Triamcinolone_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SDK1 sidekick cell adhesion molecule 1 0.108881
HMGA2 high mobility group AT-hook 2 0.103707
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0990821
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0845415
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0843142
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0799562
HIPK2 homeodomain interacting protein kinase 2 0.0668339
VEGFA vascular endothelial growth factor A 0.065857
TGM2 transglutaminase 2 0.0630891
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0617592
HDAC4 histone deacetylase 4 0.0604197
EFNA5 ephrin-A5 0.0603955
FAM20C family with sequence similarity 20, member C 0.0562558
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0550868
SMAD3 SMAD family member 3 0.0543873
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0519701
INTS6 integrator complex subunit 6 0.0497017
PCBP2 poly(rC) binding protein 2 0.0484965
EEF2 eukaryotic translation elongation factor 2 0.0457587
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0457583
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0443136
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0437892
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0415093
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0411799
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0400985
AADAC arylacetamide deacetylase 0.0398711
AKAP12 A kinase (PRKA) anchor protein 12 0.0397442
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.038144
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0368792
NAV2 neuron navigator 2 0.0365734
NCOR2 nuclear receptor corepressor 2 0.0360922
MCL1 myeloid cell leukemia 1 0.0355186
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0347684
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0341892
EPS8 epidermal growth factor receptor pathway substrate 8 0.0336017
SEPTIN9 septin 9 0.0332955
ZSWIM6 zinc finger, SWIM-type containing 6 0.0331284
LOXL2 lysyl oxidase-like 2 0.0330352
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0326144
ASPH aspartate beta-hydroxylase 0.0325901
MYH9 myosin, heavy chain 9, non-muscle 0.0318201
IFI44L interferon-induced protein 44-like 0.0313495
FKBP5 FK506 binding protein 5 0.0306212
ZNF638 zinc finger protein 638 0.030436
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0298041
TOP1 topoisomerase (DNA) I 0.0296525
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0293033
FLNA filamin A, alpha 0.0292196
NEBL nebulette 0.0286895
R3HDM2 R3H domain containing 2 0.0285654
SOD2 superoxide dismutase 2, mitochondrial 0.0285095
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0282787
CEP250 centrosomal protein 250kDa 0.0281761
APLP2 amyloid beta (A4) precursor-like protein 2 0.0278512
NDRG1 N-myc downstream regulated 1 0.0269957
RERE arginine-glutamic acid dipeptide (RE) repeats 0.02658
MLPH melanophilin 0.0265726
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0265215
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0261277
RHCG Rh family, C glycoprotein 0.0259114
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0258136
DOCK5 dedicator of cytokinesis 5 0.0248122
PLEC plectin 0.0242762
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0240803
RNF144A ring finger protein 144A 0.0240198
MICALL2 MICAL-like 2 0.0237844
ZFYVE28 zinc finger, FYVE domain containing 28 0.0235364
TIMP2 TIMP metallopeptidase inhibitor 2 0.0234627
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0232664
CNOT12 CCR4-NOT transcription complex subunit 12 0.0231074
NPAS2 neuronal PAS domain protein 2 0.0228581
PDLIM5 PDZ and LIM domain 5 0.0228253
WWOX WW domain containing oxidoreductase 0.02281
SH3RF3 SH3 domain containing ring finger 3 0.0223487
RUNX1 runt-related transcription factor 1 0.0223115
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0222571
GSE1 Gse1 coiled-coil protein 0.0222034
FLNB filamin B, beta 0.0220728
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0219141
MBNL1 muscleblind-like splicing regulator 1 0.0218952
KSR1 kinase suppressor of ras 1 0.0214918
ATXN1 ataxin 1 0.021422
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.021407
NABP1 nucleic acid binding protein 1 0.0213909
MSN moesin 0.0213065
ZNF469 zinc finger protein 469 0.0212078
SHB Src homology 2 domain containing adaptor protein B 0.0209828
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0204888
AVIL advillin 0.0200624
FOXL1 forkhead box L1 0.019909
CCSER1 coiled-coil serine-rich protein 1 0.0198627
RAD51B RAD51 paralog B 0.0197865
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0196101
TGFB1 transforming growth factor, beta 1 0.019477
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0194045
INTS1 integrator complex subunit 1 0.0191298
PTK2 protein tyrosine kinase 2 0.0190154
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0188694
DOCK1 dedicator of cytokinesis 1 0.0188679
GPHN gephyrin 0.018666

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.207717
NAMPT nicotinamide phosphoribosyltransferase -0.168757
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.143172
VIM vimentin -0.102073
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0977832
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0905346
IGFBP3 insulin-like growth factor binding protein 3 -0.0849631
GOLGA4 golgin A4 -0.0834814
LMAN1 lectin, mannose-binding, 1 -0.0815462
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0810069
TMSB10 thymosin beta 10 -0.0808748
OSMR oncostatin M receptor -0.0778129
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.069836
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0662019
LOX lysyl oxidase -0.0631928
PSD3 pleckstrin and Sec7 domain containing 3 -0.0631176
ENO1 enolase 1, (alpha) -0.0608635
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0594459
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0577044
KDM3A lysine (K)-specific demethylase 3A -0.0576347
CD44 CD44 molecule (Indian blood group) -0.0570824
RAI14 retinoic acid induced 14 -0.0565516
CDCP1 CUB domain containing protein 1 -0.0560331
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0552921
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0538952
MAP1B microtubule-associated protein 1B -0.0535658
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0533344
RAB27B RAB27B, member RAS oncogene family -0.0533284
DPYD dihydropyrimidine dehydrogenase -0.0529277
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0520781
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0515246
PTMA prothymosin, alpha -0.0509298
ZMYND8 zinc finger, MYND-type containing 8 -0.050868
PGK1 phosphoglycerate kinase 1 -0.0499209
MEF2A myocyte enhancer factor 2A -0.0490894
IER3 immediate early response 3 -0.0482672
ARHGAP5 Rho GTPase activating protein 5 -0.0477045
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0452799
USP34 ubiquitin specific peptidase 34 -0.0451694
GCC2 GRIP and coiled-coil domain containing 2 -0.0443746
EIF1 eukaryotic translation initiation factor 1 -0.044175
FN1 fibronectin 1 -0.0440101
ZEB2 zinc finger E-box binding homeobox 2 -0.0439018
RBM39 RNA binding motif protein 39 -0.0428398
FAM13A family with sequence similarity 13, member A -0.0420172
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0418969
ZBTB20 zinc finger and BTB domain containing 20 -0.0415158
CANX calnexin -0.0403345
DST dystonin -0.039629
RIOK3 RIO kinase 3 -0.0393315
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0391892
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0391467
TFPI2 tissue factor pathway inhibitor 2 -0.0390651
PTPRR protein tyrosine phosphatase, receptor type, R -0.0389277
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0384382
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0383018
NPC1 Niemann-Pick disease, type C1 -0.0381636
GPC6 glypican 6 -0.0378616
FBXL13 F-box and leucine-rich repeat protein 13 -0.0377617
FTL ferritin, light polypeptide -0.0365994
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0362403
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0356387
SYT1 synaptotagmin I -0.0353946
MAP4 microtubule-associated protein 4 -0.035221
ZNF292 zinc finger protein 292 -0.0351542
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0350164
S100A6 S100 calcium binding protein A6 -0.0344651
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0344227
COL12A1 collagen, type XII, alpha 1 -0.0342908
NPEPPS aminopeptidase puromycin sensitive -0.0336962
LRRC49 leucine rich repeat containing 49 -0.0333306
TMEM263 transmembrane protein 263 -0.033247
ELL2 elongation factor, RNA polymerase II, 2 -0.0331042
RAB1A RAB1A, member RAS oncogene family -0.0329741
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0328314
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0327785
NAV3 neuron navigator 3 -0.032599
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0323253
ETV6 ets variant 6 -0.0321061
SAMD9 sterile alpha motif domain containing 9 -0.0320133
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0313209
FNBP1 formin binding protein 1 -0.0312126
NCOA7 nuclear receptor coactivator 7 -0.0311359
JMJD1C jumonji domain containing 1C -0.0310822
KMT2E lysine (K)-specific methyltransferase 2E -0.0310139
AKAP9 A kinase (PRKA) anchor protein 9 -0.0308548
TPM4 tropomyosin 4 -0.0305098
C15ORF48 chromosome 15 open reading frame 48 -0.0296966
MECOM MDS1 and EVI1 complex locus -0.0296677
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0296548
DENND4A DENN/MADD domain containing 4A -0.0294125
PRRC2C proline-rich coiled-coil 2C -0.0292706
NF1 neurofibromin 1 -0.0291937
BTG1 B-cell translocation gene 1, anti-proliferative -0.029162
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0288325
SBF2 SET binding factor 2 -0.0288004
WSB1 WD repeat and SOCS box containing 1 -0.028496
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0284712
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0284698
ANTXR2 anthrax toxin receptor 2 -0.0281203