Triamcinolone_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.154011
TP63 tumor protein p63 0.139783
CD44 CD44 molecule (Indian blood group) 0.139022
DST dystonin 0.120784
MT1E metallothionein 1E 0.117921
PSD3 pleckstrin and Sec7 domain containing 3 0.115871
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.103321
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0975938
MT2A metallothionein 2A 0.0836406
HLA-B major histocompatibility complex, class I, B 0.0817446
ZDHHC14 zinc finger, DHHC-type containing 14 0.0793005
TSC22D1 TSC22 domain family, member 1 0.073069
CADM2 cell adhesion molecule 2 0.0709764
RPS12 ribosomal protein S12 0.0707225
MACF1 microtubule-actin crosslinking factor 1 0.0673438
RPS10 ribosomal protein S10 0.0638881
DNER delta/notch-like EGF repeat containing 0.0630493
BCAR3 breast cancer anti-estrogen resistance 3 0.0621599
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0614541
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0572853
EEF2 eukaryotic translation elongation factor 2 0.0539747
RUNX1 runt-related transcription factor 1 0.0528658
CAPRIN2 caprin family member 2 0.0514206
RPL37A ribosomal protein L37a 0.0502417
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0474718
APP amyloid beta (A4) precursor protein 0.0462383
SLK STE20-like kinase 0.0448717
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0424921
ESYT2 extended synaptotagmin-like protein 2 0.041371
DPYD dihydropyrimidine dehydrogenase 0.041022
ANGPTL4 angiopoietin-like 4 0.0405733
PIAS2 protein inhibitor of activated STAT, 2 0.0398841
B2M beta-2-microglobulin 0.0396691
PTPRF protein tyrosine phosphatase, receptor type, F 0.0392807
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0368464
NPAS2 neuronal PAS domain protein 2 0.0358707
RAB27B RAB27B, member RAS oncogene family 0.035755
RAD51B RAD51 paralog B 0.0355025
CSMD3 CUB and Sushi multiple domains 3 0.035257
PLSCR1 phospholipid scramblase 1 0.0348118
PLEC plectin 0.034511
BIRC3 baculoviral IAP repeat containing 3 0.0332547
JUN jun proto-oncogene 0.0329727
RIGI RNA sensor RIG-I 0.0321965
LPP LIM domain containing preferred translocation partner in lipoma 0.0321327
HDAC9 histone deacetylase 9 0.0317173
FTH1 ferritin, heavy polypeptide 1 0.0315354
PRELID2 PRELI domain containing 2 0.03151
GYS1 glycogen synthase 1 (muscle) 0.0308214
TRIM56 tripartite motif containing 56 0.0303252
MT1X metallothionein 1X 0.0302349
RPS8 ribosomal protein S8 0.03016
PLK2 polo-like kinase 2 0.0298744
RACK1 receptor for activated C kinase 1 0.0292532
RPS3 ribosomal protein S3 0.0288813
SMYD3 SET and MYND domain containing 3 0.0287916
EPHA4 EPH receptor A4 0.0286806
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0286684
TNS3 tensin 3 0.0283152
ENO2 enolase 2 (gamma, neuronal) 0.0281806
PCDH1 protocadherin 1 0.0281792
IFI6 interferon, alpha-inducible protein 6 0.0280494
AHNAK2 AHNAK nucleoprotein 2 0.0273188
KRT18 keratin 18, type I 0.0267631
SUMF1 sulfatase modifying factor 1 0.0264948
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.02649
RNF213 ring finger protein 213 0.0264781
TNIP1 TNFAIP3 interacting protein 1 0.0261715
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0260581
RPS17 ribosomal protein S17 0.0259966
EHBP1 EH domain binding protein 1 0.0256982
RPL36A ribosomal protein L36a 0.0255399
SOD2 superoxide dismutase 2, mitochondrial 0.0252984
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0249352
CEP250 centrosomal protein 250kDa 0.024879
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0247443
VEGFA vascular endothelial growth factor A 0.0245197
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.024018
ZFP36L1 ZFP36 ring finger protein-like 1 0.0238104
TPRG1 tumor protein p63 regulated 1 0.0235702
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0232055
LYST lysosomal trafficking regulator 0.0230942
NONO non-POU domain containing, octamer-binding 0.0230272
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0225836
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0225323
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0225114
ERRFI1 ERBB receptor feedback inhibitor 1 0.022371
KTN1 kinectin 1 (kinesin receptor) 0.0221932
DOCK11 dedicator of cytokinesis 11 0.022028
MYO18A myosin XVIIIA 0.0218916
RPS27 ribosomal protein S27 0.0218615
PODXL podocalyxin-like 0.0215892
PMP22 peripheral myelin protein 22 0.0215659
PDE10A phosphodiesterase 10A 0.0212882
DPYSL2 dihydropyrimidinase-like 2 0.0211338
ITGB4 integrin, beta 4 0.0210857
EGFR epidermal growth factor receptor 0.0210737
RAD50 RAD50 homolog (S. cerevisiae) 0.0210409
FKBP5 FK506 binding protein 5 0.0209708
FBXL4 F-box and leucine-rich repeat protein 4 0.0209303

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.345804
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.177565
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.171433
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143612
TXNRD1 thioredoxin reductase 1 -0.136046
PTMA prothymosin, alpha -0.099325
TM4SF1 transmembrane 4 L six family member 1 -0.0912878
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0840304
TMSB10 thymosin beta 10 -0.075104
CENPF centromere protein F, 350/400kDa -0.0740429
RAI1 retinoic acid induced 1 -0.0629595
SMC4 structural maintenance of chromosomes 4 -0.0533286
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0526906
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0496089
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.049087
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0485064
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0466404
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.046136
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0461103
GARS1 glycyl-tRNA synthetase 1 -0.0456744
USP34 ubiquitin specific peptidase 34 -0.0454498
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0452335
EIF1 eukaryotic translation initiation factor 1 -0.0440273
TMEM41B transmembrane protein 41B -0.0418821
HDLBP high density lipoprotein binding protein -0.0411429
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0410727
AHNAK AHNAK nucleoprotein -0.0397606
PRDX1 peroxiredoxin 1 -0.0384876
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0383191
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0377264
MKI67 marker of proliferation Ki-67 -0.0374335
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0373198
RTN4 reticulon 4 -0.0367031
KMT2E lysine (K)-specific methyltransferase 2E -0.0355512
RPL5 ribosomal protein L5 -0.0354791
KPNB1 karyopherin (importin) beta 1 -0.0346282
RPS6 ribosomal protein S6 -0.0344427
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0343687
SEPTIN7 septin 7 -0.034139
RRM2 ribonucleotide reductase M2 -0.0334034
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0330703
RBM25 RNA binding motif protein 25 -0.0329538
KDM3A lysine (K)-specific demethylase 3A -0.0318707
IQGAP1 IQ motif containing GTPase activating protein 1 -0.031633
GCLM glutamate-cysteine ligase, modifier subunit -0.0312205
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0307093
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0297197
DIAPH3 diaphanous-related formin 3 -0.0296541
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0295117
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.029076
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0288273
ANLN anillin, actin binding protein -0.0285603
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0283926
ADGRG6 adhesion G protein-coupled receptor G6 -0.0283575
KIF5B kinesin family member 5B -0.028348
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0282856
CANX calnexin -0.0282781
SLC38A2 solute carrier family 38, member 2 -0.028265
SON SON DNA binding protein -0.028203
ARHGAP29 Rho GTPase activating protein 29 -0.0278422
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0277249
ACTG1 actin gamma 1 -0.0275954
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0275435
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0275229
MORF4L2 mortality factor 4 like 2 -0.0273677
SGO2 shugoshin 2 -0.0271916
GOLGA4 golgin A4 -0.0270398
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0262108
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0260287
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0258315
ECT2 epithelial cell transforming 2 -0.0257895
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0252488
GAN gigaxonin -0.0252313
ANXA1 annexin A1 -0.0251355
TNPO1 transportin 1 -0.0247411
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0247225
RBM39 RNA binding motif protein 39 -0.0247076
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0246764
FTL ferritin, light polypeptide -0.0246067
RPLP1 ribosomal protein, large, P1 -0.024597
GLS2 glutaminase 2 (liver, mitochondrial) -0.0245752
ARID4B AT rich interactive domain 4B (RBP1-like) -0.024553
ZEB1 zinc finger E-box binding homeobox 1 -0.0244293
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0240812
JMJD1C jumonji domain containing 1C -0.0240451
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0239471
ZFAND3 zinc finger, AN1-type domain 3 -0.0236692
WDR45B WD repeat domain 45B -0.0236367
SLC38A1 solute carrier family 38, member 1 -0.0236167
CELF1 CUGBP, Elav-like family member 1 -0.0236046
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0233659
FLNB filamin B, beta -0.023287
RPL13A ribosomal protein L13a -0.0231644
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.023143
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0230312
MYL12B myosin, light chain 12B, regulatory -0.0228433
KIF14 kinesin family member 14 -0.0227328
DEK DEK proto-oncogene -0.0226182
NSD2 nuclear receptor binding SET domain protein 2 -0.0225683
ETNK1 ethanolamine kinase 1 -0.0224995