Transposition of Great Vessels Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A complex congenital heart defect in which the aorta arises from the morphologic right ventricle and the pulmonary artery arises from the morphologic left ventricle. (Human Phenotype Ontology, HP_0001669)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D014188
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Genes

155 genes/proteins associated with the disease Transposition of Great Vessels from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CFC1 cripto, FRL-1, cryptic family 1 2.88009
GDF1 growth differentiation factor 1 2.88009
ASL argininosuccinate lyase 1.53456
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.35473
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.33523
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.30635
MMP13 matrix metallopeptidase 13 1.30604
CCND1 cyclin D1 1.27936
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.27378
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.27255
TGIF1 TGFB-induced factor homeobox 1 1.2707
IGFBP3 insulin-like growth factor binding protein 3 1.26607
PIR pirin (iron-binding nuclear protein) 1.2639
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.25121
TAT tyrosine aminotransferase 1.24465
CD36 CD36 molecule (thrombospondin receptor) 1.24465
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.24056
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.23806
ULK2 unc-51 like autophagy activating kinase 2 1.23712
SOCS2 suppressor of cytokine signaling 2 1.23648
SAT1 spermidine/spermine N1-acetyltransferase 1 1.23456
GSTO1 glutathione S-transferase omega 1 1.23265
GSR glutathione reductase 1.23042
ODC1 ornithine decarboxylase 1 1.22371
DUSP1 dual specificity phosphatase 1 1.22274
ACIN1 apoptotic chromatin condensation inducer 1 1.22177
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.21567
NEFH neurofilament, heavy polypeptide 1.21043
ALDOA aldolase A, fructose-bisphosphate 1.20526
TAGLN transgelin 1.18882
CTSL cathepsin L 1.18521
GPX1 glutathione peroxidase 1 1.17497
LGALS3 lectin, galactoside-binding, soluble, 3 1.17168
TANK TRAF family member-associated NFKB activator 1.166
NQO1 NAD(P)H dehydrogenase, quinone 1 1.16236
S100A8 S100 calcium binding protein A8 1.16137
TIMP1 TIMP metallopeptidase inhibitor 1 1.15729
EPHX2 epoxide hydrolase 2, cytoplasmic 1.15729
ARNT aryl hydrocarbon receptor nuclear translocator 1.15593
TCF3 transcription factor 3 1.15593
BLNK B-cell linker 1.1556
MEOX2 mesenchyme homeobox 2 1.15189
HDAC3 histone deacetylase 3 1.14919
DDR1 discoidin domain receptor tyrosine kinase 1 1.1485
GADD45A growth arrest and DNA-damage-inducible, alpha 1.14644
SDS serine dehydratase 1.14541
EIF3A eukaryotic translation initiation factor 3, subunit A 1.14541
IRS1 insulin receptor substrate 1 1.14507
CYR61 cysteine-rich, angiogenic inducer, 61 1.14507
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.14438
KRT8 keratin 8, type II 1.1437
ZEB2 zinc finger E-box binding homeobox 2 1.142
OTC ornithine carbamoyltransferase 1.13621
VEGFA vascular endothelial growth factor A 1.13484
COL1A1 collagen, type I, alpha 1 1.13381
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.13347
STAT5B signal transducer and activator of transcription 5B 1.13279
RB1 retinoblastoma 1 1.12906
NUPR1 nuclear protein, transcriptional regulator, 1 1.12838
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 1.12703
CTSB cathepsin B 1.12117
PDLIM7 PDZ and LIM domain 7 (enigma) 1.12082
GSTM3 glutathione S-transferase mu 3 (brain) 1.1198
ATF4 activating transcription factor 4 1.11877
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.11536
CAV1 caveolin 1, caveolae protein, 22kDa 1.11536
CHKA choline kinase alpha 1.11501
FAS Fas cell surface death receptor 1.11151
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 1.10942
TBXAS1 thromboxane A synthase 1 (platelet) 1.10699
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.10562
C10ORF10 chromosome 10 open reading frame 10 1.10459
NINJ1 ninjurin 1 1.10459
CP ceruloplasmin (ferroxidase) 1.10175
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 1.09611
DDIT3 DNA-damage-inducible transcript 3 1.0919
FOS FBJ murine osteosarcoma viral oncogene homolog 1.08904
PTMA prothymosin, alpha 1.08904
KRT17 keratin 17, type I 1.08868
RELN reelin 1.08619
NR2F2 nuclear receptor subfamily 2, group F, member 2 1.08619
MXD1 MAX dimerization protein 1 1.08619
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.08196
LYN LYN proto-oncogene, Src family tyrosine kinase 1.08126
PRKCA protein kinase C, alpha 1.08055
EGLN3 egl-9 family hypoxia-inducible factor 3 1.07447
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.0734
EVI2B ecotropic viral integration site 2B 1.07128
VCL vinculin 1.06987
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 1.06987
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.06808
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.06552
GDF15 growth differentiation factor 15 1.06552
IRF7 interferon regulatory factor 7 1.06552
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.06406
FOLR1 folate receptor 1 (adult) 1.0637
E2F8 E2F transcription factor 8 1.06333
NREP neuronal regeneration related protein 1.06333
DCBLD1 discoidin, CUB and LCCL domain containing 1 1.06225
CDX4 caudal type homeobox 4 1.06188
EIF5 eukaryotic translation initiation factor 5 1.059
XDH xanthine dehydrogenase 1.059
CLU clusterin 1.059
TCF4 transcription factor 4 1.05461
HOXB4 homeobox B4 1.05461
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.05349
SREBF1 sterol regulatory element binding transcription factor 1 1.05349
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.05052
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.04794
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.04239
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 1.04201
TP53 tumor protein p53 1.04126
CDK4 cyclin-dependent kinase 4 1.04088
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.04088
CBS cystathionine-beta-synthase 1.04051
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.04014
LPL lipoprotein lipase 1.03901
HSPA1A heat shock 70kDa protein 1A 1.03901
CDC25A cell division cycle 25A 1.03901
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.03901
GSTP1 glutathione S-transferase pi 1 1.03827
FOSL2 FOS-like antigen 2 1.03827
GAS6 growth arrest-specific 6 1.03827
EZR ezrin 1.03641
MFSD10 major facilitator superfamily domain containing 10 1.0353
RNF152 ring finger protein 152 1.03382
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.03382
HAND2 heart and neural crest derivatives expressed 2 1.03345
ICAM1 intercellular adhesion molecule 1 1.03197
CCNE1 cyclin E1 1.03122
JAG1 jagged 1 1.03084
HADH hydroxyacyl-CoA dehydrogenase 1.03084
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.02971
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.02933
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.02746
JAK1 Janus kinase 1 1.02522
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.02522
GSTA2 glutathione S-transferase alpha 2 1.02299
IFT57 intraflagellar transport 57 1.02151
SIN3A SIN3 transcription regulator family member A 1.02151
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 1.02114
VLDLR very low density lipoprotein receptor 1.01852
TSPO translocator protein (18kDa) 1.01701
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.01625
UNG uracil-DNA glycosylase 1.01625
CDK2 cyclin-dependent kinase 2 1.01625
ANKRD44 ankyrin repeat domain 44 1.01587
RAB2A RAB2A, member RAS oncogene family 1.01549
GCK glucokinase (hexokinase 4) 1.01512
PKDCC protein kinase domain containing, cytoplasmic 1.01512
KLF9 Kruppel-like factor 9 1.01437
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.01286
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.01174
STK24 serine/threonine kinase 24 1.01025
FGB fibrinogen beta chain 1.01025