Triamcinolone_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.24787
EGR1 early growth response 1 0.142659
PDE4D phosphodiesterase 4D, cAMP-specific 0.140651
YBX3 Y box binding protein 3 0.119843
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.115275
EEF2 eukaryotic translation elongation factor 2 0.0969371
TPM3 tropomyosin 3 0.0861209
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0780716
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0721817
ELL2 elongation factor, RNA polymerase II, 2 0.0673225
MCL1 myeloid cell leukemia 1 0.0642303
PDE10A phosphodiesterase 10A 0.0615781
CSNK1A1 casein kinase 1, alpha 1 0.0602642
COPA coatomer protein complex, subunit alpha 0.0592973
GRAMD1B GRAM domain containing 1B 0.057621
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0575889
STC1 stanniocalcin 1 0.0569115
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0557508
RAB7A RAB7A, member RAS oncogene family 0.0545914
MYH9 myosin, heavy chain 9, non-muscle 0.0518586
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0514948
FUS FUS RNA binding protein 0.0470659
DOCK5 dedicator of cytokinesis 5 0.0431534
PRRC2A proline-rich coiled-coil 2A 0.0424313
SFPQ splicing factor proline/glutamine-rich 0.0423056
UBAP2L ubiquitin associated protein 2-like 0.0404961
SRSF5 serine/arginine-rich splicing factor 5 0.0396717
CEP250 centrosomal protein 250kDa 0.0395793
KRT18 keratin 18, type I 0.0378692
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.037183
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0368867
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0367086
GOLGB1 golgin B1 0.035288
BRD2 bromodomain containing 2 0.03447
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.033842
KMT2D lysine (K)-specific methyltransferase 2D 0.0334819
PUM1 pumilio RNA-binding family member 1 0.0333401
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.03233
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0323199
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0320479
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0317519
SPRED2 sprouty-related, EVH1 domain containing 2 0.0316615
NONO non-POU domain containing, octamer-binding 0.0300628
TPM2 tropomyosin 2 (beta) 0.0298096
MACF1 microtubule-actin crosslinking factor 1 0.0296884
WNK1 WNK lysine deficient protein kinase 1 0.0296649
JUN jun proto-oncogene 0.0295024
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0293999
HOMER1 homer scaffolding protein 1 0.0287853
R3HDM2 R3H domain containing 2 0.0287029
HSPA8 heat shock 70kDa protein 8 0.0284977
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0282936
IGF2 insulin-like growth factor 2 0.0282458
USP36 ubiquitin specific peptidase 36 0.0276472
AFF3 AF4/FMR2 family, member 3 0.0276191
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0269184
EPAS1 endothelial PAS domain protein 1 0.0265031
AEBP2 AE binding protein 2 0.0262364
RPL3 ribosomal protein L3 0.0257886
RAD51B RAD51 paralog B 0.0256694
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0251898
ATXN1 ataxin 1 0.0251008
FLNA filamin A, alpha 0.0249688
SDK1 sidekick cell adhesion molecule 1 0.0249374
PRH1 proline-rich protein HaeIII subfamily 1 0.0248386
VCL vinculin 0.02438
RPS10 ribosomal protein S10 0.0242823
PDLIM5 PDZ and LIM domain 5 0.0241747
INTS6 integrator complex subunit 6 0.0239601
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0239171
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0239084
APP amyloid beta (A4) precursor protein 0.023876
PRELID2 PRELI domain containing 2 0.0236271
FOSL2 FOS-like antigen 2 0.0235266
NRDC nardilysin convertase 0.0235162
SMYD3 SET and MYND domain containing 3 0.0235088
CTNND1 catenin (cadherin-associated protein), delta 1 0.0234595
MSN moesin 0.0234435
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0231826
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0228018
VMP1 vacuole membrane protein 1 0.0226783
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0224678
FMNL2 formin-like 2 0.0224348
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0222825
NIPBL Nipped-B homolog (Drosophila) 0.0221929
BCAR3 breast cancer anti-estrogen resistance 3 0.0221011
ACIN1 apoptotic chromatin condensation inducer 1 0.0216412
DCAF8 DDB1 and CUL4 associated factor 8 0.0213874
SERBP1 SERPINE1 mRNA binding protein 1 0.0213091
NUMA1 nuclear mitotic apparatus protein 1 0.0212635
LPP LIM domain containing preferred translocation partner in lipoma 0.0212285
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.021094
WDR1 WD repeat domain 1 0.0210518
MCTP1 multiple C2 domains, transmembrane 1 0.0210488
AKAP9 A kinase (PRKA) anchor protein 9 0.0209464
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0205592
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0204298
TLN1 talin 1 0.0203302
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0200908
USP9X ubiquitin specific peptidase 9, X-linked 0.0200538

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.192042
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139947
TFPI2 tissue factor pathway inhibitor 2 -0.1342
VIM vimentin -0.132054
TMSB10 thymosin beta 10 -0.0985636
PTMA prothymosin, alpha -0.0908929
AHNAK AHNAK nucleoprotein -0.0572539
RPS21 ribosomal protein S21 -0.0545676
TXNRD1 thioredoxin reductase 1 -0.0525951
RPLP1 ribosomal protein, large, P1 -0.0484748
RPL12 ribosomal protein L12 -0.0484446
ZFR zinc finger RNA binding protein -0.0476267
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0467142
TPI1 triosephosphate isomerase 1 -0.0458997
BBX bobby sox homolog (Drosophila) -0.0434169
CCND2 cyclin D2 -0.0432583
PGK1 phosphoglycerate kinase 1 -0.0414132
RPS15 ribosomal protein S15 -0.0412681
RPL34 ribosomal protein L34 -0.0411392
TAS2R14 taste receptor, type 2, member 14 -0.0410794
KDM3A lysine (K)-specific demethylase 3A -0.0386572
RPL19 ribosomal protein L19 -0.0379604
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0366457
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0363178
TRIO trio Rho guanine nucleotide exchange factor -0.0356241
RPS24 ribosomal protein S24 -0.0354708
H1-0 H1.0 linker histone -0.0347205
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0345343
CSDE1 cold shock domain containing E1, RNA-binding -0.0342654
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0340807
RTN4 reticulon 4 -0.0338967
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0337338
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0335777
RPL35A ribosomal protein L35a -0.0335664
KDM2A lysine (K)-specific demethylase 2A -0.0332481
UBB ubiquitin B -0.0330089
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0328401
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.032604
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0324609
NCOA7 nuclear receptor coactivator 7 -0.0322975
BSG basigin (Ok blood group) -0.0320926
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0320318
RPLP2 ribosomal protein, large, P2 -0.0320316
SMC4 structural maintenance of chromosomes 4 -0.0318834
OGA O-GlcNAcase -0.0318133
GLO1 glyoxalase I -0.0316075
LDHB lactate dehydrogenase B -0.0315986
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0313297
ATP5F1B ATP synthase F1 subunit beta -0.0311406
RPL32 ribosomal protein L32 -0.0309418
RPS29 ribosomal protein S29 -0.0304319
UBE2H ubiquitin-conjugating enzyme E2H -0.0300812
TNPO3 transportin 3 -0.0298429
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0293205
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0291629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0287041
RPS25 ribosomal protein S25 -0.0284416
EIF1 eukaryotic translation initiation factor 1 -0.0283749
U2SURP U2 snRNP-associated SURP domain containing -0.0282618
S100A6 S100 calcium binding protein A6 -0.0281306
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0281008
RPS20 ribosomal protein S20 -0.0277963
RPL4 ribosomal protein L4 -0.0277875
MAP4 microtubule-associated protein 4 -0.0276784
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0274402
WASF2 WAS protein family, member 2 -0.0272731
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -0.0272113
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0271576
KMT2A lysine (K)-specific methyltransferase 2A -0.0271369
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0270359
CCND1 cyclin D1 -0.0270316
RPL8 ribosomal protein L8 -0.0270102
MYL12B myosin, light chain 12B, regulatory -0.0268873
KMT2E lysine (K)-specific methyltransferase 2E -0.0268775
SINHCAF SIN3-HDAC complex associated factor -0.0268338
PFN1 profilin 1 -0.0267914
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0265297
XPO1 exportin 1 -0.0263045
PHIP pleckstrin homology domain interacting protein -0.026001
ZBTB20 zinc finger and BTB domain containing 20 -0.0257358
RPS6 ribosomal protein S6 -0.0256429
HMGA1 high mobility group AT-hook 1 -0.025635
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0253393
ZNF292 zinc finger protein 292 -0.025225
RPS5 ribosomal protein S5 -0.0244821
RPS19 ribosomal protein S19 -0.0244082
RPL13A ribosomal protein L13a -0.0238732
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0235035
MIS18BP1 MIS18 binding protein 1 -0.0233866
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0233728
RPS8 ribosomal protein S8 -0.0232168
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0231975
UBE2K ubiquitin-conjugating enzyme E2K -0.0231933
DEK DEK proto-oncogene -0.0228248
RAP1B RAP1B, member of RAS oncogene family -0.0227288
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0226415
TLK1 tousled-like kinase 1 -0.0223461
SBF2 SET binding factor 2 -0.0222547
CD2AP CD2-associated protein -0.0222009
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0221761