Triamcinolone_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.180415
FAT1 FAT atypical cadherin 1 0.102137
LMO7 LIM domain 7 0.0994409
EZR ezrin 0.0963577
EEF2 eukaryotic translation elongation factor 2 0.0930043
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0797915
MYO1E myosin IE 0.0729335
MYH9 myosin, heavy chain 9, non-muscle 0.0673412
DSPP dentin sialophosphoprotein 0.0572748
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0566052
AFF1 AF4/FMR2 family, member 1 0.0552801
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0538124
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0535327
APP amyloid beta (A4) precursor protein 0.0504628
HSPA8 heat shock 70kDa protein 8 0.0490967
PLEC plectin 0.0489131
NUMA1 nuclear mitotic apparatus protein 1 0.0476006
MACF1 microtubule-actin crosslinking factor 1 0.047168
MUC13 mucin 13, cell surface associated 0.0465071
SVIL supervillin 0.0450598
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0450257
RPL3 ribosomal protein L3 0.0423592
MYO5B myosin VB 0.0423487
EXT1 exostosin glycosyltransferase 1 0.0406433
SRRM2 serine/arginine repetitive matrix 2 0.0405369
MT2A metallothionein 2A 0.0401284
ITGA6 integrin, alpha 6 0.0383825
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0364021
TGFBR3 transforming growth factor, beta receptor III 0.0359336
KRT18 keratin 18, type I 0.0356584
MYH14 myosin, heavy chain 14, non-muscle 0.0343023
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0337966
NCOR2 nuclear receptor corepressor 2 0.0335926
P4HB prolyl 4-hydroxylase, beta polypeptide 0.033321
MYO18A myosin XVIIIA 0.032905
ANXA1 annexin A1 0.0327039
PABPC1 poly(A) binding protein, cytoplasmic 1 0.032366
ONECUT3 one cut homeobox 3 0.0323442
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0322767
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0316533
BACE2 beta-site APP-cleaving enzyme 2 0.0316365
UNC13B unc-13 homolog B (C. elegans) 0.0304691
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0302062
EPHB2 EPH receptor B2 0.0296878
TMC5 transmembrane channel-like 5 0.0296801
EMP1 epithelial membrane protein 1 0.0293668
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0292795
WHRN whirlin 0.0292067
PARD3B par-3 family cell polarity regulator beta 0.0291403
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0290929
TNIP1 TNFAIP3 interacting protein 1 0.0288703
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0283472
TPM3 tropomyosin 3 0.0282621
SET SET nuclear proto-oncogene 0.0274575
B2M beta-2-microglobulin 0.0273519
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0272985
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.027187
CEMIP cell migration inducing protein, hyaluronan binding 0.026879
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0264153
ATF3 activating transcription factor 3 0.0263363
PTPRF protein tyrosine phosphatase, receptor type, F 0.0261847
MED13 mediator complex subunit 13 0.0256216
LOC112694756 uncharaterized LOC112694756 0.0256152
FOS FBJ murine osteosarcoma viral oncogene homolog 0.025374
GRB10 growth factor receptor-bound protein 10 0.0253423
SNX9 sorting nexin 9 0.0252598
KMT2D lysine (K)-specific methyltransferase 2D 0.0251605
JUN jun proto-oncogene 0.0249993
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.024924
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0248169
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0247228
KRT8 keratin 8, type II 0.0244857
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0244527
ARHGAP42 Rho GTPase activating protein 42 0.0243342
CCNY cyclin Y 0.0243134
FBXO32 F-box protein 32 0.0240731
MINK1 misshapen-like kinase 1 0.0240295
AKAP12 A kinase (PRKA) anchor protein 12 0.0239733
RORA RAR-related orphan receptor A 0.0238526
PDZD8 PDZ domain containing 8 0.0236749
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.0236528
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0236287
LOC102724023 ES1 protein homolog, mitochondrial 0.0235767
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0235406
SIK3 SIK family kinase 3 0.0227116
CALR calreticulin 0.0226322
TMSB4X thymosin beta 4, X-linked 0.0225764
LMNA lamin A/C 0.0225428
PTPRK protein tyrosine phosphatase, receptor type, K 0.0218897
KLF6 Kruppel-like factor 6 0.0216118
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0214587
CLIP2 CAP-GLY domain containing linker protein 2 0.0213466
MBNL1 muscleblind-like splicing regulator 1 0.0212579
SEPTIN9 septin 9 0.0212433
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0210443
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0210057
SUN1 Sad1 and UNC84 domain containing 1 0.0208854
AHI1 Abelson helper integration site 1 0.0208805
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0208545
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0208194

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.191691
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.146601
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.142761
NPSR1 neuropeptide S receptor 1 -0.116248
TMSB10 thymosin beta 10 -0.0818787
RNF43 ring finger protein 43 -0.0750952
TNS4 tensin 4 -0.0749176
RPS24 ribosomal protein S24 -0.0723767
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0684328
GMDS GDP-mannose 4,6-dehydratase -0.0677448
VCL vinculin -0.0674242
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0666172
GPHN gephyrin -0.065331
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0652373
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0634218
GOLGA4 golgin A4 -0.0632416
CD46 CD46 molecule, complement regulatory protein -0.0622162
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0617347
TPT1 tumor protein, translationally-controlled 1 -0.0612395
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0611663
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0608607
EREG epiregulin -0.0606582
MBD5 methyl-CpG binding domain protein 5 -0.0587867
DSCAM Down syndrome cell adhesion molecule -0.057153
MON2 MON2 homolog (S. cerevisiae) -0.0537352
ZFAND3 zinc finger, AN1-type domain 3 -0.0529832
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0502838
NALF1 NALCN channel auxiliary factor 1 -0.0494108
PCDHB16 protocadherin beta 16 -0.0487176
RPL9 ribosomal protein L9 -0.0475349
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0465822
PRSS3 protease, serine, 3 -0.0462567
FERMT1 fermitin family member 1 -0.0453267
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0440214
PNISR PNN-interacting serine/arginine-rich protein -0.0430422
ANTXR2 anthrax toxin receptor 2 -0.042972
RPS6 ribosomal protein S6 -0.0424267
LDHA lactate dehydrogenase A -0.041589
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.041447
ACTN4 actinin, alpha 4 -0.0412023
TM9SF3 transmembrane 9 superfamily member 3 -0.0397173
PPARG peroxisome proliferator-activated receptor gamma -0.0395918
GCC2 GRIP and coiled-coil domain containing 2 -0.0392998
MBNL2 muscleblind-like splicing regulator 2 -0.0390083
USP3 ubiquitin specific peptidase 3 -0.0386155
SERINC5 serine incorporator 5 -0.038527
NFIA nuclear factor I/A -0.0385058
INSIG1 insulin induced gene 1 -0.0379507
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0375156
PERP PERP, TP53 apoptosis effector -0.0373436
PRELID2 PRELI domain containing 2 -0.0372913
NCOR1 nuclear receptor corepressor 1 -0.0365571
OGA O-GlcNAcase -0.0363617
RPL5 ribosomal protein L5 -0.0353626
SEC24D SEC24 family member D -0.0353231
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0351891
RAP1B RAP1B, member of RAS oncogene family -0.0346289
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0345575
DERA deoxyribose-phosphate aldolase (putative) -0.0343807
HMGA1 high mobility group AT-hook 1 -0.0343173
RBM39 RNA binding motif protein 39 -0.0340075
NKTR natural killer cell triggering receptor -0.0338768
DLG1 discs, large homolog 1 (Drosophila) -0.0337566
FNDC3B fibronectin type III domain containing 3B -0.0332065
RNF145 ring finger protein 145 -0.0329578
RPLP2 ribosomal protein, large, P2 -0.032935
EHF ets homologous factor -0.032815
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0325055
FAM13A family with sequence similarity 13, member A -0.0323241
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0322061
NT5C2 5'-nucleotidase, cytosolic II -0.0318603
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0314544
RPL26 ribosomal protein L26 -0.0314501
TRIM2 tripartite motif containing 2 -0.0310118
NBAS neuroblastoma amplified sequence -0.0307776
EXOC1 exocyst complex component 1 -0.0307492
RPS19 ribosomal protein S19 -0.0307293
MED13L mediator complex subunit 13-like -0.0307187
RPL37A ribosomal protein L37a -0.0300881
COG5 component of oligomeric golgi complex 5 -0.0296825
BIRC6 baculoviral IAP repeat containing 6 -0.0296578
S100P S100 calcium binding protein P -0.0296376
MYOF myoferlin -0.0294923
PKM pyruvate kinase, muscle -0.029423
ETNK1 ethanolamine kinase 1 -0.0292477
TAS2R14 taste receptor, type 2, member 14 -0.0290646
GSK3B glycogen synthase kinase 3 beta -0.0290397
TMEM135 transmembrane protein 135 -0.029005
ZNF292 zinc finger protein 292 -0.0290012
IER3 immediate early response 3 -0.0289645
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0289552
NF1 neurofibromin 1 -0.0289128
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0287384
ARHGAP32 Rho GTPase activating protein 32 -0.0286994
ITGB4 integrin, beta 4 -0.0285802
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0285222
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0282441
MAML2 mastermind-like 2 (Drosophila) -0.0281514
TRA2A transformer 2 alpha homolog (Drosophila) -0.028073
ZMYM2 zinc finger, MYM-type 2 -0.0279977