Triamcinolone_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.296162
ANTXR1 anthrax toxin receptor 1 0.0569045
EEF2 eukaryotic translation elongation factor 2 0.0550712
VEGFA vascular endothelial growth factor A 0.0490076
PLAT plasminogen activator, tissue 0.0483268
CEMIP cell migration inducing protein, hyaluronan binding 0.0391219
ACTN1 actinin, alpha 1 0.0350644
HSPA8 heat shock 70kDa protein 8 0.0349991
MACF1 microtubule-actin crosslinking factor 1 0.0346199
PTPRE protein tyrosine phosphatase, receptor type, E 0.0343831
CTSB cathepsin B 0.0338707
PCBP3 poly(rC) binding protein 3 0.0320131
COL18A1 collagen, type XVIII, alpha 1 0.0300672
MYH9 myosin, heavy chain 9, non-muscle 0.0293538
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0272046
RABGAP1L RAB GTPase activating protein 1-like 0.0268162
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0265325
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0265086
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0261053
RET ret proto-oncogene 0.0260078
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0253922
SYTL3 synaptotagmin-like 3 0.0252797
PRRC2B proline-rich coiled-coil 2B 0.0248845
AKAP9 A kinase (PRKA) anchor protein 9 0.024868
FLNB filamin B, beta 0.0246756
RGS4 regulator of G-protein signaling 4 0.0245767
PUM3 pumilio RNA binding family member 3 0.0239329
ARHGAP9 Rho GTPase activating protein 9 0.0238811
CEP250 centrosomal protein 250kDa 0.0235803
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0233424
NONO non-POU domain containing, octamer-binding 0.023169
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0224742
BPTF bromodomain PHD finger transcription factor 0.0224434
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0221873
SEPTIN9 septin 9 0.0220605
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0218017
RPL36 ribosomal protein L36 0.021796
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0217282
UNC5B unc-5 homolog B (C. elegans) 0.0216794
SMAD3 SMAD family member 3 0.0214206
HMGA2 high mobility group AT-hook 2 0.0214058
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0211373
NCOR2 nuclear receptor corepressor 2 0.0209447
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0208344
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0205361
DNMBP dynamin binding protein 0.0204767
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0204747
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0196012
CUL3 cullin 3 0.019584
SAMD4B sterile alpha motif domain containing 4B 0.0195276
KMT2D lysine (K)-specific methyltransferase 2D 0.0192052
PLEC plectin 0.0190455
GIGYF2 GRB10 interacting GYF protein 2 0.0190268
MEF2A myocyte enhancer factor 2A 0.0190045
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0190033
CSNK1A1 casein kinase 1, alpha 1 0.018841
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0187595
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0187535
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0186211
EGFR epidermal growth factor receptor 0.0185648
AKAP12 A kinase (PRKA) anchor protein 12 0.0185197
MYO6 myosin VI 0.0183251
SVIL supervillin 0.0182283
TJP1 tight junction protein 1 0.0181436
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.0181312
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0180938
COL4A2 collagen, type IV, alpha 2 0.018053
SPOP speckle-type POZ protein 0.018049
RPL3 ribosomal protein L3 0.0179685
GOLGB1 golgin B1 0.017945
SMYD3 SET and MYND domain containing 3 0.0178775
MSI2 musashi RNA-binding protein 2 0.0178417
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.017789
EPAS1 endothelial PAS domain protein 1 0.0176533
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0176369
RAB7A RAB7A, member RAS oncogene family 0.0176222
NEO1 neogenin 1 0.017539
NFE2L1 nuclear factor, erythroid 2-like 1 0.0175081
AAK1 AP2 associated kinase 1 0.0173367
MCL1 myeloid cell leukemia 1 0.017173
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0170901
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0169103
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0168054
CAB39 calcium binding protein 39 0.016763
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0166657
EP300 E1A binding protein p300 0.0165911
MT2A metallothionein 2A 0.0165836
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0164871
BRWD3 bromodomain and WD repeat domain containing 3 0.016415
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0163656
RPL30 ribosomal protein L30 0.0161838
PEAK1 pseudopodium-enriched atypical kinase 1 0.0161456
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0161062
FHIT fragile histidine triad 0.0160918
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0160221
ZNF609 zinc finger protein 609 0.0159831
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0159356
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0159007
SRSF6 serine/arginine-rich splicing factor 6 0.0156275
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0155721

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.210398
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107367
VIM vimentin -0.0903457
LSAMP limbic system-associated membrane protein -0.0846395
MEIS2 Meis homeobox 2 -0.0833302
TOP2A topoisomerase (DNA) II alpha 170kDa -0.068214
VCL vinculin -0.0672659
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0651528
FMN1 formin 1 -0.0616182
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0605878
COL3A1 collagen, type III, alpha 1 -0.0574369
MBD5 methyl-CpG binding domain protein 5 -0.0552769
EXT1 exostosin glycosyltransferase 1 -0.0524377
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0516061
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0514248
PTMA prothymosin, alpha -0.0502807
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0501579
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.045491
NREP neuronal regeneration related protein -0.0425028
SYT1 synaptotagmin I -0.0421972
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.039512
HELZ helicase with zinc finger -0.0389937
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0388925
TRIB2 tribbles pseudokinase 2 -0.0382344
MAPK10 mitogen-activated protein kinase 10 -0.0382015
RPS6 ribosomal protein S6 -0.0378635
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0368352
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0365422
MAP1B microtubule-associated protein 1B -0.0365185
ZNF292 zinc finger protein 292 -0.036374
VMP1 vacuole membrane protein 1 -0.0348588
NCAM2 neural cell adhesion molecule 2 -0.0346045
NPEPPS aminopeptidase puromycin sensitive -0.0345216
TPT1 tumor protein, translationally-controlled 1 -0.0343318
CENPF centromere protein F, 350/400kDa -0.0333468
DTNA dystrobrevin, alpha -0.0331538
TENT5A terminal nucleotidyltransferase 5A -0.0329113
RPS24 ribosomal protein S24 -0.0326053
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0325696
SOS1 son of sevenless homolog 1 (Drosophila) -0.0319664
DLC1 DLC1 Rho GTPase activating protein -0.0304866
GOLGA4 golgin A4 -0.0297426
PKM pyruvate kinase, muscle -0.0289222
GREM2 gremlin 2, DAN family BMP antagonist -0.0288684
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0285808
PCDH15 protocadherin-related 15 -0.0283399
CDH10 cadherin 10, type 2 (T2-cadherin) -0.028292
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0282008
TPM4 tropomyosin 4 -0.0278109
MARCHF6 membrane associated ring-CH-type finger 6 -0.0275797
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.027329
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0272628
HILPDA hypoxia inducible lipid droplet-associated -0.0268577
OGA O-GlcNAcase -0.0267617
RPLP1 ribosomal protein, large, P1 -0.0264247
SCLT1 sodium channel and clathrin linker 1 -0.0264076
FNBP1 formin binding protein 1 -0.0262879
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0262155
CCDC47 coiled-coil domain containing 47 -0.0262127
LRP1B low density lipoprotein receptor-related protein 1B -0.0260731
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0259058
NAMPT nicotinamide phosphoribosyltransferase -0.025606
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0247732
LCORL ligand dependent nuclear receptor corepressor-like -0.0246942
RPL34 ribosomal protein L34 -0.0244437
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0243353
FRMD4A FERM domain containing 4A -0.0241542
RNF150 ring finger protein 150 -0.0241301
PRR11 proline rich 11 -0.0238789
COL1A1 collagen, type I, alpha 1 -0.0237551
IGF1R insulin-like growth factor 1 receptor -0.0235902
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -0.0232287
NDRG1 N-myc downstream regulated 1 -0.0230457
AOPEP aminopeptidase O (putative) -0.0229875
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.02272
GPBP1 GC-rich promoter binding protein 1 -0.0225262
SLITRK6 SLIT and NTRK-like family, member 6 -0.022465
GNAS GNAS complex locus -0.021952
RNF24 ring finger protein 24 -0.0219049
HMGB2 high mobility group box 2 -0.0218755
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0217094
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0213687
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0211781
DACH2 dachshund family transcription factor 2 -0.0210012
S100A6 S100 calcium binding protein A6 -0.0209946
RPS19 ribosomal protein S19 -0.0206994
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0206853
RPL32 ribosomal protein L32 -0.0204541
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0204118
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0204116
ADGRB3 adhesion G protein-coupled receptor B3 -0.0203665
TLK2 tousled-like kinase 2 -0.0202996
GLG1 golgi glycoprotein 1 -0.0202963
ENAH enabled homolog (Drosophila) -0.0202425
MBNL1 muscleblind-like splicing regulator 1 -0.0201653
LDHA lactate dehydrogenase A -0.0198976
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0197929
CADM1 cell adhesion molecule 1 -0.0197435
SEPTIN2 septin 2 -0.019692
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0195417