Triamcinolone_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.113318
KRT6A keratin 6A, type II 0.0894985
FKBP5 FK506 binding protein 5 0.0725682
ZMYND8 zinc finger, MYND-type containing 8 0.0688235
FTH1 ferritin, heavy polypeptide 1 0.067411
AKAP13 A kinase (PRKA) anchor protein 13 0.0566684
MYOF myoferlin 0.0495784
MACF1 microtubule-actin crosslinking factor 1 0.0493997
CUL4B cullin 4B 0.0480359
ESYT2 extended synaptotagmin-like protein 2 0.0430474
INTS6 integrator complex subunit 6 0.0430133
SRRM2 serine/arginine repetitive matrix 2 0.0406026
ABLIM3 actin binding LIM protein family, member 3 0.0376705
TGM2 transglutaminase 2 0.0375222
HMGA2 high mobility group AT-hook 2 0.0352461
YAP1 Yes-associated protein 1 0.0346617
LMO7 LIM domain 7 0.0345542
EPS8 epidermal growth factor receptor pathway substrate 8 0.0343098
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0341151
APLP2 amyloid beta (A4) precursor-like protein 2 0.0333391
EFNB2 ephrin-B2 0.0329263
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0327952
SOD2 superoxide dismutase 2, mitochondrial 0.0324676
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0321992
VEGFA vascular endothelial growth factor A 0.0321812
EFNA5 ephrin-A5 0.0315711
CEP250 centrosomal protein 250kDa 0.0313442
NCOA3 nuclear receptor coactivator 3 0.0306921
MSN moesin 0.030628
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0304926
STC1 stanniocalcin 1 0.0298283
HLA-E major histocompatibility complex, class I, E 0.0297446
MYH9 myosin, heavy chain 9, non-muscle 0.0290177
SQSTM1 sequestosome 1 0.0273393
CTTN cortactin 0.0266467
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0262949
HIPK3 homeodomain interacting protein kinase 3 0.0262799
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0259943
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.025917
PODXL podocalyxin-like 0.0257933
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.025306
KRT14 keratin 14, type I 0.0252833
MED13L mediator complex subunit 13-like 0.0246998
PCDH1 protocadherin 1 0.0246334
HSPA8 heat shock 70kDa protein 8 0.0242112
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0241239
MT1E metallothionein 1E 0.0241064
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0240701
CSNK1A1 casein kinase 1, alpha 1 0.0239941
IGF2 insulin-like growth factor 2 0.0239298
EHBP1L1 EH domain binding protein 1-like 1 0.0234317
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.02336
TNS4 tensin 4 0.0228083
TPM3 tropomyosin 3 0.0226898
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0226059
PDIA3 protein disulfide isomerase family A, member 3 0.0225981
HIPK2 homeodomain interacting protein kinase 2 0.0223067
EFHD2 EF-hand domain family, member D2 0.0222983
PTK2 protein tyrosine kinase 2 0.0216966
MN1 meningioma (disrupted in balanced translocation) 1 0.0215827
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0215087
SULF2 sulfatase 2 0.0208074
MED15 mediator complex subunit 15 0.0204792
UBC ubiquitin C 0.0202949
SEPTIN9 septin 9 0.0201047
CLMB calcimembrin 0.0201028
SET SET nuclear proto-oncogene 0.0200701
NONO non-POU domain containing, octamer-binding 0.0199498
TOP1 topoisomerase (DNA) I 0.0199082
DOCK5 dedicator of cytokinesis 5 0.0198853
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0198139
ENO2 enolase 2 (gamma, neuronal) 0.0195795
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0192703
GLUL glutamate-ammonia ligase 0.0191041
UBAP2L ubiquitin associated protein 2-like 0.0189979
LCOR ligand dependent nuclear receptor corepressor 0.0188959
BCAR1 breast cancer anti-estrogen resistance 1 0.0188923
KDM4C lysine (K)-specific demethylase 4C 0.0187753
NUMA1 nuclear mitotic apparatus protein 1 0.0185902
FMNL2 formin-like 2 0.0185736
EEF2 eukaryotic translation elongation factor 2 0.0185601
ITSN2 intersectin 2 0.0185308
USP47 ubiquitin specific peptidase 47 0.0185251
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.018479
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0183185
RPL3 ribosomal protein L3 0.0182116
SETD5 SET domain containing 5 0.0181985
JPH2 junctophilin 2 0.018062
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0179551
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0177901
CYB5R3 cytochrome b5 reductase 3 0.0177837
HM13 histocompatibility (minor) 13 0.0176184
CFLAR CASP8 and FADD-like apoptosis regulator 0.0175017
AHNAK2 AHNAK nucleoprotein 2 0.0174765
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0173197
NECTIN4 nectin cell adhesion molecule 4 0.0172984
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0172481
ITGB8 integrin, beta 8 0.0170144
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0169364
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0169263

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.189587
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.149683
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.147515
TMSB10 thymosin beta 10 -0.127612
TXNIP thioredoxin interacting protein -0.105306
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0958518
RPS21 ribosomal protein S21 -0.0821603
SULF1 sulfatase 1 -0.0799686
FLNB filamin B, beta -0.0703008
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0702418
MT1X metallothionein 1X -0.0646957
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0576415
ASPH aspartate beta-hydroxylase -0.0554807
RPLP2 ribosomal protein, large, P2 -0.0511764
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0506083
DPYD dihydropyrimidine dehydrogenase -0.0469269
RPLP1 ribosomal protein, large, P1 -0.0439012
ANXA2 annexin A2 -0.0425083
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0422137
RPS19 ribosomal protein S19 -0.0417281
CD44 CD44 molecule (Indian blood group) -0.0413354
ARHGAP29 Rho GTPase activating protein 29 -0.0408366
RPL12 ribosomal protein L12 -0.0407022
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398151
TMSB4X thymosin beta 4, X-linked -0.0396021
NRG1 neuregulin 1 -0.0390713
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.038984
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0386034
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0374846
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0373425
IFI16 interferon, gamma-inducible protein 16 -0.035923
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0353417
VCL vinculin -0.0351486
PALLD palladin, cytoskeletal associated protein -0.0349646
NAMPT nicotinamide phosphoribosyltransferase -0.0342628
MAML2 mastermind-like 2 (Drosophila) -0.0342228
KMT2E lysine (K)-specific methyltransferase 2E -0.0341611
S100A10 S100 calcium binding protein A10 -0.0338238
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0336601
POTEF POTE ankyrin domain family, member F -0.0334551
RPL8 ribosomal protein L8 -0.0327062
S100A4 S100 calcium binding protein A4 -0.0322803
OSMR oncostatin M receptor -0.0313844
RAP1B RAP1B, member of RAS oncogene family -0.0312187
NT5C2 5'-nucleotidase, cytosolic II -0.0309819
RPL11 ribosomal protein L11 -0.0307352
PLAT plasminogen activator, tissue -0.030724
NAP1L1 nucleosome assembly protein 1-like 1 -0.0303601
PSD3 pleckstrin and Sec7 domain containing 3 -0.0300241
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0299246
LMNA lamin A/C -0.0297167
IFITM3 interferon induced transmembrane protein 3 -0.0292875
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0291492
NEK7 NIMA-related kinase 7 -0.0290802
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0290294
SLC38A2 solute carrier family 38, member 2 -0.028893
RPS6 ribosomal protein S6 -0.0288116
RIN2 Ras and Rab interactor 2 -0.0286891
FOXP1 forkhead box P1 -0.0284615
FOXO1 forkhead box O1 -0.0276402
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.027192
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0271002
RPS24 ribosomal protein S24 -0.0270712
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0267525
YBX3 Y box binding protein 3 -0.0265962
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0265336
MYO10 myosin X -0.0263486
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0263198
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0258135
S100A6 S100 calcium binding protein A6 -0.0255494
RPL32 ribosomal protein L32 -0.0253107
EIF1 eukaryotic translation initiation factor 1 -0.0248966
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0241596
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0239731
LOC112694756 uncharaterized LOC112694756 -0.0239302
ANLN anillin, actin binding protein -0.023588
THBD thrombomodulin -0.0235389
TM4SF1 transmembrane 4 L six family member 1 -0.0232612
RPS4X ribosomal protein S4, X-linked -0.0231981
H1-0 H1.0 linker histone -0.0230793
RPL35 ribosomal protein L35 -0.0230608
LMAN1 lectin, mannose-binding, 1 -0.0228095
CLINT1 clathrin interactor 1 -0.0227308
ITGA6 integrin, alpha 6 -0.0227285
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0226751
KIAA1217 KIAA1217 -0.022666
ACTN4 actinin, alpha 4 -0.0226377
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0225135
NRIP1 nuclear receptor interacting protein 1 -0.0224462
ENO1 enolase 1, (alpha) -0.0224
RPL5 ribosomal protein L5 -0.0222196
CNRIP1 cannabinoid receptor interacting protein 1 -0.0219339
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0218917
S100A9 S100 calcium binding protein A9 -0.021842
MECOM MDS1 and EVI1 complex locus -0.021813
PRSS23 protease, serine, 23 -0.0218037
GARS1 glycyl-tRNA synthetase 1 -0.0218033
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0217724
CDK6 cyclin-dependent kinase 6 -0.0216096
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0216008