Triamcinolone_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.10224
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0999874
HDAC9 histone deacetylase 9 0.0718652
MACF1 microtubule-actin crosslinking factor 1 0.0653299
APP amyloid beta (A4) precursor protein 0.0643284
EEF2 eukaryotic translation elongation factor 2 0.0639666
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0603302
LRRC4C leucine rich repeat containing 4C 0.0603256
NPAS3 neuronal PAS domain protein 3 0.0574548
DSCAM Down syndrome cell adhesion molecule 0.0568637
PHF21A PHD finger protein 21A 0.0560296
TBL1X transducin (beta)-like 1X-linked 0.05164
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0502095
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0499697
AKAP9 A kinase (PRKA) anchor protein 9 0.0494403
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0474531
INTS6 integrator complex subunit 6 0.0472813
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0466833
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0459999
PRRC2B proline-rich coiled-coil 2B 0.045975
CAMTA1 calmodulin binding transcription activator 1 0.0450933
MYH9 myosin, heavy chain 9, non-muscle 0.0441445
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0438645
NFIA nuclear factor I/A 0.0434706
WSB1 WD repeat and SOCS box containing 1 0.0433071
ARID1A AT rich interactive domain 1A (SWI-like) 0.0429147
GSE1 Gse1 coiled-coil protein 0.0417488
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0408489
ITGAV integrin, alpha V 0.0402134
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0402077
CHD1 chromodomain helicase DNA binding protein 1 0.0398346
ATXN2 ataxin 2 0.0396269
GREB1L growth regulation by estrogen in breast cancer-like 0.039201
FN1 fibronectin 1 0.0391627
SRRM2 serine/arginine repetitive matrix 2 0.0387577
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0385942
SAMD4A sterile alpha motif domain containing 4A 0.0381988
CTBP2 C-terminal binding protein 2 0.037017
SREBF2 sterol regulatory element binding transcription factor 2 0.036621
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.036417
KDM3A lysine (K)-specific demethylase 3A 0.0358387
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0358167
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0355729
NIPBL Nipped-B homolog (Drosophila) 0.0351668
KMT2D lysine (K)-specific methyltransferase 2D 0.0350122
DENND1A DENN/MADD domain containing 1A 0.0348605
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.0348301
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.0345911
ATOSA atos homolog A 0.0339245
WNK1 WNK lysine deficient protein kinase 1 0.0339234
APLP2 amyloid beta (A4) precursor-like protein 2 0.0337616
GPHN gephyrin 0.0337357
RCOR1 REST corepressor 1 0.0325981
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0322999
UBE3C ubiquitin protein ligase E3C 0.0322233
SARS1 seryl-tRNA synthetase 1 0.0319671
PARD3B par-3 family cell polarity regulator beta 0.0318985
TARS1 threonyl-tRNA synthetase 1 0.0317341
RBM20 RNA binding motif protein 20 0.0316626
VEGFA vascular endothelial growth factor A 0.0314767
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0314139
FKBP5 FK506 binding protein 5 0.0313155
AHCTF1 AT hook containing transcription factor 1 0.0312525
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0303671
IGF2 insulin-like growth factor 2 0.0303092
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0301187
RPS3 ribosomal protein S3 0.0299847
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0299301
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0298267
MBD5 methyl-CpG binding domain protein 5 0.0297878
NKTR natural killer cell triggering receptor 0.0294703
PDE4D phosphodiesterase 4D, cAMP-specific 0.0288783
MCL1 myeloid cell leukemia 1 0.0286223
GLS2 glutaminase 2 (liver, mitochondrial) 0.0284731
NCOA6 nuclear receptor coactivator 6 0.0283742
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0283589
KCTD16 potassium channel tetramerization domain containing 16 0.0281464
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0279419
REST RE1-silencing transcription factor 0.0279298
YAP1 Yes-associated protein 1 0.0277018
MIDEAS mitotic deacetylase associated SANT domain protein 0.0276642
SLIT2 slit homolog 2 (Drosophila) 0.0275979
EXT1 exostosin glycosyltransferase 1 0.0275923
AARS1 alanyl-tRNA synthetase 1 0.02759
ADD3 adducin 3 (gamma) 0.027417
ZFC3H1 zinc finger, C3H1-type containing 0.0273849
LMTK2 lemur tyrosine kinase 2 0.0273765
BRD2 bromodomain containing 2 0.0273407
KDM6B lysine (K)-specific demethylase 6B 0.0272984
SORBS2 sorbin and SH3 domain containing 2 0.0272637
MED13 mediator complex subunit 13 0.0272226
FUS FUS RNA binding protein 0.0270532
CALR calreticulin 0.0269111
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0268083
RPS12 ribosomal protein S12 0.02673
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0266026
ZC3H13 zinc finger CCCH-type containing 13 0.0264933
RPTOR regulatory associated protein of MTOR, complex 1 0.0264469
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.026378
RPL3 ribosomal protein L3 0.0262602

decreased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa -0.130248
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.12878
VIM vimentin -0.121802
ADGRL2 adhesion G protein-coupled receptor L2 -0.118909
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.110195
ZNF292 zinc finger protein 292 -0.0996327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0827545
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0815727
CADM2 cell adhesion molecule 2 -0.0735172
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0596845
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0568631
NRG1 neuregulin 1 -0.0564445
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0550429
TMSB10 thymosin beta 10 -0.0549002
CKAP2 cytoskeleton associated protein 2 -0.0526117
SMC4 structural maintenance of chromosomes 4 -0.0521404
GPC3 glypican 3 -0.0520772
RASAL2 RAS protein activator like 2 -0.0503558
COL1A2 collagen, type I, alpha 2 -0.0494311
CENPE centromere protein E, 312kDa -0.0485021
METAP2 methionyl aminopeptidase 2 -0.0480637
MKI67 marker of proliferation Ki-67 -0.0480291
MRPS30 mitochondrial ribosomal protein S30 -0.0474894
TPX2 TPX2, microtubule-associated -0.0460609
EMP1 epithelial membrane protein 1 -0.0446669
COL5A2 collagen, type V, alpha 2 -0.0437672
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0433789
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0432621
TSC22D2 TSC22 domain family, member 2 -0.0419653
RAI1 retinoic acid induced 1 -0.0419063
SGO2 shugoshin 2 -0.0417937
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0414264
CENPF centromere protein F, 350/400kDa -0.0409066
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0405587
KIF4A kinesin family member 4A -0.0405126
USP3 ubiquitin specific peptidase 3 -0.040219
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.040087
CSMD3 CUB and Sushi multiple domains 3 -0.0397198
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E -0.0397151
CCDC88A coiled-coil domain containing 88A -0.0393643
RTN4 reticulon 4 -0.0387198
TEX11 testis expressed 11 -0.037199
PTMA prothymosin, alpha -0.0336838
ATP5F1B ATP synthase F1 subunit beta -0.033466
HMGB1 high mobility group box 1 -0.032528
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0324846
MAP4 microtubule-associated protein 4 -0.0324466
RPS16 ribosomal protein S16 -0.0322874
DIAPH3 diaphanous-related formin 3 -0.0316434
ANXA2 annexin A2 -0.0313932
PDS5A PDS5 cohesin associated factor A -0.031068
POTEF POTE ankyrin domain family, member F -0.0305568
RPS27A ribosomal protein S27a -0.0301154
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0298119
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0296795
PROS1 protein S (alpha) -0.0293467
RPLP1 ribosomal protein, large, P1 -0.028897
ZFPM2 zinc finger protein, FOG family member 2 -0.028842
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0278317
ADAM9 ADAM metallopeptidase domain 9 -0.0275083
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0274476
NHSL1 NHS-like 1 -0.0272917
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0271158
RHOA ras homolog family member A -0.0270639
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0268998
CAVIN1 caveolae associated protein 1 -0.0268601
MORF4L2 mortality factor 4 like 2 -0.0267746
TMEM123 transmembrane protein 123 -0.0265874
DEK DEK proto-oncogene -0.0260418
CDC27 cell division cycle 27 -0.0258109
RTN3 reticulon 3 -0.0256981
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0256376
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0253713
ARHGAP12 Rho GTPase activating protein 12 -0.0252331
CDC73 cell division cycle 73 -0.025144
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0251033
PHACTR4 phosphatase and actin regulator 4 -0.0250333
PRR11 proline rich 11 -0.0249757
RHEB Ras homolog enriched in brain -0.0249453
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0246495
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0245872
COL3A1 collagen, type III, alpha 1 -0.0243398
AHNAK AHNAK nucleoprotein -0.024307
CLINT1 clathrin interactor 1 -0.0242599
NRXN1 neurexin 1 -0.0242001
TRPS1 trichorhinophalangeal syndrome I -0.0241776
PTK2 protein tyrosine kinase 2 -0.0241772
MCTP1 multiple C2 domains, transmembrane 1 -0.0238617
TMSB4X thymosin beta 4, X-linked -0.0238292
ZNF385D zinc finger protein 385D -0.0238149
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0237294
PBX3 pre-B-cell leukemia homeobox 3 -0.0234853
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0234715
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0234545
RACGAP1 Rac GTPase activating protein 1 -0.0230526
FST follistatin -0.0230477
FIGN fidgetin -0.0229669
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.0229635
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0229477
FAM177A1 family with sequence similarity 177, member A1 -0.0229136