Tranilast_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tranilast_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDLIM5 PDZ and LIM domain 5 0.0507221
COL5A2 collagen, type V, alpha 2 0.0368729
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0364897
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0346765
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0292322
GRAMD1B GRAM domain containing 1B 0.0230886
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0229241
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0215816
COL4A5 collagen, type IV, alpha 5 0.0188195
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0186936
SAMD4A sterile alpha motif domain containing 4A 0.0176103
KYNU kynureninase 0.0173236
ADGRD1 adhesion G protein-coupled receptor D1 0.0171235
SET SET nuclear proto-oncogene 0.0162018
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0159909
RPH3AL rabphilin 3A-like (without C2 domains) 0.0157084
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0150486
SORBS2 sorbin and SH3 domain containing 2 0.0142239
BCAR3 breast cancer anti-estrogen resistance 3 0.0140842
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0140265
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0138259
CD44 CD44 molecule (Indian blood group) 0.0137512
KIAA0825 KIAA0825 0.0129672
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0124888
OSMR oncostatin M receptor 0.0122424
AOPEP aminopeptidase O (putative) 0.0119118
DOCK5 dedicator of cytokinesis 5 0.0117292
DNAH14 dynein, axonemal, heavy chain 14 0.0115194
PDE10A phosphodiesterase 10A 0.0114327
RPL3 ribosomal protein L3 0.0112875
NT5E 5'-nucleotidase, ecto (CD73) 0.0109498
CCDC68 coiled-coil domain containing 68 0.0107315
EXT1 exostosin glycosyltransferase 1 0.0105636
NBEA neurobeachin 0.0100174
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.00999539
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.00985556
CFLAR CASP8 and FADD-like apoptosis regulator 0.00985299
STAG2 stromal antigen 2 0.00978278
NT5C2 5'-nucleotidase, cytosolic II 0.00975164
SMOC1 SPARC related modular calcium binding 1 0.00972
EVA1C eva-1 homolog C (C. elegans) 0.00971893
NTN4 netrin 4 0.00951031
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.00931769
WWTR1 WW domain containing transcription regulator 1 0.00926464
TFPI2 tissue factor pathway inhibitor 2 0.00922825
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.00920529
IRS2 insulin receptor substrate 2 0.00920279
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00907566
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0090098
GPATCH2 G patch domain containing 2 0.00890163
AEBP2 AE binding protein 2 0.00886872
RABGAP1L RAB GTPase activating protein 1-like 0.00880159
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00876009
RANBP17 RAN binding protein 17 0.00871762
DCAF8 DDB1 and CUL4 associated factor 8 0.00867966
HDAC8 histone deacetylase 8 0.0086475
ALPK2 alpha-kinase 2 0.00851802
PCED1B PC-esterase domain containing 1B 0.00830756
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00818155
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.00812269
UNC5D unc-5 homolog D (C. elegans) 0.00795725
DYNC2I1 dynein 2 intermediate chain 1 0.00793292
PCNX4 pecanex 4 0.00792314
USP40 ubiquitin specific peptidase 40 0.00790389
TNRC18 trinucleotide repeat containing 18 0.00785787
RBBP6 retinoblastoma binding protein 6 0.00782761
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.00779843
NIBAN1 niban apoptosis regulator 1 0.00777678
ARHGAP29 Rho GTPase activating protein 29 0.00771446
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.00766513
COMMD10 COMM domain containing 10 0.00764903
ANTXR1 anthrax toxin receptor 1 0.00763661
TUSC3 tumor suppressor candidate 3 0.00759909
FAM120B family with sequence similarity 120B 0.00756131
TRAPPC9 trafficking protein particle complex 9 0.00752923
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.00751983
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.00750344
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.00740493
ZBTB20 zinc finger and BTB domain containing 20 0.00739593
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.00736564
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00708029
TENM3 teneurin transmembrane protein 3 0.00706516
ALCAM activated leukocyte cell adhesion molecule 0.00693786
BCAS3 breast carcinoma amplified sequence 3 0.00692215
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00691984
STEAP1B STEAP family member 1B 0.00688751
GCC2 GRIP and coiled-coil domain containing 2 0.00687691
PHF14 PHD finger protein 14 0.00686514
TCEAL4 transcription elongation factor A (SII)-like 4 0.00675946
IFT43 intraflagellar transport 43 0.00673178
CAPN2 calpain 2, (m/II) large subunit 0.00670516
TM4SF1 transmembrane 4 L six family member 1 0.00668682
RPS7 ribosomal protein S7 0.00662522
GLP2R glucagon-like peptide 2 receptor 0.0065955
H1-4 H1.4 linker histone, cluster member 0.00658774
DKC1 dyskeratosis congenita 1, dyskerin 0.00658674
RAB28 RAB28, member RAS oncogene family 0.00658662
ASMTL acetylserotonin O-methyltransferase-like 0.00652634
AHCYL2 adenosylhomocysteinase-like 2 0.00649701
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.00645532

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.310333
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117368
FTL ferritin, light polypeptide -0.108043
NAMPT nicotinamide phosphoribosyltransferase -0.106915
FN1 fibronectin 1 -0.0972533
TMSB10 thymosin beta 10 -0.0906385
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0802113
NDRG1 N-myc downstream regulated 1 -0.0740397
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0711547
EFNA5 ephrin-A5 -0.0674054
RPS6 ribosomal protein S6 -0.0640428
VIM vimentin -0.0624918
ELL2 elongation factor, RNA polymerase II, 2 -0.0609817
RPS23 ribosomal protein S23 -0.06084
TPT1 tumor protein, translationally-controlled 1 -0.0591667
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.058355
PGK1 phosphoglycerate kinase 1 -0.0575247
IGFBP3 insulin-like growth factor binding protein 3 -0.0567339
RPL37A ribosomal protein L37a -0.0550426
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0527536
FNDC3B fibronectin type III domain containing 3B -0.0515043
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0510913
RPL19 ribosomal protein L19 -0.0506449
RPS19 ribosomal protein S19 -0.050385
SPAG9 sperm associated antigen 9 -0.0499255
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0493934
RPLP1 ribosomal protein, large, P1 -0.0490831
ESYT2 extended synaptotagmin-like protein 2 -0.0490238
RPL31 ribosomal protein L31 -0.0483008
WSB1 WD repeat and SOCS box containing 1 -0.0455975
LIMCH1 LIM and calponin homology domains 1 -0.0451851
MT2A metallothionein 2A -0.0449474
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0435053
KMT2E lysine (K)-specific methyltransferase 2E -0.0433436
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0432061
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0430932
SLC38A2 solute carrier family 38, member 2 -0.0430234
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0428683
RPL12 ribosomal protein L12 -0.0427625
RPLP0 ribosomal protein, large, P0 -0.0423269
KMT2C lysine (K)-specific methyltransferase 2C -0.0416303
RPL35A ribosomal protein L35a -0.0410023
PTMA prothymosin, alpha -0.0396106
RPS24 ribosomal protein S24 -0.0395702
RPS3 ribosomal protein S3 -0.0388131
RPL36 ribosomal protein L36 -0.0381857
TRIO trio Rho guanine nucleotide exchange factor -0.0377374
AGFG1 ArfGAP with FG repeats 1 -0.0374384
TXNRD1 thioredoxin reductase 1 -0.0367372
DDIT4 DNA-damage-inducible transcript 4 -0.036538
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0364047
LDHA lactate dehydrogenase A -0.0363645
FLNB filamin B, beta -0.0363419
AUTS2 autism susceptibility candidate 2 -0.0361823
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0361455
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0360915
PDIA3 protein disulfide isomerase family A, member 3 -0.0348397
NUP58 nucleoporin 58 -0.0344516
NEK7 NIMA-related kinase 7 -0.0342723
RPLP2 ribosomal protein, large, P2 -0.0341994
RPS14 ribosomal protein S14 -0.0335276
RPS25 ribosomal protein S25 -0.0333411
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0330969
HILPDA hypoxia inducible lipid droplet-associated -0.0328359
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0325181
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.032505
EIF1 eukaryotic translation initiation factor 1 -0.0321521
RPL7A ribosomal protein L7a -0.0321287
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0320554
PDGFA platelet-derived growth factor alpha polypeptide -0.0317342
RPS8 ribosomal protein S8 -0.0317084
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0316849
FAM13A family with sequence similarity 13, member A -0.0316336
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0312231
RPS29 ribosomal protein S29 -0.0311439
RTN4 reticulon 4 -0.0305493
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0296012
HELZ helicase with zinc finger -0.0295524
RPL23 ribosomal protein L23 -0.029459
ATP13A3 ATPase type 13A3 -0.0293953
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0293812
RNF145 ring finger protein 145 -0.0291516
GARS1 glycyl-tRNA synthetase 1 -0.0290593
ZNF292 zinc finger protein 292 -0.02895
RPS16 ribosomal protein S16 -0.0289241
MYOF myoferlin -0.0287402
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0282259
GNAS GNAS complex locus -0.0281491
WDR45B WD repeat domain 45B -0.0279304
SRGN serglycin -0.0279092
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0268841
RPS12 ribosomal protein S12 -0.0267553
DGKD diacylglycerol kinase, delta 130kDa -0.026428
BIRC6 baculoviral IAP repeat containing 6 -0.0264198
USP34 ubiquitin specific peptidase 34 -0.026355
WDFY2 WD repeat and FYVE domain containing 2 -0.0263441
RPS17 ribosomal protein S17 -0.0258643
PFN1 profilin 1 -0.025746
RPL9 ribosomal protein L9 -0.0256951
ANXA1 annexin A1 -0.0255312