Transcriptional misregulation in cancer Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process. (Kyoto Encyclopedia of Genes and Genomes, hsa05202)
External Link https://www.kegg.jp/entry/hsa05202
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Genes

189 proteins participating in the Transcriptional misregulation in cancer pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AFF1 AF4/FMR2 family, member 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATM ATM serine/threonine kinase
BAIAP3 BAI1-associated protein 3
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2K BMP2 inducible kinase
CCNA1 cyclin A1
CCNA2 cyclin A2
CCND2 cyclin D2
CCNT1 cyclin T1
CCNT2 cyclin T2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD86 CD86 molecule
CDK14 cyclin-dependent kinase 14
CDK9 cyclin-dependent kinase 9
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDPF1 cysteine-rich, DPF motif domain containing 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
COMMD3-BMI1 COMMD3-BMI1 readthrough
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
DAND5 DAN domain family member 5, BMP antagonist
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEFA1 defensin, alpha 1
DEFA1B defensin, alpha 1B
DEFA3 defensin, alpha 3, neutrophil-specific
DEFA4 defensin, alpha 4, corticostatin
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFA6 defensin, alpha 6, Paneth cell-specific
DOT1L DOT1-like histone H3K79 methyltransferase
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
ETV6 ets variant 6
ETV7 ets variant 7
EWSR1 EWS RNA-binding protein 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FEV FEV (ETS oncogene family)
FLII flightless I homolog (Drosophila)
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FOXO1 forkhead box O1
FUS FUS RNA binding protein
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GDNF glial cell derived neurotrophic factor
GRIA3 glutamate receptor, ionotropic, AMPA 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H3-3A H3.3 histone A
H3-3B H3.3 histone B
H3-4 H3.4 histone, cluster member
H3-5 H3.5 histone
H3-7 H3.7 histone (putative)
H3C13 H3 clustered histone 13
H3C7 H3 clustered histone 7
H3Y2 H3.Y histone 2
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HHEX hematopoietically expressed homeobox
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXA9 homeobox A9
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
IL2RB interleukin 2 receptor, beta
IL3 interleukin 3
IL6 interleukin 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB7 integrin, beta 7
JMJD1C jumonji domain containing 1C
JUP junction plakoglobin
KDM6A lysine (K)-specific demethylase 6A
KLF3 Kruppel-like factor 3 (basic)
KMT2A lysine (K)-specific methyltransferase 2A
LDB2 LIM domain binding 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MEN1 multiple endocrine neoplasia I
MITF microphthalmia-associated transcription factor
MLF1 myeloid leukemia factor 1
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCOR1 nuclear receptor corepressor 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NGFR nerve growth factor receptor
NR4A1AS NR4A1 antisense RNA
NR4A3 nuclear receptor subfamily 4, group A, member 3
NSD2 nuclear receptor binding SET domain protein 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAX3 paired box 3
PAX5 paired box 5
PAX7 paired box 7
PAX8 paired box 8
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PML promyelocytic leukemia
POLK polymerase (DNA directed) kappa
PPARG peroxisome proliferator-activated receptor gamma
PRCC papillary renal cell carcinoma (translocation-associated)
PROM1 prominin 1
PTCRA pre T-cell antigen receptor alpha
PTK2 protein tyrosine kinase 2
RARA retinoic acid receptor, alpha
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SIN3A SIN3 transcription regulator family member A
SIX1 SIX homeobox 1
SIX4 SIX homeobox 4
SLC45A3 solute carrier family 45, member 3
SLTM SAFB-like, transcription modulator
SMAD1 SMAD family member 1
SPI1 Spi-1 proto-oncogene
SPINT1 serine peptidase inhibitor, Kunitz type 1
SS18 synovial sarcoma translocation, chromosome 18
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
SSX1 synovial sarcoma, X breakpoint 1
SSX2 synovial sarcoma, X breakpoint 2
SSX2B synovial sarcoma, X breakpoint 2B
SSX3 synovial sarcoma, X breakpoint 3
SSX4 synovial sarcoma, X breakpoint 4
SSX4B synovial sarcoma, X breakpoint 4B
SSX5 synovial sarcoma, X breakpoint 5
SSX7 synovial sarcoma, X breakpoint 7
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCF3 transcription factor 3
TFE3 transcription factor binding to IGHM enhancer 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLX1 T-cell leukemia homeobox 1
TLX3 T-cell leukemia homeobox 3
TMPRSS2 transmembrane protease, serine 2
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TSPAN7 tetraspanin 7
WNT16 wingless-type MMTV integration site family, member 16
WT1 Wilms tumor 1
ZBTB16 zinc finger and BTB domain containing 16
ZBTB17 zinc finger and BTB domain containing 17
ZEB1 zinc finger E-box binding homeobox 1