Triamcinolone_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.16698
AKAP12 A kinase (PRKA) anchor protein 12 0.154416
MT1X metallothionein 1X 0.107562
VEGFA vascular endothelial growth factor A 0.102883
NDRG1 N-myc downstream regulated 1 0.0835621
FKBP5 FK506 binding protein 5 0.0549266
ANGPTL4 angiopoietin-like 4 0.050722
COL6A3 collagen, type VI, alpha 3 0.0464287
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0417059
SAA2 serum amyloid A2 0.0412158
HMGA2 high mobility group AT-hook 2 0.0406065
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0376205
TRAM2 translocation associated membrane protein 2 0.0354078
PCBP3 poly(rC) binding protein 3 0.035321
HIPK2 homeodomain interacting protein kinase 2 0.0352813
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0326158
COL5A1 collagen, type V, alpha 1 0.031179
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0309724
INTS6 integrator complex subunit 6 0.029906
TSC22D3 TSC22 domain family, member 3 0.0299049
MT1E metallothionein 1E 0.0297679
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0273158
CEP250 centrosomal protein 250kDa 0.0269262
EFNA5 ephrin-A5 0.026598
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0262644
ZMYND8 zinc finger, MYND-type containing 8 0.0261589
FBXO32 F-box protein 32 0.0259628
SAA2-SAA4 SAA2-SAA4 readthrough 0.025568
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0248099
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0245833
STC2 stanniocalcin 2 0.0244184
LOX lysyl oxidase 0.0244087
GLUL glutamate-ammonia ligase 0.0241944
RPS10 ribosomal protein S10 0.0240995
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0237194
MLPH melanophilin 0.0230526
EEF2 eukaryotic translation elongation factor 2 0.0221967
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0219082
OSBPL8 oxysterol binding protein-like 8 0.0206352
VAC14 Vac14 homolog (S. cerevisiae) 0.0205317
KLHL29 kelch-like family member 29 0.0205202
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0202436
EPAS1 endothelial PAS domain protein 1 0.0195135
BRD2 bromodomain containing 2 0.0194236
FLNB filamin B, beta 0.0192178
MACF1 microtubule-actin crosslinking factor 1 0.0189849
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0188803
SDC4 syndecan 4 0.0184472
NCOR2 nuclear receptor corepressor 2 0.0184149
GLRX glutaredoxin (thioltransferase) 0.0183027
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0170319
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0168253
FLNA filamin A, alpha 0.0166423
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0163443
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0163308
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0161529
COL27A1 collagen, type XXVII, alpha 1 0.0161333
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0161198
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0160846
NONO non-POU domain containing, octamer-binding 0.0159028
DPYD dihydropyrimidine dehydrogenase 0.0158947
IRS2 insulin receptor substrate 2 0.0158336
SEPTIN9 septin 9 0.0157147
JPH2 junctophilin 2 0.0156571
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0155288
DOCK5 dedicator of cytokinesis 5 0.015254
RPL37A ribosomal protein L37a 0.0151915
PGM3 phosphoglucomutase 3 0.0151804
NFE2L1 nuclear factor, erythroid 2-like 1 0.0151506
BACE2 beta-site APP-cleaving enzyme 2 0.0151305
CUL4B cullin 4B 0.015105
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0148163
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0144258
BASP1 brain abundant, membrane attached signal protein 1 0.0142512
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0141982
WNK1 WNK lysine deficient protein kinase 1 0.0140252
CTBP2 C-terminal binding protein 2 0.0138829
PRKCA protein kinase C, alpha 0.0135288
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0134214
STC1 stanniocalcin 1 0.01339
WWOX WW domain containing oxidoreductase 0.0133708
DEPP1 DEPP autophagy regulator 1 0.0131674
CDK19 cyclin-dependent kinase 19 0.0130925
ABHD5 abhydrolase domain containing 5 0.0130171
RPS12 ribosomal protein S12 0.012963
ADM adrenomedullin 0.012931
BCL9L B-cell CLL/lymphoma 9-like 0.012893
FAM13A family with sequence similarity 13, member A 0.0128853
ESYT2 extended synaptotagmin-like protein 2 0.0126664
ABLIM3 actin binding LIM protein family, member 3 0.0125664
PLEC plectin 0.0124464
SMC1A structural maintenance of chromosomes 1A 0.0122551
VAV2 vav 2 guanine nucleotide exchange factor 0.0121711
BCL2L1 BCL2-like 1 0.0121021
IGF1R insulin-like growth factor 1 receptor 0.0120303
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0119072
HDAC9 histone deacetylase 9 0.011857
RND3 Rho family GTPase 3 0.0116336
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0115686
PLIN2 perilipin 2 0.0114697

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.281469
FRMD4A FERM domain containing 4A -0.151827
FN1 fibronectin 1 -0.135093
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.134674
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12836
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.122354
CADM1 cell adhesion molecule 1 -0.101689
IER3 immediate early response 3 -0.0877154
SOD2 superoxide dismutase 2, mitochondrial -0.0876835
CD44 CD44 molecule (Indian blood group) -0.0812325
PGK1 phosphoglycerate kinase 1 -0.0777785
NAMPT nicotinamide phosphoribosyltransferase -0.0737204
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0714957
FNDC3B fibronectin type III domain containing 3B -0.0707349
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0689993
ELL2 elongation factor, RNA polymerase II, 2 -0.0685682
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0667629
VCAN versican -0.0667337
EXT1 exostosin glycosyltransferase 1 -0.0650618
DST dystonin -0.063297
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.063111
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0612083
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0608534
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0570909
AHNAK AHNAK nucleoprotein -0.056806
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0563462
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0557084
ENO1 enolase 1, (alpha) -0.0545495
TRIO trio Rho guanine nucleotide exchange factor -0.0539175
UBC ubiquitin C -0.0531315
PTMA prothymosin, alpha -0.0528123
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0510131
IGFBP3 insulin-like growth factor binding protein 3 -0.0498941
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0487538
UGCG UDP-glucose ceramide glucosyltransferase -0.0486729
VCL vinculin -0.0480624
THBS1 thrombospondin 1 -0.0474291
ZNF292 zinc finger protein 292 -0.0472986
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0463936
FTL ferritin, light polypeptide -0.0462328
PDE10A phosphodiesterase 10A -0.0449058
ATP13A3 ATPase type 13A3 -0.0430586
COL1A2 collagen, type I, alpha 2 -0.0422942
RTN4 reticulon 4 -0.0416731
SBF2 SET binding factor 2 -0.0410267
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0407551
DLG1 discs, large homolog 1 (Drosophila) -0.0407078
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0403954
FRMD5 FERM domain containing 5 -0.0401131
RPS6 ribosomal protein S6 -0.0400569
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0399222
ZFAND3 zinc finger, AN1-type domain 3 -0.0397705
TPM4 tropomyosin 4 -0.0397565
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0392633
SPAG9 sperm associated antigen 9 -0.0388388
TMSB10 thymosin beta 10 -0.0373663
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0371035
PCBP2 poly(rC) binding protein 2 -0.0368197
COL1A1 collagen, type I, alpha 1 -0.0358308
PLPP6 phospholipid phosphatase 6 -0.0354692
CENPF centromere protein F, 350/400kDa -0.0345269
RPS27A ribosomal protein S27a -0.0343677
GOLGA4 golgin A4 -0.0339096
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0338469
SFRP1 secreted frizzled-related protein 1 -0.0338046
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0335449
MAP4 microtubule-associated protein 4 -0.0334883
RAI14 retinoic acid induced 14 -0.0334118
KMT2E lysine (K)-specific methyltransferase 2E -0.0332648
ANLN anillin, actin binding protein -0.0331778
OGA O-GlcNAcase -0.032759
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0324044
NT5C2 5'-nucleotidase, cytosolic II -0.0322095
TMEM123 transmembrane protein 123 -0.0317668
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0313397
KDM3A lysine (K)-specific demethylase 3A -0.0309994
FRMPD4 FERM and PDZ domain containing 4 -0.0308787
JMJD1C jumonji domain containing 1C -0.0307124
GLIS3 GLIS family zinc finger 3 -0.030705
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0305774
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0304434
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0303494
TPM1 tropomyosin 1 (alpha) -0.0296515
CANX calnexin -0.0292933
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0292083
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0291332
MKI67 marker of proliferation Ki-67 -0.0289574
BICC1 BicC family RNA binding protein 1 -0.0287053
TKT transketolase -0.0286924
SMAD3 SMAD family member 3 -0.0286483
CDH13 cadherin 13 -0.0280689
CLIC4 chloride intracellular channel 4 -0.0280287
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0276922
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0271399
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0270427
LCORL ligand dependent nuclear receptor corepressor-like -0.0267656
CALD1 caldesmon 1 -0.0263072
HLA-E major histocompatibility complex, class I, E -0.0260778
LPP LIM domain containing preferred translocation partner in lipoma -0.0259035
MX1 MX dynamin-like GTPase 1 -0.0259007