Triamcinolone_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triamcinolone perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triamcinolone_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0865941
STC2 stanniocalcin 2 0.0730722
HIPK2 homeodomain interacting protein kinase 2 0.05795
GLUL glutamate-ammonia ligase 0.0496759
VEGFA vascular endothelial growth factor A 0.0468869
MT2A metallothionein 2A 0.0465736
ZSWIM6 zinc finger, SWIM-type containing 6 0.0425987
ANKRD28 ankyrin repeat domain 28 0.0418847
NRG1 neuregulin 1 0.0373644
MCL1 myeloid cell leukemia 1 0.0344418
IRS2 insulin receptor substrate 2 0.0309205
INTS6 integrator complex subunit 6 0.0308911
FN1 fibronectin 1 0.0295318
WSB1 WD repeat and SOCS box containing 1 0.0293729
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.027919
CSNK1A1 casein kinase 1, alpha 1 0.0274938
SLC38A2 solute carrier family 38, member 2 0.0267138
APLP2 amyloid beta (A4) precursor-like protein 2 0.0264452
MLPH melanophilin 0.0257999
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0249292
MACF1 microtubule-actin crosslinking factor 1 0.0247834
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0242517
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0239076
FLNA filamin A, alpha 0.0238483
LMNA lamin A/C 0.023603
EZR ezrin 0.0234441
AEBP2 AE binding protein 2 0.0232559
B2M beta-2-microglobulin 0.0232445
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0226882
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0224182
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0223644
SAMD4A sterile alpha motif domain containing 4A 0.0222217
EEF2 eukaryotic translation elongation factor 2 0.0221429
SEPTIN9 septin 9 0.0215056
BRD2 bromodomain containing 2 0.0213843
FKBP5 FK506 binding protein 5 0.0212539
SFTPA2 surfactant protein A2 0.0209994
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0207547
EGR1 early growth response 1 0.0205773
SRRM2 serine/arginine repetitive matrix 2 0.0204671
LIMCH1 LIM and calponin homology domains 1 0.0203754
FLNB filamin B, beta 0.0200548
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0199471
PER1 period circadian clock 1 0.0198062
EPAS1 endothelial PAS domain protein 1 0.0196941
HMGA2 high mobility group AT-hook 2 0.0196931
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0196656
FOS FBJ murine osteosarcoma viral oncogene homolog 0.019632
RNF213 ring finger protein 213 0.0195923
DDIT4 DNA-damage-inducible transcript 4 0.0193875
WNK1 WNK lysine deficient protein kinase 1 0.0189596
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0188313
MBNL1 muscleblind-like splicing regulator 1 0.0187244
DOCK5 dedicator of cytokinesis 5 0.0183685
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0180823
PTPRG protein tyrosine phosphatase, receptor type, G 0.018002
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0179007
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.017712
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0176432
IGF2 insulin-like growth factor 2 0.0176109
ESYT2 extended synaptotagmin-like protein 2 0.0170467
MYH9 myosin, heavy chain 9, non-muscle 0.0168364
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0167594
PDE4D phosphodiesterase 4D, cAMP-specific 0.0166567
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0165768
LOC102724023 ES1 protein homolog, mitochondrial 0.0162852
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0162365
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0160876
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0159819
SHB Src homology 2 domain containing adaptor protein B 0.0159557
FRY furry homolog (Drosophila) 0.015935
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0158032
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0156347
AOPEP aminopeptidase O (putative) 0.0155284
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0154879
PRKCA protein kinase C, alpha 0.0153358
KLHL29 kelch-like family member 29 0.015301
NEBL nebulette 0.0150859
KMT2D lysine (K)-specific methyltransferase 2D 0.0150694
TCIM transcriptional and immune response regulator 0.0149722
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0149445
FAM193B family with sequence similarity 193, member B 0.0149437
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0147869
TPM3 tropomyosin 3 0.014656
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.0146392
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0145442
PLEC plectin 0.0145291
TTC3 tetratricopeptide repeat domain 3 0.0145109
USP8 ubiquitin specific peptidase 8 0.0144506
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0143845
NCOA3 nuclear receptor coactivator 3 0.0143769
NALF1 NALCN channel auxiliary factor 1 0.014354
CLIC4 chloride intracellular channel 4 0.0143136
TOM1L2 target of myb1-like 2 (chicken) 0.0143089
CTBP2 C-terminal binding protein 2 0.0143065
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0142936
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0140555
NCOR2 nuclear receptor corepressor 2 0.0140113
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.014002
NFE2L1 nuclear factor, erythroid 2-like 1 0.0139799

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.337177
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210404
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.155143
ITGA1 integrin, alpha 1 -0.107911
CXCL8 chemokine (C-X-C motif) ligand 8 -0.105768
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0987119
SQSTM1 sequestosome 1 -0.0942147
NAMPT nicotinamide phosphoribosyltransferase -0.0909778
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0822379
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0762669
FTH1 ferritin, heavy polypeptide 1 -0.0718847
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0648308
CANX calnexin -0.0637188
AHR aryl hydrocarbon receptor -0.062766
GLIS3 GLIS family zinc finger 3 -0.0574431
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.056437
VIM vimentin -0.0549619
FNBP1 formin binding protein 1 -0.053296
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0518223
OSMR oncostatin M receptor -0.0510936
MAP1B microtubule-associated protein 1B -0.0510575
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0492035
ASPH aspartate beta-hydroxylase -0.0484946
FNDC3B fibronectin type III domain containing 3B -0.0464614
CD44 CD44 molecule (Indian blood group) -0.0445399
SYT1 synaptotagmin I -0.0440748
NRP1 neuropilin 1 -0.043276
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0421535
TRIO trio Rho guanine nucleotide exchange factor -0.0414761
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0411645
PELO pelota homolog (Drosophila) -0.0398362
MCTP2 multiple C2 domains, transmembrane 2 -0.039558
ETV1 ets variant 1 -0.0395523
PRRC2C proline-rich coiled-coil 2C -0.0393906
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0389106
LCORL ligand dependent nuclear receptor corepressor-like -0.0382561
RPS6 ribosomal protein S6 -0.0366775
ETNK1 ethanolamine kinase 1 -0.0366067
RTN4 reticulon 4 -0.0360131
OGA O-GlcNAcase -0.0345352
S100A6 S100 calcium binding protein A6 -0.0344688
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0342644
EXT1 exostosin glycosyltransferase 1 -0.0339955
TMEM156 transmembrane protein 156 -0.0339884
TXNRD1 thioredoxin reductase 1 -0.0337738
CAB39 calcium binding protein 39 -0.0337112
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0329661
PTMA prothymosin, alpha -0.0328017
CENPF centromere protein F, 350/400kDa -0.0323604
CDCP1 CUB domain containing protein 1 -0.0320645
PTBP3 polypyrimidine tract binding protein 3 -0.0318497
WDR45B WD repeat domain 45B -0.0315462
FBXW11 F-box and WD repeat domain containing 11 -0.031378
PTK2 protein tyrosine kinase 2 -0.0310451
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0306547
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0305104
GNAS GNAS complex locus -0.0300918
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0300138
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0296584
FOXP1 forkhead box P1 -0.0295985
ZNF292 zinc finger protein 292 -0.0291329
CDC73 cell division cycle 73 -0.0290039
SPAG9 sperm associated antigen 9 -0.0289824
PKM pyruvate kinase, muscle -0.0286322
ETV6 ets variant 6 -0.0285026
TM9SF3 transmembrane 9 superfamily member 3 -0.0284882
KLHL5 kelch-like family member 5 -0.0282247
RBM39 RNA binding motif protein 39 -0.027492
SMOX spermine oxidase -0.0273789
NRIP1 nuclear receptor interacting protein 1 -0.0272376
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0272152
ZFR zinc finger RNA binding protein -0.0269563
NEK7 NIMA-related kinase 7 -0.0268242
NPEPPS aminopeptidase puromycin sensitive -0.0264198
COG5 component of oligomeric golgi complex 5 -0.0261373
TMEM263 transmembrane protein 263 -0.0260641
SYNJ2 synaptojanin 2 -0.0253172
HMGA1 high mobility group AT-hook 1 -0.0252169
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.025173
FTL ferritin, light polypeptide -0.025068
TMSB10 thymosin beta 10 -0.0250491
RAB31 RAB31, member RAS oncogene family -0.024931
IER3 immediate early response 3 -0.0249156
DST dystonin -0.0247831
PNISR PNN-interacting serine/arginine-rich protein -0.0246062
NAP1L1 nucleosome assembly protein 1-like 1 -0.0245213
USP3 ubiquitin specific peptidase 3 -0.0239577
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0238583
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0238425
STAU1 staufen double-stranded RNA binding protein 1 -0.023804
TMEM165 transmembrane protein 165 -0.0235354
RAB1A RAB1A, member RAS oncogene family -0.023091
TMSB4X thymosin beta 4, X-linked -0.0230812
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0229922
EREG epiregulin -0.0229435
CLINT1 clathrin interactor 1 -0.0229258
MARCHF6 membrane associated ring-CH-type finger 6 -0.0228212
UBE2K ubiquitin-conjugating enzyme E2K -0.0227949
ARHGAP35 Rho GTPase activating protein 35 -0.0226609
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0226333