Triamcinolone_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.159352
MT2A metallothionein 2A 0.136152
ACTG1 actin gamma 1 0.115027
MYH9 myosin, heavy chain 9, non-muscle 0.111645
VEGFA vascular endothelial growth factor A 0.107438
ERRFI1 ERBB receptor feedback inhibitor 1 0.0908021
EEF2 eukaryotic translation elongation factor 2 0.0880254
BIRC3 baculoviral IAP repeat containing 3 0.0795694
MACF1 microtubule-actin crosslinking factor 1 0.0794191
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0763605
AKAP13 A kinase (PRKA) anchor protein 13 0.0747809
DSPP dentin sialophosphoprotein 0.0688981
FKBP5 FK506 binding protein 5 0.0659288
KRT18 keratin 18, type I 0.0651899
HOMER2 homer scaffolding protein 2 0.0645739
FLNB filamin B, beta 0.0640298
LPP LIM domain containing preferred translocation partner in lipoma 0.0619298
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0616604
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0601567
KRT8 keratin 8, type II 0.0599007
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0554218
TPM3 tropomyosin 3 0.0549378
EPS8 epidermal growth factor receptor pathway substrate 8 0.0526585
EGR1 early growth response 1 0.0517525
MSN moesin 0.0504095
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.049635
DPP4 dipeptidyl-peptidase 4 0.0491624
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0486257
LAMB3 laminin, beta 3 0.0471311
HSPA8 heat shock 70kDa protein 8 0.0466623
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0439814
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0427674
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0421647
CSNK1A1 casein kinase 1, alpha 1 0.0420875
TOP1 topoisomerase (DNA) I 0.0399189
PRRC2C proline-rich coiled-coil 2C 0.0386527
TAOK3 TAO kinase 3 0.0382298
YAP1 Yes-associated protein 1 0.0376817
IL6ST interleukin 6 signal transducer 0.0373348
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0369869
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0368745
BCL2L1 BCL2-like 1 0.0364145
POTEF POTE ankyrin domain family, member F 0.0359679
AHNAK2 AHNAK nucleoprotein 2 0.0358378
APLP2 amyloid beta (A4) precursor-like protein 2 0.0356785
MCL1 myeloid cell leukemia 1 0.0355088
WNK1 WNK lysine deficient protein kinase 1 0.0353984
ELL2 elongation factor, RNA polymerase II, 2 0.0346054
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0345293
BASP1 brain abundant, membrane attached signal protein 1 0.0345137
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0337092
ZBTB20 zinc finger and BTB domain containing 20 0.0335567
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0330361
EGFR epidermal growth factor receptor 0.0326116
KRT7 keratin 7, type II 0.0325445
PSEN1 presenilin 1 0.0321448
SSBP2 single-stranded DNA binding protein 2 0.0318193
KLF6 Kruppel-like factor 6 0.0316625
ANXA2 annexin A2 0.0310944
AHNAK AHNAK nucleoprotein 0.0309838
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.030692
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0306698
BRD2 bromodomain containing 2 0.0306435
FN1 fibronectin 1 0.0305418
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0296958
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0293898
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0293813
MBNL1 muscleblind-like splicing regulator 1 0.0292519
CFLAR CASP8 and FADD-like apoptosis regulator 0.0288507
CTSB cathepsin B 0.0282867
PTPRF protein tyrosine phosphatase, receptor type, F 0.0277281
ESYT2 extended synaptotagmin-like protein 2 0.0276726
AREG amphiregulin 0.0273796
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.027031
UGP2 UDP-glucose pyrophosphorylase 2 0.0269549
FCHO2 FCH domain only 2 0.0267388
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0263143
DOCK5 dedicator of cytokinesis 5 0.0261196
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0259762
FUS FUS RNA binding protein 0.0258446
RPL3 ribosomal protein L3 0.0255181
EFNA5 ephrin-A5 0.0254582
FLNA filamin A, alpha 0.0254113
SET SET nuclear proto-oncogene 0.0252507
IQGAP1 IQ motif containing GTPase activating protein 1 0.0251477
GOLGB1 golgin B1 0.0251065
MT1E metallothionein 1E 0.0249443
RCOR1 REST corepressor 1 0.0248393
TJP1 tight junction protein 1 0.0248116
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0246216
WSB1 WD repeat and SOCS box containing 1 0.0244678
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0243013
NIBAN2 niban apoptosis regulator 2 0.0240982
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0240866
ERBIN erbb2 interacting protein 0.0240201
NEBL nebulette 0.0240049
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.023877
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.023591
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0232914
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0232394

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.22476
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173648
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.173337
ASPH aspartate beta-hydroxylase -0.143561
GRB10 growth factor receptor-bound protein 10 -0.0811518
FTL ferritin, light polypeptide -0.0781656
HMGA1 high mobility group AT-hook 1 -0.0737385
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0726299
NAMPT nicotinamide phosphoribosyltransferase -0.0700584
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0692381
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0680893
TSC22D2 TSC22 domain family, member 2 -0.0663309
TM4SF1 transmembrane 4 L six family member 1 -0.0633335
FNDC3B fibronectin type III domain containing 3B -0.0626031
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0592698
NPEPPS aminopeptidase puromycin sensitive -0.0592222
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.057692
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.05535
TMSB10 thymosin beta 10 -0.0536568
TPT1 tumor protein, translationally-controlled 1 -0.0521026
PLAU plasminogen activator, urokinase -0.0519199
PGK1 phosphoglycerate kinase 1 -0.0517508
SQSTM1 sequestosome 1 -0.0504141
PTMA prothymosin, alpha -0.0479929
FAM13A family with sequence similarity 13, member A -0.0478558
ALCAM activated leukocyte cell adhesion molecule -0.0478368
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0465126
FAM3C family with sequence similarity 3, member C -0.0460175
RPL35A ribosomal protein L35a -0.0453963
CD2AP CD2-associated protein -0.0453742
FAM162A family with sequence similarity 162, member A -0.0452493
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0430576
RPL34 ribosomal protein L34 -0.0399597
LIMCH1 LIM and calponin homology domains 1 -0.0397982
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0392698
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0386797
GARS1 glycyl-tRNA synthetase 1 -0.0379824
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0376843
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0375019
KMT2E lysine (K)-specific methyltransferase 2E -0.0360929
IGFBP3 insulin-like growth factor binding protein 3 -0.0359272
ZNF292 zinc finger protein 292 -0.0353272
MRPS6 mitochondrial ribosomal protein S6 -0.0351837
GNAS GNAS complex locus -0.0348032
SLC38A1 solute carrier family 38, member 1 -0.0347175
RPS19 ribosomal protein S19 -0.0339901
ISG15 ISG15 ubiquitin-like modifier -0.0338835
CD46 CD46 molecule, complement regulatory protein -0.0333906
RPLP1 ribosomal protein, large, P1 -0.0332614
DTNA dystrobrevin, alpha -0.0331631
RPS24 ribosomal protein S24 -0.0327154
EPCAM epithelial cell adhesion molecule -0.0326533
CD47 CD47 molecule -0.0325206
ENO1 enolase 1, (alpha) -0.0324778
TOP2A topoisomerase (DNA) II alpha 170kDa -0.032353
ARHGAP29 Rho GTPase activating protein 29 -0.0316394
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0310037
MXD1 MAX dimerization protein 1 -0.0306711
TXNRD1 thioredoxin reductase 1 -0.0305859
C15ORF48 chromosome 15 open reading frame 48 -0.0301552
LMO7 LIM domain 7 -0.0300815
CSTB cystatin B (stefin B) -0.0299383
RPL32 ribosomal protein L32 -0.0296862
CDC73 cell division cycle 73 -0.0283982
S100A6 S100 calcium binding protein A6 -0.027686
CPNE8 copine VIII -0.0276058
LMAN1 lectin, mannose-binding, 1 -0.0275091
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0274052
SOX4 SRY (sex determining region Y)-box 4 -0.027405
NDRG1 N-myc downstream regulated 1 -0.0268841
TFG TRK-fused gene -0.0265619
SAMD4A sterile alpha motif domain containing 4A -0.0258166
RPS23 ribosomal protein S23 -0.0257577
PPARD peroxisome proliferator-activated receptor delta -0.025665
PRRC1 proline-rich coiled-coil 1 -0.0252005
OSBPL3 oxysterol binding protein-like 3 -0.0251558
USP3 ubiquitin specific peptidase 3 -0.0249441
CCND1 cyclin D1 -0.0245132
RPLP2 ribosomal protein, large, P2 -0.0244735
CDK17 cyclin-dependent kinase 17 -0.0243149
MARCHF6 membrane associated ring-CH-type finger 6 -0.0242531
TMEM123 transmembrane protein 123 -0.0241723
CAPN2 calpain 2, (m/II) large subunit -0.0241328
TMEM263 transmembrane protein 263 -0.0239045
VIM vimentin -0.0236007
MYO6 myosin VI -0.0235962
RNF145 ring finger protein 145 -0.0234352
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0231975
RPL27A ribosomal protein L27a -0.0230608
RPL12 ribosomal protein L12 -0.0230525
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0229505
RPS6 ribosomal protein S6 -0.0228551
MSI2 musashi RNA-binding protein 2 -0.0228512
TKT transketolase -0.0228457
RLF rearranged L-myc fusion -0.0228416
DSCAM Down syndrome cell adhesion molecule -0.0228339
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0228336
SH3KBP1 SH3-domain kinase binding protein 1 -0.0225825
QKI QKI, KH domain containing, RNA binding -0.0225469
TMSB4X thymosin beta 4, X-linked -0.0224643