Tranilast_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RNF145 ring finger protein 145 0.0550153
WAC WW domain containing adaptor with coiled-coil 0.050213
ATP13A3 ATPase type 13A3 0.0472514
RBM39 RNA binding motif protein 39 0.045603
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0451367
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.04234
NAMPT nicotinamide phosphoribosyltransferase 0.0422445
BCLAF1 BCL2-associated transcription factor 1 0.039909
TFG TRK-fused gene 0.0392392
ITCH itchy E3 ubiquitin protein ligase 0.0384289
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0381618
NUP58 nucleoporin 58 0.0360019
ANLN anillin, actin binding protein 0.0345394
TOP2B topoisomerase (DNA) II beta 180kDa 0.0339541
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0338541
SETD5 SET domain containing 5 0.0331784
PUM2 pumilio RNA-binding family member 2 0.0318852
MKI67 marker of proliferation Ki-67 0.0315357
DIAPH3 diaphanous-related formin 3 0.0311472
FXR1 fragile X mental retardation, autosomal homolog 1 0.0306779
IARS1 isoleucyl-tRNA synthetase 1 0.0304887
PNISR PNN-interacting serine/arginine-rich protein 0.0302915
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.029701
MATR3 matrin 3 0.0296271
SNX14 sorting nexin 14 0.0292179
ZNF292 zinc finger protein 292 0.0290022
KDM3A lysine (K)-specific demethylase 3A 0.0285772
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0284944
XPO1 exportin 1 0.028464
PHIP pleckstrin homology domain interacting protein 0.0283208
HELZ helicase with zinc finger 0.0281593
UBA6 ubiquitin-like modifier activating enzyme 6 0.0281334
ZNF207 zinc finger protein 207 0.0281039
ARHGAP21 Rho GTPase activating protein 21 0.0278794
WBP11 WW domain binding protein 11 0.0274265
TENT2 terminal nucleotidyltransferase 2 0.0273606
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0272754
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.027115
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0269263
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0267091
MARCHF6 membrane associated ring-CH-type finger 6 0.0265295
TBC1D5 TBC1 domain family, member 5 0.0262486
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.025619
NAV2 neuron navigator 2 0.025528
USP3 ubiquitin specific peptidase 3 0.0254771
MMP1 matrix metallopeptidase 1 0.0254402
EWSR1 EWS RNA-binding protein 1 0.0253912
CLASP1 cytoplasmic linker associated protein 1 0.0253856
TMEM39A transmembrane protein 39A 0.0253552
CAPRIN2 caprin family member 2 0.0250302
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0249287
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0242781
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0242373
GARS1 glycyl-tRNA synthetase 1 0.0239654
RICTOR RPTOR independent companion of MTOR, complex 2 0.0237564
COLEC11 collectin sub-family member 11 0.023706
ITGB5 integrin, beta 5 0.0235603
PICALM phosphatidylinositol binding clathrin assembly protein 0.0231837
FOXJ3 forkhead box J3 0.0229416
PIAS2 protein inhibitor of activated STAT, 2 0.0228651
COG6 component of oligomeric golgi complex 6 0.022759
TPD52 tumor protein D52 0.022744
PBX3 pre-B-cell leukemia homeobox 3 0.0225678
H1-4 H1.4 linker histone, cluster member 0.0223475
FRS2 fibroblast growth factor receptor substrate 2 0.022239
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0220731
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0218415
BRWD1 bromodomain and WD repeat domain containing 1 0.0216882
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0216877
KMT2C lysine (K)-specific methyltransferase 2C 0.0216487
TRIM37 tripartite motif containing 37 0.0216424
IWS1 IWS1 homolog (S. cerevisiae) 0.0215769
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0213302
TPM3 tropomyosin 3 0.0212677
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0211611
ZC3H13 zinc finger CCCH-type containing 13 0.0211125
YTHDC1 YTH domain containing 1 0.0211121
NOP58 NOP58 ribonucleoprotein 0.0209511
UBAC2 UBA domain containing 2 0.0209345
TLK1 tousled-like kinase 1 0.0209027
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.020893
KDM6A lysine (K)-specific demethylase 6A 0.0208556
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.020736
AFDN afadin, adherens junction formation factor 0.0206511
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0203217
RASA2 RAS p21 protein activator 2 0.020242
PDE4D phosphodiesterase 4D, cAMP-specific 0.0201846
IPO11 importin 11 0.020106
GOLGA4 golgin A4 0.0200872
FBXL17 F-box and leucine-rich repeat protein 17 0.0200358
SET SET nuclear proto-oncogene 0.0199483
ECPAS Ecm29 proteasome adaptor and scaffold 0.0196457
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 0.0196061
RBM33 RNA binding motif protein 33 0.0195975
ECT2 epithelial cell transforming 2 0.0195701
NUP153 nucleoporin 153kDa 0.0195386
ANKRD17 ankyrin repeat domain 17 0.0194263
EVI5 ecotropic viral integration site 5 0.0193249
SRBD1 S1 RNA binding domain 1 0.0193195
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.019233

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.292643
VIM vimentin -0.169618
TMSB10 thymosin beta 10 -0.118612
LDHA lactate dehydrogenase A -0.106488
CD44 CD44 molecule (Indian blood group) -0.0880506
IGFBP3 insulin-like growth factor binding protein 3 -0.067279
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.066347
TPT1 tumor protein, translationally-controlled 1 -0.0662708
LOC112694756 uncharaterized LOC112694756 -0.0643626
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0582135
SLC38A2 solute carrier family 38, member 2 -0.05371
EIF1 eukaryotic translation initiation factor 1 -0.0499956
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0497811
RIGI RNA sensor RIG-I -0.0482373
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0470148
PKM pyruvate kinase, muscle -0.0436125
ZBTB20 zinc finger and BTB domain containing 20 -0.0424944
MAP1B microtubule-associated protein 1B -0.0420163
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0414913
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0408129
RPLP1 ribosomal protein, large, P1 -0.0404441
PRKCA protein kinase C, alpha -0.0403548
SDC4 syndecan 4 -0.0383854
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0380047
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0375913
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0374278
HMGA2 high mobility group AT-hook 2 -0.0369284
ANGPTL4 angiopoietin-like 4 -0.0365944
ENO2 enolase 2 (gamma, neuronal) -0.0357286
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0356892
EGR1 early growth response 1 -0.0356268
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0344624
RAI14 retinoic acid induced 14 -0.0341657
BTG1 B-cell translocation gene 1, anti-proliferative -0.0340934
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0328754
TPI1 triosephosphate isomerase 1 -0.0320425
ATM ATM serine/threonine kinase -0.0315664
ACTG1 actin gamma 1 -0.0309003
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0308331
ATXN1 ataxin 1 -0.0308164
GOLGB1 golgin B1 -0.0305469
RPL31 ribosomal protein L31 -0.0304763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0304146
PTMA prothymosin, alpha -0.0303232
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0301767
RPS8 ribosomal protein S8 -0.0299954
PRRC2C proline-rich coiled-coil 2C -0.0298681
MBNL1 muscleblind-like splicing regulator 1 -0.0298024
HILPDA hypoxia inducible lipid droplet-associated -0.029333
NT5E 5'-nucleotidase, ecto (CD73) -0.0292857
INTS6 integrator complex subunit 6 -0.0291084
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0287251
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.028437
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0283682
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0282734
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0280629
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0280477
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0278237
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0276742
ZMYND8 zinc finger, MYND-type containing 8 -0.0273521
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0272548
FMN1 formin 1 -0.0271455
SQSTM1 sequestosome 1 -0.0271324
POTEF POTE ankyrin domain family, member F -0.0270942
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0270292
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0267385
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0266753
BPTF bromodomain PHD finger transcription factor -0.0261904
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0257246
RPS23 ribosomal protein S23 -0.0257171
S100A10 S100 calcium binding protein A10 -0.0257084
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0256452
SMAD3 SMAD family member 3 -0.0256259
ENO1 enolase 1, (alpha) -0.0253197
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0252023
RPS3 ribosomal protein S3 -0.0252023
BIRC3 baculoviral IAP repeat containing 3 -0.025165
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0250512
TXNIP thioredoxin interacting protein -0.0248986
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0244012
ESYT2 extended synaptotagmin-like protein 2 -0.0239806
FTH1 ferritin, heavy polypeptide 1 -0.0239405
ANXA2 annexin A2 -0.0238508
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0236746
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0233941
OSMR oncostatin M receptor -0.0233702
RPS27A ribosomal protein S27a -0.0232846
MYO9A myosin IXA -0.0232267
HLA-B major histocompatibility complex, class I, B -0.0229779
BZW1 basic leucine zipper and W2 domains 1 -0.0227976
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0227299
DSCAM Down syndrome cell adhesion molecule -0.0226157
RPS17 ribosomal protein S17 -0.0224871
AHNAK AHNAK nucleoprotein -0.0224354
EPAS1 endothelial PAS domain protein 1 -0.0221875
SH3KBP1 SH3-domain kinase binding protein 1 -0.0220671
LAMB1 laminin, beta 1 -0.0220414
RPL36 ribosomal protein L36 -0.0219975
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0218029
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0215983