG1 actin gamma 1 -0.0368699
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0367722
RPL37A ribosomal protein L37a -0.0367022
RPL36 ribosomal protein L36 -0.0359293
TM4SF1 transmembrane 4 L six family member 1 -0.0357776
RPL19 ribosomal protein L19 -0.035435
LOC112694756 uncharaterized LOC112694756 -0.034833
RPL31 ribosomal protein L31 -0.0347728
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0344864
RPLP1 ribosomal protein, large, P1 -0.0337874
CADM2 cell adhesion molecule 2 -0.0333818
RPL26 ribosomal protein L26 -0.0329459
RPS23 ribosomal protein S23 -0.0325097
RPS24 ribosomal protein S24 -0.0321694
RPS3 ribosomal protein S3 -0.0317194
PSD3 pleckstrin and Sec7 domain containing 3 -0.0314416
RPLP2 ribosomal protein, large, P2 -0.031229
RPL23 ribosomal protein L23 -0.030878
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.029742
DLG1 discs, large homolog 1 (Drosophila) -0.0292845
SRGN serglycin -0.0281088
RACK1 receptor for activated C kinase 1 -0.0278426
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0270122
WSB1 WD repeat and SOCS box containing 1 -0.0268699
RPS29 ribosomal protein S29 -0.0266889
EIF1 eukaryotic translation initiation factor 1 -0.02661
RPL38 ribosomal protein L38 -0.0264112
HMGA1 high mobility group AT-hook 1 -0.026208
RPS27A ribosomal protein S27a -0.0261092
RPL37 ribosomal protein L37 -0.0252013
RPL8 ribosomal protein L8 -0.0250746
RAB7A RAB7A, member RAS oncogene family -0.0249268
EHBP1 EH domain binding protein 1 -0.0246609
RPL36A ribosomal protein L36a -0.0239982
RPS14 ribosomal protein S14 -0.0239368
SLC38A2 solute carrier family 38, member 2 -0.023888
RPL34 ribosomal protein L34 -0.0238395
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0238391
MT1E metallothionein 1E -0.0231936
RPS25 ribosomal protein S25 -0.0231837
RPL35 ribosomal protein L35 -0.0229572
PTPRF protein tyrosine phosphatase, receptor type, F -0.0228441
IFI6 interferon, alpha-inducible protein 6 -0.0228277
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.022535
EPHA4 EPH receptor A4 -0.0224414
RPL11 ribosomal protein L11 -0.0224024
RPS13 ribosomal protein S13 -0.0217897
S100A9 S100 calcium binding protein A9 -0.0217516
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0215313
RPL18 ribosomal protein L18 -0.0213841
DST dystonin -0.0213048
RPL28 ribosomal protein L28 -0.0211348
TMEM123 transmembrane protein 123 -0.0209448
RPS27 ribosomal protein S27 -0.0209244
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0208023
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0207691
CANX calnexin -0.0202009
HDLBP high density lipoprotein binding protein -0.0200127
IFITM1 interferon induced transmembrane protein 1 -0.0200118
RPS21 ribosomal protein S21 -0.0198227
RPLP0 ribosomal protein, large, P0 -0.019724
RPL32 ribosomal protein L32 -0.0196007
TPI1 triosephosphate isomerase 1 -0.0194303
RPS16 ribosomal protein S16 -0.0194034
RPL7A ribosomal protein L7a -0.0193653
RPL5 ribosomal protein L5 -0.0193138
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0189529
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0188152
RPS10 ribosomal protein S10 -0.0185829
MYOF myoferlin -0.0184755
RPS15 ribosomal protein S15 -0.0183788
S100A10 S100 calcium binding protein A10 -0.0182484
EGR1 early growth response 1 -0.0181238
RPL27A ribosomal protein L27a -0.0179918
GNAS GNAS complex locus -0.017824
RPS12 ribosomal protein S12 -0.0178235
RPS5 ribosomal protein S5 -0.0175162