Triamcinolone_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.199502
PLAT plasminogen activator, tissue 0.0941066
PODXL podocalyxin-like 0.0934286
MYH9 myosin, heavy chain 9, non-muscle 0.0857471
TRIO trio Rho guanine nucleotide exchange factor 0.0835095
FLNA filamin A, alpha 0.0720284
PLEC plectin 0.0630261
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0563869
CALR calreticulin 0.0543427
SEPTIN9 septin 9 0.0514079
EEF2 eukaryotic translation elongation factor 2 0.0509064
COL5A1 collagen, type V, alpha 1 0.0457386
APP amyloid beta (A4) precursor protein 0.0455926
FLNB filamin B, beta 0.0454272
AHNAK2 AHNAK nucleoprotein 2 0.0453419
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0449692
TPM3 tropomyosin 3 0.0416826
ZMYND8 zinc finger, MYND-type containing 8 0.0411419
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0409291
CANX calnexin 0.0403974
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0392053
HIPK2 homeodomain interacting protein kinase 2 0.0386296
BHLHE40 basic helix-loop-helix family, member e40 0.0361481
HDAC9 histone deacetylase 9 0.0359904
ANXA2 annexin A2 0.0342651
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0331333
DST dystonin 0.0330252
ERRFI1 ERBB receptor feedback inhibitor 1 0.0330003
VEGFA vascular endothelial growth factor A 0.0328132
NAV2 neuron navigator 2 0.0326038
FUS FUS RNA binding protein 0.0325521
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0315701
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0307173
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0306818
ANKRD11 ankyrin repeat domain 11 0.0303118
TNIP1 TNFAIP3 interacting protein 1 0.0302207
FSTL1 follistatin-like 1 0.0297495
TRAM2 translocation associated membrane protein 2 0.0292134
FNDC3B fibronectin type III domain containing 3B 0.0292063
NFE2L1 nuclear factor, erythroid 2-like 1 0.028513
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0276582
KLF6 Kruppel-like factor 6 0.0273637
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0271937
MSN moesin 0.0267762
MPRIP myosin phosphatase Rho interacting protein 0.0266315
NDRG1 N-myc downstream regulated 1 0.0266134
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0261454
PDIA3 protein disulfide isomerase family A, member 3 0.0259769
BCL2L1 BCL2-like 1 0.0255999
LOXL2 lysyl oxidase-like 2 0.0251013
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0249572
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.024066
CSNK1A1 casein kinase 1, alpha 1 0.0236735
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0234559
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0234213
NCOR2 nuclear receptor corepressor 2 0.0232409
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0230936
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0228694
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.022627
CEP250 centrosomal protein 250kDa 0.0218954
SLFN5 schlafen family member 5 0.0218449
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0218255
MINK1 misshapen-like kinase 1 0.0214845
LOC112694756 uncharaterized LOC112694756 0.0213082
AHNAK AHNAK nucleoprotein 0.0203783
NUMA1 nuclear mitotic apparatus protein 1 0.0201482
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0200904
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.019858
SFTPA2 surfactant protein A2 0.0198313
OGA O-GlcNAcase 0.0198013
SET SET nuclear proto-oncogene 0.0197606
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0196209
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0195113
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0192784
SRRM2 serine/arginine repetitive matrix 2 0.0192624
SQSTM1 sequestosome 1 0.0192489
MACF1 microtubule-actin crosslinking factor 1 0.0190732
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.018707
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0184936
BACE2 beta-site APP-cleaving enzyme 2 0.0184396
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0182311
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0179626
TLE4 transducin-like enhancer of split 4 0.0178346
TPM4 tropomyosin 4 0.0178258
COPA coatomer protein complex, subunit alpha 0.017825
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0177921
IQGAP1 IQ motif containing GTPase activating protein 1 0.0177869
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.017721
DBN1 drebrin 1 0.0177141
TMSB4X thymosin beta 4, X-linked 0.0171504
DSPP dentin sialophosphoprotein 0.0170443
LENG8 leukocyte receptor cluster (LRC) member 8 0.0170296
ZMAT3 zinc finger, matrin-type 3 0.0169313
HIP1 huntingtin interacting protein 1 0.016757
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0165817
FAM13A family with sequence similarity 13, member A 0.0164826
RUNX1 runt-related transcription factor 1 0.0163379
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.016264
DPYSL2 dihydropyrimidinase-like 2 0.0162639
MKI67 marker of proliferation Ki-67 0.0162536

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.122183
VIM vimentin -0.109914
TMSB10 thymosin beta 10 -0.105238
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0878985
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0730215
ABI3BP ABI family, member 3 (NESH) binding protein -0.0725127
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0607448
DLG1 discs, large homolog 1 (Drosophila) -0.0466967
PBX3 pre-B-cell leukemia homeobox 3 -0.0460397
COL8A1 collagen, type VIII, alpha 1 -0.0440247
SLC39A11 solute carrier family 39, member 11 -0.0391608
CCND1 cyclin D1 -0.0382989
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0369098
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0352079
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0348866
SUCNR1 succinate receptor 1 -0.0344798
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0339179
SAMD9 sterile alpha motif domain containing 9 -0.0337057
AUTS2 autism susceptibility candidate 2 -0.0333171
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.033272
MT2A metallothionein 2A -0.0307067
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0301534
LOX lysyl oxidase -0.0289417
RIGI RNA sensor RIG-I -0.0282009
POTEF POTE ankyrin domain family, member F -0.0278182
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0254729
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0250729
MYADM myeloid-associated differentiation marker -0.0248299
FN1 fibronectin 1 -0.0239045
CSTB cystatin B (stefin B) -0.0233405
MEIS2 Meis homeobox 2 -0.0228486
IFITM1 interferon induced transmembrane protein 1 -0.0221001
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0212214
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.021021
MRPS6 mitochondrial ribosomal protein S6 -0.0206339
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0200174
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0196101
IFITM3 interferon induced transmembrane protein 3 -0.0193521
FLT1 fms-related tyrosine kinase 1 -0.0193371
COL1A2 collagen, type I, alpha 2 -0.0188135
TPM1 tropomyosin 1 (alpha) -0.0183765
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0176094
MSI2 musashi RNA-binding protein 2 -0.0175968
PRSS23 protease, serine, 23 -0.0173954
TOX thymocyte selection-associated high mobility group box -0.0169425
SORBS2 sorbin and SH3 domain containing 2 -0.0169407
CDH13 cadherin 13 -0.0168077
S100A6 S100 calcium binding protein A6 -0.016717
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0166536
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0165147
IL7R interleukin 7 receptor -0.0164179
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0163472
EGFR epidermal growth factor receptor -0.0161713
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0159842
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0156927
BSG basigin (Ok blood group) -0.0155394
FBXL7 F-box and leucine-rich repeat protein 7 -0.0154731
ISG15 ISG15 ubiquitin-like modifier -0.0153796
MAP1B microtubule-associated protein 1B -0.0149218
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0145485
JAZF1 JAZF zinc finger 1 -0.0145198
PDE10A phosphodiesterase 10A -0.0141875
FNDC3A fibronectin type III domain containing 3A -0.0139865
ZEB1 zinc finger E-box binding homeobox 1 -0.0138951
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0138606
RBM25 RNA binding motif protein 25 -0.0138543
WARS1 tryptophanyl-tRNA synthetase 1 -0.0137728
MX2 MX dynamin-like GTPase 2 -0.0137049
IFI44 interferon-induced protein 44 -0.0136842
OASL 2'-5'-oligoadenylate synthetase-like -0.0135403
IFIH1 interferon induced with helicase C domain 1 -0.0135349
TNS3 tensin 3 -0.0130893
RPL35A ribosomal protein L35a -0.0128938
TM4SF1 transmembrane 4 L six family member 1 -0.0124547
FGF13 fibroblast growth factor 13 -0.0124371
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0120713
FTL ferritin, light polypeptide -0.0119021
S100A11 S100 calcium binding protein A11 -0.0115677
ALCAM activated leukocyte cell adhesion molecule -0.0114871
SP3 Sp3 transcription factor -0.0114062
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0113683
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.011292
ULK1 unc-51 like autophagy activating kinase 1 -0.0112747
FRMD4A FERM domain containing 4A -0.011259
FBN1 fibrillin 1 -0.0111575
ENO2 enolase 2 (gamma, neuronal) -0.0110916
CYTH3 cytohesin 3 -0.0110181
TAGLN2 transgelin 2 -0.0109689
GLIS3 GLIS family zinc finger 3 -0.0109622
MED13L mediator complex subunit 13-like -0.0108884
PLCB4 phospholipase C, beta 4 -0.0107119
INSIG1 insulin induced gene 1 -0.0106591
RPLP2 ribosomal protein, large, P2 -0.0106512
SLC38A1 solute carrier family 38, member 1 -0.0102068
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0100677
SAMD9L sterile alpha motif domain containing 9-like -0.00995315
PLAUR plasminogen activator, urokinase receptor -0.00989035
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.00985069
MT1X metallothionein 1X -0.00972033
TAPBP TAP binding protein (tapasin) -0.00952736