Tranilast_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0348918
PTPRM protein tyrosine phosphatase, receptor type, M 0.0294313
PDLIM5 PDZ and LIM domain 5 0.0293098
ANKRD10 ankyrin repeat domain 10 0.0281383
PDE4D phosphodiesterase 4D, cAMP-specific 0.020118
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0181552
DENND4A DENN/MADD domain containing 4A 0.0166939
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0148149
MYO5B myosin VB 0.0145747
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0144885
HOMER1 homer scaffolding protein 1 0.0142639
ZSWIM6 zinc finger, SWIM-type containing 6 0.014084
SPIRE1 spire-type actin nucleation factor 1 0.0136018
SAMD4A sterile alpha motif domain containing 4A 0.0131888
TUFT1 tuftelin 1 0.0120949
MYO1D myosin ID 0.0120705
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0119354
GLS2 glutaminase 2 (liver, mitochondrial) 0.011927
VCL vinculin 0.0117881
SENP5 SUMO1/sentrin specific peptidase 5 0.0117255
MCTP1 multiple C2 domains, transmembrane 1 0.0117226
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0108649
KDM3B lysine (K)-specific demethylase 3B 0.0105725
NUP98 nucleoporin 98kDa 0.0103931
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0103001
CAMTA1 calmodulin binding transcription activator 1 0.0102512
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0102092
PMM2 phosphomannomutase 2 0.00992321
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00979683
LRP1B low density lipoprotein receptor-related protein 1B 0.0095854
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.00948132
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00945865
NCOA3 nuclear receptor coactivator 3 0.00941949
LRP12 low density lipoprotein receptor-related protein 12 0.00928474
CATSPERB catsper channel auxiliary subunit beta 0.00926053
TMEM184B transmembrane protein 184B 0.00924545
LPP LIM domain containing preferred translocation partner in lipoma 0.00914862
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0089721
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00884478
ERI2 ERI1 exoribonuclease family member 2 0.00873291
NRIP1 nuclear receptor interacting protein 1 0.00869815
NABP1 nucleic acid binding protein 1 0.00863717
AEBP2 AE binding protein 2 0.00859364
GPC5 glypican 5 0.0085216
LARP1B La ribonucleoprotein domain family, member 1B 0.00845485
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.00840818
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.00840307
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00834756
PLSCR2 phospholipid scramblase 2 0.00817054
KRT86 keratin 86, type II 0.00816548
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.00814142
GOSR2 golgi SNAP receptor complex member 2 0.00805043
WNT2B wingless-type MMTV integration site family, member 2B 0.00803343
CCDC138 coiled-coil domain containing 138 0.00792389
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.00786655
EPS8 epidermal growth factor receptor pathway substrate 8 0.00780991
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.00780697
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00776047
BCAR3 breast cancer anti-estrogen resistance 3 0.00770654
CYSTM1 cysteine-rich transmembrane module containing 1 0.00760354
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 0.00758008
SH3D19 SH3 domain containing 19 0.00733797
FBXO34 F-box protein 34 0.0072016
C1S complement component 1, s subcomponent 0.00716973
TTC27 tetratricopeptide repeat domain 27 0.0071673
NTN4 netrin 4 0.00713765
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.00713715
BICD1 bicaudal D homolog 1 (Drosophila) 0.00712676
CEMIP cell migration inducing protein, hyaluronan binding 0.00712495
NSUN6 NOP2/Sun domain family, member 6 0.00704847
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.00704034
MAML2 mastermind-like 2 (Drosophila) 0.00695726
AGO3 argonaute RISC catalytic component 3 0.00680342
MOSMO modulator of smoothened 0.00674366
TNS3 tensin 3 0.00672609
RERE arginine-glutamic acid dipeptide (RE) repeats 0.006697
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00666792
RBM19 RNA binding motif protein 19 0.0066336
GON4L gon-4-like (C. elegans) 0.00657822
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00653785
ZNF407 zinc finger protein 407 0.0064717
DOCK4 dedicator of cytokinesis 4 0.00645452
PTPRK protein tyrosine phosphatase, receptor type, K 0.0063953
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.006375
SETX senataxin 0.00633214
MCF2L MCF.2 cell line derived transforming sequence-like 0.00627615
NEU3 sialidase 3 (membrane sialidase) 0.00627266
MCL1 myeloid cell leukemia 1 0.00622392
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.00620783
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00618195
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0061695
TCF20 transcription factor 20 (AR1) 0.00611482
TRAPPC8 trafficking protein particle complex 8 0.00607661
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 0.00603832
CDK13 cyclin-dependent kinase 13 0.00597289
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.00596376
XG Xg blood group 0.00594335
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00592798
HAP1 huntingtin-associated protein 1 0.00588321
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.00583272

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.484646
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.246384
MT2A metallothionein 2A -0.172243
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.138979
NDRG1 N-myc downstream regulated 1 -0.136697
FAM13A family with sequence similarity 13, member A -0.0922511
RPS3 ribosomal protein S3 -0.0919995
TXNRD1 thioredoxin reductase 1 -0.0757587
FTL ferritin, light polypeptide -0.0755607
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0726668
TMSB10 thymosin beta 10 -0.0721523
PTMA prothymosin, alpha -0.0657647
LDHA lactate dehydrogenase A -0.0641401
FTH1 ferritin, heavy polypeptide 1 -0.0626268
PKM pyruvate kinase, muscle -0.0625149
CAV1 caveolin 1, caveolae protein, 22kDa -0.0621849
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0618018
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.061307
SEC61G Sec61 gamma subunit -0.0609274
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0606764
LOC112694756 uncharaterized LOC112694756 -0.058334
TPT1 tumor protein, translationally-controlled 1 -0.0578708
STC1 stanniocalcin 1 -0.0547781
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.053855
RPS6 ribosomal protein S6 -0.0537228
EIF1 eukaryotic translation initiation factor 1 -0.0522946
RPLP1 ribosomal protein, large, P1 -0.0517366
ANKRD12 ankyrin repeat domain 12 -0.0485586
NAMPT nicotinamide phosphoribosyltransferase -0.0485555
S100A10 S100 calcium binding protein A10 -0.0461829
ENO1 enolase 1, (alpha) -0.0452788
RPS8 ribosomal protein S8 -0.0449974
RPS12 ribosomal protein S12 -0.0436132
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0430322
RPL37A ribosomal protein L37a -0.0426478
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0419094
RPS25 ribosomal protein S25 -0.0413356
GCLC glutamate-cysteine ligase, catalytic subunit -0.0398084
RPL12 ribosomal protein L12 -0.0396582
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0381105
RPLP0 ribosomal protein, large, P0 -0.0380423
MT1X metallothionein 1X -0.0377544
RPL34 ribosomal protein L34 -0.037355
CDCP1 CUB domain containing protein 1 -0.0366376
PDIA3 protein disulfide isomerase family A, member 3 -0.0365616
PRRC2C proline-rich coiled-coil 2C -0.0362091
RPL11 ribosomal protein L11 -0.0351202
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0348921
KMT2E lysine (K)-specific methyltransferase 2E -0.0345304
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0338228
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0330498
RPS19 ribosomal protein S19 -0.0325891
RPS23 ribosomal protein S23 -0.0317366
RPL19 ribosomal protein L19 -0.031433
ANKRD37 ankyrin repeat domain 37 -0.0313871
B2M beta-2-microglobulin -0.0313739
RPL8 ribosomal protein L8 -0.0312339
UBC ubiquitin C -0.0312181
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0311198
CSTB cystatin B (stefin B) -0.0310654
ZMYND8 zinc finger, MYND-type containing 8 -0.0304875
MXI1 MAX interactor 1, dimerization protein -0.0296849
RACK1 receptor for activated C kinase 1 -0.0292782
PDE8A phosphodiesterase 8A -0.0291205
RPL23 ribosomal protein L23 -0.0287229
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0285454
RPS27A ribosomal protein S27a -0.0285335
SLC38A1 solute carrier family 38, member 1 -0.0284657
CSNK1A1 casein kinase 1, alpha 1 -0.028209
NGLY1 N-glycanase 1 -0.0282039
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0279717
S100P S100 calcium binding protein P -0.0278995
TMEM165 transmembrane protein 165 -0.027857
KMT2A lysine (K)-specific methyltransferase 2A -0.027583
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.027492
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0273316
ZNF292 zinc finger protein 292 -0.0271691
CES1 carboxylesterase 1 -0.0267877
MORF4L2 mortality factor 4 like 2 -0.0266768
IER3 immediate early response 3 -0.0266309
S100A9 S100 calcium binding protein A9 -0.0260804
HILPDA hypoxia inducible lipid droplet-associated -0.0258587
CCNI cyclin I -0.0257436
RPS24 ribosomal protein S24 -0.0256745
RPL36 ribosomal protein L36 -0.0254939
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0254554
EGR1 early growth response 1 -0.0252569
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.024988
RPL35A ribosomal protein L35a -0.0249183
YBX3 Y box binding protein 3 -0.0249079
BTG1 B-cell translocation gene 1, anti-proliferative -0.0247786
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0247757
CIB1 calcium and integrin binding 1 (calmyrin) -0.0247358
BRWD1 bromodomain and WD repeat domain containing 1 -0.0246805
WDR45B WD repeat domain 45B -0.0245567
RPLP2 ribosomal protein, large, P2 -0.0244336
SEPTIN2 septin 2 -0.0244079
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0243999
MKI67 marker of proliferation Ki-67 -0.0239676
IGFBP3 insulin-like growth factor binding protein 3 -0.0239634