Tranilast_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.0772452
MYH9 myosin, heavy chain 9, non-muscle 0.0738013
TRIO trio Rho guanine nucleotide exchange factor 0.0648526
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0626964
CD44 CD44 molecule (Indian blood group) 0.0615176
DST dystonin 0.0606975
FRMD4A FERM domain containing 4A 0.0600713
COL6A3 collagen, type VI, alpha 3 0.0578384
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0501072
FTH1 ferritin, heavy polypeptide 1 0.0484061
FNDC3B fibronectin type III domain containing 3B 0.0473915
ENO1 enolase 1, (alpha) 0.0465964
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0446053
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0442004
NAV2 neuron navigator 2 0.0432195
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0431705
RAI14 retinoic acid induced 14 0.0422038
NAMPT nicotinamide phosphoribosyltransferase 0.0420837
MACF1 microtubule-actin crosslinking factor 1 0.0415364
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0413886
IGFBP3 insulin-like growth factor binding protein 3 0.0410595
CADM1 cell adhesion molecule 1 0.0399721
CDH13 cadherin 13 0.0375695
ZMYND8 zinc finger, MYND-type containing 8 0.0368863
FN1 fibronectin 1 0.0361706
PDE10A phosphodiesterase 10A 0.0358996
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.035033
AKAP12 A kinase (PRKA) anchor protein 12 0.0348098
MYOF myoferlin 0.0347686
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.034671
TNS3 tensin 3 0.0343637
VCAN versican 0.032956
EEF2 eukaryotic translation elongation factor 2 0.0317765
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0316492
HMGA2 high mobility group AT-hook 2 0.0314531
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0308475
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0306556
ASPH aspartate beta-hydroxylase 0.0305507
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0295802
ELL2 elongation factor, RNA polymerase II, 2 0.0291426
STC1 stanniocalcin 1 0.0290865
GLIS3 GLIS family zinc finger 3 0.0288573
TMEM132D transmembrane protein 132D 0.0281484
BASP1 brain abundant, membrane attached signal protein 1 0.0276582
MSN moesin 0.0273641
PRELID2 PRELI domain containing 2 0.0263727
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0257895
JMJD1C jumonji domain containing 1C 0.0251665
PLIN2 perilipin 2 0.0251573
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0251263
CANX calnexin 0.0248085
ATXN1 ataxin 1 0.0243937
AFF3 AF4/FMR2 family, member 3 0.0242072
SEPTIN9 septin 9 0.0241178
APLP2 amyloid beta (A4) precursor-like protein 2 0.0237455
MMP12 matrix metallopeptidase 12 0.0234306
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0233425
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0233067
FRMPD4 FERM and PDZ domain containing 4 0.0230006
TPM4 tropomyosin 4 0.0224723
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0223983
ADAM12 ADAM metallopeptidase domain 12 0.022397
SDK1 sidekick cell adhesion molecule 1 0.0223394
EFNA5 ephrin-A5 0.0221224
RAD51B RAD51 paralog B 0.0216011
TNIP1 TNFAIP3 interacting protein 1 0.0215977
PSD3 pleckstrin and Sec7 domain containing 3 0.0215248
OPTN optineurin 0.0214513
COL5A1 collagen, type V, alpha 1 0.0213949
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0213285
PHF21A PHD finger protein 21A 0.0212051
SFRP1 secreted frizzled-related protein 1 0.021173
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.0210246
ZNF292 zinc finger protein 292 0.0207165
FMNL2 formin-like 2 0.0205849
LAMP2 lysosomal-associated membrane protein 2 0.0197333
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0195841
BNC2 basonuclin 2 0.0194443
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.019334
TENT5A terminal nucleotidyltransferase 5A 0.0192766
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0192147
STAG2 stromal antigen 2 0.0191787
DIAPH2 diaphanous-related formin 2 0.0191728
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0190444
RUNX1 runt-related transcription factor 1 0.0187541
FNIP1 folliculin interacting protein 1 0.0186184
MXI1 MAX interactor 1, dimerization protein 0.0185517
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0184247
ZMIZ1 zinc finger, MIZ-type containing 1 0.018365
IL6ST interleukin 6 signal transducer 0.0182581
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0180394
BTG1 B-cell translocation gene 1, anti-proliferative 0.0179791
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0179453
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0176548
SLC35F3 solute carrier family 35, member F3 0.0176441
EGFR epidermal growth factor receptor 0.0176084
UTRN utrophin 0.0173078
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0170623
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0170432
DLG1 discs, large homolog 1 (Drosophila) 0.016895

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0746214
HLA-B major histocompatibility complex, class I, B -0.0509551
TMSB10 thymosin beta 10 -0.0492206
BICC1 BicC family RNA binding protein 1 -0.03787
VCL vinculin -0.035043
MT2A metallothionein 2A -0.0348495
RPS3 ribosomal protein S3 -0.0340119
FTL ferritin, light polypeptide -0.0330059
RPL37A ribosomal protein L37a -0.0301003
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.027251
RPS6 ribosomal protein S6 -0.0256426
RPL23 ribosomal protein L23 -0.0247125
RPL36 ribosomal protein L36 -0.0234168
EIF1 eukaryotic translation initiation factor 1 -0.0225424
RPL35A ribosomal protein L35a -0.0210515
SLC38A2 solute carrier family 38, member 2 -0.0202471
RPL19 ribosomal protein L19 -0.0199287
RPL36A ribosomal protein L36a -0.0198058
LOC112694756 uncharaterized LOC112694756 -0.0192817
PALLD palladin, cytoskeletal associated protein -0.0190142
RPS12 ribosomal protein S12 -0.0183234
RPS8 ribosomal protein S8 -0.01814
RPS19 ribosomal protein S19 -0.017675
RPS23 ribosomal protein S23 -0.0174518
RPS24 ribosomal protein S24 -0.0174183
EGR1 early growth response 1 -0.017187
RPL31 ribosomal protein L31 -0.0169494
RPLP2 ribosomal protein, large, P2 -0.016495
RPS4X ribosomal protein S4, X-linked -0.0163255
RPS14 ribosomal protein S14 -0.0162345
RPL9 ribosomal protein L9 -0.0157415
RPL26 ribosomal protein L26 -0.0157078
RPL12 ribosomal protein L12 -0.0153638
KYNU kynureninase -0.0153106
RPL32 ribosomal protein L32 -0.0148897
NCOA7 nuclear receptor coactivator 7 -0.0148125
RPS27A ribosomal protein S27a -0.0135774
RPS15 ribosomal protein S15 -0.0130203
LDHA lactate dehydrogenase A -0.0128671
RPLP1 ribosomal protein, large, P1 -0.0127718
RPS29 ribosomal protein S29 -0.0127226
WSB1 WD repeat and SOCS box containing 1 -0.012372
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0121368
RPL11 ribosomal protein L11 -0.0120324
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0114992
UBE2B ubiquitin-conjugating enzyme E2B -0.011375
RPL27A ribosomal protein L27a -0.0113328
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0112918
NABP1 nucleic acid binding protein 1 -0.0112459
RPL35 ribosomal protein L35 -0.0112236
IER3 immediate early response 3 -0.0112135
RPL13A ribosomal protein L13a -0.0110717
IFITM3 interferon induced transmembrane protein 3 -0.0110341
RPS17 ribosomal protein S17 -0.011004
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0108799
RPL34 ribosomal protein L34 -0.0107938
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0106945
INTS6 integrator complex subunit 6 -0.0106534
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0104513
TPT1 tumor protein, translationally-controlled 1 -0.0104451
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0103634
SH3RF2 SH3 domain containing ring finger 2 -0.0103595
RPL38 ribosomal protein L38 -0.00996675
FUS FUS RNA binding protein -0.00995846
RPS25 ribosomal protein S25 -0.0094766
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.00943927
IFITM1 interferon induced transmembrane protein 1 -0.00940334
RPS13 ribosomal protein S13 -0.0093316
S100A9 S100 calcium binding protein A9 -0.00928427
RPL15 ribosomal protein L15 -0.00925627
RPL8 ribosomal protein L8 -0.00921
UBB ubiquitin B -0.00908961
CDK17 cyclin-dependent kinase 17 -0.00906518
RACK1 receptor for activated C kinase 1 -0.00899921
RPL7A ribosomal protein L7a -0.00899652
RPS11 ribosomal protein S11 -0.00898306
SAR1A secretion associated, Ras related GTPase 1A -0.00897593
RPL28 ribosomal protein L28 -0.00894796
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00891166
AHI1 Abelson helper integration site 1 -0.00883975
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.00878168
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00877798
GOPC golgi-associated PDZ and coiled-coil motif containing -0.0087667
SMAD3 SMAD family member 3 -0.00872503
IFI6 interferon, alpha-inducible protein 6 -0.00870557
SMAD2 SMAD family member 2 -0.00869172
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0085403
RPL37 ribosomal protein L37 -0.00853818
RPS5 ribosomal protein S5 -0.00848263
RPS10 ribosomal protein S10 -0.00845141
TUBB tubulin, beta class I -0.00826861
PFN1 profilin 1 -0.0082378
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00816536
SDC4 syndecan 4 -0.00794915
ASTN2 astrotactin 2 -0.00790961
MON2 MON2 homolog (S. cerevisiae) -0.00778868
RPS16 ribosomal protein S16 -0.00778645
OLA1 Obg-like ATPase 1 -0.00777912
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.00777535
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.00771353