Tranilast_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.053521
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0340604
FNDC3B fibronectin type III domain containing 3B 0.0283281
OGA O-GlcNAcase 0.0264904
COL1A1 collagen, type I, alpha 1 0.0250568
NAMPT nicotinamide phosphoribosyltransferase 0.0246213
PRRC2C proline-rich coiled-coil 2C 0.0234339
AKAP12 A kinase (PRKA) anchor protein 12 0.0229076
MEF2A myocyte enhancer factor 2A 0.0227467
RND3 Rho family GTPase 3 0.0224064
TRA2A transformer 2 alpha homolog (Drosophila) 0.0202053
SYNJ2 synaptojanin 2 0.019228
FOXJ3 forkhead box J3 0.0191707
JAK1 Janus kinase 1 0.0184878
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0182813
APP amyloid beta (A4) precursor protein 0.0179398
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0174676
KDM6A lysine (K)-specific demethylase 6A 0.0173404
FXR1 fragile X mental retardation, autosomal homolog 1 0.016884
TPST1 tyrosylprotein sulfotransferase 1 0.0168174
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0165234
RLF rearranged L-myc fusion 0.0164867
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0163407
KMT2E lysine (K)-specific methyltransferase 2E 0.0161981
RAI1 retinoic acid induced 1 0.0154796
PCBP2 poly(rC) binding protein 2 0.0149145
ARHGAP24 Rho GTPase activating protein 24 0.0148999
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0148229
NDRG1 N-myc downstream regulated 1 0.0147724
PRPF4B pre-mRNA processing factor 4B 0.0147361
MACF1 microtubule-actin crosslinking factor 1 0.0146225
ERBIN erbb2 interacting protein 0.0145989
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0145678
FAM120A family with sequence similarity 120A 0.0145168
TENT2 terminal nucleotidyltransferase 2 0.0144527
FAM13A family with sequence similarity 13, member A 0.0141849
HILPDA hypoxia inducible lipid droplet-associated 0.0140887
ABI1 abl-interactor 1 0.0140502
CAPN2 calpain 2, (m/II) large subunit 0.0140449
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0140067
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0138841
RBM39 RNA binding motif protein 39 0.0137841
THSD4 thrombospondin, type I, domain containing 4 0.0136187
EXOC6B exocyst complex component 6B 0.0135241
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0133846
TXNIP thioredoxin interacting protein 0.0131972
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.0131334
BHLHE40 basic helix-loop-helix family, member e40 0.0130412
SMC6 structural maintenance of chromosomes 6 0.0128799
YME1L1 YME1-like 1 ATPase 0.0128206
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0127169
IRF1 interferon regulatory factor 1 0.012595
MARCHF7 membrane associated ring-CH-type finger 7 0.0125445
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0125386
SHB Src homology 2 domain containing adaptor protein B 0.0124866
ODF2 outer dense fiber of sperm tails 2 0.012454
TMEM131L transmembrane 131 like 0.0124306
HOOK2 hook microtubule-tethering protein 2 0.0124082
BCAR3 breast cancer anti-estrogen resistance 3 0.0123408
FRMD4A FERM domain containing 4A 0.0123364
SETD2 SET domain containing 2 0.0123307
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0123307
RAB8B RAB8B, member RAS oncogene family 0.0122682
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0122618
KIF1B kinesin family member 1B 0.01226
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0122336
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0121956
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0121894
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0120916
USP3 ubiquitin specific peptidase 3 0.0120689
MKRN1 makorin ring finger protein 1 0.0120355
SKP1 S-phase kinase-associated protein 1 0.0119813
TGFB2 transforming growth factor, beta 2 0.0119273
HPCAL1 hippocalcin-like 1 0.0118587
DAPK3 death-associated protein kinase 3 0.011852
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0118467
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0118203
TRAF3 TNF receptor-associated factor 3 0.0118182
MSI2 musashi RNA-binding protein 2 0.0117673
ATP13A3 ATPase type 13A3 0.0116844
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0116215
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0116081
AFF4 AF4/FMR2 family, member 4 0.0115779
PHACTR2 phosphatase and actin regulator 2 0.0114601
WTAP Wilms tumor 1 associated protein 0.0114358
PUM1 pumilio RNA-binding family member 1 0.0113945
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0113936
WASHC4 WASH complex subunit 4 0.0113302
SRPK2 SRSF protein kinase 2 0.0113036
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0112974
NCKAP1 NCK-associated protein 1 0.0112791
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0112147
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0111733
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0110682
LAMP2 lysosomal-associated membrane protein 2 0.0110551
NOCT nocturnin 0.0110052
ATRN attractin 0.0110019
WDR43 WD repeat domain 43 0.01099
SRSF10 serine/arginine-rich splicing factor 10 0.0109582
SUB1 SUB1 homolog (S. cerevisiae) 0.0109437

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.190621
IGFBP3 insulin-like growth factor binding protein 3 -0.14089
CXCL8 chemokine (C-X-C motif) ligand 8 -0.13066
TMSB10 thymosin beta 10 -0.120097
VIM vimentin -0.0949621
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0750314
HLA-B major histocompatibility complex, class I, B -0.0721188
TGFBI transforming growth factor, beta-induced, 68kDa -0.0683563
TRIO trio Rho guanine nucleotide exchange factor -0.0550998
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0540924
IL6 interleukin 6 -0.053834
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0431855
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0430055
LGALS1 lectin, galactoside-binding, soluble, 1 -0.042993
CALR calreticulin -0.0428313
ASPH aspartate beta-hydroxylase -0.041859
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0407288
COL6A1 collagen, type VI, alpha 1 -0.039886
EXT1 exostosin glycosyltransferase 1 -0.037567
FTL ferritin, light polypeptide -0.0372439
MT1X metallothionein 1X -0.0359128
STC1 stanniocalcin 1 -0.0357419
CALU calumenin -0.035516
GLIS3 GLIS family zinc finger 3 -0.0352638
FN1 fibronectin 1 -0.0348734
HLA-C major histocompatibility complex, class I, C -0.0347097
B2M beta-2-microglobulin -0.0347097
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0340452
TENT5A terminal nucleotidyltransferase 5A -0.0339373
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0329288
EGFR epidermal growth factor receptor -0.0326922
RPL37A ribosomal protein L37a -0.0315944
EFNA5 ephrin-A5 -0.0309973
PDIA3 protein disulfide isomerase family A, member 3 -0.0304705
FMNL2 formin-like 2 -0.0303302
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0302949
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.029597
CD44 CD44 molecule (Indian blood group) -0.0290183
LDHA lactate dehydrogenase A -0.0289113
ACTG1 actin gamma 1 -0.0288095
POTEF POTE ankyrin domain family, member F -0.0284975
NALF1 NALCN channel auxiliary factor 1 -0.0277377
ZMYND8 zinc finger, MYND-type containing 8 -0.027621
COL1A2 collagen, type I, alpha 2 -0.0274535
MORF4L2 mortality factor 4 like 2 -0.0272878
RPS6 ribosomal protein S6 -0.0271698
RPL11 ribosomal protein L11 -0.0268171
TPT1 tumor protein, translationally-controlled 1 -0.0264231
PGK1 phosphoglycerate kinase 1 -0.0263304
PTMA prothymosin, alpha -0.0262513
SEC31A SEC31 homolog A (S. cerevisiae) -0.0261919
LOX lysyl oxidase -0.0259729
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0258158
ESYT2 extended synaptotagmin-like protein 2 -0.0246282
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0245563
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0244328
TNS3 tensin 3 -0.024197
CDH13 cadherin 13 -0.0241622
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0241553
ANLN anillin, actin binding protein -0.0241249
F3 coagulation factor III (thromboplastin, tissue factor) -0.0240934
PKM pyruvate kinase, muscle -0.0240408
JMJD1C jumonji domain containing 1C -0.0239529
RPL36 ribosomal protein L36 -0.0237689
RPL34 ribosomal protein L34 -0.0237414
HLA-A major histocompatibility complex, class I, A -0.0236097
RPL23 ribosomal protein L23 -0.0233928
NF1 neurofibromin 1 -0.0231772
RPLP2 ribosomal protein, large, P2 -0.02308
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0230352
RPL26 ribosomal protein L26 -0.023026
RPS3 ribosomal protein S3 -0.022269
TM9SF3 transmembrane 9 superfamily member 3 -0.0220511
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0216193
RPLP1 ribosomal protein, large, P1 -0.0206937
RPS5 ribosomal protein S5 -0.0206669
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0206333
RAB1A RAB1A, member RAS oncogene family -0.0206071
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0203185
VDAC1 voltage-dependent anion channel 1 -0.0202036
RPS19 ribosomal protein S19 -0.0201974
PDE10A phosphodiesterase 10A -0.0200402
COL5A1 collagen, type V, alpha 1 -0.019646
RPS29 ribosomal protein S29 -0.0195657
SDK1 sidekick cell adhesion molecule 1 -0.0195448
RPS8 ribosomal protein S8 -0.019423
TM4SF1 transmembrane 4 L six family member 1 -0.0194026
RPL32 ribosomal protein L32 -0.0192024
RPS14 ribosomal protein S14 -0.0185605
RPL19 ribosomal protein L19 -0.0184851
RPL28 ribosomal protein L28 -0.0182496
CANX calnexin -0.0180472
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0177196
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.01749
MAP1B microtubule-associated protein 1B -0.017453
EEF2 eukaryotic translation elongation factor 2 -0.0173635
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0172477
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0172015
RPL37 ribosomal protein L37 -0.0168195
RORA RAR-related orphan receptor A -0.0167482