Tranilast_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.322465
MCL1 myeloid cell leukemia 1 0.0905495
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.078238
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0772907
OSMR oncostatin M receptor 0.0713235
PDE10A phosphodiesterase 10A 0.0707938
GRAMD1B GRAM domain containing 1B 0.0600731
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0597784
ERRFI1 ERBB receptor feedback inhibitor 1 0.0570966
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0550304
DOCK5 dedicator of cytokinesis 5 0.0524002
THSD4 thrombospondin, type I, domain containing 4 0.051782
TPM3 tropomyosin 3 0.0506531
IGF1R insulin-like growth factor 1 receptor 0.0481257
TM4SF1 transmembrane 4 L six family member 1 0.0463435
EXT1 exostosin glycosyltransferase 1 0.0452543
KTN1 kinectin 1 (kinesin receptor) 0.0448498
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0423484
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0419912
NIPBL Nipped-B homolog (Drosophila) 0.0418044
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0417416
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0414893
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0409218
YBX3 Y box binding protein 3 0.0408614
TPM4 tropomyosin 4 0.0406413
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0383758
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0375675
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0375079
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0369606
IFI6 interferon, alpha-inducible protein 6 0.035962
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0356971
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0347206
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0346913
SVIL supervillin 0.0336704
VCL vinculin 0.0336628
PDLIM5 PDZ and LIM domain 5 0.0331818
PDE4D phosphodiesterase 4D, cAMP-specific 0.0330643
CDK17 cyclin-dependent kinase 17 0.032909
HLA-B major histocompatibility complex, class I, B 0.0325731
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0307025
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0301818
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.030126
TRIP12 thyroid hormone receptor interactor 12 0.0301091
RAB7A RAB7A, member RAS oncogene family 0.0298925
WWOX WW domain containing oxidoreductase 0.0298197
BASP1 brain abundant, membrane attached signal protein 1 0.0293958
ELL2 elongation factor, RNA polymerase II, 2 0.0289468
ATP11A ATPase, class VI, type 11A 0.0288389
RTN4 reticulon 4 0.028583
CDCP1 CUB domain containing protein 1 0.0283653
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0279463
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.027832
FMNL2 formin-like 2 0.0276405
IPO7 importin 7 0.027157
VMP1 vacuole membrane protein 1 0.0269559
STC1 stanniocalcin 1 0.0268984
MYH9 myosin, heavy chain 9, non-muscle 0.0266166
YAP1 Yes-associated protein 1 0.0263783
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0260471
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0259303
FTH1 ferritin, heavy polypeptide 1 0.0257834
USP34 ubiquitin specific peptidase 34 0.0256608
LOC102724023 ES1 protein homolog, mitochondrial 0.024983
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0249562
WAC WW domain containing adaptor with coiled-coil 0.0245469
POTEF POTE ankyrin domain family, member F 0.0244917
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0244342
H1-0 H1.0 linker histone 0.0241926
BMAL2 basic helix-loop-helix ARNT like 2 0.0241094
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0240872
WWTR1 WW domain containing transcription regulator 1 0.0240782
PRKCE protein kinase C, epsilon 0.0240411
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0239251
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0237031
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0235574
PRELID2 PRELI domain containing 2 0.023232
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0231749
SFPQ splicing factor proline/glutamine-rich 0.0228955
ANO6 anoctamin 6 0.022806
RUNX1 runt-related transcription factor 1 0.0225972
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.022536
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0225011
APLP2 amyloid beta (A4) precursor-like protein 2 0.0224406
MACF1 microtubule-actin crosslinking factor 1 0.02229
BRD2 bromodomain containing 2 0.0222299
SENP6 SUMO1/sentrin specific peptidase 6 0.0222165
CSNK1A1 casein kinase 1, alpha 1 0.0220704
CCNL1 cyclin L1 0.0218848
RBM39 RNA binding motif protein 39 0.0218802
LATS2 large tumor suppressor kinase 2 0.0217967
BRD4 bromodomain containing 4 0.0212268
ACTG1 actin gamma 1 0.0211578
AFF3 AF4/FMR2 family, member 3 0.0211372
WNK1 WNK lysine deficient protein kinase 1 0.0210972
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0210924
PRH1 proline-rich protein HaeIII subfamily 1 0.0208181
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.020751
TCIM transcriptional and immune response regulator 0.0206588
WDPCP WD repeat containing planar cell polarity effector 0.0206519
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0205136

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0975344
RPS3 ribosomal protein S3 -0.0774864
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0537011
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.050349
RPS29 ribosomal protein S29 -0.0475301
MT2A metallothionein 2A -0.0474375
RPS8 ribosomal protein S8 -0.0460166
RPL19 ribosomal protein L19 -0.0457974
RPL23 ribosomal protein L23 -0.0447281
EIF1 eukaryotic translation initiation factor 1 -0.043086
RPS27A ribosomal protein S27a -0.040859
RPL12 ribosomal protein L12 -0.03969
TMSB10 thymosin beta 10 -0.039194
GOLGA4 golgin A4 -0.0385712
RPS19 ribosomal protein S19 -0.0381703
RPLP2 ribosomal protein, large, P2 -0.0364716
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0362075
RPL26 ribosomal protein L26 -0.0352714
RPL37A ribosomal protein L37a -0.0346002
RPS12 ribosomal protein S12 -0.0344238
RPL36 ribosomal protein L36 -0.0340258
RPS10 ribosomal protein S10 -0.0329576
RPL32 ribosomal protein L32 -0.031558
RPL9 ribosomal protein L9 -0.0312313
RPS23 ribosomal protein S23 -0.0302235
RPL11 ribosomal protein L11 -0.0301645
RPL37 ribosomal protein L37 -0.0292842
WSB1 WD repeat and SOCS box containing 1 -0.0287495
RPL5 ribosomal protein L5 -0.0274222
RPS27 ribosomal protein S27 -0.0261118
RPL18 ribosomal protein L18 -0.025948
NACA nascent polypeptide-associated complex alpha subunit -0.0258044
RAD51B RAD51 paralog B -0.0255679
MYL12B myosin, light chain 12B, regulatory -0.0251822
MT1X metallothionein 1X -0.0250919
VIM vimentin -0.0249084
PTMA prothymosin, alpha -0.0247298
RPL34 ribosomal protein L34 -0.0245151
WASF2 WAS protein family, member 2 -0.0241346
RPS6 ribosomal protein S6 -0.0240204
RPL8 ribosomal protein L8 -0.0239843
CAMKMT calmodulin-lysine N-methyltransferase -0.0234502
FTL ferritin, light polypeptide -0.0231279
PFN1 profilin 1 -0.0228328
RPL7A ribosomal protein L7a -0.0221805
FCHSD2 FCH and double SH3 domains 2 -0.0220271
RPS16 ribosomal protein S16 -0.0213393
BBX bobby sox homolog (Drosophila) -0.0203931
RPS21 ribosomal protein S21 -0.0202639
TPI1 triosephosphate isomerase 1 -0.020115
EXOC4 exocyst complex component 4 -0.0196233
RPS5 ribosomal protein S5 -0.0195881
RPL7 ribosomal protein L7 -0.0189878
MORF4L2 mortality factor 4 like 2 -0.018683
S100A9 S100 calcium binding protein A9 -0.0185854
RAN RAN, member RAS oncogene family -0.0185275
RPS4X ribosomal protein S4, X-linked -0.0180993
RPS14 ribosomal protein S14 -0.0179705
RPL35 ribosomal protein L35 -0.0178094
NAP1L1 nucleosome assembly protein 1-like 1 -0.0177715
RPL27A ribosomal protein L27a -0.0176887
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0174818
PARD3 par-3 family cell polarity regulator -0.0174691
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0173691
MT1E metallothionein 1E -0.0171172
GARS1 glycyl-tRNA synthetase 1 -0.0170331
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0170099
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0169786
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0169233
RACK1 receptor for activated C kinase 1 -0.0168824
RPL31 ribosomal protein L31 -0.0168549
YBX1 Y box binding protein 1 -0.0168138
ZBTB20 zinc finger and BTB domain containing 20 -0.0166115
RPL36A ribosomal protein L36a -0.0164989
PDIA4 protein disulfide isomerase family A, member 4 -0.0164785
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0163734
TULP3 tubby like protein 3 -0.0163258
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0162997
KMT2E lysine (K)-specific methyltransferase 2E -0.0162919
RPS13 ribosomal protein S13 -0.0161641
PNISR PNN-interacting serine/arginine-rich protein -0.0161373
MON2 MON2 homolog (S. cerevisiae) -0.0161044
CANX calnexin -0.0159606
HMGA1 high mobility group AT-hook 1 -0.0159271
RPS25 ribosomal protein S25 -0.0158836
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0158729
RPS24 ribosomal protein S24 -0.0158429
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0157654
BCAS3 breast carcinoma amplified sequence 3 -0.0157175
LMNA lamin A/C -0.0156536
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0155344
ATXN2 ataxin 2 -0.0155114
SRBD1 S1 RNA binding domain 1 -0.0153104
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0152501
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.0152093
THOC2 THO complex 2 -0.0151315
RPS15 ribosomal protein S15 -0.0150146
DYM dymeclin -0.015005
PHF20 PHD finger protein 20 -0.0149875
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0148212