Triamcinolone_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.251254
AKAP13 A kinase (PRKA) anchor protein 13 0.208073
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.191119
ESYT2 extended synaptotagmin-like protein 2 0.122149
EFNA5 ephrin-A5 0.120457
HSPH1 heat shock 105kDa/110kDa protein 1 0.119285
TOP1 topoisomerase (DNA) I 0.108177
ERRFI1 ERBB receptor feedback inhibitor 1 0.103398
IRS2 insulin receptor substrate 2 0.096351
EZR ezrin 0.0946591
RNF145 ring finger protein 145 0.0941067
DSPP dentin sialophosphoprotein 0.0910297
NCOA3 nuclear receptor coactivator 3 0.090866
ELL2 elongation factor, RNA polymerase II, 2 0.0905487
PLEC plectin 0.0874825
S100P S100 calcium binding protein P 0.084018
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0819941
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0785336
KRT6A keratin 6A, type II 0.0756833
HSPA8 heat shock 70kDa protein 8 0.0752335
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.073443
BACE2 beta-site APP-cleaving enzyme 2 0.0721042
NDRG1 N-myc downstream regulated 1 0.0714063
ANXA2 annexin A2 0.0657554
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.062915
NIBAN2 niban apoptosis regulator 2 0.0611795
MT2A metallothionein 2A 0.0609223
KLF6 Kruppel-like factor 6 0.0603997
PTPRM protein tyrosine phosphatase, receptor type, M 0.0588132
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0572335
AHNAK AHNAK nucleoprotein 0.0570153
AGFG1 ArfGAP with FG repeats 1 0.0560242
PM20D1 peptidase M20 domain containing 1 0.0544728
VCL vinculin 0.0543229
FKBP5 FK506 binding protein 5 0.0539952
SSBP2 single-stranded DNA binding protein 2 0.0531914
BIRC3 baculoviral IAP repeat containing 3 0.0523934
ZNF292 zinc finger protein 292 0.0521114
EPS8 epidermal growth factor receptor pathway substrate 8 0.0505202
COL6A1 collagen, type VI, alpha 1 0.0501787
EGFR epidermal growth factor receptor 0.0499029
SFTPA2 surfactant protein A2 0.0496072
ADAM9 ADAM metallopeptidase domain 9 0.0495897
AKAP12 A kinase (PRKA) anchor protein 12 0.049539
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0491954
LAMC2 laminin, gamma 2 0.0487346
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.048069
GPC6 glypican 6 0.0474036
TXNIP thioredoxin interacting protein 0.046906
IGF1R insulin-like growth factor 1 receptor 0.0461327
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0443948
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0434926
RDX radixin 0.0432287
DSCAM Down syndrome cell adhesion molecule 0.0430105
HPCAL1 hippocalcin-like 1 0.0414446
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0410509
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.040846
AHNAK2 AHNAK nucleoprotein 2 0.0405791
CHD9 chromodomain helicase DNA binding protein 9 0.0400691
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0397574
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0380289
PID1 phosphotyrosine interaction domain containing 1 0.0376053
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0375672
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0373429
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0365896
KRT7 keratin 7, type II 0.0356511
TP53BP2 tumor protein p53 binding protein 2 0.0355213
YAP1 Yes-associated protein 1 0.0354714
SLC38A2 solute carrier family 38, member 2 0.0351703
LIMCH1 LIM and calponin homology domains 1 0.0349958
WAC WW domain containing adaptor with coiled-coil 0.0345667
USP53 ubiquitin specific peptidase 53 0.0343031
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0341911
FNDC3A fibronectin type III domain containing 3A 0.0340987
MPRIP myosin phosphatase Rho interacting protein 0.0339878
BCAR3 breast cancer anti-estrogen resistance 3 0.0338553
FNIP1 folliculin interacting protein 1 0.0331515
PUM2 pumilio RNA-binding family member 2 0.0328199
JAK1 Janus kinase 1 0.0327734
BCL2L1 BCL2-like 1 0.0324408
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0324003
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0323036
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0322558
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.03201
FN1 fibronectin 1 0.0316628
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0312839
ANGPTL4 angiopoietin-like 4 0.0312051
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0311301
IER5 immediate early response 5 0.031038
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.031033
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0306549
CCNY cyclin Y 0.0306085
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0305932
CTBP2 C-terminal binding protein 2 0.030541
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0305256
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0301642
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0300437
PATJ PATJ crumbs cell polarity complex component 0.0300212
RAD51B RAD51 paralog B 0.0296388
HOMER2 homer scaffolding protein 2 0.0295538

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.156373
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.1407
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116996
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0845867
EXT1 exostosin glycosyltransferase 1 -0.0843285
PTMA prothymosin, alpha -0.0841969
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0778136
SLC38A1 solute carrier family 38, member 1 -0.0775391
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0723393
TMSB10 thymosin beta 10 -0.068678
SRPK2 SRSF protein kinase 2 -0.0673245
VIM vimentin -0.0669627
GOLGA4 golgin A4 -0.0669093
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0666317
FTH1 ferritin, heavy polypeptide 1 -0.0644714
RPL35A ribosomal protein L35a -0.0630656
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0628861
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0616585
NAMPT nicotinamide phosphoribosyltransferase -0.0606423
GRB10 growth factor receptor-bound protein 10 -0.0605665
KTN1 kinectin 1 (kinesin receptor) -0.0600128
SPAG9 sperm associated antigen 9 -0.059763
S100A6 S100 calcium binding protein A6 -0.0564988
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0564173
B2M beta-2-microglobulin -0.0556993
FNDC3B fibronectin type III domain containing 3B -0.0542263
DICER1 dicer 1, ribonuclease type III -0.0531184
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0529587
KMT2C lysine (K)-specific methyltransferase 2C -0.0519753
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0510561
GCC2 GRIP and coiled-coil domain containing 2 -0.0509184
ATOSA atos homolog A -0.0504706
NPEPPS aminopeptidase puromycin sensitive -0.0494421
RPS19 ribosomal protein S19 -0.0492827
CD2AP CD2-associated protein -0.0474762
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0474651
RPL12 ribosomal protein L12 -0.0473896
NF1 neurofibromin 1 -0.0462536
H3-3B H3.3 histone B -0.046234
RPL11 ribosomal protein L11 -0.0456766
NIPBL Nipped-B homolog (Drosophila) -0.0455055
PTK2 protein tyrosine kinase 2 -0.0454695
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0450809
IER3 immediate early response 3 -0.0444129
MXD1 MAX dimerization protein 1 -0.0442143
CDK6 cyclin-dependent kinase 6 -0.04399
AFAP1 actin filament associated protein 1 -0.0432596
RNF149 ring finger protein 149 -0.0431803
AFF1 AF4/FMR2 family, member 1 -0.0431031
ZNF638 zinc finger protein 638 -0.0430235
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0427028
SNX9 sorting nexin 9 -0.0423925
RAI14 retinoic acid induced 14 -0.0421113
PICALM phosphatidylinositol binding clathrin assembly protein -0.0412319
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0405781
RPS6 ribosomal protein S6 -0.040571
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0404646
MBD5 methyl-CpG binding domain protein 5 -0.0402669
SSH2 slingshot protein phosphatase 2 -0.0396006
PGK1 phosphoglycerate kinase 1 -0.0394251
RIGI RNA sensor RIG-I -0.0394248
IFIH1 interferon induced with helicase C domain 1 -0.0394043
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0393015
ASPH aspartate beta-hydroxylase -0.0390981
DTNA dystrobrevin, alpha -0.0390684
NPTN neuroplastin -0.0389022
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0386907
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0381661
RPS8 ribosomal protein S8 -0.0379896
F3 coagulation factor III (thromboplastin, tissue factor) -0.0374076
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0371272
TRA2A transformer 2 alpha homolog (Drosophila) -0.0367255
MTDH metadherin -0.0363752
RPL31 ribosomal protein L31 -0.0362457
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0362415
AFF4 AF4/FMR2 family, member 4 -0.0361846
S100A9 S100 calcium binding protein A9 -0.0357572
PNN pinin, desmosome associated protein -0.0356816
NEK7 NIMA-related kinase 7 -0.035656
SOD2 superoxide dismutase 2, mitochondrial -0.0354908
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.035398
NAP1L1 nucleosome assembly protein 1-like 1 -0.035312
WSB1 WD repeat and SOCS box containing 1 -0.0350755
MAP1B microtubule-associated protein 1B -0.0349063
RBM47 RNA binding motif protein 47 -0.0347508
JUN jun proto-oncogene -0.0347096
BBX bobby sox homolog (Drosophila) -0.0340003
EIF1 eukaryotic translation initiation factor 1 -0.033857
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0337996
GCLC glutamate-cysteine ligase, catalytic subunit -0.0337767
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0331752
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0331465
TPT1 tumor protein, translationally-controlled 1 -0.0323437
NBEAL1 neurobeachin-like 1 -0.0321338
CANX calnexin -0.0318844
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0316286
ANKRD12 ankyrin repeat domain 12 -0.0314009
KPNB1 karyopherin (importin) beta 1 -0.0311654
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0311315
LSAMP limbic system-associated membrane protein -0.0310812