Tranilast_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0978053
FNDC3B fibronectin type III domain containing 3B 0.0744265
KDM3A lysine (K)-specific demethylase 3A 0.0578391
CDH13 cadherin 13 0.0556827
WAC WW domain containing adaptor with coiled-coil 0.050287
ZFAND3 zinc finger, AN1-type domain 3 0.0465568
ANKRD11 ankyrin repeat domain 11 0.0438544
PARD3 par-3 family cell polarity regulator 0.0431884
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0418449
SDK1 sidekick cell adhesion molecule 1 0.0413695
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0391223
INTS6 integrator complex subunit 6 0.0387125
USP3 ubiquitin specific peptidase 3 0.0379172
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0374781
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0362175
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0359766
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0355216
SOD2 superoxide dismutase 2, mitochondrial 0.034946
NAP1L1 nucleosome assembly protein 1-like 1 0.0345601
ATP13A3 ATPase type 13A3 0.0338133
CDC73 cell division cycle 73 0.0326333
EXT1 exostosin glycosyltransferase 1 0.0321948
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0319103
PTK2 protein tyrosine kinase 2 0.0310426
ZSWIM6 zinc finger, SWIM-type containing 6 0.0310051
AADAC arylacetamide deacetylase 0.0304836
SP100 SP100 nuclear antigen 0.0300182
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0292331
TPT1 tumor protein, translationally-controlled 1 0.0290574
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0282813
VCL vinculin 0.0282159
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.027933
MARCHF6 membrane associated ring-CH-type finger 6 0.0275734
EPS8 epidermal growth factor receptor pathway substrate 8 0.0270919
TXNRD1 thioredoxin reductase 1 0.0268229
PEAK1 pseudopodium-enriched atypical kinase 1 0.0267569
COL12A1 collagen, type XII, alpha 1 0.0266955
RAB8B RAB8B, member RAS oncogene family 0.0262251
JMJD1C jumonji domain containing 1C 0.0260874
POTEF POTE ankyrin domain family, member F 0.0257778
RNF145 ring finger protein 145 0.0256815
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0256266
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0255376
PUM1 pumilio RNA-binding family member 1 0.0253591
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0252494
HELZ helicase with zinc finger 0.0248691
SSBP2 single-stranded DNA binding protein 2 0.0246637
RPL35A ribosomal protein L35a 0.0243936
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0243476
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0238455
OGA O-GlcNAcase 0.023686
ATXN1 ataxin 1 0.0235373
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0235149
FUS FUS RNA binding protein 0.0232729
KCTD16 potassium channel tetramerization domain containing 16 0.0232647
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0232341
ITCH itchy E3 ubiquitin protein ligase 0.0232131
TRA2A transformer 2 alpha homolog (Drosophila) 0.0231917
USP15 ubiquitin specific peptidase 15 0.0229735
APP amyloid beta (A4) precursor protein 0.0229392
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0224365
NEK7 NIMA-related kinase 7 0.0224309
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0223095
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0222544
QKI QKI, KH domain containing, RNA binding 0.0219606
NUP58 nucleoporin 58 0.021854
ARL8B ADP-ribosylation factor-like 8B 0.0217475
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0217293
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0214099
FOXJ3 forkhead box J3 0.0211151
PUM2 pumilio RNA-binding family member 2 0.0207616
STAU1 staufen double-stranded RNA binding protein 1 0.0207439
MCL1 myeloid cell leukemia 1 0.0207142
NCKAP1 NCK-associated protein 1 0.0206777
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0204913
UBA6 ubiquitin-like modifier activating enzyme 6 0.0203791
PID1 phosphotyrosine interaction domain containing 1 0.0201482
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0201096
WNT2B wingless-type MMTV integration site family, member 2B 0.0198634
ARHGAP32 Rho GTPase activating protein 32 0.0198393
SIK3 SIK family kinase 3 0.0198302
OSBPL9 oxysterol binding protein-like 9 0.0197446
IFRD1 interferon-related developmental regulator 1 0.0196405
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0194647
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.019301
ABI1 abl-interactor 1 0.0191868
MAP4 microtubule-associated protein 4 0.019121
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0190207
GCLC glutamate-cysteine ligase, catalytic subunit 0.0189299
ATG7 autophagy related 7 0.0186526
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0185797
DIAPH2 diaphanous-related formin 2 0.018493
TRAF3 TNF receptor-associated factor 3 0.018459
RBM33 RNA binding motif protein 33 0.0184319
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0183866
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0182938
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0181769
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0181185
KCMF1 potassium channel modulatory factor 1 0.0180181
DENND4A DENN/MADD domain containing 4A 0.0180139

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.216966
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111472
VIM vimentin -0.100845
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0996991
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.087519
MT2A metallothionein 2A -0.0864144
IGFBP3 insulin-like growth factor binding protein 3 -0.0826931
GOLGA4 golgin A4 -0.0814669
PDE4D phosphodiesterase 4D, cAMP-specific -0.0775589
TMSB10 thymosin beta 10 -0.0731019
LOX lysyl oxidase -0.0715057
GRB10 growth factor receptor-bound protein 10 -0.0713761
OSMR oncostatin M receptor -0.0673241
ARHGAP5 Rho GTPase activating protein 5 -0.0672771
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0665472
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0626894
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0589597
STC1 stanniocalcin 1 -0.0533705
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0522527
BASP1 brain abundant, membrane attached signal protein 1 -0.0521065
MEF2A myocyte enhancer factor 2A -0.0494106
FTH1 ferritin, heavy polypeptide 1 -0.0489613
ZEB2 zinc finger E-box binding homeobox 2 -0.048305
RPS19 ribosomal protein S19 -0.0459903
RPL36 ribosomal protein L36 -0.0430163
ETV6 ets variant 6 -0.0400231
KTN1 kinectin 1 (kinesin receptor) -0.0397516
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0376075
EIF1 eukaryotic translation initiation factor 1 -0.0360732
KMT2E lysine (K)-specific methyltransferase 2E -0.0356387
ANGPTL4 angiopoietin-like 4 -0.0349994
LMAN1 lectin, mannose-binding, 1 -0.0342504
NRP1 neuropilin 1 -0.0342221
RPS21 ribosomal protein S21 -0.0340199
RPL18 ribosomal protein L18 -0.0327951
RPS12 ribosomal protein S12 -0.0321798
RPL32 ribosomal protein L32 -0.0318805
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0317428
KDM2A lysine (K)-specific demethylase 2A -0.0317219
AKAP9 A kinase (PRKA) anchor protein 9 -0.0316361
RPS6 ribosomal protein S6 -0.0308937
KLF6 Kruppel-like factor 6 -0.0306788
PTPRR protein tyrosine phosphatase, receptor type, R -0.0298578
PFN1 profilin 1 -0.0297356
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0296362
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0295517
DOCK5 dedicator of cytokinesis 5 -0.0292213
ZFP91 ZFP91 zinc finger protein -0.0290155
CDCP1 CUB domain containing protein 1 -0.0290138
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0289301
VEGFC vascular endothelial growth factor C -0.0283504
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0283032
RPL12 ribosomal protein L12 -0.0281786
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0278528
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0273827
RPS3 ribosomal protein S3 -0.0273016
TSPAN5 tetraspanin 5 -0.0270505
CHD1L chromodomain helicase DNA binding protein 1-like -0.0270153
ZC3H12C zinc finger CCCH-type containing 12C -0.0265287
TFPI2 tissue factor pathway inhibitor 2 -0.026328
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0261254
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260253
PSD3 pleckstrin and Sec7 domain containing 3 -0.0255307
DPYD dihydropyrimidine dehydrogenase -0.0254368
RNF24 ring finger protein 24 -0.0253316
FN1 fibronectin 1 -0.0252625
ADM adrenomedullin -0.0250992
EGR1 early growth response 1 -0.0250446
HAS2 hyaluronan synthase 2 -0.0248433
RPL34 ribosomal protein L34 -0.0247067
MAP1B microtubule-associated protein 1B -0.0244911
NPC1 Niemann-Pick disease, type C1 -0.0244092
ANTXR2 anthrax toxin receptor 2 -0.0240207
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0238852
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0238533
MYO9A myosin IXA -0.023853
CCDC88A coiled-coil domain containing 88A -0.0236323
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0229987
RPS29 ribosomal protein S29 -0.0229554
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0229088
C15ORF48 chromosome 15 open reading frame 48 -0.0227972
YEATS2 YEATS domain containing 2 -0.022621
GLCCI1 glucocorticoid induced 1 -0.0224437
ZBTB20 zinc finger and BTB domain containing 20 -0.0223963
TMEM165 transmembrane protein 165 -0.0219562
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0218973
RPLP2 ribosomal protein, large, P2 -0.0216367
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0216281
SLC38A1 solute carrier family 38, member 1 -0.0214811
MRPS6 mitochondrial ribosomal protein S6 -0.0211265
SYNJ2 synaptojanin 2 -0.0210915
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0209864
RND3 Rho family GTPase 3 -0.0209862
NLRP1 NLR family, pyrin domain containing 1 -0.020854
GSTP1 glutathione S-transferase pi 1 -0.0208092
ZMYND8 zinc finger, MYND-type containing 8 -0.0207521
NPAS2 neuronal PAS domain protein 2 -0.0207126
NIPBL Nipped-B homolog (Drosophila) -0.0204888
SYAP1 synapse associated protein 1 -0.0204858
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0204553