Tranilast_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tranilast perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tranilast_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0574141
NAMPT nicotinamide phosphoribosyltransferase 0.0493524
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0441151
WAC WW domain containing adaptor with coiled-coil 0.0321206
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027321
PTK2 protein tyrosine kinase 2 0.0267218
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0252549
SUCO SUN domain containing ossification factor 0.0252397
NUP58 nucleoporin 58 0.0246674
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0245849
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0242768
MYH9 myosin, heavy chain 9, non-muscle 0.0241488
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.023955
LCOR ligand dependent nuclear receptor corepressor 0.0222836
ETNK1 ethanolamine kinase 1 0.0219299
QKI QKI, KH domain containing, RNA binding 0.0218308
IL6ST interleukin 6 signal transducer 0.0217453
RUNX2 runt-related transcription factor 2 0.0215601
TFG TRK-fused gene 0.0214494
NEK7 NIMA-related kinase 7 0.0212249
ZFAND3 zinc finger, AN1-type domain 3 0.0208871
FNDC3B fibronectin type III domain containing 3B 0.0202347
CDC73 cell division cycle 73 0.0201465
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0193913
SMAD3 SMAD family member 3 0.0186747
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.018523
KDM6A lysine (K)-specific demethylase 6A 0.0184325
UBA6 ubiquitin-like modifier activating enzyme 6 0.0184147
RAB8B RAB8B, member RAS oncogene family 0.0183606
PICALM phosphatidylinositol binding clathrin assembly protein 0.0179417
WDR26 WD repeat domain 26 0.0179349
NRIP1 nuclear receptor interacting protein 1 0.0179132
USP12 ubiquitin specific peptidase 12 0.0179107
TRIP12 thyroid hormone receptor interactor 12 0.017856
PUM2 pumilio RNA-binding family member 2 0.0177931
ADAM9 ADAM metallopeptidase domain 9 0.0174978
ATP13A3 ATPase type 13A3 0.0173819
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0172976
SS18 synovial sarcoma translocation, chromosome 18 0.0172084
SOD2 superoxide dismutase 2, mitochondrial 0.0169756
OGA O-GlcNAcase 0.0169503
EPS8 epidermal growth factor receptor pathway substrate 8 0.0167306
CORO1C coronin, actin binding protein, 1C 0.0167015
EWSR1 EWS RNA-binding protein 1 0.0166343
GPC6 glypican 6 0.0166094
GLS2 glutaminase 2 (liver, mitochondrial) 0.0163577
FAT1 FAT atypical cadherin 1 0.0162177
COG5 component of oligomeric golgi complex 5 0.016154
FOXJ3 forkhead box J3 0.0160624
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0157179
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.015689
SSBP2 single-stranded DNA binding protein 2 0.0156002
CNOT4 CCR4-NOT transcription complex, subunit 4 0.014964
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0149051
UBQLN1 ubiquilin 1 0.014382
TM9SF3 transmembrane 9 superfamily member 3 0.0142839
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0141732
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.014106
EREG epiregulin 0.0140728
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.014051
RHEB Ras homolog enriched in brain 0.0139817
RYBP RING1 and YY1 binding protein 0.0139801
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0138341
CCNL1 cyclin L1 0.0138053
CUL3 cullin 3 0.013734
SPRED2 sprouty-related, EVH1 domain containing 2 0.013717
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0136113
HELZ helicase with zinc finger 0.013531
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0134421
TENT2 terminal nucleotidyltransferase 2 0.0134284
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.013284
YAP1 Yes-associated protein 1 0.0131967
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.013126
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0127998
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0127939
WDR43 WD repeat domain 43 0.0125375
FRYL FRY-like 0.0125138
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0124885
ZFAND6 zinc finger, AN1-type domain 6 0.0124452
OTUD7B OTU deubiquitinase 7B 0.0124163
CDK17 cyclin-dependent kinase 17 0.0123477
USP9X ubiquitin specific peptidase 9, X-linked 0.0123116
ERBIN erbb2 interacting protein 0.0123041
OLA1 Obg-like ATPase 1 0.0122436
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0120637
FOXO3 forkhead box O3 0.0120305
MTMR3 myotubularin related protein 3 0.0119997
ADAM17 ADAM metallopeptidase domain 17 0.0119335
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0118795
ADD3 adducin 3 (gamma) 0.0118047
MARCHF6 membrane associated ring-CH-type finger 6 0.011802
ZNF292 zinc finger protein 292 0.0117938
CD109 CD109 molecule 0.0117879
STK24 serine/threonine kinase 24 0.0117751
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0117146
SPRED1 sprouty-related, EVH1 domain containing 1 0.0117008
TNIP1 TNFAIP3 interacting protein 1 0.0116898
MYO1B myosin IB 0.0116788
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0115711
MB21D2 Mab-21 domain containing 2 0.0115511

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.362399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.187623
PTMA prothymosin, alpha -0.177098
FN1 fibronectin 1 -0.16723
MT2A metallothionein 2A -0.152965
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.125663
TMSB10 thymosin beta 10 -0.117854
HMGA2 high mobility group AT-hook 2 -0.115965
VIM vimentin -0.111167
HLA-B major histocompatibility complex, class I, B -0.104166
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10206
NRG1 neuregulin 1 -0.0969033
CANX calnexin -0.0890169
SQSTM1 sequestosome 1 -0.087444
FTL ferritin, light polypeptide -0.0865868
RPL26 ribosomal protein L26 -0.0798137
NDRG1 N-myc downstream regulated 1 -0.0782968
S100A6 S100 calcium binding protein A6 -0.0781913
ASPH aspartate beta-hydroxylase -0.0777424
IFI27 interferon, alpha-inducible protein 27 -0.0710561
RPL37A ribosomal protein L37a -0.0709013
B2M beta-2-microglobulin -0.0698944
TMSB4X thymosin beta 4, X-linked -0.0693185
RPS12 ribosomal protein S12 -0.0688172
RPS19 ribosomal protein S19 -0.0680416
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0677471
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0667731
TPT1 tumor protein, translationally-controlled 1 -0.0641313
ENO1 enolase 1, (alpha) -0.0637651
RACK1 receptor for activated C kinase 1 -0.0611604
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0610927
RPS6 ribosomal protein S6 -0.0602905
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0564631
LMNA lamin A/C -0.0527793
RPS21 ribosomal protein S21 -0.0527012
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0510352
RPS27 ribosomal protein S27 -0.0507306
RPS8 ribosomal protein S8 -0.0506407
SOX4 SRY (sex determining region Y)-box 4 -0.0503774
CALR calreticulin -0.0495749
TPI1 triosephosphate isomerase 1 -0.0492969
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0480965
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0478248
RPS27A ribosomal protein S27a -0.0472533
LIMCH1 LIM and calponin homology domains 1 -0.0472103
S100A10 S100 calcium binding protein A10 -0.0470434
RPL12 ribosomal protein L12 -0.0467053
MRPS6 mitochondrial ribosomal protein S6 -0.0458173
ITGA1 integrin, alpha 1 -0.0453212
PLIN2 perilipin 2 -0.0443395
RAI14 retinoic acid induced 14 -0.0440457
RPS3 ribosomal protein S3 -0.0439393
RPL36 ribosomal protein L36 -0.0438517
RPL9 ribosomal protein L9 -0.0435644
RPLP1 ribosomal protein, large, P1 -0.0431757
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.043159
RPL31 ribosomal protein L31 -0.0426794
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0426622
RPS29 ribosomal protein S29 -0.0421542
RPL28 ribosomal protein L28 -0.041788
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0409326
RPL11 ribosomal protein L11 -0.0408866
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0402942
EIF1 eukaryotic translation initiation factor 1 -0.0393955
IER3 immediate early response 3 -0.0393849
BASP1 brain abundant, membrane attached signal protein 1 -0.0390575
RPL18 ribosomal protein L18 -0.0379754
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0372283
NAP1L1 nucleosome assembly protein 1-like 1 -0.0371704
LOC112694756 uncharaterized LOC112694756 -0.0370649
RPL19 ribosomal protein L19 -0.0369813
SFTPA2 surfactant protein A2 -0.0366033
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0365719
IFI16 interferon, gamma-inducible protein 16 -0.0358778
RPL34 ribosomal protein L34 -0.0350277
RPS16 ribosomal protein S16 -0.0345186
IFI6 interferon, alpha-inducible protein 6 -0.0343239
EFNA5 ephrin-A5 -0.0342677
HLA-A major histocompatibility complex, class I, A -0.0336557
GNAS GNAS complex locus -0.0334676
AKAP12 A kinase (PRKA) anchor protein 12 -0.0331941
RPS11 ribosomal protein S11 -0.0330333
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0328923
RPL8 ribosomal protein L8 -0.0324212
HMGA1 high mobility group AT-hook 1 -0.0324023
RPS24 ribosomal protein S24 -0.0320196
RPL35A ribosomal protein L35a -0.0319472
H1-0 H1.0 linker histone -0.031931
RPS23 ribosomal protein S23 -0.0317792
RPLP2 ribosomal protein, large, P2 -0.0315938
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0314859
ACTG1 actin gamma 1 -0.0310827
HILPDA hypoxia inducible lipid droplet-associated -0.0309845
TMEM165 transmembrane protein 165 -0.030959
RPL37 ribosomal protein L37 -0.0308798
EXT1 exostosin glycosyltransferase 1 -0.0305962
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0305599
PRRC2C proline-rich coiled-coil 2C -0.0305529
RPL38 ribosomal protein L38 -0.0303592
RPS25 ribosomal protein S25 -0.0301427