Tranilast_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.27504
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.152815
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.118493
NAMPT nicotinamide phosphoribosyltransferase 0.107343
ASPH aspartate beta-hydroxylase 0.098034
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0872001
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0783826
TSC22D2 TSC22 domain family, member 2 0.0720662
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0691827
ADAM9 ADAM metallopeptidase domain 9 0.066495
NDRG1 N-myc downstream regulated 1 0.0652829
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0640271
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0637552
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0619822
FXR1 fragile X mental retardation, autosomal homolog 1 0.0612182
TFG TRK-fused gene 0.0589823
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0587721
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0581332
ANXA2 annexin A2 0.0556483
RNF145 ring finger protein 145 0.0545715
RAD21 RAD21 homolog (S. pombe) 0.0533943
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0501703
PGK1 phosphoglycerate kinase 1 0.0476494
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0474573
FNDC3B fibronectin type III domain containing 3B 0.0468138
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0467922
CCNL1 cyclin L1 0.0462344
EEF2 eukaryotic translation elongation factor 2 0.0461616
MARCHF6 membrane associated ring-CH-type finger 6 0.0461426
TXNRD1 thioredoxin reductase 1 0.0443115
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0436366
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0428968
LAMC2 laminin, gamma 2 0.042358
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0412278
USP3 ubiquitin specific peptidase 3 0.0410945
UBC ubiquitin C 0.0406068
MATR3 matrin 3 0.0402267
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0383748
MSMO1 methylsterol monooxygenase 1 0.0377011
ELL2 elongation factor, RNA polymerase II, 2 0.0374802
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0351884
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0351192
NCKAP1 NCK-associated protein 1 0.0348294
ZNF292 zinc finger protein 292 0.0335392
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0334021
TMEM123 transmembrane protein 123 0.0333811
TOP2A topoisomerase (DNA) II alpha 170kDa 0.032654
BHLHE40 basic helix-loop-helix family, member e40 0.0324207
UBA6 ubiquitin-like modifier activating enzyme 6 0.0323506
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0319945
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0317915
GARS1 glycyl-tRNA synthetase 1 0.0310399
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0310293
MSN moesin 0.0308569
HSPA8 heat shock 70kDa protein 8 0.0308267
LDHA lactate dehydrogenase A 0.0305048
PAPOLA poly(A) polymerase alpha 0.0301268
SLC38A1 solute carrier family 38, member 1 0.0300094
ANXA5 annexin A5 0.029844
ATP13A3 ATPase type 13A3 0.0296946
PTK2 protein tyrosine kinase 2 0.0296616
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0290566
CPNE8 copine VIII 0.0289846
S100A6 S100 calcium binding protein A6 0.0289036
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0286322
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0285075
RPL4 ribosomal protein L4 0.0283054
HMGA1 high mobility group AT-hook 1 0.0279346
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0278119
HMGB2 high mobility group box 2 0.0275559
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0273368
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0271807
RTN4 reticulon 4 0.0271214
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0268504
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.026358
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0261427
IRF6 interferon regulatory factor 6 0.0260119
ANLN anillin, actin binding protein 0.0259142
IL6ST interleukin 6 signal transducer 0.0257027
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0256755
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.02564
ARRDC3 arrestin domain containing 3 0.0255589
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0254489
CLINT1 clathrin interactor 1 0.0253585
CANX calnexin 0.0252124
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0250704
FAM13A family with sequence similarity 13, member A 0.0250286
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0249451
NUP58 nucleoporin 58 0.0248228
RIOK3 RIO kinase 3 0.024806
FAM162A family with sequence similarity 162, member A 0.0247084
CD46 CD46 molecule, complement regulatory protein 0.0246375
WAC WW domain containing adaptor with coiled-coil 0.0245726
SSBP2 single-stranded DNA binding protein 2 0.0245131
FTH1 ferritin, heavy polypeptide 1 0.0244564
EPS8 epidermal growth factor receptor pathway substrate 8 0.0243438
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0242186
KMT2E lysine (K)-specific methyltransferase 2E 0.0241567
CAPN2 calpain 2, (m/II) large subunit 0.0240822
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.024014

decreased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A -0.113878
ZSWIM6 zinc finger, SWIM-type containing 6 -0.095712
EXT1 exostosin glycosyltransferase 1 -0.0764529
LPP LIM domain containing preferred translocation partner in lipoma -0.0744938
TMSB10 thymosin beta 10 -0.0723529
EFNA5 ephrin-A5 -0.0720106
LIMCH1 LIM and calponin homology domains 1 -0.065995
FTL ferritin, light polypeptide -0.0657088
FBXO32 F-box protein 32 -0.052614
ISG15 ISG15 ubiquitin-like modifier -0.0489842
RPS29 ribosomal protein S29 -0.0473532
ACTG1 actin gamma 1 -0.047102
GOLGB1 golgin B1 -0.0452192
RNF213 ring finger protein 213 -0.0443433
PTMA prothymosin, alpha -0.0441471
MYO1E myosin IE -0.0441353
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0439832
RPS19 ribosomal protein S19 -0.0427161
PDLIM5 PDZ and LIM domain 5 -0.0411638
MT2A metallothionein 2A -0.040788
FNIP1 folliculin interacting protein 1 -0.0404562
CTBP2 C-terminal binding protein 2 -0.0399716
RAB7A RAB7A, member RAS oncogene family -0.039827
RPLP2 ribosomal protein, large, P2 -0.0377577
VCL vinculin -0.0365907
ARHGAP20 Rho GTPase activating protein 20 -0.0365291
PGBD5 piggyBac transposable element derived 5 -0.0362997
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0359253
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0346102
GRB10 growth factor receptor-bound protein 10 -0.0345019
IFI27 interferon, alpha-inducible protein 27 -0.034056
RPL37A ribosomal protein L37a -0.0337569
RPS3 ribosomal protein S3 -0.0336319
IFI6 interferon, alpha-inducible protein 6 -0.0324615
WSB1 WD repeat and SOCS box containing 1 -0.0320651
TTC3 tetratricopeptide repeat domain 3 -0.031897
RPS8 ribosomal protein S8 -0.0309668
LMNA lamin A/C -0.0307806
IFI16 interferon, gamma-inducible protein 16 -0.0305508
HLA-B major histocompatibility complex, class I, B -0.0293401
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0292365
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0291556
RPL9 ribosomal protein L9 -0.028804
SCFD1 sec1 family domain containing 1 -0.0286296
EIF1 eukaryotic translation initiation factor 1 -0.028583
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0284138
S100A9 S100 calcium binding protein A9 -0.0280681
RPS23 ribosomal protein S23 -0.0277702
RIGI RNA sensor RIG-I -0.0276414
RPS12 ribosomal protein S12 -0.0276157
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.027512
RCOR1 REST corepressor 1 -0.0275003
MX1 MX dynamin-like GTPase 1 -0.0274982
INTS6 integrator complex subunit 6 -0.0272496
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.027222
RAD51B RAD51 paralog B -0.0272019
ATP11A ATPase, class VI, type 11A -0.0266934
RPL34 ribosomal protein L34 -0.0265015
RAI14 retinoic acid induced 14 -0.0259002
RBM47 RNA binding motif protein 47 -0.0258373
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0257375
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0256516
NAV2 neuron navigator 2 -0.0255787
MX2 MX dynamin-like GTPase 2 -0.0254213
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0253938
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0250858
CDK13 cyclin-dependent kinase 13 -0.025057
CEP350 centrosomal protein 350kDa -0.0245978
IFITM3 interferon induced transmembrane protein 3 -0.0244139
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0244
SEC31A SEC31 homolog A (S. cerevisiae) -0.0238668
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0238075
RPL36 ribosomal protein L36 -0.0236547
BASP1 brain abundant, membrane attached signal protein 1 -0.023535
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0235097
TBC1D22A TBC1 domain family, member 22A -0.0233102
ZBTB20 zinc finger and BTB domain containing 20 -0.023222
ATXN1 ataxin 1 -0.0231678
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0230401
TBCA tubulin folding cofactor A -0.0228559
PRKCA protein kinase C, alpha -0.0227516
WARS1 tryptophanyl-tRNA synthetase 1 -0.022717
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0227077
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0225896
TMEM165 transmembrane protein 165 -0.0224646
PALLD palladin, cytoskeletal associated protein -0.0222723
BLZF1 basic leucine zipper nuclear factor 1 -0.0222492
FAM107B family with sequence similarity 107, member B -0.0219884
ANKRD17 ankyrin repeat domain 17 -0.0219373
NF1 neurofibromin 1 -0.0219135
KDM2A lysine (K)-specific demethylase 2A -0.021882
ANKHD1 ankyrin repeat and KH domain containing 1 -0.021758
DTNA dystrobrevin, alpha -0.0216679
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0216241
RSF1 remodeling and spacing factor 1 -0.0215975
FBXO34 F-box protein 34 -0.0214912
IFITM1 interferon induced transmembrane protein 1 -0.0213229
IGFBP3 insulin-like growth factor binding protein 3 -0.0212792
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0212155
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0211736