Triamcinolone_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.307863
SMAD3 SMAD family member 3 0.160562
HMGA2 high mobility group AT-hook 2 0.156044
TRIO trio Rho guanine nucleotide exchange factor 0.142744
DSCAM Down syndrome cell adhesion molecule 0.142056
ASPH aspartate beta-hydroxylase 0.128061
VCL vinculin 0.120809
GLIS3 GLIS family zinc finger 3 0.118893
AHNAK AHNAK nucleoprotein 0.116575
EXT1 exostosin glycosyltransferase 1 0.113868
PRKCA protein kinase C, alpha 0.112421
ANKRD17 ankyrin repeat domain 17 0.102644
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0993069
NF1 neurofibromin 1 0.0974857
ANKRD11 ankyrin repeat domain 11 0.0898097
COL6A3 collagen, type VI, alpha 3 0.0895771
EEF2 eukaryotic translation elongation factor 2 0.085269
NAMPT nicotinamide phosphoribosyltransferase 0.0768607
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0757535
LPP LIM domain containing preferred translocation partner in lipoma 0.0723139
MCL1 myeloid cell leukemia 1 0.0719569
CANX calnexin 0.0711387
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0709512
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0694765
OXR1 oxidation resistance 1 0.0693016
PLEC plectin 0.0671612
CD44 CD44 molecule (Indian blood group) 0.0666754
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0645355
PMEPA1 prostate transmembrane protein, androgen induced 1 0.064398
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0618198
PARD3 par-3 family cell polarity regulator 0.0606793
PTK2 protein tyrosine kinase 2 0.0566475
DSPP dentin sialophosphoprotein 0.0565868
SEC31A SEC31 homolog A (S. cerevisiae) 0.0560407
MYH9 myosin, heavy chain 9, non-muscle 0.0546481
MYO10 myosin X 0.054115
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0538216
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0498383
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0490795
RPS12 ribosomal protein S12 0.0469867
SMYD3 SET and MYND domain containing 3 0.0451696
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0451341
MACF1 microtubule-actin crosslinking factor 1 0.041748
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0387128
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0384227
ATXN1 ataxin 1 0.0382127
ERRFI1 ERBB receptor feedback inhibitor 1 0.0378622
GIGYF2 GRB10 interacting GYF protein 2 0.0371532
THSD4 thrombospondin, type I, domain containing 4 0.0371367
GOLGB1 golgin B1 0.0361474
RPL35 ribosomal protein L35 0.0359036
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0356966
NAP1L1 nucleosome assembly protein 1-like 1 0.0356546
DOCK5 dedicator of cytokinesis 5 0.0352334
CXCL8 chemokine (C-X-C motif) ligand 8 0.0349274
SAMD4A sterile alpha motif domain containing 4A 0.0344089
ADGRB3 adhesion G protein-coupled receptor B3 0.0342907
VMP1 vacuole membrane protein 1 0.0342655
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0295632
COPA coatomer protein complex, subunit alpha 0.0289729
EFNA5 ephrin-A5 0.0285451
TSC22D2 TSC22 domain family, member 2 0.0273438
HELZ helicase with zinc finger 0.026887
NPAS2 neuronal PAS domain protein 2 0.026535
PM20D1 peptidase M20 domain containing 1 0.0258766
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0254502
PRRC2C proline-rich coiled-coil 2C 0.024478
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0244747
SUCO SUN domain containing ossification factor 0.0241769
FTH1 ferritin, heavy polypeptide 1 0.0238031
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0235005
NCOR1 nuclear receptor corepressor 1 0.0231976
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0230884
BIRC6 baculoviral IAP repeat containing 6 0.0229359
GPHN gephyrin 0.0207383
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0203271
RPL11 ribosomal protein L11 0.0195548
SRPK2 SRSF protein kinase 2 0.019508
DST dystonin 0.0194464
RPLP0 ribosomal protein, large, P0 0.0193374
MYO1E myosin IE 0.0186677
EHBP1 EH domain binding protein 1 0.0181909
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0173549
PRELID2 PRELI domain containing 2 0.0164848
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0158645
RAD51B RAD51 paralog B 0.0155599
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0155526
GLG1 golgi glycoprotein 1 0.0155229
OSMR oncostatin M receptor 0.0153923
CUX1 cut-like homeobox 1 0.0132043
PTPRM protein tyrosine phosphatase, receptor type, M 0.013081
MAP2K1 mitogen-activated protein kinase kinase 1 0.0125122
SPIDR scaffolding protein involved in DNA repair 0.0112248
SND1 staphylococcal nuclease and tudor domain containing 1 0.0112144
EIF1 eukaryotic translation initiation factor 1 0.0109315
PKM pyruvate kinase, muscle 0.0101057
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00953475
FNDC3B fibronectin type III domain containing 3B 0.00898569
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.00844427
KMT2E lysine (K)-specific methyltransferase 2E 0.00842997

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.16099
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.156534
FN1 fibronectin 1 -0.146015
VIM vimentin -0.139983
PDE4D phosphodiesterase 4D, cAMP-specific -0.131912
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131341
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122023
IGFBP3 insulin-like growth factor binding protein 3 -0.120633
PDE10A phosphodiesterase 10A -0.119235
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.114774
PSD3 pleckstrin and Sec7 domain containing 3 -0.096639
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0952041
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0843439
TMSB10 thymosin beta 10 -0.0814303
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0811497
PTMA prothymosin, alpha -0.0787942
FNDC3A fibronectin type III domain containing 3A -0.0739514
IGFBP5 insulin-like growth factor binding protein 5 -0.0739397
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0736452
MAML3 mastermind-like 3 (Drosophila) -0.0714029
KMT2C lysine (K)-specific methyltransferase 2C -0.069252
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0687722
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0653678
POTEF POTE ankyrin domain family, member F -0.0652703
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0651204
TMEM165 transmembrane protein 165 -0.0644246
MT2A metallothionein 2A -0.0635362
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.063477
CDH13 cadherin 13 -0.0617477
SPAG9 sperm associated antigen 9 -0.0605452
KTN1 kinectin 1 (kinesin receptor) -0.0603468
RPS6 ribosomal protein S6 -0.0596619
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0596207
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0577983
PGK1 phosphoglycerate kinase 1 -0.0543078
OGA O-GlcNAcase -0.0535595
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0531718
NDRG1 N-myc downstream regulated 1 -0.0525603
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0519159
INHBA inhibin, beta A -0.0514979
ENO1 enolase 1, (alpha) -0.050777
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.047915
GPC6 glypican 6 -0.0475861
PDLIM5 PDZ and LIM domain 5 -0.0475605
SBF2 SET binding factor 2 -0.0465838
NKD1 naked cuticle homolog 1 (Drosophila) -0.0464751
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.046276
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0441349
TXNRD1 thioredoxin reductase 1 -0.0439157
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0430794
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.042828
LAMA4 laminin, alpha 4 -0.0424777
FLNB filamin B, beta -0.0422908
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0422698
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0422672
TPT1 tumor protein, translationally-controlled 1 -0.0410242
GMDS GDP-mannose 4,6-dehydratase -0.0389063
ACTG1 actin gamma 1 -0.0383437
BACE2 beta-site APP-cleaving enzyme 2 -0.0375791
SLTM SAFB-like, transcription modulator -0.0375542
TGFBI transforming growth factor, beta-induced, 68kDa -0.0369815
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.036893
RAB6A RAB6A, member RAS oncogene family -0.0367953
RPS3 ribosomal protein S3 -0.0364722
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0346384
CHD9 chromodomain helicase DNA binding protein 9 -0.0323748
SMC5 structural maintenance of chromosomes 5 -0.0313134
LDHA lactate dehydrogenase A -0.0312019
MRPS6 mitochondrial ribosomal protein S6 -0.0306782
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0304907
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0300353
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0298359
RPL12 ribosomal protein L12 -0.0297049
PIBF1 progesterone immunomodulatory binding factor 1 -0.0284166
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0260606
JMJD1C jumonji domain containing 1C -0.0258284
FRMD4A FERM domain containing 4A -0.0250786
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0223644
ANXA2 annexin A2 -0.0221203
CEP170 centrosomal protein 170kDa -0.0217046
GOLGA4 golgin A4 -0.0209632
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0190919
PICALM phosphatidylinositol binding clathrin assembly protein -0.0186989
SLK STE20-like kinase -0.0186617
WDFY3 WD repeat and FYVE domain containing 3 -0.0181345
MON2 MON2 homolog (S. cerevisiae) -0.0172246
RSF1 remodeling and spacing factor 1 -0.0172005
FNIP1 folliculin interacting protein 1 -0.016857
RPL19 ribosomal protein L19 -0.0167493
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0162964
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0139606
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.013871
MYOF myoferlin -0.01367
ANTXR2 anthrax toxin receptor 2 -0.0136355
B2M beta-2-microglobulin -0.0136185
LMO7 LIM domain 7 -0.012475
MED13L mediator complex subunit 13-like -0.0124043
RASA3 RAS p21 protein activator 3 -0.0112301
RPL35A ribosomal protein L35a -0.00941218
ELL2 elongation factor, RNA polymerase II, 2 -0.00940984