| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tranilast perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tranilast_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.041608 |
| THBS1 | thrombospondin 1 | 0.0300408 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0275453 |
| PTK2 | protein tyrosine kinase 2 | 0.0251298 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0225618 |
| DENND4A | DENN/MADD domain containing 4A | 0.021939 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | 0.0215173 |
| HSPA8 | heat shock 70kDa protein 8 | 0.019263 |
| TFRC | transferrin receptor | 0.0190898 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0188057 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0187366 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0186129 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.0185825 |
| BRD2 | bromodomain containing 2 | 0.0174754 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0170655 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0168321 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0166722 |
| ETV3 | ets variant 3 | 0.0164031 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0163346 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0160922 |
| USP15 | ubiquitin specific peptidase 15 | 0.0160171 |
| NUP93 | nucleoporin 93kDa | 0.0158939 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0157129 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0153167 |
| NEK7 | NIMA-related kinase 7 | 0.0152032 |
| SIK3 | SIK family kinase 3 | 0.0150579 |
| SCFD1 | sec1 family domain containing 1 | 0.0149333 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0148822 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0145582 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0144149 |
| FLNB | filamin B, beta | 0.0141419 |
| PTGES2 | prostaglandin E synthase 2 | 0.0139812 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0138186 |
| NXF1 | nuclear RNA export factor 1 | 0.0137767 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 0.0137669 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0135556 |
| ELOA | elongin A | 0.0135309 |
| ZFAT | zinc finger and AT hook domain containing | 0.0135159 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0134607 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0133995 |
| AMFR | autocrine motility factor receptor, E3 ubiquitin protein ligase | 0.012951 |
| RPS7 | ribosomal protein S7 | 0.0129362 |
| SMAD2 | SMAD family member 2 | 0.0129321 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0129014 |
| DHX38 | DEAH (Asp-Glu-Ala-His) box polypeptide 38 | 0.012767 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0127408 |
| RPRD1B | regulation of nuclear pre-mRNA domain containing 1B | 0.0126939 |
| ARF4 | ADP-ribosylation factor 4 | 0.0126229 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0126034 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.012549 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0124687 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0123909 |
| MYO1B | myosin IB | 0.0123662 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0123386 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0123066 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0121759 |
| RPL3 | ribosomal protein L3 | 0.0120351 |
| UIMC1 | ubiquitin interaction motif containing 1 | 0.012032 |
| TPD52 | tumor protein D52 | 0.0118688 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.0117459 |
| FLNA | filamin A, alpha | 0.0117276 |
| GRB14 | growth factor receptor-bound protein 14 | 0.0116308 |
| CAB39 | calcium binding protein 39 | 0.0115604 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0115203 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0115096 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0112173 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0111798 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0110014 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0109713 |
| CHN1 | chimerin 1 | 0.0109133 |
| SAR1A | secretion associated, Ras related GTPase 1A | 0.0108496 |
| CTNNBL1 | catenin, beta like 1 | 0.0108309 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0107606 |
| ZNF335 | zinc finger protein 335 | 0.0107202 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.010632 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0105337 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0104922 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0104837 |
| BMPR1B | bone morphogenetic protein receptor, type IB | 0.0104647 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0104352 |
| RPL34 | ribosomal protein L34 | 0.010363 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0103202 |
| MTMR3 | myotubularin related protein 3 | 0.0102234 |
| GPATCH8 | G patch domain containing 8 | 0.0102182 |
| RPL32 | ribosomal protein L32 | 0.0102109 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0101836 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0101087 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0101057 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 0.0100937 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.010083 |
| CASC3 | cancer susceptibility candidate 3 | 0.0100427 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.00997235 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00993637 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.00993292 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.00992107 |
| SGMS1 | sphingomyelin synthase 1 | 0.00989024 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.00988886 |
| CKAP5 | cytoskeleton associated protein 5 | 0.00983814 |
| RPS10 | ribosomal protein S10 | 0.00980972 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00976917 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.241933 |
| VIM | vimentin | -0.233596 |
| PM20D1 | peptidase M20 domain containing 1 | -0.193559 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.193534 |
| GRAMD1B | GRAM domain containing 1B | -0.190312 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184669 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0917468 |
| MT2A | metallothionein 2A | -0.0904242 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0882691 |
| TMSB10 | thymosin beta 10 | -0.0864908 |
| FTL | ferritin, light polypeptide | -0.0848633 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0843373 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0826425 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.074484 |
| PTMA | prothymosin, alpha | -0.0721174 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0661864 |
| KIF5B | kinesin family member 5B | -0.0660441 |
| WWOX | WW domain containing oxidoreductase | -0.0633054 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0619563 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0609295 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0601767 |
| STC1 | stanniocalcin 1 | -0.0552848 |
| CMIP | c-Maf inducing protein | -0.0515153 |
| RPLP0 | ribosomal protein, large, P0 | -0.0510722 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0472341 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.047213 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0455646 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0433288 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0418263 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0413609 |
| MYOF | myoferlin | -0.0409149 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0400107 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0381781 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0375398 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0367079 |
| RTN4 | reticulon 4 | -0.0362046 |
| RPLP1 | ribosomal protein, large, P1 | -0.0357067 |
| ERBIN | erbb2 interacting protein | -0.0345511 |
| FGB | fibrinogen beta chain | -0.0341947 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0341252 |
| FGG | fibrinogen gamma chain | -0.0338742 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0327615 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0327518 |
| TXNRD1 | thioredoxin reductase 1 | -0.032665 |
| RBM25 | RNA binding motif protein 25 | -0.0325563 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0325337 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0322834 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0321822 |
| ACTG1 | actin gamma 1 | -0.0319105 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0315959 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.031505 |
| ZFHX3 | zinc finger homeobox 3 | -0.031476 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0309595 |
| TPM3 | tropomyosin 3 | -0.0308977 |
| TNPO1 | transportin 1 | -0.0306629 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0306023 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0305947 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0304044 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0303997 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0303813 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0303725 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0302545 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0297265 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0296682 |
| GLIS3 | GLIS family zinc finger 3 | -0.0295087 |
| RRM2 | ribonucleotide reductase M2 | -0.0295069 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0294971 |
| MCL1 | myeloid cell leukemia 1 | -0.0294271 |
| S100A6 | S100 calcium binding protein A6 | -0.0294186 |
| CENPF | centromere protein F, 350/400kDa | -0.029247 |
| NHSL1 | NHS-like 1 | -0.0292357 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0291093 |
| RAD51B | RAD51 paralog B | -0.0290322 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0289666 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.028895 |
| ASPH | aspartate beta-hydroxylase | -0.0282984 |
| DST | dystonin | -0.0281724 |
| NEBL | nebulette | -0.0279393 |
| HMGB1 | high mobility group box 1 | -0.0277236 |
| PDE8A | phosphodiesterase 8A | -0.0272689 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0271326 |
| TOP1 | topoisomerase (DNA) I | -0.0270448 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0268303 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.026642 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0264369 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.026218 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0261688 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.025936 |
| TPM4 | tropomyosin 4 | -0.0258794 |
| RPL8 | ribosomal protein L8 | -0.0258692 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0258138 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0257838 |
| FBXO11 | F-box protein 11 | -0.0256638 |
| TPX2 | TPX2, microtubule-associated | -0.0256496 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0255637 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0254024 |
| YY1 | YY1 transcription factor | -0.0252472 |
| ANXA2 | annexin A2 | -0.0252321 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0250899 |
| MTDH | metadherin | -0.0249005 |
