Triamcinolone_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.158678
PM20D1 peptidase M20 domain containing 1 0.158244
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.10779
FN1 fibronectin 1 0.10464
COL5A2 collagen, type V, alpha 2 0.0892918
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0828648
DST dystonin 0.0637098
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0606746
ZEB2 zinc finger E-box binding homeobox 2 0.0565675
FMNL2 formin-like 2 0.055455
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0512817
DOCK5 dedicator of cytokinesis 5 0.0508908
CDH13 cadherin 13 0.0487621
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0470403
AGTPBP1 ATP/GTP binding protein 1 0.0432304
MAML3 mastermind-like 3 (Drosophila) 0.0425566
RAB3B RAB3B, member RAS oncogene family 0.0423961
PTPRM protein tyrosine phosphatase, receptor type, M 0.0408869
PDLIM5 PDZ and LIM domain 5 0.0406515
KYNU kynureninase 0.0388816
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0387936
WSB1 WD repeat and SOCS box containing 1 0.0378182
STC1 stanniocalcin 1 0.0363614
TBXT T-box transcription factor T 0.0345076
COL8A1 collagen, type VIII, alpha 1 0.0343053
AKAP13 A kinase (PRKA) anchor protein 13 0.0342523
EEF2 eukaryotic translation elongation factor 2 0.0337755
AKAP12 A kinase (PRKA) anchor protein 12 0.0337671
HDAC4 histone deacetylase 4 0.0334521
NTN4 netrin 4 0.0326604
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0325876
DNER delta/notch-like EGF repeat containing 0.0323409
SVIL supervillin 0.0320765
HLA-B major histocompatibility complex, class I, B 0.0306755
KIAA0825 KIAA0825 0.0301242
RPL3 ribosomal protein L3 0.0277821
SFTPA2 surfactant protein A2 0.0273038
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0271555
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0269486
RPS12 ribosomal protein S12 0.0266249
MACF1 microtubule-actin crosslinking factor 1 0.0264857
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.026261
SEPTIN9 septin 9 0.0257193
CD109 CD109 molecule 0.0245123
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0241843
SRGN serglycin 0.0241126
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0240837
LGALS3 lectin, galactoside-binding, soluble, 3 0.0239442
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0236699
MGST1 microsomal glutathione S-transferase 1 0.0236243
ZSWIM6 zinc finger, SWIM-type containing 6 0.0234142
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0231449
NALF1 NALCN channel auxiliary factor 1 0.023128
SMOC1 SPARC related modular calcium binding 1 0.0228803
SRRM2 serine/arginine repetitive matrix 2 0.0227808
CHL1 cell adhesion molecule L1-like 0.022589
IGF1R insulin-like growth factor 1 receptor 0.0225531
PTPRG protein tyrosine phosphatase, receptor type, G 0.0224839
HMGA2 high mobility group AT-hook 2 0.0221632
GRAMD1B GRAM domain containing 1B 0.0217335
RPS17 ribosomal protein S17 0.0215736
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0215023
IRS2 insulin receptor substrate 2 0.0213973
FNDC3A fibronectin type III domain containing 3A 0.0212046
CSNK1A1 casein kinase 1, alpha 1 0.0211324
GPRIN3 GPRIN family member 3 0.020988
MYH9 myosin, heavy chain 9, non-muscle 0.0205921
IGF2 insulin-like growth factor 2 0.0203243
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.0200151
FAM107B family with sequence similarity 107, member B 0.0197967
BMP6 bone morphogenetic protein 6 0.0196748
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0193512
BCAR3 breast cancer anti-estrogen resistance 3 0.0193168
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0190173
VEGFA vascular endothelial growth factor A 0.0189748
CLMP CXADR-like membrane protein 0.0184799
GPHN gephyrin 0.018418
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0183795
CD44 CD44 molecule (Indian blood group) 0.0180675
PUM1 pumilio RNA-binding family member 1 0.0176202
TPM3 tropomyosin 3 0.0175593
MAST4 microtubule associated serine/threonine kinase family member 4 0.0170922
SH3KBP1 SH3-domain kinase binding protein 1 0.0166537
GPC5 glypican 5 0.0166455
TPM4 tropomyosin 4 0.016528
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0164896
RPS3 ribosomal protein S3 0.0164604
KAT6B K(lysine) acetyltransferase 6B 0.0163774
SCARA5 scavenger receptor class A, member 5 0.0163773
ASTN2 astrotactin 2 0.0163492
CTSL cathepsin L 0.0162237
TMX4 thioredoxin-related transmembrane protein 4 0.0160636
PLK2 polo-like kinase 2 0.016051
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0159888
MYPN myopalladin 0.0159591
AOPEP aminopeptidase O (putative) 0.0157535
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0155784
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0155571
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0155405
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0153803

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228806
ASPH aspartate beta-hydroxylase -0.159808
EFNA5 ephrin-A5 -0.14005
PDE4D phosphodiesterase 4D, cAMP-specific -0.134108
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.129183
MYOF myoferlin -0.128817
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126878
PSD3 pleckstrin and Sec7 domain containing 3 -0.103412
NAMPT nicotinamide phosphoribosyltransferase -0.0940555
LIMCH1 LIM and calponin homology domains 1 -0.0901683
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0892655
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0870032
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0822851
FTL ferritin, light polypeptide -0.0819223
TFPI2 tissue factor pathway inhibitor 2 -0.0728636
RPS6 ribosomal protein S6 -0.0675141
TXNRD1 thioredoxin reductase 1 -0.066135
NRCAM neuronal cell adhesion molecule -0.0651714
RPLP1 ribosomal protein, large, P1 -0.064439
TMSB10 thymosin beta 10 -0.0622318
TM4SF1 transmembrane 4 L six family member 1 -0.0621314
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0620915
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0615793
PDE10A phosphodiesterase 10A -0.0604214
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0544253
PCBP3 poly(rC) binding protein 3 -0.0541875
NAP1L1 nucleosome assembly protein 1-like 1 -0.0500293
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0483289
RTN4 reticulon 4 -0.0483278
FNDC3B fibronectin type III domain containing 3B -0.0451773
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0448998
LSAMP limbic system-associated membrane protein -0.0446868
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0439348
TGFBR1 transforming growth factor, beta receptor 1 -0.0425389
SPAG9 sperm associated antigen 9 -0.042329
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.042146
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0395423
PRDX1 peroxiredoxin 1 -0.039068
EIF1 eukaryotic translation initiation factor 1 -0.0390074
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0386343
RPL12 ribosomal protein L12 -0.0385058
PGK1 phosphoglycerate kinase 1 -0.0381971
PALLD palladin, cytoskeletal associated protein -0.03811
ZNF292 zinc finger protein 292 -0.0374599
IGFBP3 insulin-like growth factor binding protein 3 -0.0371231
ACTG1 actin gamma 1 -0.0371162
OGA O-GlcNAcase -0.0369518
KMT2C lysine (K)-specific methyltransferase 2C -0.0369475
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0364841
GOLGA4 golgin A4 -0.0360157
DOCK4 dedicator of cytokinesis 4 -0.0347
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0345911
NBEAL1 neurobeachin-like 1 -0.0343813
PRKN parkin RBR E3 ubiquitin protein ligase -0.033899
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0331615
PDE7B phosphodiesterase 7B -0.0330246
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0323052
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0321859
NCOA7 nuclear receptor coactivator 7 -0.0314164
PTMA prothymosin, alpha -0.0303191
USP34 ubiquitin specific peptidase 34 -0.0299644
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.029679
VCL vinculin -0.029542
MORF4L2 mortality factor 4 like 2 -0.0294679
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0293805
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0287424
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0286474
LMAN1 lectin, mannose-binding, 1 -0.0284935
MBD5 methyl-CpG binding domain protein 5 -0.0281867
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0280568
RPL23 ribosomal protein L23 -0.028041
TRIO trio Rho guanine nucleotide exchange factor -0.0279605
IER3 immediate early response 3 -0.0274024
RPL19 ribosomal protein L19 -0.0273506
PRRC2C proline-rich coiled-coil 2C -0.0270811
MCTP1 multiple C2 domains, transmembrane 1 -0.0263512
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0262095
PLCB4 phospholipase C, beta 4 -0.0261346
METTL15 methyltransferase like 15 -0.0260584
RPL35A ribosomal protein L35a -0.0260412
PNISR PNN-interacting serine/arginine-rich protein -0.0257292
ARID4B AT rich interactive domain 4B (RBP1-like) -0.025625
CENPF centromere protein F, 350/400kDa -0.0255754
CREB5 cAMP responsive element binding protein 5 -0.0254815
RPLP2 ribosomal protein, large, P2 -0.0251537
PTGR1 prostaglandin reductase 1 -0.0250978
PTPRD protein tyrosine phosphatase, receptor type, D -0.0250857
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0250732
ELL2 elongation factor, RNA polymerase II, 2 -0.0250145
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0249612
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0248674
RAI1 retinoic acid induced 1 -0.0248376
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0245908
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0244409
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0241951
RPL28 ribosomal protein L28 -0.0241832
BIRC6 baculoviral IAP repeat containing 6 -0.0241322
MATR3 matrin 3 -0.0237579
ATP5F1B ATP synthase F1 subunit beta -0.0235323
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0235226