Treprostinil Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/6918140
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Genes

199 proteins with high or low expression in Treprostinil relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.55
CNTLN centlein, centrosomal protein 0.52
MYH13 myosin, heavy chain 13, skeletal muscle 0.49
TFR2 transferrin receptor 2 0.42
FKBPL FK506 binding protein like 0.4
CCDC57 coiled-coil domain containing 57 0.4
ABHD3 abhydrolase domain containing 3 0.36
CCDC170 coiled-coil domain containing 170 0.36
MPHOSPH9 M-phase phosphoprotein 9 0.36
ATXN1L ataxin 1-like 0.35
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.33
VASN vasorin 0.33
FRMPD3 FERM and PDZ domain containing 3 0.33
ATP9A ATPase, class II, type 9A 0.33
MED28 mediator complex subunit 28 0.32
DEF8 differentially expressed in FDCP 8 homolog (mouse) 0.31
CEP295 centrosomal protein 295kDa 0.3
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.3
TMEM199 transmembrane protein 199 0.3
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase 0.3
SLC10A4 solute carrier family 10, member 4 0.29
CCDC115 coiled-coil domain containing 115 0.29
GRTP1 growth hormone regulated TBC protein 1 0.29
MEGF6 multiple EGF-like-domains 6 0.28
MAP3K21 mitogen-activated protein kinase kinase kinase 21 0.28
CARD8 caspase recruitment domain family, member 8 0.27
ANKRD39 ankyrin repeat domain 39 0.27
STK19 serine/threonine kinase 19 0.27
TMEM104 transmembrane protein 104 0.27
EVA1C eva-1 homolog C (C. elegans) 0.27
NOTCH3 notch 3 0.27
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.27
ANKEF1 ankyrin repeat and EF-hand domain containing 1 0.27
TOB1 transducer of ERBB2, 1 0.27
NRP1 neuropilin 1 0.27
TWSG1 twisted gastrulation BMP signaling modulator 1 0.27
BOD1 biorientation of chromosomes in cell division 1 0.26
GEMIN2 gem (nuclear organelle) associated protein 2 0.26
KIAA1107 KIAA1107 0.26
TMEM39B transmembrane protein 39B 0.25
HOXB4 homeobox B4 0.25
TNNI3 troponin I type 3 (cardiac) 0.25
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 0.25
FAM199X family with sequence similarity 199, X-linked 0.25
C17ORF53 chromosome 17 open reading frame 53 0.24
SARAF store-operated calcium entry-associated regulatory factor 0.24
CLASP2 cytoplasmic linker associated protein 2 0.24
TTC30A tetratricopeptide repeat domain 30A 0.24
BCAS2 breast carcinoma amplified sequence 2 0.24
SPIN4 spindlin family, member 4 0.24
MSMO1 methylsterol monooxygenase 1 0.23
SMIM26 small integral membrane protein 26 0.23
ARSB arylsulfatase B 0.23
PLXNB1 plexin B1 0.23
RUSC2 RUN and SH3 domain containing 2 0.23
ADGRV1 adhesion G protein-coupled receptor V1 0.23
PHF1 PHD finger protein 1 0.23
PRKD3 protein kinase D3 0.22
ESYT2 extended synaptotagmin-like protein 2 0.22
RFLNB refilin B 0.22
ALS2CL ALS2 C-terminal like 0.22
TUBAL3 tubulin, alpha-like 3 0.22
BMP4 bone morphogenetic protein 4 0.22
RAB30 RAB30, member RAS oncogene family 0.22
CDC37 cell division cycle 37 0.22
PABPC1 poly(A) binding protein, cytoplasmic 1 0.21
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.21
GRHL1 grainyhead-like 1 (Drosophila) 0.21
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.21
DNASE1L1 deoxyribonuclease I-like 1 0.21
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.21
SETDB2 SET domain, bifurcated 2 0.21
ZFHX3 zinc finger homeobox 3 0.21
IL27RA interleukin 27 receptor, alpha 0.21
GSTA1 glutathione S-transferase alpha 1 0.21
KLF5 Kruppel-like factor 5 (intestinal) 0.21
COPZ1 coatomer protein complex, subunit zeta 1 0.21
ZC3H14 zinc finger CCCH-type containing 14 0.21
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.21
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.2
GTF2A2 general transcription factor IIA, 2, 12kDa 0.2
MICB MHC class I polypeptide-related sequence B 0.2
ZNF395 zinc finger protein 395 0.2
CFAP410 cilia and flagella associated protein 410 0.2
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.2
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 0.2
BCDIN3D BCDIN3 domain containing 0.2
REEP1 receptor accessory protein 1 0.2
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.2
ZNF276 zinc finger protein 276 0.2
CC2D2A coiled-coil and C2 domain containing 2A 0.2
USP53 ubiquitin specific peptidase 53 0.2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 0.2
ETNK2 ethanolamine kinase 2 0.2
AURKAIP1 aurora kinase A interacting protein 1 0.2
TXNL4B thioredoxin-like 4B 0.2
SOCS7 suppressor of cytokine signaling 7 0.2
AKNA AT-hook transcription factor 0.19
C2ORF76 chromosome 2 open reading frame 76 0.19

low expression

Symbol Name Standardized Value
PIP prolactin-induced protein -1.26
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -0.65
MIB2 mindbomb E3 ubiquitin protein ligase 2 -0.54
FOXO1 forkhead box O1 -0.52
SMTN smoothelin -0.5
GAB1 GRB2-associated binding protein 1 -0.48
AUNIP aurora kinase A and ninein interacting protein -0.48
ENO1 enolase 1, (alpha) -0.43
EFNB2 ephrin-B2 -0.42
MKRN1 makorin ring finger protein 1 -0.42
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -0.42
TRAF3IP2 TRAF3 interacting protein 2 -0.41
KMT2B lysine (K)-specific methyltransferase 2B -0.41
DPY19L2 dpy-19-like 2 (C. elegans) -0.4
NALCN sodium leak channel, non selective -0.38
MISP3 MISP family member 3 -0.38
GPANK1 G patch domain and ankyrin repeats 1 -0.38
XTBD1 XRN2 binding domain containing 1 -0.37
ALG3 ALG3, alpha-1,3- mannosyltransferase -0.37
ITGB1BP1 integrin beta 1 binding protein 1 -0.37
PRDM4 PR domain containing 4 -0.37
DIPK1A divergent protein kinase domain 1A -0.36
RNASE4 ribonuclease, RNase A family, 4 -0.35
EHF ets homologous factor -0.34
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -0.33
DSCAM Down syndrome cell adhesion molecule -0.33
TEN1 TEN1 CST complex subunit -0.32
ODF2L outer dense fiber of sperm tails 2-like -0.32
ZNF672 zinc finger protein 672 -0.31
HNF4A hepatocyte nuclear factor 4, alpha -0.31
SNX10 sorting nexin 10 -0.31
PTPRB protein tyrosine phosphatase, receptor type, B -0.3
TPGS2 tubulin polyglutamylase complex subunit 2 -0.3
IL6ST interleukin 6 signal transducer -0.29
TRIML2 tripartite motif family-like 2 -0.29
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.29
FAM133A family with sequence similarity 133, member A -0.29
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -0.28
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 -0.28
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 -0.28
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -0.28
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 -0.27
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.27
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 -0.27
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 -0.27
CLCN7 chloride channel, voltage-sensitive 7 -0.27
DNAL4 dynein, axonemal, light chain 4 -0.26
YBX3 Y box binding protein 3 -0.26
ZNF490 zinc finger protein 490 -0.26
BEND7 BEN domain containing 7 -0.26
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.26
FOXC1 forkhead box C1 -0.26
CILP2 cartilage intermediate layer protein 2 -0.26
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.26
ZNF483 zinc finger protein 483 -0.26
CCND3 cyclin D3 -0.25
TRAM2 translocation associated membrane protein 2 -0.25
INHBA inhibin, beta A -0.25
HIPK1 homeodomain interacting protein kinase 1 -0.25
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -0.25
CMC1 C-x(9)-C motif containing 1 -0.25
CAB39L calcium binding protein 39-like -0.25
MID1IP1 MID1 interacting protein 1 -0.25
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -0.24
HAL histidine ammonia-lyase -0.24
HSH2D hematopoietic SH2 domain containing -0.24
PML promyelocytic leukemia -0.24
PFN2 profilin 2 -0.24
ZNF823 zinc finger protein 823 -0.24
ZNF652 zinc finger protein 652 -0.24
MID2 midline 2 -0.24
AMPD1 adenosine monophosphate deaminase 1 -0.24
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta -0.24
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.23
MYZAP myocardial zonula adherens protein -0.23
ZNF362 zinc finger protein 362 -0.23
ZNF264 zinc finger protein 264 -0.23
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -0.23
TSPAN4 tetraspanin 4 -0.23
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.23
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -0.23
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -0.22
HM13 histocompatibility (minor) 13 -0.22
SARDH sarcosine dehydrogenase -0.22
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.22
ADCY6 adenylate cyclase 6 -0.22
LEPROTL1 leptin receptor overlapping transcript-like 1 -0.22
ZNF711 zinc finger protein 711 -0.22
SDCBP syndecan binding protein (syntenin) -0.21
KLC1 kinesin light chain 1 -0.21
DCAF16 DDB1 and CUL4 associated factor 16 -0.21
WDR19 WD repeat domain 19 -0.21
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -0.21
DCAF4 DDB1 and CUL4 associated factor 4 -0.21
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.21
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.21
CRELD1 cysteine-rich with EGF-like domains 1 -0.2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -0.2
C1ORF43 chromosome 1 open reading frame 43 -0.2